Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03409:Zng1'

421691

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zng1

Ensembl Gene

ENSMUSG00000024878

Gene Name

Zn regulated GTPase metalloprotein activator 1

Synonyms

Cbwd1, Zng1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

IGL03409

Quality Score

Status

Chromosome

Chromosomal Location

24897280-24938974 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 24900130 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 289 (V289A)

Ref Sequence

ENSEMBL: ENSMUSP00000025815 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025815]

AlphaFold

Q8VEH6

Predicted Effect

probably benign
Transcript: ENSMUST00000025815
AA Change: V289A

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)

SMART Domains

Protein: ENSMUSP00000025815
Gene: ENSMUSG00000024878
AA Change: V289A

Domain	Start	End	E-Value	Type
low complexity region	9	16	N/A	INTRINSIC
Pfam:cobW	41	229	7.1e-51	PFAM
CobW_C	271	374	5.34e-1	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb10	A	T	8: 124,691,762 (GRCm39)	M401K	possibly damaging	Het
Ablim3	T	A	18: 61,978,922 (GRCm39)	H203L	probably damaging	Het
Ank2	C	A	3: 126,749,519 (GRCm39)	E503D	probably damaging	Het
Aox1	T	G	1: 58,393,588 (GRCm39)	D1249E	possibly damaging	Het
Astn2	T	C	4: 65,353,423 (GRCm39)	I1116V	possibly damaging	Het
Atad3a	T	C	4: 155,831,807 (GRCm39)	D489G	probably damaging	Het
Caln1	G	T	5: 130,646,719 (GRCm39)	G52C	probably damaging	Het
Clcn7	A	G	17: 25,374,359 (GRCm39)	T467A	probably damaging	Het
Col17a1	A	T	19: 47,654,979 (GRCm39)	I599N	possibly damaging	Het
Cul2	T	A	18: 3,429,593 (GRCm39)	H547Q	probably damaging	Het
Cxcl14	T	C	13: 56,440,320 (GRCm39)	T80A	probably damaging	Het
Dscaml1	T	A	9: 45,581,401 (GRCm39)	Y407N	probably damaging	Het
Edc4	T	A	8: 106,611,748 (GRCm39)	I108N	probably damaging	Het
Exoc2	T	C	13: 31,124,720 (GRCm39)		probably benign	Het
Gm1110	T	G	9: 26,807,916 (GRCm39)	H290P	probably benign	Het
Gm16223	T	A	5: 42,225,336 (GRCm39)	W12R	unknown	Het
Herc2	C	A	7: 55,878,317 (GRCm39)	H4623Q	probably damaging	Het
Igkv18-36	A	T	6: 69,969,589 (GRCm39)	H68Q	possibly damaging	Het
Kif7	T	C	7: 79,357,301 (GRCm39)	E635G	probably benign	Het
Or2t47	T	C	11: 58,442,388 (GRCm39)	K226E	probably benign	Het
Or4c109	A	T	2: 88,817,931 (GRCm39)	I205N	possibly damaging	Het
Or52z13	T	A	7: 103,246,574 (GRCm39)	M17K	possibly damaging	Het
Or9m1b	A	T	2: 87,836,239 (GRCm39)	N285K	probably damaging	Het
Pam	C	A	1: 97,792,054 (GRCm39)	A456S	probably benign	Het
Pgap3	T	C	11: 98,289,764 (GRCm39)	T76A	possibly damaging	Het
Pkd2	C	A	5: 104,637,215 (GRCm39)	Y609*	probably null	Het
Plcg2	A	G	8: 118,310,234 (GRCm39)	D362G	probably damaging	Het
Polr3h	C	A	15: 81,801,595 (GRCm39)	A94S	probably benign	Het
Rhod	T	C	19: 4,482,186 (GRCm39)	D76G	probably damaging	Het
Rims2	T	C	15: 39,320,129 (GRCm39)	V670A	probably damaging	Het
Rpap3	G	A	15: 97,579,620 (GRCm39)	T464M	possibly damaging	Het
Rufy1	T	A	11: 50,297,310 (GRCm39)	I381L	probably benign	Het
Slc1a4	T	C	11: 20,256,506 (GRCm39)	T442A	probably damaging	Het
Slc9b1	T	C	3: 135,100,670 (GRCm39)	S472P	probably damaging	Het
Tmtc3	T	C	10: 100,287,294 (GRCm39)	T501A	possibly damaging	Het
Tnpo3	C	A	6: 29,555,181 (GRCm39)	D801Y	probably damaging	Het
Ttc39b	T	C	4: 83,179,193 (GRCm39)	Y111C	probably damaging	Het
Ubr4	A	T	4: 139,127,240 (GRCm39)	R543*	probably null	Het
Vmn1r74	T	G	7: 11,581,240 (GRCm39)	L180R	probably damaging	Het
Vps45	T	G	3: 95,960,401 (GRCm39)	E80A	probably benign	Het
Zfp677	T	C	17: 21,617,107 (GRCm39)	Y55H	probably damaging	Het

