Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03406:Cyp4a32'

421599

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Cyp4a32

Ensembl Gene

ENSMUSG00000063929

Gene Name

cytochrome P450, family 4, subfamily a, polypeptide 32

Synonyms

OTTMUSG00000008689

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

IGL03406

Quality Score

Status

Chromosome

Chromosomal Location

115600969-115621602 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 115602303 bp

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Threonine at position 78 (I78T)

Ref Sequence

ENSEMBL: ENSMUSP00000081369 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084342]

Predicted Effect

probably benign
Transcript: ENSMUST00000084342
AA Change: I78T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000081369
Gene: ENSMUSG00000063929
AA Change: I78T

Domain	Start	End	E-Value	Type
transmembrane domain	15	32	N/A	INTRINSIC
Pfam:p450	51	504	1.3e-133	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000129918

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700012P22Rik	A	G	4: 144,423,844	Y56H	probably damaging	Het
A530016L24Rik	T	A	12: 112,496,883		probably null	Het
Adcy7	C	T	8: 88,318,319	R228*	probably null	Het
Cdcp1	T	C	9: 123,185,313	H132R	probably benign	Het
Fap	A	T	2: 62,542,122		probably benign	Het
Gad1-ps	C	T	10: 99,444,779		noncoding transcript	Het
Gli3	T	C	13: 15,648,581	I296T	probably damaging	Het
H2-Q2	T	C	17: 35,342,825	V97A	probably benign	Het
Hr	T	A	14: 70,563,420		probably null	Het
Itgax	C	T	7: 128,149,198	T1133I	possibly damaging	Het
L3mbtl2	G	A	15: 81,681,993	R339H	probably damaging	Het
Mast4	T	C	13: 102,737,107	K1726E	possibly damaging	Het
Nlrc5	T	C	8: 94,476,855	Y528H	probably benign	Het
Nmnat3	G	A	9: 98,399,477	G44D	probably damaging	Het
Nol8	A	T	13: 49,661,568	D366V	probably damaging	Het
Olfr539	C	A	7: 140,667,511	L68M	probably damaging	Het
Pde4d	A	T	13: 109,954,591		probably benign	Het
Ptpn22	C	A	3: 103,912,016	N795K	probably benign	Het
Rabgap1l	A	T	1: 160,722,169	V289D	probably damaging	Het
Slc50a1	T	C	3: 89,270,101	D40G	possibly damaging	Het
Slco6b1	T	C	1: 96,947,585		noncoding transcript	Het
Smarcad1	T	A	6: 65,092,526	F530Y	probably damaging	Het
Spag6	A	G	2: 18,742,873		probably benign	Het
Supt16	A	T	14: 52,178,141	I379N	possibly damaging	Het
Tmem154	A	G	3: 84,684,260	N39S	probably benign	Het
Ubash3b	T	A	9: 41,037,479	Y180F	probably damaging	Het
Usp48	T	A	4: 137,639,295	D921E	possibly damaging	Het
Zdhhc20	T	C	14: 57,839,099	T366A	probably benign	Het
Zfp456	A	T	13: 67,366,331	C419S	probably damaging	Het
Zfp69	T	C	4: 120,931,084	T345A	probably benign	Het

Other mutations in Cyp4a32

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02225:Cyp4a32	APN	4	115610503	missense	probably benign
IGL02546:Cyp4a32	APN	4	115611323	missense	probably damaging	0.98
IGL02578:Cyp4a32	APN	4	115609742	missense	possibly damaging	0.79
IGL02663:Cyp4a32	APN	4	115610590	missense	probably damaging	1.00
IGL02832:Cyp4a32	APN	4	115614621	missense	probably damaging	0.99
IGL03283:Cyp4a32	APN	4	115611083	missense	possibly damaging	0.79
IGL03357:Cyp4a32	APN	4	115611601	missense	probably benign	0.00
R0379:Cyp4a32	UTSW	4	115621474	missense	probably damaging	1.00
R1339:Cyp4a32	UTSW	4	115611563	missense	probably damaging	0.98
R1435:Cyp4a32	UTSW	4	115606666	missense	probably damaging	0.97
R1445:Cyp4a32	UTSW	4	115602950	nonsense	probably null
R1520:Cyp4a32	UTSW	4	115614652	missense	probably damaging	0.97
R1587:Cyp4a32	UTSW	4	115610534	missense	probably benign	0.06
R1719:Cyp4a32	UTSW	4	115611308	missense	possibly damaging	0.61
R1932:Cyp4a32	UTSW	4	115611277	missense	possibly damaging	0.78
R4184:Cyp4a32	UTSW	4	115621523	missense	possibly damaging	0.94
R4580:Cyp4a32	UTSW	4	115602929	splice site	silent
R5004:Cyp4a32	UTSW	4	115601041	missense	probably damaging	0.98
R6345:Cyp4a32	UTSW	4	115602363	missense	possibly damaging	0.81
R7231:Cyp4a32	UTSW	4	115609697	missense	probably damaging	1.00
R7241:Cyp4a32	UTSW	4	115602302	missense	probably benign
R7419:Cyp4a32	UTSW	4	115611037	missense	probably benign
R7716:Cyp4a32	UTSW	4	115601086	missense	probably damaging	1.00
Z1177:Cyp4a32	UTSW	4	115611345	missense	probably benign	0.03

Posted On

2016-08-02