Incidental Mutation 'IGL03403:Oosp1'
ID421487
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Oosp1
Ensembl Gene ENSMUSG00000041857
Gene Nameoocyte secreted protein 1
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.085) question?
Stock #IGL03403
Quality Score
Status
Chromosome19
Chromosomal Location11667460-11691150 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 11687380 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Isoleucine at position 104 (N104I)
Ref Sequence ENSEMBL: ENSMUSP00000036529 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048214] [ENSMUST00000139158] [ENSMUST00000186557]
Predicted Effect probably damaging
Transcript: ENSMUST00000048214
AA Change: N104I

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000036529
Gene: ENSMUSG00000041857
AA Change: N104I

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000139158
SMART Domains Protein: ENSMUSP00000123469
Gene: ENSMUSG00000041857

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000186557
SMART Domains Protein: ENSMUSP00000139444
Gene: ENSMUSG00000041857

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik A C 15: 8,201,342 K1034N probably damaging Het
Adamts12 T A 15: 11,241,488 I382N probably damaging Het
Adamts5 T C 16: 85,863,014 T797A probably damaging Het
Ahr A T 12: 35,504,326 V598E possibly damaging Het
Akap10 A G 11: 61,915,273 S210P probably benign Het
Asb5 G T 8: 54,583,547 probably benign Het
AU041133 T C 10: 82,138,344 V31A probably damaging Het
Bcar3 T C 3: 122,512,969 V197A probably benign Het
Bptf A G 11: 107,099,733 V510A possibly damaging Het
Ccar2 A T 14: 70,140,068 D712E probably damaging Het
Cenpt G A 8: 105,849,665 Q85* probably null Het
Ciita C A 16: 10,503,872 H98N probably damaging Het
Csn1s1 T A 5: 87,667,293 M16K probably benign Het
Fah A G 7: 84,593,209 I297T probably damaging Het
Fbxo25 A G 8: 13,929,423 N214D probably benign Het
Frem3 A C 8: 80,611,090 D4A probably benign Het
Gm12800 T C 4: 101,909,928 S125P probably benign Het
Gm3409 A G 5: 146,539,524 K162E probably benign Het
Gxylt1 T C 15: 93,261,775 D148G possibly damaging Het
Hoxd4 A T 2: 74,728,337 E168V possibly damaging Het
Ifna6 A G 4: 88,827,458 S15G possibly damaging Het
Iqck T A 7: 118,876,271 H97Q probably benign Het
Kif16b T A 2: 142,711,869 E1003V probably damaging Het
Lrp1b G A 2: 40,702,824 P3761L probably benign Het
Mc4r C T 18: 66,859,526 C172Y possibly damaging Het
Olfr373 A G 8: 72,100,497 T246A probably benign Het
Pram1 A T 17: 33,642,143 I513F probably damaging Het
Rasef A G 4: 73,734,534 S577P probably damaging Het
Rfx8 T C 1: 39,690,173 D144G possibly damaging Het
Rreb1 A C 13: 37,929,574 N303T possibly damaging Het
Rrn3 A T 16: 13,799,945 K351* probably null Het
Sox30 A T 11: 46,017,208 E734V probably damaging Het
Spns1 C T 7: 126,371,536 probably null Het
Tgfbr2 T A 9: 116,110,302 E177D probably benign Het
Tnfaip8l3 A G 9: 54,027,457 M78T possibly damaging Het
Vmn2r92 C T 17: 18,166,852 T151I probably damaging Het
Wwc1 A G 11: 35,915,284 Y41H possibly damaging Het
Zfp407 A T 18: 84,560,797 N730K probably damaging Het
Other mutations in Oosp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00754:Oosp1 APN 19 11667705 missense possibly damaging 0.66
R0304:Oosp1 UTSW 19 11690969 missense probably benign 0.04
R0593:Oosp1 UTSW 19 11668412 missense probably benign 0.05
R1266:Oosp1 UTSW 19 11667799 missense possibly damaging 0.55
R1889:Oosp1 UTSW 19 11667794 missense possibly damaging 0.46
R2131:Oosp1 UTSW 19 11690950 missense probably damaging 0.98
R4386:Oosp1 UTSW 19 11667794 missense possibly damaging 0.46
R4909:Oosp1 UTSW 19 11688716 missense probably benign 0.02
R6614:Oosp1 UTSW 19 11690950 missense probably damaging 1.00
R7303:Oosp1 UTSW 19 11668410 missense probably benign 0.06
R7522:Oosp1 UTSW 19 11688701 missense probably benign 0.02
R7828:Oosp1 UTSW 19 11691005 missense probably benign
R8139:Oosp1 UTSW 19 11667754 missense possibly damaging 0.82
Posted On2016-08-02