Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03403:Tnfaip8l3'

421482

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Tnfaip8l3

Ensembl Gene

ENSMUSG00000074345

Gene Name

tumor necrosis factor, alpha-induced protein 8-like 3

Synonyms

LOC244882, 9930029P06Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.141) question?

Stock #

IGL03403

Quality Score

Status

Chromosome

Chromosomal Location

53932890-53975695 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 53934741 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Threonine at position 78 (M78T)

Ref Sequence

ENSEMBL: ENSMUSP00000096356 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000098760]

AlphaFold

Q3TBL6

Predicted Effect

possibly damaging
Transcript: ENSMUST00000098760
AA Change: M78T

PolyPhen 2 Score 0.605 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000096356
Gene: ENSMUSG00000074345
AA Change: M78T

Domain	Start	End	E-Value	Type
Pfam:DUF758	22	202	9.2e-78	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts12	T	A	15: 11,241,574 (GRCm39)	I382N	probably damaging	Het
Adamts5	T	C	16: 85,659,902 (GRCm39)	T797A	probably damaging	Het
Ahr	A	T	12: 35,554,325 (GRCm39)	V598E	possibly damaging	Het
Akap10	A	G	11: 61,806,099 (GRCm39)	S210P	probably benign	Het
Asb5	G	T	8: 55,036,582 (GRCm39)		probably benign	Het
AU041133	T	C	10: 81,974,178 (GRCm39)	V31A	probably damaging	Het
Bcar3	T	C	3: 122,306,618 (GRCm39)	V197A	probably benign	Het
Bptf	A	G	11: 106,990,559 (GRCm39)	V510A	possibly damaging	Het
Ccar2	A	T	14: 70,377,517 (GRCm39)	D712E	probably damaging	Het
Cenpt	G	A	8: 106,576,297 (GRCm39)	Q85*	probably null	Het
Ciita	C	A	16: 10,321,736 (GRCm39)	H98N	probably damaging	Het
Cplane1	A	C	15: 8,230,826 (GRCm39)	K1034N	probably damaging	Het
Csn1s1	T	A	5: 87,815,152 (GRCm39)	M16K	probably benign	Het
Fah	A	G	7: 84,242,417 (GRCm39)	I297T	probably damaging	Het
Fbxo25	A	G	8: 13,979,423 (GRCm39)	N214D	probably benign	Het
Frem3	A	C	8: 81,337,719 (GRCm39)	D4A	probably benign	Het
Gm3409	A	G	5: 146,476,334 (GRCm39)	K162E	probably benign	Het
Gxylt1	T	C	15: 93,159,656 (GRCm39)	D148G	possibly damaging	Het
Hoxd4	A	T	2: 74,558,681 (GRCm39)	E168V	possibly damaging	Het
Ifna6	A	G	4: 88,745,695 (GRCm39)	S15G	possibly damaging	Het
Iqck	T	A	7: 118,475,494 (GRCm39)	H97Q	probably benign	Het
Kif16b	T	A	2: 142,553,789 (GRCm39)	E1003V	probably damaging	Het
Lrp1b	G	A	2: 40,592,836 (GRCm39)	P3761L	probably benign	Het
Mc4r	C	T	18: 66,992,597 (GRCm39)	C172Y	possibly damaging	Het
Oosp1	T	A	19: 11,664,744 (GRCm39)	N104I	probably damaging	Het
Or2z9	A	G	8: 72,854,341 (GRCm39)	T246A	probably benign	Het
Pram1	A	T	17: 33,861,117 (GRCm39)	I513F	probably damaging	Het
Pramel18	T	C	4: 101,767,125 (GRCm39)	S125P	probably benign	Het
Rasef	A	G	4: 73,652,771 (GRCm39)	S577P	probably damaging	Het
Rfx8	T	C	1: 39,729,333 (GRCm39)	D144G	possibly damaging	Het
Rreb1	A	C	13: 38,113,550 (GRCm39)	N303T	possibly damaging	Het
Rrn3	A	T	16: 13,617,809 (GRCm39)	K351*	probably null	Het
Sox30	A	T	11: 45,908,035 (GRCm39)	E734V	probably damaging	Het
Spns1	C	T	7: 125,970,708 (GRCm39)		probably null	Het
Tgfbr2	T	A	9: 115,939,370 (GRCm39)	E177D	probably benign	Het
Vmn2r92	C	T	17: 18,387,114 (GRCm39)	T151I	probably damaging	Het
Wwc1	A	G	11: 35,806,111 (GRCm39)	Y41H	possibly damaging	Het
Zfp407	A	T	18: 84,578,922 (GRCm39)	N730K	probably damaging	Het

Other mutations in Tnfaip8l3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1218:Tnfaip8l3	UTSW	9	53,934,760 (GRCm39)	missense	probably damaging	1.00
R6826:Tnfaip8l3	UTSW	9	53,934,783 (GRCm39)	missense	possibly damaging	0.95
R8113:Tnfaip8l3	UTSW	9	53,934,421 (GRCm39)	missense	probably damaging	1.00
R8256:Tnfaip8l3	UTSW	9	53,934,528 (GRCm39)	missense	probably benign	0.12
R9516:Tnfaip8l3	UTSW	9	53,934,777 (GRCm39)	missense	probably benign	0.00

Posted On

2016-08-02