Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03410:Oprm1'

421744

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Oprm1

Ensembl Gene

ENSMUSG00000000766

Gene Name

opioid receptor, mu 1

Synonyms

Oprm, MOP receptor, mor, muOR, MOR-1, MOP-R

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.090) question?

Stock #

IGL03410

Quality Score

Status

Chromosome

Chromosomal Location

6758506-7038198 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 6830051 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 238 (I238F)

Ref Sequence

ENSEMBL: ENSMUSP00000114342 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000783] [ENSMUST00000052751] [ENSMUST00000056385] [ENSMUST00000063036] [ENSMUST00000078634] [ENSMUST00000092729] [ENSMUST00000092731] [ENSMUST00000092734] [ENSMUST00000105597] [ENSMUST00000105601] [ENSMUST00000105602] [ENSMUST00000105603] [ENSMUST00000105611] [ENSMUST00000144264] [ENSMUST00000105604] [ENSMUST00000154941] [ENSMUST00000105605] [ENSMUST00000129954] [ENSMUST00000105607] [ENSMUST00000135502] [ENSMUST00000129221] [ENSMUST00000105615] [ENSMUST00000123861] [ENSMUST00000154906] [ENSMUST00000147171] [ENSMUST00000152674] [ENSMUST00000150374] [ENSMUST00000143875]

AlphaFold

P42866

Predicted Effect

probably damaging
Transcript: ENSMUST00000000783
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000000783
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	339	1.6e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1.3e-10	PFAM
Pfam:7tm_1	85	336	4e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000052751
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000060329
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1.1e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1e-10	PFAM
Pfam:7tm_1	85	336	3.2e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000056385
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000060590
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1.7e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1e-10	PFAM
Pfam:7tm_1	85	336	3.3e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000063036
AA Change: I170F

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000053498
Gene: ENSMUSG00000000766
AA Change: I170F

Domain	Start	End	E-Value	Type
Pfam:7tm_1	24	268	8.7e-64	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000078634
AA Change: I238F

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000077704
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	339	2.1e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	2.4e-10	PFAM
Pfam:7tm_1	85	336	9e-60	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000092729
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000090405
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1.7e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	9.6e-11	PFAM
Pfam:7tm_1	85	336	3.1e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000092731
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000090407
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	9.9e-11	PFAM
Pfam:7tm_1	85	336	3.2e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000092734
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000090410
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1.7e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1e-10	PFAM
Pfam:7tm_1	85	336	3.3e-67	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000105597

Predicted Effect

probably benign
Transcript: ENSMUST00000105601
AA Change: H120L

PolyPhen 2 Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)

SMART Domains

Protein: ENSMUSP00000101226
Gene: ENSMUSG00000000766
AA Change: H120L

Domain	Start	End	E-Value	Type
SCOP:d1l9ha_	46	100	3e-9	SMART
PDB:4DKL\|A	52	100	3e-21	PDB
low complexity region	119	131	N/A	INTRINSIC
low complexity region	173	184	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000105602
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000101227
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1.8e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	9.8e-11	PFAM
Pfam:7tm_1	85	336	3.1e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000105603
AA Change: I238F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000101228
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	6.7e-8	PFAM
Pfam:7TM_GPCR_Srsx	79	351	9.6e-11	PFAM
Pfam:7tm_1	85	336	3.6e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000105611
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000101236
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	338	1.7e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1.4e-10	PFAM
Pfam:7tm_1	85	336	4.4e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000144264
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000115836
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1.7e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1e-10	PFAM
Pfam:7tm_1	85	336	3.4e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000105604
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000101229
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	332	5.1e-8	PFAM
Pfam:7TM_GPCR_Srsx	79	351	9.9e-11	PFAM
Pfam:7tm_1	85	336	3.8e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000154941
AA Change: I174F

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000115413
Gene: ENSMUSG00000000766
AA Change: I174F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	12	261	9.6e-8	PFAM
Pfam:7TM_GPCR_Srsx	15	287	6.1e-11	PFAM
Pfam:7tm_1	21	272	2e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000105605
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000101230
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	9.8e-11	PFAM
Pfam:7tm_1	85	336	3.2e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000129954
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000122385
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	338	6.9e-8	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1.5e-10	PFAM
Pfam:7tm_1	85	336	5.4e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000105607
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000101232
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	325	1.7e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1e-10	PFAM
Pfam:7tm_1	85	336	3.3e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000135502
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000135143
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	339	2.2e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1.9e-10	PFAM
Pfam:7tm_1	85	336	7.5e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000129221
AA Change: I174F

