Incidental Mutation 'IGL03403:Ifna6'
ID421478
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ifna6
Ensembl Gene ENSMUSG00000101252
Gene Nameinterferon alpha 6
SynonymsIfna8, Ifa6
Accession Numbers

VEGA: OTTMUST00000026427; MGI: 107662; Ncbi RefSeq: NM_206871

Is this an essential gene? Probably non essential (E-score: 0.086) question?
Stock #IGL03403
Quality Score
Status
Chromosome4
Chromosomal Location88827416-88827985 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 88827458 bp
ZygosityHeterozygous
Amino Acid Change Serine to Glycine at position 15 (S15G)
Ref Sequence ENSEMBL: ENSMUSP00000100777 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000105146]
Predicted Effect possibly damaging
Transcript: ENSMUST00000105146
AA Change: S15G

PolyPhen 2 Score 0.693 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000100777
Gene: ENSMUSG00000101252
AA Change: S15G

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IFabd 58 175 5.8e-71 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice heterozygous for reporter allele are viable and fertile, and show normal production of interferon-alpha in response to viral infection. [provided by MGI curators]
Allele List at MGI

All alleles(1) : Targeted(1)

Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik A C 15: 8,201,342 K1034N probably damaging Het
Adamts12 T A 15: 11,241,488 I382N probably damaging Het
Adamts5 T C 16: 85,863,014 T797A probably damaging Het
Ahr A T 12: 35,504,326 V598E possibly damaging Het
Akap10 A G 11: 61,915,273 S210P probably benign Het
Asb5 G T 8: 54,583,547 probably benign Het
AU041133 T C 10: 82,138,344 V31A probably damaging Het
Bcar3 T C 3: 122,512,969 V197A probably benign Het
Bptf A G 11: 107,099,733 V510A possibly damaging Het
Ccar2 A T 14: 70,140,068 D712E probably damaging Het
Cenpt G A 8: 105,849,665 Q85* probably null Het
Ciita C A 16: 10,503,872 H98N probably damaging Het
Csn1s1 T A 5: 87,667,293 M16K probably benign Het
Fah A G 7: 84,593,209 I297T probably damaging Het
Fbxo25 A G 8: 13,929,423 N214D probably benign Het
Frem3 A C 8: 80,611,090 D4A probably benign Het
Gm12800 T C 4: 101,909,928 S125P probably benign Het
Gm3409 A G 5: 146,539,524 K162E probably benign Het
Gxylt1 T C 15: 93,261,775 D148G possibly damaging Het
Hoxd4 A T 2: 74,728,337 E168V possibly damaging Het
Iqck T A 7: 118,876,271 H97Q probably benign Het
Kif16b T A 2: 142,711,869 E1003V probably damaging Het
Lrp1b G A 2: 40,702,824 P3761L probably benign Het
Mc4r C T 18: 66,859,526 C172Y possibly damaging Het
Olfr373 A G 8: 72,100,497 T246A probably benign Het
Oosp1 T A 19: 11,687,380 N104I probably damaging Het
Pram1 A T 17: 33,642,143 I513F probably damaging Het
Rasef A G 4: 73,734,534 S577P probably damaging Het
Rfx8 T C 1: 39,690,173 D144G possibly damaging Het
Rreb1 A C 13: 37,929,574 N303T possibly damaging Het
Rrn3 A T 16: 13,799,945 K351* probably null Het
Sox30 A T 11: 46,017,208 E734V probably damaging Het
Spns1 C T 7: 126,371,536 probably null Het
Tgfbr2 T A 9: 116,110,302 E177D probably benign Het
Tnfaip8l3 A G 9: 54,027,457 M78T possibly damaging Het
Vmn2r92 C T 17: 18,166,852 T151I probably damaging Het
Wwc1 A G 11: 35,915,284 Y41H possibly damaging Het
Zfp407 A T 18: 84,560,797 N730K probably damaging Het
Other mutations in Ifna6
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0336:Ifna6 UTSW 4 88827941 missense probably damaging 0.97
R0521:Ifna6 UTSW 4 88827650 missense probably benign 0.30
R2863:Ifna6 UTSW 4 88827862 missense probably benign 0.36
R2863:Ifna6 UTSW 4 88827849 missense probably benign
R2865:Ifna6 UTSW 4 88827849 missense probably benign
R2865:Ifna6 UTSW 4 88827862 missense probably benign 0.36
R4171:Ifna6 UTSW 4 88827801 missense probably benign 0.06
R4534:Ifna6 UTSW 4 88827849 missense probably benign
R4534:Ifna6 UTSW 4 88827862 missense probably benign 0.36
R4992:Ifna6 UTSW 4 88827540 missense probably benign 0.00
R5667:Ifna6 UTSW 4 88827669 missense probably damaging 1.00
R5671:Ifna6 UTSW 4 88827669 missense probably damaging 1.00
R5677:Ifna6 UTSW 4 88827719 missense probably benign 0.00
R6487:Ifna6 UTSW 4 88827506 missense probably damaging 1.00
R6751:Ifna6 UTSW 4 88827750 missense probably damaging 1.00
R7424:Ifna6 UTSW 4 88827807 missense possibly damaging 0.53
R7711:Ifna6 UTSW 4 88827734 missense probably benign 0.06
Posted On2016-08-02