Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03404:Vmn1r217'

421517

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r217

Ensembl Gene

ENSMUSG00000115791

Gene Name

vomeronasal 1 receptor 217

Synonyms

V1rh14

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.236) question?

Stock #

IGL03404

Quality Score

Status

Chromosome

Chromosomal Location

23298004-23298900 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 23298810 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 31 (F31I)

Ref Sequence

ENSEMBL: ENSMUSP00000154563 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000091721] [ENSMUST00000227110] [ENSMUST00000228656]

AlphaFold

Q8R270

Predicted Effect

probably benign
Transcript: ENSMUST00000091721
AA Change: F31I

PolyPhen 2 Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000089314
Gene: ENSMUSG00000115791
AA Change: F31I

Domain	Start	End	E-Value	Type
transmembrane domain	9	31	N/A	INTRINSIC
Pfam:V1R	33	296	7.1e-37	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000227110
AA Change: F31I

PolyPhen 2 Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)

Predicted Effect

probably benign
Transcript: ENSMUST00000228656
AA Change: F31I

PolyPhen 2 Score 0.103 (Sensitivity: 0.93; Specificity: 0.86)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap8	T	G	17: 32,531,250 (GRCm39)		probably benign	Het
Ap3d1	A	G	10: 80,565,871 (GRCm39)	S99P	probably damaging	Het
Arhgef1	T	A	7: 24,616,268 (GRCm39)	M304K	probably benign	Het
Arpc5l	T	C	2: 38,903,895 (GRCm39)	L128P	probably damaging	Het
Chl1	A	T	6: 103,670,052 (GRCm39)	I497F	probably damaging	Het
Dnah3	C	T	7: 119,538,200 (GRCm39)	G616E	probably damaging	Het
Filip1	T	C	9: 79,725,841 (GRCm39)	E926G	probably damaging	Het
Fras1	A	T	5: 96,876,440 (GRCm39)	H2391L	probably damaging	Het
Fry	A	T	5: 150,249,633 (GRCm39)	D148V	probably damaging	Het
Glg1	A	T	8: 111,886,534 (GRCm39)	M1086K	probably damaging	Het
Gm12185	T	A	11: 48,798,864 (GRCm39)	Y543F	probably damaging	Het
Gtf3a	T	C	5: 146,887,449 (GRCm39)		probably null	Het
Hydin	A	T	8: 111,296,409 (GRCm39)	Y3646F	probably benign	Het
Itpr3	A	G	17: 27,310,492 (GRCm39)	D425G	probably damaging	Het
Lipo3	A	C	19: 33,560,440 (GRCm39)		probably benign	Het
Ltbp1	A	C	17: 75,532,301 (GRCm39)	K443T	probably damaging	Het
Mylk3	A	G	8: 86,069,310 (GRCm39)	I497T	probably damaging	Het
Nlrp5	A	G	7: 23,129,459 (GRCm39)	D842G	probably benign	Het
Or10j3	T	C	1: 173,031,766 (GRCm39)	V281A	probably benign	Het
Or52s6	A	T	7: 103,092,195 (GRCm39)	V45E	possibly damaging	Het
Or6n1	A	G	1: 173,917,464 (GRCm39)	N286S	probably damaging	Het
Or8k3b	A	G	2: 86,520,372 (GRCm39)		probably benign	Het
Pkd1	A	T	17: 24,783,380 (GRCm39)	I120L	probably damaging	Het
Ptprc	T	C	1: 138,020,739 (GRCm39)	N401S	probably damaging	Het
Rptn	A	G	3: 93,305,436 (GRCm39)	H923R	possibly damaging	Het
Rrp8	T	C	7: 105,384,145 (GRCm39)	K119R	probably benign	Het
Setd7	A	T	3: 51,440,407 (GRCm39)	Y211*	probably null	Het
Sfxn5	G	A	6: 85,276,518 (GRCm39)		probably benign	Het
Sun5	T	C	2: 153,712,924 (GRCm39)		probably benign	Het
Tnks	A	T	8: 35,407,858 (GRCm39)	V290D	probably damaging	Het
Trrap	C	T	5: 144,769,996 (GRCm39)	P2740L	probably benign	Het
Ttc23	G	T	7: 67,328,645 (GRCm39)	L195F	probably damaging	Het
Tubb1	G	T	2: 174,299,241 (GRCm39)	G308C	probably damaging	Het
Zp1	A	T	19: 10,891,825 (GRCm39)		probably benign	Het

Other mutations in Vmn1r217

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0147:Vmn1r217	UTSW	13	23,298,107 (GRCm39)	missense	probably benign
R0325:Vmn1r217	UTSW	13	23,298,764 (GRCm39)	missense	probably damaging	1.00
R1249:Vmn1r217	UTSW	13	23,298,818 (GRCm39)	missense	probably benign	0.01
R1554:Vmn1r217	UTSW	13	23,298,464 (GRCm39)	missense	possibly damaging	0.79
R1777:Vmn1r217	UTSW	13	23,298,495 (GRCm39)	missense	probably benign	0.03
R2061:Vmn1r217	UTSW	13	23,298,698 (GRCm39)	missense	probably benign	0.19
R2168:Vmn1r217	UTSW	13	23,298,714 (GRCm39)	nonsense	probably null
R3122:Vmn1r217	UTSW	13	23,298,249 (GRCm39)	missense	probably damaging	1.00
R4832:Vmn1r217	UTSW	13	23,298,159 (GRCm39)	missense	probably damaging	1.00
R6500:Vmn1r217	UTSW	13	23,298,073 (GRCm39)	nonsense	probably null
R6623:Vmn1r217	UTSW	13	23,298,846 (GRCm39)	missense	possibly damaging	0.65
R6909:Vmn1r217	UTSW	13	23,298,108 (GRCm39)	missense	probably benign
R7708:Vmn1r217	UTSW	13	23,298,269 (GRCm39)	missense	probably benign	0.01
R8223:Vmn1r217	UTSW	13	23,298,369 (GRCm39)	missense	probably benign	0.03
R8774:Vmn1r217	UTSW	13	23,298,108 (GRCm39)	missense	probably benign
R8774-TAIL:Vmn1r217	UTSW	13	23,298,108 (GRCm39)	missense	probably benign
R9129:Vmn1r217	UTSW	13	23,298,876 (GRCm39)	missense	probably benign	0.24
R9182:Vmn1r217	UTSW	13	23,298,495 (GRCm39)	missense	probably benign	0.03

Posted On

2016-08-02