Incidental Mutation 'IGL03403:Gm3409'
ID421509
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm3409
Ensembl Gene ENSMUSG00000096664
Gene Namepredicted gene 3409
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.073) question?
Stock #IGL03403
Quality Score
Status
Chromosome5
Chromosomal Location146537647-146540427 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 146539524 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Glutamic Acid at position 162 (K162E)
Ref Sequence ENSEMBL: ENSMUSP00000106227 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110597] [ENSMUST00000110599] [ENSMUST00000199142]
Predicted Effect probably benign
Transcript: ENSMUST00000110597
AA Change: K162E

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000106227
Gene: ENSMUSG00000096664
AA Change: K162E

DomainStartEndE-ValueType
RasGEFN 66 181 1.96e-3 SMART
low complexity region 265 279 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110599
AA Change: K162E

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000106229
Gene: ENSMUSG00000096664
AA Change: K162E

DomainStartEndE-ValueType
RasGEFN 66 181 1.96e-3 SMART
low complexity region 265 287 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000199142
AA Change: K162E

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000142652
Gene: ENSMUSG00000096664
AA Change: K162E

DomainStartEndE-ValueType
RasGEFN 66 181 9.5e-6 SMART
low complexity region 269 291 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2410089E03Rik A C 15: 8,201,342 K1034N probably damaging Het
Adamts12 T A 15: 11,241,488 I382N probably damaging Het
Adamts5 T C 16: 85,863,014 T797A probably damaging Het
Ahr A T 12: 35,504,326 V598E possibly damaging Het
Akap10 A G 11: 61,915,273 S210P probably benign Het
Asb5 G T 8: 54,583,547 probably benign Het
AU041133 T C 10: 82,138,344 V31A probably damaging Het
Bcar3 T C 3: 122,512,969 V197A probably benign Het
Bptf A G 11: 107,099,733 V510A possibly damaging Het
Ccar2 A T 14: 70,140,068 D712E probably damaging Het
Cenpt G A 8: 105,849,665 Q85* probably null Het
Ciita C A 16: 10,503,872 H98N probably damaging Het
Csn1s1 T A 5: 87,667,293 M16K probably benign Het
Fah A G 7: 84,593,209 I297T probably damaging Het
Fbxo25 A G 8: 13,929,423 N214D probably benign Het
Frem3 A C 8: 80,611,090 D4A probably benign Het
Gm12800 T C 4: 101,909,928 S125P probably benign Het
Gxylt1 T C 15: 93,261,775 D148G possibly damaging Het
Hoxd4 A T 2: 74,728,337 E168V possibly damaging Het
Ifna6 A G 4: 88,827,458 S15G possibly damaging Het
Iqck T A 7: 118,876,271 H97Q probably benign Het
Kif16b T A 2: 142,711,869 E1003V probably damaging Het
Lrp1b G A 2: 40,702,824 P3761L probably benign Het
Mc4r C T 18: 66,859,526 C172Y possibly damaging Het
Olfr373 A G 8: 72,100,497 T246A probably benign Het
Oosp1 T A 19: 11,687,380 N104I probably damaging Het
Pram1 A T 17: 33,642,143 I513F probably damaging Het
Rasef A G 4: 73,734,534 S577P probably damaging Het
Rfx8 T C 1: 39,690,173 D144G possibly damaging Het
Rreb1 A C 13: 37,929,574 N303T possibly damaging Het
Rrn3 A T 16: 13,799,945 K351* probably null Het
Sox30 A T 11: 46,017,208 E734V probably damaging Het
Spns1 C T 7: 126,371,536 probably null Het
Tgfbr2 T A 9: 116,110,302 E177D probably benign Het
Tnfaip8l3 A G 9: 54,027,457 M78T possibly damaging Het
Vmn2r92 C T 17: 18,166,852 T151I probably damaging Het
Wwc1 A G 11: 35,915,284 Y41H possibly damaging Het
Zfp407 A T 18: 84,560,797 N730K probably damaging Het
Other mutations in Gm3409
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1928:Gm3409 UTSW 5 146539608 missense probably benign 0.00
R5149:Gm3409 UTSW 5 146537761 missense possibly damaging 0.89
R6475:Gm3409 UTSW 5 146537786 missense possibly damaging 0.79
R7299:Gm3409 UTSW 5 146539547 missense probably benign 0.28
R7301:Gm3409 UTSW 5 146539547 missense probably benign 0.28
R7480:Gm3409 UTSW 5 146539501 missense probably damaging 0.99
Posted On2016-08-02