Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03410:Nkiras1'

421751

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nkiras1

Ensembl Gene

ENSMUSG00000021772

Gene Name

NFKB inhibitor interacting Ras-like protein 1

Synonyms

2400004O09Rik, KBRAS1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.105) question?

Stock #

IGL03410

Quality Score

Status

Chromosome

Chromosomal Location

18271136-18284003 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 18280073 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Glycine at position 155 (R155G)

Ref Sequence

ENSEMBL: ENSMUSP00000121496 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000022294] [ENSMUST00000022296] [ENSMUST00000132374] [ENSMUST00000133460] [ENSMUST00000225612]

AlphaFold

Q8CEC5

Predicted Effect

probably benign
Transcript: ENSMUST00000022294

SMART Domains

Protein: ENSMUSP00000022294
Gene: ENSMUSG00000021772

Domain	Start	End	E-Value	Type
SCOP:d1i2ma_	5	39	1e-6	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000022296

SMART Domains

Protein: ENSMUSP00000022296
Gene: ENSMUSG00000021774

Domain	Start	End	E-Value	Type
low complexity region	2	18	N/A	INTRINSIC
UBCc	50	193	2.41e-71	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000132374
AA Change: R155G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000121496
Gene: ENSMUSG00000021772
AA Change: R155G

Domain	Start	End	E-Value	Type
Pfam:Arf	1	168	7.8e-11	PFAM
Pfam:Roc	6	124	1.6e-13	PFAM
Pfam:Ras	6	170	5.2e-28	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000133460

SMART Domains

Protein: ENSMUSP00000122235
Gene: ENSMUSG00000021772

Domain	Start	End	E-Value	Type
Pfam:Arf	4	115	1.7e-7	PFAM
Pfam:Ras	4	118	1.3e-21	PFAM
Pfam:Miro	5	97	1.7e-12	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000145355

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000150209

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000152735

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000156186

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160266

Predicted Effect

probably benign
Transcript: ENSMUST00000225612

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	T	A	17: 9,001,896	V409E	probably damaging	Het
1700086D15Rik	A	G	11: 65,152,567		probably benign	Het
Apba1	A	G	19: 23,937,581	N715S	possibly damaging	Het
Arfgef3	G	T	10: 18,600,490	A1527D	probably damaging	Het
Cmtm2a	G	T	8: 104,283,869	P133T	probably damaging	Het
Cyp2d9	T	C	15: 82,456,699	V483A	probably benign	Het
Dclre1b	T	A	3: 103,808,140	D14V	probably damaging	Het
Dock5	T	C	14: 67,846,086	I125V	probably benign	Het
Dok3	G	T	13: 55,524,231	Y211*	probably null	Het
Fat4	T	C	3: 38,891,176	V1406A	probably damaging	Het
Fbn2	A	G	18: 58,050,243	F1790S	possibly damaging	Het
Gm13083	C	A	4: 143,615,281	H93Q	probably benign	Het
Gm4787	A	T	12: 81,379,174	M70K	probably damaging	Het
Gulp1	A	T	1: 44,708,617	D10V	probably damaging	Het
Hagh	T	C	17: 24,860,942		probably benign	Het
Htt	A	G	5: 34,799,445	E206G	probably damaging	Het
Hyou1	A	G	9: 44,388,058	E682G	probably benign	Het
Igkv4-59	G	T	6: 69,438,466	A35E	probably damaging	Het
Krt78	A	G	15: 101,953,986	V80A	probably damaging	Het
Lars2	G	A	9: 123,418,776	A333T	possibly damaging	Het
Lrrc4	G	A	6: 28,830,516	R367W	probably damaging	Het
Med1	A	T	11: 98,189,183	M44K	possibly damaging	Het
Mep1a	T	A	17: 43,478,095		probably null	Het
Mmrn1	A	G	6: 60,975,835	I367V	probably benign	Het
Myo18a	T	C	11: 77,848,004	L1677P	probably damaging	Het
Neb	T	C	2: 52,319,705	T246A	probably benign	Het
Nrip1	T	C	16: 76,292,491	N726S	probably benign	Het
Nyap2	A	G	1: 81,241,441	T393A	possibly damaging	Het
Olfr1029	T	A	2: 85,975,420	M59K	probably damaging	Het
Olfr1272	A	G	2: 90,282,213	Y121H	probably damaging	Het
Olfr32	G	A	2: 90,139,145		probably benign	Het
Oprm1	A	T	10: 6,830,051	I238F	probably damaging	Het
Pcnx2	T	A	8: 125,887,040	E557D	probably damaging	Het
Pole	A	G	5: 110,324,559	I1563V	probably benign	Het
Prdx3	T	G	19: 60,871,410		probably benign	Het
Rgsl1	C	T	1: 153,793,755	R295K	probably null	Het
Rhbdl2	T	A	4: 123,829,670	L289*	probably null	Het
Rnps1	A	G	17: 24,421,861		probably benign	Het
Rpgrip1	A	G	14: 52,158,366		probably benign	Het
Ryr2	A	T	13: 11,588,147	Y4518N	probably damaging	Het
Scyl3	A	G	1: 163,944,867	N296S	probably damaging	Het
Sipa1l3	G	A	7: 29,348,539	T1308M	probably damaging	Het
Slc39a9	A	G	12: 80,644,888	D3G	probably damaging	Het
Slc4a9	A	G	18: 36,529,687	E165G	probably benign	Het
Slc6a3	A	T	13: 73,538,657	I48F	probably benign	Het
Stxbp3	C	T	3: 108,802,160	C354Y	probably damaging	Het
Terb1	C	A	8: 104,473,042		probably benign	Het
Tfrc	G	A	16: 32,624,831		probably null	Het
Toporsl	A	C	4: 52,611,134	R342S	probably benign	Het
Ttc26	T	C	6: 38,385,500	L70P	probably damaging	Het
Ube2d3	T	A	3: 135,465,217	W141R	probably damaging	Het
Vps13b	G	T	15: 35,910,340	V3417L	probably benign	Het

Other mutations in Nkiras1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00518:Nkiras1	APN	14	18278435	missense	probably benign	0.03
IGL01986:Nkiras1	APN	14	18280071	missense	probably damaging	0.99
IGL02593:Nkiras1	APN	14	18278475	missense	possibly damaging	0.49
R0230:Nkiras1	UTSW	14	18280185	missense	probably benign	0.01
R0508:Nkiras1	UTSW	14	18278524	missense	probably damaging	1.00
R1835:Nkiras1	UTSW	14	18276732	missense	probably damaging	1.00
R2400:Nkiras1	UTSW	14	18280011	missense	possibly damaging	0.50
R4789:Nkiras1	UTSW	14	18276935	start gained	probably benign
R7232:Nkiras1	UTSW	14	18276732	missense	probably damaging	1.00
R8201:Nkiras1	UTSW	14	18276908	start gained	probably benign

Posted On

2016-08-02