Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03406:Zfp69'

421592

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp69

Ensembl Gene

ENSMUSG00000064141

Gene Name

zinc finger protein 69

Synonyms

Zfp63, LOC381549, KRAB2

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03406

Quality Score

Status

Chromosome

Chromosomal Location

120930137-120951699 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 120931084 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 345 (T345A)

Ref Sequence

ENSEMBL: ENSMUSP00000101888 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000106280] [ENSMUST00000106281] [ENSMUST00000130702]

AlphaFold

A2A761

Predicted Effect

probably benign
Transcript: ENSMUST00000106280
AA Change: T345A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000101887
Gene: ENSMUSG00000064141
AA Change: T345A

Domain	Start	End	E-Value	Type
internal_repeat_1	32	80	1.53e-8	PROSPERO
KRAB	131	192	1.15e-32	SMART
ZnF_C2H2	324	346	1.13e-4	SMART
ZnF_C2H2	352	374	2.79e-4	SMART
ZnF_C2H2	380	402	1.04e-3	SMART
ZnF_C2H2	408	430	1.12e-3	SMART
ZnF_C2H2	436	458	1.82e-3	SMART
ZnF_C2H2	464	486	3.29e-1	SMART
ZnF_C2H2	492	514	1.38e-3	SMART
ZnF_C2H2	520	542	3.29e-1	SMART
ZnF_C2H2	548	570	2.12e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000106281
AA Change: T345A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000101888
Gene: ENSMUSG00000064141
AA Change: T345A

Domain	Start	End	E-Value	Type
internal_repeat_1	32	80	1.53e-8	PROSPERO
KRAB	131	192	1.15e-32	SMART
ZnF_C2H2	324	346	1.13e-4	SMART
ZnF_C2H2	352	374	2.79e-4	SMART
ZnF_C2H2	380	402	1.04e-3	SMART
ZnF_C2H2	408	430	1.12e-3	SMART
ZnF_C2H2	436	458	1.82e-3	SMART
ZnF_C2H2	464	486	3.29e-1	SMART
ZnF_C2H2	492	514	1.38e-3	SMART
ZnF_C2H2	520	542	3.29e-1	SMART
ZnF_C2H2	548	570	2.12e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000130702

SMART Domains

Protein: ENSMUSP00000133312
Gene: ENSMUSG00000064141

Domain	Start	End	E-Value	Type
KRAB	1	32	2.6e-2	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000132839

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700012P22Rik	A	G	4: 144,423,844	Y56H	probably damaging	Het
A530016L24Rik	T	A	12: 112,496,883		probably null	Het
Adcy7	C	T	8: 88,318,319	R228*	probably null	Het
Cdcp1	T	C	9: 123,185,313	H132R	probably benign	Het
Cyp4a32	T	C	4: 115,602,303	I78T	probably benign	Het
Fap	A	T	2: 62,542,122		probably benign	Het
Gad1-ps	C	T	10: 99,444,779		noncoding transcript	Het
Gli3	T	C	13: 15,648,581	I296T	probably damaging	Het
H2-Q2	T	C	17: 35,342,825	V97A	probably benign	Het
Hr	T	A	14: 70,563,420		probably null	Het
Itgax	C	T	7: 128,149,198	T1133I	possibly damaging	Het
L3mbtl2	G	A	15: 81,681,993	R339H	probably damaging	Het
Mast4	T	C	13: 102,737,107	K1726E	possibly damaging	Het
Nlrc5	T	C	8: 94,476,855	Y528H	probably benign	Het
Nmnat3	G	A	9: 98,399,477	G44D	probably damaging	Het
Nol8	A	T	13: 49,661,568	D366V	probably damaging	Het
Olfr539	C	A	7: 140,667,511	L68M	probably damaging	Het
Pde4d	A	T	13: 109,954,591		probably benign	Het
Ptpn22	C	A	3: 103,912,016	N795K	probably benign	Het
Rabgap1l	A	T	1: 160,722,169	V289D	probably damaging	Het
Slc50a1	T	C	3: 89,270,101	D40G	possibly damaging	Het
Slco6b1	T	C	1: 96,947,585		noncoding transcript	Het
Smarcad1	T	A	6: 65,092,526	F530Y	probably damaging	Het
Spag6	A	G	2: 18,742,873		probably benign	Het
Supt16	A	T	14: 52,178,141	I379N	possibly damaging	Het
Tmem154	A	G	3: 84,684,260	N39S	probably benign	Het
Ubash3b	T	A	9: 41,037,479	Y180F	probably damaging	Het
Usp48	T	A	4: 137,639,295	D921E	possibly damaging	Het
Zdhhc20	T	C	14: 57,839,099	T366A	probably benign	Het
Zfp456	A	T	13: 67,366,331	C419S	probably damaging	Het

Other mutations in Zfp69

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01621:Zfp69	APN	4	120931500	missense	probably damaging	1.00
IGL02604:Zfp69	APN	4	120931463	missense	probably benign	0.10
R0505:Zfp69	UTSW	4	120931095	missense	probably damaging	1.00
R0613:Zfp69	UTSW	4	120934347	missense	probably benign
R0628:Zfp69	UTSW	4	120949425	nonsense	probably null
R0838:Zfp69	UTSW	4	120931281	missense	probably benign	0.09
R1669:Zfp69	UTSW	4	120947498	utr 5 prime	probably benign
R2060:Zfp69	UTSW	4	120930832	missense	probably damaging	0.98
R3740:Zfp69	UTSW	4	120930874	splice site	probably null
R4242:Zfp69	UTSW	4	120934475	intron	probably benign
R4770:Zfp69	UTSW	4	120934417	missense	probably damaging	0.99
R4998:Zfp69	UTSW	4	120947325	missense	possibly damaging	0.52
R5620:Zfp69	UTSW	4	120930522	missense	probably damaging	1.00
R6312:Zfp69	UTSW	4	120949517	unclassified	probably benign
R6534:Zfp69	UTSW	4	120931197	missense	probably benign	0.05
R7056:Zfp69	UTSW	4	120931098	missense	probably benign	0.01
R7061:Zfp69	UTSW	4	120931401	missense	possibly damaging	0.69
R7663:Zfp69	UTSW	4	120935126	missense	probably benign	0.17
R8169:Zfp69	UTSW	4	120930534	missense	probably damaging	1.00
R8348:Zfp69	UTSW	4	120930637	missense	probably damaging	1.00
R8389:Zfp69	UTSW	4	120949352	missense	possibly damaging	0.93
R9182:Zfp69	UTSW	4	120935111	missense	probably damaging	1.00
R9340:Zfp69	UTSW	4	120930816	missense	probably damaging	1.00
RF053:Zfp69	UTSW	4	120947347	utr 5 prime	probably benign

Posted On

2016-08-02