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000123117
Gene: ENSMUSG00000000766
AA Change: I174F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	12	261	1.1e-7	PFAM
Pfam:7TM_GPCR_Srsx	15	287	7.3e-11	PFAM
Pfam:7tm_1	21	272	2.4e-67	PFAM
low complexity region	340	351	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000105615
AA Change: I170F

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000101240
Gene: ENSMUSG00000000766
AA Change: I170F

Domain	Start	End	E-Value	Type
Pfam:7tm_1	24	268	1.3e-63	PFAM

Predicted Effect

possibly damaging
Transcript: ENSMUST00000123861
AA Change: H120L

PolyPhen 2 Score 0.787 (Sensitivity: 0.85; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000120187
Gene: ENSMUSG00000000766
AA Change: H120L

Domain	Start	End	E-Value	Type
SCOP:d1l9ha_	46	100	3e-9	SMART
PDB:4DKL\|A	52	100	3e-21	PDB
low complexity region	119	131	N/A	INTRINSIC
low complexity region	173	184	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000154906
AA Change: I238F

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000114342
Gene: ENSMUSG00000000766
AA Change: I238F

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	76	332	1.5e-7	PFAM
Pfam:7TM_GPCR_Srsx	79	351	1.1e-10	PFAM
Pfam:7tm_1	85	336	3.6e-67	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000147171
AA Change: I170F

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000117950
Gene: ENSMUSG00000000766
AA Change: I170F

Domain	Start	End	E-Value	Type
Pfam:7tm_1	24	268	9.2e-64	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000141897

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000148625

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133486

Predicted Effect

probably benign
Transcript: ENSMUST00000152674

SMART Domains

Protein: ENSMUSP00000115552
Gene: ENSMUSG00000000766

Domain	Start	End	E-Value	Type
SCOP:d1l9ha_	46	94	8e-8	SMART
PDB:4DKL\|A	52	94	7e-23	PDB

Predicted Effect

probably benign
Transcript: ENSMUST00000150374

Predicted Effect

probably benign
Transcript: ENSMUST00000143875

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]
PHENOTYPE: Homozygotes for null mutations exhibit isoform dependent loss of behavioral and gastrointestinal opioid responses and may also show impaired spatial memory, heightened nociception, reduced locomotor activity, increased hematopoietic proliferation, and decreased male fertility. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	T	A	17: 9,001,896	V409E	probably damaging	Het
1700086D15Rik	A	G	11: 65,152,567		probably benign	Het
Apba1	A	G	19: 23,937,581	N715S	possibly damaging	Het
Arfgef3	G	T	10: 18,600,490	A1527D	probably damaging	Het
Cmtm2a	G	T	8: 104,283,869	P133T	probably damaging	Het
Cyp2d9	T	C	15: 82,456,699	V483A	probably benign	Het
Dclre1b	T	A	3: 103,808,140	D14V	probably damaging	Het
Dock5	T	C	14: 67,846,086	I125V	probably benign	Het
Dok3	G	T	13: 55,524,231	Y211*	probably null	Het
Fat4	T	C	3: 38,891,176	V1406A	probably damaging	Het
Fbn2	A	G	18: 58,050,243	F1790S	possibly damaging	Het
Gm13083	C	A	4: 143,615,281	H93Q	probably benign	Het
Gm4787	A	T	12: 81,379,174	M70K	probably damaging	Het
Gulp1	A	T	1: 44,708,617	D10V	probably damaging	Het
Hagh	T	C	17: 24,860,942		probably benign	Het
Htt	A	G	5: 34,799,445	E206G	probably damaging	Het
Hyou1	A	G	9: 44,388,058	E682G	probably benign	Het
Igkv4-59	G	T	6: 69,438,466	A35E	probably damaging	Het
Krt78	A	G	15: 101,953,986	V80A	probably damaging	Het
Lars2	G	A	9: 123,418,776	A333T	possibly damaging	Het
Lrrc4	G	A	6: 28,830,516	R367W	probably damaging	Het
Med1	A	T	11: 98,189,183	M44K	possibly damaging	Het
Mep1a	T	A	17: 43,478,095		probably null	Het
Mmrn1	A	G	6: 60,975,835	I367V	probably benign	Het
Myo18a	T	C	11: 77,848,004	L1677P	probably damaging	Het
Neb	T	C	2: 52,319,705	T246A	probably benign	Het
Nkiras1	A	G	14: 18,280,073	R155G	probably benign	Het
Nrip1	T	C	16: 76,292,491	N726S	probably benign	Het
Nyap2	A	G	1: 81,241,441	T393A	possibly damaging	Het
Olfr1029	T	A	2: 85,975,420	M59K	probably damaging	Het
Olfr1272	A	G	2: 90,282,213	Y121H	probably damaging	Het
Olfr32	G	A	2: 90,139,145		probably benign	Het
Pcnx2	T	A	8: 125,887,040	E557D	probably damaging	Het
Pole	A	G	5: 110,324,559	I1563V	probably benign	Het
Prdx3	T	G	19: 60,871,410		probably benign	Het
Rgsl1	C	T	1: 153,793,755	R295K	probably null	Het
Rhbdl2	T	A	4: 123,829,670	L289*	probably null	Het
Rnps1	A	G	17: 24,421,861		probably benign	Het
Rpgrip1	A	G	14: 52,158,366		probably benign	Het
Ryr2	A	T	13: 11,588,147	Y4518N	probably damaging	Het
Scyl3	A	G	1: 163,944,867	N296S	probably damaging	Het
Sipa1l3	G	A	7: 29,348,539	T1308M	probably damaging	Het
Slc39a9	A	G	12: 80,644,888	D3G	probably damaging	Het
Slc4a9	A	G	18: 36,529,687	E165G	probably benign	Het
Slc6a3	A	T	13: 73,538,657	I48F	probably benign	Het
Stxbp3	C	T	3: 108,802,160	C354Y	probably damaging	Het
Terb1	C	A	8: 104,473,042		probably benign	Het
Tfrc	G	A	16: 32,624,831		probably null	Het
Toporsl	A	C	4: 52,611,134	R342S	probably benign	Het
Ttc26	T	C	6: 38,385,500	L70P	probably damaging	Het
Ube2d3	T	A	3: 135,465,217	W141R	probably damaging	Het
Vps13b	G	T	15: 35,910,340	V3417L	probably benign	Het

