Incidental Mutation 'IGL03406:Cyp4a32'
ID421599
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cyp4a32
Ensembl Gene ENSMUSG00000063929
Gene Namecytochrome P450, family 4, subfamily a, polypeptide 32
SynonymsOTTMUSG00000008689
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.081) question?
Stock #IGL03406
Quality Score
Status
Chromosome4
Chromosomal Location115600969-115621602 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 115602303 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Threonine at position 78 (I78T)
Ref Sequence ENSEMBL: ENSMUSP00000081369 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084342]
Predicted Effect probably benign
Transcript: ENSMUST00000084342
AA Change: I78T

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000081369
Gene: ENSMUSG00000063929
AA Change: I78T

DomainStartEndE-ValueType
transmembrane domain 15 32 N/A INTRINSIC
Pfam:p450 51 504 1.3e-133 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129918
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012P22Rik A G 4: 144,423,844 Y56H probably damaging Het
A530016L24Rik T A 12: 112,496,883 probably null Het
Adcy7 C T 8: 88,318,319 R228* probably null Het
Cdcp1 T C 9: 123,185,313 H132R probably benign Het
Fap A T 2: 62,542,122 probably benign Het
Gad1-ps C T 10: 99,444,779 noncoding transcript Het
Gli3 T C 13: 15,648,581 I296T probably damaging Het
H2-Q2 T C 17: 35,342,825 V97A probably benign Het
Hr T A 14: 70,563,420 probably null Het
Itgax C T 7: 128,149,198 T1133I possibly damaging Het
L3mbtl2 G A 15: 81,681,993 R339H probably damaging Het
Mast4 T C 13: 102,737,107 K1726E possibly damaging Het
Nlrc5 T C 8: 94,476,855 Y528H probably benign Het
Nmnat3 G A 9: 98,399,477 G44D probably damaging Het
Nol8 A T 13: 49,661,568 D366V probably damaging Het
Olfr539 C A 7: 140,667,511 L68M probably damaging Het
Pde4d A T 13: 109,954,591 probably benign Het
Ptpn22 C A 3: 103,912,016 N795K probably benign Het
Rabgap1l A T 1: 160,722,169 V289D probably damaging Het
Slc50a1 T C 3: 89,270,101 D40G possibly damaging Het
Slco6b1 T C 1: 96,947,585 noncoding transcript Het
Smarcad1 T A 6: 65,092,526 F530Y probably damaging Het
Spag6 A G 2: 18,742,873 probably benign Het
Supt16 A T 14: 52,178,141 I379N possibly damaging Het
Tmem154 A G 3: 84,684,260 N39S probably benign Het
Ubash3b T A 9: 41,037,479 Y180F probably damaging Het
Usp48 T A 4: 137,639,295 D921E possibly damaging Het
Zdhhc20 T C 14: 57,839,099 T366A probably benign Het
Zfp456 A T 13: 67,366,331 C419S probably damaging Het
Zfp69 T C 4: 120,931,084 T345A probably benign Het
Other mutations in Cyp4a32
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02225:Cyp4a32 APN 4 115610503 missense probably benign
IGL02546:Cyp4a32 APN 4 115611323 missense probably damaging 0.98
IGL02578:Cyp4a32 APN 4 115609742 missense possibly damaging 0.79
IGL02663:Cyp4a32 APN 4 115610590 missense probably damaging 1.00
IGL02832:Cyp4a32 APN 4 115614621 missense probably damaging 0.99
IGL03283:Cyp4a32 APN 4 115611083 missense possibly damaging 0.79
IGL03357:Cyp4a32 APN 4 115611601 missense probably benign 0.00
R0379:Cyp4a32 UTSW 4 115621474 missense probably damaging 1.00
R1339:Cyp4a32 UTSW 4 115611563 missense probably damaging 0.98
R1435:Cyp4a32 UTSW 4 115606666 missense probably damaging 0.97
R1445:Cyp4a32 UTSW 4 115602950 nonsense probably null
R1520:Cyp4a32 UTSW 4 115614652 missense probably damaging 0.97
R1587:Cyp4a32 UTSW 4 115610534 missense probably benign 0.06
R1719:Cyp4a32 UTSW 4 115611308 missense possibly damaging 0.61
R1932:Cyp4a32 UTSW 4 115611277 missense possibly damaging 0.78
R4184:Cyp4a32 UTSW 4 115621523 missense possibly damaging 0.94
R4580:Cyp4a32 UTSW 4 115602929 splice site silent
R5004:Cyp4a32 UTSW 4 115601041 missense probably damaging 0.98
R6345:Cyp4a32 UTSW 4 115602363 missense possibly damaging 0.81
R7231:Cyp4a32 UTSW 4 115609697 missense probably damaging 1.00
R7241:Cyp4a32 UTSW 4 115602302 missense probably benign
R7419:Cyp4a32 UTSW 4 115611037 missense probably benign
R7716:Cyp4a32 UTSW 4 115601086 missense probably damaging 1.00
Z1177:Cyp4a32 UTSW 4 115611345 missense probably benign 0.03
Posted On2016-08-02