Incidental Mutation 'IGL03406:Spag6'
ID 421617
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Spag6
Ensembl Gene ENSMUSG00000037708
Gene Name sperm associated antigen 6
Synonyms BC061194, Spag6l
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # IGL03406
Quality Score
Status
Chromosome 2
Chromosomal Location 18698808-18754561 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 18747684 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000092751 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095132]
AlphaFold Q3V0U9
Predicted Effect probably benign
Transcript: ENSMUST00000095132
SMART Domains Protein: ENSMUSP00000092751
Gene: ENSMUSG00000037708

DomainStartEndE-ValueType
ARM 30 70 2.26e-3 SMART
ARM 114 154 1.67e-6 SMART
ARM 156 196 4.28e-4 SMART
ARM 198 238 5.43e-6 SMART
ARM 240 280 4.6e0 SMART
ARM 282 322 3.09e1 SMART
ARM 323 365 3.93e-3 SMART
Blast:ARM 367 409 7e-17 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000174811
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 30 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A530016L24Rik T A 12: 112,463,317 (GRCm39) probably null Het
Adcy7 C T 8: 89,044,947 (GRCm39) R228* probably null Het
Cdcp1 T C 9: 123,014,378 (GRCm39) H132R probably benign Het
Cfap107 A G 4: 144,150,414 (GRCm39) Y56H probably damaging Het
Cyp4a32 T C 4: 115,459,500 (GRCm39) I78T probably benign Het
Fap A T 2: 62,372,466 (GRCm39) probably benign Het
Gad1-ps C T 10: 99,280,641 (GRCm39) noncoding transcript Het
Gli3 T C 13: 15,823,166 (GRCm39) I296T probably damaging Het
H2-Q2 T C 17: 35,561,801 (GRCm39) V97A probably benign Het
Hr T A 14: 70,800,860 (GRCm39) probably null Het
Itgax C T 7: 127,748,370 (GRCm39) T1133I possibly damaging Het
L3mbtl2 G A 15: 81,566,194 (GRCm39) R339H probably damaging Het
Mast4 T C 13: 102,873,615 (GRCm39) K1726E possibly damaging Het
Nlrc5 T C 8: 95,203,483 (GRCm39) Y528H probably benign Het
Nmnat3 G A 9: 98,281,530 (GRCm39) G44D probably damaging Het
Nol8 A T 13: 49,815,044 (GRCm39) D366V probably damaging Het
Or13a25 C A 7: 140,247,424 (GRCm39) L68M probably damaging Het
Pde4d A T 13: 110,091,125 (GRCm39) probably benign Het
Ptpn22 C A 3: 103,819,332 (GRCm39) N795K probably benign Het
Rabgap1l A T 1: 160,549,739 (GRCm39) V289D probably damaging Het
Slc50a1 T C 3: 89,177,408 (GRCm39) D40G possibly damaging Het
Slco6b1 T C 1: 96,875,310 (GRCm39) noncoding transcript Het
Smarcad1 T A 6: 65,069,510 (GRCm39) F530Y probably damaging Het
Supt16 A T 14: 52,415,598 (GRCm39) I379N possibly damaging Het
Tmem154 A G 3: 84,591,567 (GRCm39) N39S probably benign Het
Ubash3b T A 9: 40,948,775 (GRCm39) Y180F probably damaging Het
Usp48 T A 4: 137,366,606 (GRCm39) D921E possibly damaging Het
Zdhhc20 T C 14: 58,076,556 (GRCm39) T366A probably benign Het
Zfp456 A T 13: 67,514,450 (GRCm39) C419S probably damaging Het
Zfp69 T C 4: 120,788,281 (GRCm39) T345A probably benign Het
Other mutations in Spag6
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00505:Spag6 APN 2 18,738,995 (GRCm39) missense probably benign 0.31
IGL01352:Spag6 APN 2 18,715,284 (GRCm39) missense possibly damaging 0.77
IGL02795:Spag6 APN 2 18,737,894 (GRCm39) missense probably benign
R0362:Spag6 UTSW 2 18,715,302 (GRCm39) missense probably damaging 0.99
R0423:Spag6 UTSW 2 18,715,404 (GRCm39) missense probably benign 0.00
R1309:Spag6 UTSW 2 18,739,027 (GRCm39) missense probably damaging 1.00
R1386:Spag6 UTSW 2 18,739,057 (GRCm39) missense possibly damaging 0.49
R1568:Spag6 UTSW 2 18,737,925 (GRCm39) missense probably benign
R1716:Spag6 UTSW 2 18,750,420 (GRCm39) splice site probably null
R1771:Spag6 UTSW 2 18,738,928 (GRCm39) missense probably benign 0.22
R1911:Spag6 UTSW 2 18,720,616 (GRCm39) nonsense probably null
R1985:Spag6 UTSW 2 18,736,930 (GRCm39) missense probably benign 0.00
R2029:Spag6 UTSW 2 18,738,916 (GRCm39) unclassified probably benign
R2131:Spag6 UTSW 2 18,737,908 (GRCm39) nonsense probably null
R3705:Spag6 UTSW 2 18,715,368 (GRCm39) missense probably damaging 0.99
R4230:Spag6 UTSW 2 18,720,449 (GRCm39) splice site probably null
R4585:Spag6 UTSW 2 18,736,958 (GRCm39) critical splice donor site probably null
R4586:Spag6 UTSW 2 18,736,958 (GRCm39) critical splice donor site probably null
R4692:Spag6 UTSW 2 18,704,054 (GRCm39) missense probably benign 0.24
R4745:Spag6 UTSW 2 18,742,107 (GRCm39) missense possibly damaging 0.78
R4890:Spag6 UTSW 2 18,747,588 (GRCm39) missense probably benign 0.00
R4914:Spag6 UTSW 2 18,750,360 (GRCm39) missense probably benign 0.00
R4918:Spag6 UTSW 2 18,750,360 (GRCm39) missense probably benign 0.00
R5086:Spag6 UTSW 2 18,747,688 (GRCm39) splice site probably benign
R5264:Spag6 UTSW 2 18,750,324 (GRCm39) missense probably benign 0.00
R5729:Spag6 UTSW 2 18,720,525 (GRCm39) missense probably benign
R5754:Spag6 UTSW 2 18,703,613 (GRCm39) unclassified probably benign
R5781:Spag6 UTSW 2 18,736,804 (GRCm39) missense probably benign
R5954:Spag6 UTSW 2 18,715,417 (GRCm39) missense probably damaging 1.00
R6246:Spag6 UTSW 2 18,703,906 (GRCm39) critical splice donor site probably null
R7607:Spag6 UTSW 2 18,736,773 (GRCm39) missense possibly damaging 0.87
R8261:Spag6 UTSW 2 18,750,301 (GRCm39) missense probably benign 0.01
R8411:Spag6 UTSW 2 18,715,394 (GRCm39) missense probably damaging 1.00
R8865:Spag6 UTSW 2 18,738,928 (GRCm39) missense probably benign 0.22
R9275:Spag6 UTSW 2 18,703,985 (GRCm39) missense probably benign 0.28
R9278:Spag6 UTSW 2 18,703,985 (GRCm39) missense probably benign 0.28
R9413:Spag6 UTSW 2 18,739,029 (GRCm39) missense probably benign
R9451:Spag6 UTSW 2 18,715,369 (GRCm39) nonsense probably null
R9660:Spag6 UTSW 2 18,704,047 (GRCm39) missense probably benign 0.37
Posted On 2016-08-02