Incidental Mutation 'IGL03408:Olfr498'
ID421650
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr498
Ensembl Gene ENSMUSG00000096679
Gene Nameolfactory receptor 498
SynonymsMOR204-36, GA_x6K02T2PBJ9-10795522-10796514
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.081) question?
Stock #IGL03408
Quality Score
Status
Chromosome7
Chromosomal Location108465326-108467585 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 108465347 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Tyrosine at position 8 (N8Y)
Ref Sequence ENSEMBL: ENSMUSP00000150971 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000217616]
Predicted Effect probably damaging
Transcript: ENSMUST00000074787
AA Change: N8Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000074343
Gene: ENSMUSG00000096679
AA Change: N8Y

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 1.7e-51 PFAM
Pfam:7tm_1 44 293 5.2e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217616
AA Change: N8Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730559C18Rik T C 1: 136,214,405 Y652C probably benign Het
Abca12 A T 1: 71,264,795 F2108I probably damaging Het
Aco2 T C 15: 81,899,223 probably null Het
Ccdc186 T C 19: 56,798,731 K602E probably benign Het
Ccdc85a T A 11: 28,576,528 H360L probably damaging Het
Cited2 A G 10: 17,724,400 H152R possibly damaging Het
Cluh C A 11: 74,665,953 R940S probably benign Het
Corin T A 5: 72,342,961 Y432F probably benign Het
Creb1 A G 1: 64,576,332 probably null Het
Dhx15 A T 5: 52,160,312 D568E probably damaging Het
Esam G T 9: 37,534,653 R162S possibly damaging Het
Fat3 T A 9: 15,997,957 K2250* probably null Het
Fbxl17 G A 17: 63,080,546 R133* probably null Het
Gm11639 T A 11: 104,710,621 S253R probably benign Het
Gzmc C T 14: 56,234,016 G23R probably damaging Het
Idh3a A G 9: 54,596,922 N189D probably benign Het
Il31ra A T 13: 112,525,888 D462E probably benign Het
Inpp5j G A 11: 3,502,809 A147V possibly damaging Het
Kalrn G A 16: 34,314,176 A412V probably damaging Het
Lrp1b A G 2: 40,858,582 V2968A probably damaging Het
Morc1 G A 16: 48,442,412 G42R probably damaging Het
Notch4 T C 17: 34,565,568 L85P probably benign Het
Olfr1263 G A 2: 90,015,571 V214M probably benign Het
Parp4 T A 14: 56,602,408 H524Q probably damaging Het
Pole T C 5: 110,294,560 F285L probably damaging Het
Scn9a A G 2: 66,526,747 M1070T probably benign Het
Slc25a32 G A 15: 39,100,030 A132V probably benign Het
Sult2a2 T G 7: 13,738,229 I117S probably damaging Het
Suv39h2 T C 2: 3,459,876 N183S probably damaging Het
Trhr2 G A 8: 122,358,795 T150M probably damaging Het
Usp34 T A 11: 23,446,957 F614I possibly damaging Het
Vmn2r17 A G 5: 109,429,372 probably benign Het
Wfdc2 T A 2: 164,563,363 C61* probably null Het
Zfp384 T C 6: 125,035,713 S377P probably damaging Het
Zfp945 A T 17: 22,852,537 Y150* probably null Het
Other mutations in Olfr498
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03232:Olfr498 APN 7 108465605 missense probably benign 0.06
IGL03348:Olfr498 APN 7 108465408 missense probably benign
IGL03047:Olfr498 UTSW 7 108465776 missense probably damaging 0.97
R0208:Olfr498 UTSW 7 108465543 missense probably damaging 1.00
R0363:Olfr498 UTSW 7 108465734 missense possibly damaging 0.81
R1481:Olfr498 UTSW 7 108465960 missense probably benign 0.00
R1886:Olfr498 UTSW 7 108465740 missense probably benign 0.39
R2065:Olfr498 UTSW 7 108465668 missense possibly damaging 0.69
R2103:Olfr498 UTSW 7 108465603 missense probably benign 0.03
R3731:Olfr498 UTSW 7 108465426 missense possibly damaging 0.88
R4763:Olfr498 UTSW 7 108466186 missense probably benign 0.34
R4839:Olfr498 UTSW 7 108465731 missense probably benign 0.03
R4997:Olfr498 UTSW 7 108465494 missense probably benign 0.01
R5533:Olfr498 UTSW 7 108466262 missense probably benign 0.00
R7286:Olfr498 UTSW 7 108465435 missense possibly damaging 0.52
R7910:Olfr498 UTSW 7 108465771 missense probably benign 0.01
R7991:Olfr498 UTSW 7 108465771 missense probably benign 0.01
R8005:Olfr498 UTSW 7 108465486 missense probably benign 0.01
Z1088:Olfr498 UTSW 7 108465371 missense probably benign
Z1176:Olfr498 UTSW 7 108465371 missense probably benign
Z1177:Olfr498 UTSW 7 108465371 missense probably benign
Z1177:Olfr498 UTSW 7 108466021 missense probably benign 0.08
Posted On2016-08-02