Incidental Mutation 'IGL03406:Zdhhc20'
ID 421601
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zdhhc20
Ensembl Gene ENSMUSG00000021969
Gene Name zinc finger, DHHC domain containing 20
Synonyms 5033406L14Rik, 4930542A17Rik, ENSMUSG00000055956, B230110O18Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.187) question?
Stock # IGL03406
Quality Score
Status
Chromosome 14
Chromosomal Location 58070160-58127733 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58076556 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 366 (T366A)
Ref Sequence ENSEMBL: ENSMUSP00000153568 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089473] [ENSMUST00000226057]
AlphaFold Q5Y5T1
Predicted Effect probably benign
Transcript: ENSMUST00000089473
AA Change: T354A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000086900
Gene: ENSMUSG00000021969
AA Change: T354A

DomainStartEndE-ValueType
transmembrane domain 13 32 N/A INTRINSIC
transmembrane domain 52 74 N/A INTRINSIC
Pfam:zf-DHHC 121 250 2.2e-41 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224133
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226029
Predicted Effect probably benign
Transcript: ENSMUST00000226057
AA Change: T366A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530016L24Rik T A 12: 112,463,317 (GRCm39) probably null Het
Adcy7 C T 8: 89,044,947 (GRCm39) R228* probably null Het
Cdcp1 T C 9: 123,014,378 (GRCm39) H132R probably benign Het
Cfap107 A G 4: 144,150,414 (GRCm39) Y56H probably damaging Het
Cyp4a32 T C 4: 115,459,500 (GRCm39) I78T probably benign Het
Fap A T 2: 62,372,466 (GRCm39) probably benign Het
Gad1-ps C T 10: 99,280,641 (GRCm39) noncoding transcript Het
Gli3 T C 13: 15,823,166 (GRCm39) I296T probably damaging Het
H2-Q2 T C 17: 35,561,801 (GRCm39) V97A probably benign Het
Hr T A 14: 70,800,860 (GRCm39) probably null Het
Itgax C T 7: 127,748,370 (GRCm39) T1133I possibly damaging Het
L3mbtl2 G A 15: 81,566,194 (GRCm39) R339H probably damaging Het
Mast4 T C 13: 102,873,615 (GRCm39) K1726E possibly damaging Het
Nlrc5 T C 8: 95,203,483 (GRCm39) Y528H probably benign Het
Nmnat3 G A 9: 98,281,530 (GRCm39) G44D probably damaging Het
Nol8 A T 13: 49,815,044 (GRCm39) D366V probably damaging Het
Or13a25 C A 7: 140,247,424 (GRCm39) L68M probably damaging Het
Pde4d A T 13: 110,091,125 (GRCm39) probably benign Het
Ptpn22 C A 3: 103,819,332 (GRCm39) N795K probably benign Het
Rabgap1l A T 1: 160,549,739 (GRCm39) V289D probably damaging Het
Slc50a1 T C 3: 89,177,408 (GRCm39) D40G possibly damaging Het
Slco6b1 T C 1: 96,875,310 (GRCm39) noncoding transcript Het
Smarcad1 T A 6: 65,069,510 (GRCm39) F530Y probably damaging Het
Spag6 A G 2: 18,747,684 (GRCm39) probably benign Het
Supt16 A T 14: 52,415,598 (GRCm39) I379N possibly damaging Het
Tmem154 A G 3: 84,591,567 (GRCm39) N39S probably benign Het
Ubash3b T A 9: 40,948,775 (GRCm39) Y180F probably damaging Het
Usp48 T A 4: 137,366,606 (GRCm39) D921E possibly damaging Het
Zfp456 A T 13: 67,514,450 (GRCm39) C419S probably damaging Het
Zfp69 T C 4: 120,788,281 (GRCm39) T345A probably benign Het
Other mutations in Zdhhc20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00492:Zdhhc20 APN 14 58,111,381 (GRCm39) missense probably damaging 0.99
IGL00983:Zdhhc20 APN 14 58,076,613 (GRCm39) missense possibly damaging 0.62
IGL01107:Zdhhc20 APN 14 58,103,046 (GRCm39) missense probably damaging 1.00
IGL01350:Zdhhc20 APN 14 58,111,444 (GRCm39) missense probably benign 0.03
IGL02572:Zdhhc20 APN 14 58,127,564 (GRCm39) missense probably benign 0.20
IGL02748:Zdhhc20 APN 14 58,096,010 (GRCm39) missense probably benign 0.08
R0314:Zdhhc20 UTSW 14 58,094,076 (GRCm39) missense probably damaging 1.00
R0631:Zdhhc20 UTSW 14 58,095,097 (GRCm39) missense probably damaging 0.99
R1144:Zdhhc20 UTSW 14 58,094,135 (GRCm39) missense probably benign 0.07
R1703:Zdhhc20 UTSW 14 58,076,545 (GRCm39) critical splice donor site probably null
R1815:Zdhhc20 UTSW 14 58,127,600 (GRCm39) missense probably benign 0.10
R1816:Zdhhc20 UTSW 14 58,127,600 (GRCm39) missense probably benign 0.10
R6219:Zdhhc20 UTSW 14 58,078,340 (GRCm39) missense probably damaging 0.99
R6488:Zdhhc20 UTSW 14 58,078,289 (GRCm39) missense probably benign 0.00
R6650:Zdhhc20 UTSW 14 58,096,032 (GRCm39) missense probably damaging 1.00
R6790:Zdhhc20 UTSW 14 58,127,600 (GRCm39) missense probably benign 0.00
R7196:Zdhhc20 UTSW 14 58,111,348 (GRCm39) critical splice donor site probably null
R7365:Zdhhc20 UTSW 14 58,111,377 (GRCm39) missense possibly damaging 0.95
R8126:Zdhhc20 UTSW 14 58,084,402 (GRCm39) missense probably damaging 1.00
R8832:Zdhhc20 UTSW 14 58,103,089 (GRCm39) missense probably benign 0.05
R8832:Zdhhc20 UTSW 14 58,080,721 (GRCm39) missense possibly damaging 0.86
R8885:Zdhhc20 UTSW 14 58,127,671 (GRCm39) start gained probably benign
Z1176:Zdhhc20 UTSW 14 58,076,562 (GRCm39) nonsense probably null
Posted On 2016-08-02