Incidental Mutation 'IGL03406:Tmem154'
ID421600
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmem154
Ensembl Gene ENSMUSG00000056498
Gene Nametransmembrane protein 154
Synonyms9930117H01Rik
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.056) question?
Stock #IGL03406
Quality Score
Status
Chromosome3
Chromosomal Location84666192-84704575 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 84684260 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Serine at position 39 (N39S)
Ref Sequence ENSEMBL: ENSMUSP00000103310 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000107682] [ENSMUST00000154148]
Predicted Effect probably benign
Transcript: ENSMUST00000107682
AA Change: N39S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000103310
Gene: ENSMUSG00000056498
AA Change: N39S

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
Pfam:TMEM154 24 163 6.2e-52 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129417
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134890
Predicted Effect probably benign
Transcript: ENSMUST00000154148
SMART Domains Protein: ENSMUSP00000116393
Gene: ENSMUSG00000102805

DomainStartEndE-ValueType
Arfaptin 1 227 7.15e-121 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700012P22Rik A G 4: 144,423,844 Y56H probably damaging Het
A530016L24Rik T A 12: 112,496,883 probably null Het
Adcy7 C T 8: 88,318,319 R228* probably null Het
Cdcp1 T C 9: 123,185,313 H132R probably benign Het
Cyp4a32 T C 4: 115,602,303 I78T probably benign Het
Fap A T 2: 62,542,122 probably benign Het
Gad1-ps C T 10: 99,444,779 noncoding transcript Het
Gli3 T C 13: 15,648,581 I296T probably damaging Het
H2-Q2 T C 17: 35,342,825 V97A probably benign Het
Hr T A 14: 70,563,420 probably null Het
Itgax C T 7: 128,149,198 T1133I possibly damaging Het
L3mbtl2 G A 15: 81,681,993 R339H probably damaging Het
Mast4 T C 13: 102,737,107 K1726E possibly damaging Het
Nlrc5 T C 8: 94,476,855 Y528H probably benign Het
Nmnat3 G A 9: 98,399,477 G44D probably damaging Het
Nol8 A T 13: 49,661,568 D366V probably damaging Het
Olfr539 C A 7: 140,667,511 L68M probably damaging Het
Pde4d A T 13: 109,954,591 probably benign Het
Ptpn22 C A 3: 103,912,016 N795K probably benign Het
Rabgap1l A T 1: 160,722,169 V289D probably damaging Het
Slc50a1 T C 3: 89,270,101 D40G possibly damaging Het
Slco6b1 T C 1: 96,947,585 noncoding transcript Het
Smarcad1 T A 6: 65,092,526 F530Y probably damaging Het
Spag6 A G 2: 18,742,873 probably benign Het
Supt16 A T 14: 52,178,141 I379N possibly damaging Het
Ubash3b T A 9: 41,037,479 Y180F probably damaging Het
Usp48 T A 4: 137,639,295 D921E possibly damaging Het
Zdhhc20 T C 14: 57,839,099 T366A probably benign Het
Zfp456 A T 13: 67,366,331 C419S probably damaging Het
Zfp69 T C 4: 120,931,084 T345A probably benign Het
Other mutations in Tmem154
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Tmem154 APN 3 84684415 missense probably benign 0.05
IGL01516:Tmem154 APN 3 84684590 missense probably benign
IGL01670:Tmem154 APN 3 84684230 missense probably damaging 0.98
IGL02955:Tmem154 APN 3 84684201 intron probably benign
R6245:Tmem154 UTSW 3 84684296 missense possibly damaging 0.83
R6885:Tmem154 UTSW 3 84692506 missense possibly damaging 0.95
R7287:Tmem154 UTSW 3 84690563 missense possibly damaging 0.95
Posted On2016-08-02