Incidental Mutation 'IGL03408:Sult2a2'
ID421654
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sult2a2
Ensembl Gene ENSMUSG00000070811
Gene Namesulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 2
SynonymsC730007P19Rik, Sth2, mSTa2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.100) question?
Stock #IGL03408
Quality Score
Status
Chromosome7
Chromosomal Location13733505-13779636 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 13738229 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Serine at position 117 (I117S)
Ref Sequence ENSEMBL: ENSMUSP00000083317 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086148]
Predicted Effect probably damaging
Transcript: ENSMUST00000086148
AA Change: I117S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000083317
Gene: ENSMUSG00000070811
AA Change: I117S

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 162 2.3e-37 PFAM
Pfam:Sulfotransfer_1 157 187 1.3e-8 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: This is one of seven sulfotransferase family 2A genes in a chromosome 7 A1 cluster. [provided by RefSeq, May 2010]
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5730559C18Rik T C 1: 136,214,405 Y652C probably benign Het
Abca12 A T 1: 71,264,795 F2108I probably damaging Het
Aco2 T C 15: 81,899,223 probably null Het
Ccdc186 T C 19: 56,798,731 K602E probably benign Het
Ccdc85a T A 11: 28,576,528 H360L probably damaging Het
Cited2 A G 10: 17,724,400 H152R possibly damaging Het
Cluh C A 11: 74,665,953 R940S probably benign Het
Corin T A 5: 72,342,961 Y432F probably benign Het
Creb1 A G 1: 64,576,332 probably null Het
Dhx15 A T 5: 52,160,312 D568E probably damaging Het
Esam G T 9: 37,534,653 R162S possibly damaging Het
Fat3 T A 9: 15,997,957 K2250* probably null Het
Fbxl17 G A 17: 63,080,546 R133* probably null Het
Gm11639 T A 11: 104,710,621 S253R probably benign Het
Gzmc C T 14: 56,234,016 G23R probably damaging Het
Idh3a A G 9: 54,596,922 N189D probably benign Het
Il31ra A T 13: 112,525,888 D462E probably benign Het
Inpp5j G A 11: 3,502,809 A147V possibly damaging Het
Kalrn G A 16: 34,314,176 A412V probably damaging Het
Lrp1b A G 2: 40,858,582 V2968A probably damaging Het
Morc1 G A 16: 48,442,412 G42R probably damaging Het
Notch4 T C 17: 34,565,568 L85P probably benign Het
Olfr1263 G A 2: 90,015,571 V214M probably benign Het
Olfr498 A T 7: 108,465,347 N8Y probably damaging Het
Parp4 T A 14: 56,602,408 H524Q probably damaging Het
Pole T C 5: 110,294,560 F285L probably damaging Het
Scn9a A G 2: 66,526,747 M1070T probably benign Het
Slc25a32 G A 15: 39,100,030 A132V probably benign Het
Suv39h2 T C 2: 3,459,876 N183S probably damaging Het
Trhr2 G A 8: 122,358,795 T150M probably damaging Het
Usp34 T A 11: 23,446,957 F614I possibly damaging Het
Vmn2r17 A G 5: 109,429,372 probably benign Het
Wfdc2 T A 2: 164,563,363 C61* probably null Het
Zfp384 T C 6: 125,035,713 S377P probably damaging Het
Zfp945 A T 17: 22,852,537 Y150* probably null Het
Other mutations in Sult2a2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00541:Sult2a2 APN 7 13734759 missense probably damaging 1.00
IGL01504:Sult2a2 APN 7 13738264 missense probably damaging 1.00
IGL01833:Sult2a2 APN 7 13734796 missense probably damaging 0.99
IGL03162:Sult2a2 APN 7 13734897 missense probably damaging 0.96
R0941:Sult2a2 UTSW 7 13734890 nonsense probably null
R1109:Sult2a2 UTSW 7 13734873 missense probably benign 0.01
R1376:Sult2a2 UTSW 7 13734771 missense probably damaging 0.99
R1376:Sult2a2 UTSW 7 13734771 missense probably damaging 0.99
R4114:Sult2a2 UTSW 7 13734783 missense probably benign 0.00
R4116:Sult2a2 UTSW 7 13734783 missense probably benign 0.00
R4940:Sult2a2 UTSW 7 13738298 missense probably benign 0.03
R5023:Sult2a2 UTSW 7 13734860 missense possibly damaging 0.79
R5510:Sult2a2 UTSW 7 13738303 missense probably damaging 0.99
R7424:Sult2a2 UTSW 7 13734897 missense possibly damaging 0.79
R7569:Sult2a2 UTSW 7 13779505 missense probably benign
R7800:Sult2a2 UTSW 7 13734785 missense probably benign 0.30
Posted On2016-08-02