Other mutations in Zng1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00720:Zng1	APN	19	24,898,495 (GRCm39)	missense	probably benign	0.01
IGL01618:Zng1	APN	19	24,918,140 (GRCm39)	missense	possibly damaging	0.83
IGL02351:Zng1	APN	19	24,909,026 (GRCm39)	critical splice donor site	probably null
IGL02358:Zng1	APN	19	24,909,026 (GRCm39)	critical splice donor site	probably null
IGL02628:Zng1	APN	19	24,935,269 (GRCm39)	missense	probably damaging	1.00
IGL03001:Zng1	APN	19	24,900,002 (GRCm39)	missense	probably benign	0.01
IGL03053:Zng1	APN	19	24,932,741 (GRCm39)	missense	probably damaging	1.00
R0544:Zng1	UTSW	19	24,926,575 (GRCm39)	missense	possibly damaging	0.79
R0655:Zng1	UTSW	19	24,930,684 (GRCm39)	missense	possibly damaging	0.90
R0833:Zng1	UTSW	19	24,918,203 (GRCm39)	splice site	probably benign
R1296:Zng1	UTSW	19	24,920,039 (GRCm39)	splice site	probably benign
R1723:Zng1	UTSW	19	24,925,458 (GRCm39)	missense	possibly damaging	0.89
R1888:Zng1	UTSW	19	24,932,769 (GRCm39)	missense	probably damaging	1.00
R1888:Zng1	UTSW	19	24,932,769 (GRCm39)	missense	probably damaging	1.00
R4526:Zng1	UTSW	19	24,935,328 (GRCm39)	missense	probably benign	0.20
R5092:Zng1	UTSW	19	24,898,383 (GRCm39)	critical splice donor site	probably null
R5238:Zng1	UTSW	19	24,897,994 (GRCm39)	missense	probably damaging	0.99
R5852:Zng1	UTSW	19	24,932,769 (GRCm39)	missense	possibly damaging	0.89
R7248:Zng1	UTSW	19	24,898,505 (GRCm39)	missense	probably damaging	0.99
R7699:Zng1	UTSW	19	24,920,045 (GRCm39)	critical splice donor site	probably null
R7700:Zng1	UTSW	19	24,920,045 (GRCm39)	critical splice donor site	probably null
R7733:Zng1	UTSW	19	24,918,158 (GRCm39)	missense	probably damaging	1.00
R8363:Zng1	UTSW	19	24,920,091 (GRCm39)	missense	probably benign	0.01
R8825:Zng1	UTSW	19	24,926,601 (GRCm39)	missense	probably benign	0.23
R8931:Zng1	UTSW	19	24,932,780 (GRCm39)	missense	probably damaging	1.00
R9118:Zng1	UTSW	19	24,920,048 (GRCm39)	missense	probably damaging	1.00
R9467:Zng1	UTSW	19	24,930,684 (GRCm39)	missense	possibly damaging	0.90

Posted On

2016-08-02