Incidental Mutation 'IGL03406:Tmem154'
ID 421600
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem154
Ensembl Gene ENSMUSG00000056498
Gene Name transmembrane protein 154
Synonyms 9930117H01Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # IGL03406
Quality Score
Chromosome 3
Chromosomal Location 84573499-84611882 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 84591567 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 39 (N39S)
Ref Sequence ENSEMBL: ENSMUSP00000103310 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107682] [ENSMUST00000154148]
AlphaFold Q8C4Q9
Predicted Effect probably benign
Transcript: ENSMUST00000107682
AA Change: N39S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000103310
Gene: ENSMUSG00000056498
AA Change: N39S

signal peptide 1 22 N/A INTRINSIC
Pfam:TMEM154 24 163 6.2e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129417
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134890
Predicted Effect probably benign
Transcript: ENSMUST00000154148
SMART Domains Protein: ENSMUSP00000116393
Gene: ENSMUSG00000102805

Arfaptin 1 227 7.15e-121 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530016L24Rik T A 12: 112,463,317 (GRCm39) probably null Het
Adcy7 C T 8: 89,044,947 (GRCm39) R228* probably null Het
Cdcp1 T C 9: 123,014,378 (GRCm39) H132R probably benign Het
Cfap107 A G 4: 144,150,414 (GRCm39) Y56H probably damaging Het
Cyp4a32 T C 4: 115,459,500 (GRCm39) I78T probably benign Het
Fap A T 2: 62,372,466 (GRCm39) probably benign Het
Gad1-ps C T 10: 99,280,641 (GRCm39) noncoding transcript Het
Gli3 T C 13: 15,823,166 (GRCm39) I296T probably damaging Het
H2-Q2 T C 17: 35,561,801 (GRCm39) V97A probably benign Het
Hr T A 14: 70,800,860 (GRCm39) probably null Het
Itgax C T 7: 127,748,370 (GRCm39) T1133I possibly damaging Het
L3mbtl2 G A 15: 81,566,194 (GRCm39) R339H probably damaging Het
Mast4 T C 13: 102,873,615 (GRCm39) K1726E possibly damaging Het
Nlrc5 T C 8: 95,203,483 (GRCm39) Y528H probably benign Het
Nmnat3 G A 9: 98,281,530 (GRCm39) G44D probably damaging Het
Nol8 A T 13: 49,815,044 (GRCm39) D366V probably damaging Het
Or13a25 C A 7: 140,247,424 (GRCm39) L68M probably damaging Het
Pde4d A T 13: 110,091,125 (GRCm39) probably benign Het
Ptpn22 C A 3: 103,819,332 (GRCm39) N795K probably benign Het
Rabgap1l A T 1: 160,549,739 (GRCm39) V289D probably damaging Het
Slc50a1 T C 3: 89,177,408 (GRCm39) D40G possibly damaging Het
Slco6b1 T C 1: 96,875,310 (GRCm39) noncoding transcript Het
Smarcad1 T A 6: 65,069,510 (GRCm39) F530Y probably damaging Het
Spag6 A G 2: 18,747,684 (GRCm39) probably benign Het
Supt16 A T 14: 52,415,598 (GRCm39) I379N possibly damaging Het
Ubash3b T A 9: 40,948,775 (GRCm39) Y180F probably damaging Het
Usp48 T A 4: 137,366,606 (GRCm39) D921E possibly damaging Het
Zdhhc20 T C 14: 58,076,556 (GRCm39) T366A probably benign Het
Zfp456 A T 13: 67,514,450 (GRCm39) C419S probably damaging Het
Zfp69 T C 4: 120,788,281 (GRCm39) T345A probably benign Het
Other mutations in Tmem154
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Tmem154 APN 3 84,591,722 (GRCm39) missense probably benign 0.05
IGL01516:Tmem154 APN 3 84,591,897 (GRCm39) missense probably benign
IGL01670:Tmem154 APN 3 84,591,537 (GRCm39) missense probably damaging 0.98
IGL02955:Tmem154 APN 3 84,591,508 (GRCm39) intron probably benign
R6245:Tmem154 UTSW 3 84,591,603 (GRCm39) missense possibly damaging 0.83
R6885:Tmem154 UTSW 3 84,599,813 (GRCm39) missense possibly damaging 0.95
R7287:Tmem154 UTSW 3 84,597,870 (GRCm39) missense possibly damaging 0.95
R9748:Tmem154 UTSW 3 84,573,693 (GRCm39) missense possibly damaging 0.96
Posted On 2016-08-02