Other mutations in Oprm1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01018:Oprm1	APN	10	7037170	utr 3 prime	probably benign
IGL01768:Oprm1	APN	10	6829186	missense	probably damaging	1.00
IGL02455:Oprm1	APN	10	6830219	missense	probably damaging	1.00
IGL03391:Oprm1	APN	10	7014077	intron	probably benign
IGL03048:Oprm1	UTSW	10	6829064	missense	probably damaging	1.00
R0189:Oprm1	UTSW	10	6789071	missense	possibly damaging	0.94
R0321:Oprm1	UTSW	10	6829183	missense	probably damaging	1.00
R0629:Oprm1	UTSW	10	6832604	splice site	probably null
R0730:Oprm1	UTSW	10	6832652	intron	probably benign
R1542:Oprm1	UTSW	10	6788960	missense	probably damaging	1.00
R1743:Oprm1	UTSW	10	6830105	missense	probably damaging	0.99
R1874:Oprm1	UTSW	10	6789035	missense	probably benign	0.17
R2864:Oprm1	UTSW	10	6794226	splice site	probably null
R2964:Oprm1	UTSW	10	6788914	missense	probably damaging	0.98
R3792:Oprm1	UTSW	10	6839544	missense	probably benign	0.00
R4008:Oprm1	UTSW	10	6832520	missense	probably benign
R4049:Oprm1	UTSW	10	6829087	missense	probably benign	0.36
R4088:Oprm1	UTSW	10	6830234	missense	probably damaging	1.00
R4724:Oprm1	UTSW	10	6758656	nonsense	probably null
R4812:Oprm1	UTSW	10	6832698	intron	probably benign
R4822:Oprm1	UTSW	10	6829036	missense	probably damaging	0.99
R4855:Oprm1	UTSW	10	6838468	missense	probably benign	0.01
R5072:Oprm1	UTSW	10	6832550	missense	probably benign	0.15
R5768:Oprm1	UTSW	10	6789026	missense	probably damaging	1.00
R5770:Oprm1	UTSW	10	6789026	missense	probably damaging	1.00
R5995:Oprm1	UTSW	10	6832520	missense	probably benign
R6327:Oprm1	UTSW	10	6830063	missense	probably damaging	0.99
R7135:Oprm1	UTSW	10	6830203	missense	possibly damaging	0.77
R7413:Oprm1	UTSW	10	6828919	missense	probably damaging	1.00
R7455:Oprm1	UTSW	10	6830204	missense	probably damaging	1.00
R8192:Oprm1	UTSW	10	6838417	missense	probably benign	0.04
R8210:Oprm1	UTSW	10	6830442	missense	probably benign	0.02
R8945:Oprm1	UTSW	10	6832644	intron	probably benign
R9054:Oprm1	UTSW	10	6823914	intron	probably benign
R9723:Oprm1	UTSW	10	6838514	missense	possibly damaging	0.66
R9726:Oprm1	UTSW	10	6979694	missense	probably benign	0.00
X0066:Oprm1	UTSW	10	6830462	missense	probably damaging	0.99

Posted On

2016-08-02