Incidental Mutation 'IGL03410:Nkiras1'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Nkiras1
Ensembl Gene ENSMUSG00000021772
Gene NameNFKB inhibitor interacting Ras-like protein 1
Synonyms2400004O09Rik, KBRAS1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.120) question?
Stock #IGL03410
Quality Score
Chromosomal Location18271136-18284003 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 18280073 bp
Amino Acid Change Arginine to Glycine at position 155 (R155G)
Ref Sequence ENSEMBL: ENSMUSP00000121496 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022294] [ENSMUST00000022296] [ENSMUST00000132374] [ENSMUST00000133460] [ENSMUST00000225612]
Predicted Effect probably benign
Transcript: ENSMUST00000022294
SMART Domains Protein: ENSMUSP00000022294
Gene: ENSMUSG00000021772

SCOP:d1i2ma_ 5 39 1e-6 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000022296
SMART Domains Protein: ENSMUSP00000022296
Gene: ENSMUSG00000021774

low complexity region 2 18 N/A INTRINSIC
UBCc 50 193 2.41e-71 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000132374
AA Change: R155G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000121496
Gene: ENSMUSG00000021772
AA Change: R155G

Pfam:Arf 1 168 7.8e-11 PFAM
Pfam:Roc 6 124 1.6e-13 PFAM
Pfam:Ras 6 170 5.2e-28 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000133460
SMART Domains Protein: ENSMUSP00000122235
Gene: ENSMUSG00000021772

Pfam:Arf 4 115 1.7e-7 PFAM
Pfam:Ras 4 118 1.3e-21 PFAM
Pfam:Miro 5 97 1.7e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145355
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150209
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152735
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156186
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160266
Predicted Effect probably benign
Transcript: ENSMUST00000225612
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik T A 17: 9,001,896 V409E probably damaging Het
1700086D15Rik A G 11: 65,152,567 probably benign Het
Apba1 A G 19: 23,937,581 N715S possibly damaging Het
Arfgef3 G T 10: 18,600,490 A1527D probably damaging Het
Cmtm2a G T 8: 104,283,869 P133T probably damaging Het
Cyp2d9 T C 15: 82,456,699 V483A probably benign Het
Dclre1b T A 3: 103,808,140 D14V probably damaging Het
Dock5 T C 14: 67,846,086 I125V probably benign Het
Dok3 G T 13: 55,524,231 Y211* probably null Het
Fat4 T C 3: 38,891,176 V1406A probably damaging Het
Fbn2 A G 18: 58,050,243 F1790S possibly damaging Het
Gm13083 C A 4: 143,615,281 H93Q probably benign Het
Gm4787 A T 12: 81,379,174 M70K probably damaging Het
Gulp1 A T 1: 44,708,617 D10V probably damaging Het
Hagh T C 17: 24,860,942 probably benign Het
Htt A G 5: 34,799,445 E206G probably damaging Het
Hyou1 A G 9: 44,388,058 E682G probably benign Het
Igkv4-59 G T 6: 69,438,466 A35E probably damaging Het
Krt78 A G 15: 101,953,986 V80A probably damaging Het
Lars2 G A 9: 123,418,776 A333T possibly damaging Het
Lrrc4 G A 6: 28,830,516 R367W probably damaging Het
Med1 A T 11: 98,189,183 M44K possibly damaging Het
Mep1a T A 17: 43,478,095 probably null Het
Mmrn1 A G 6: 60,975,835 I367V probably benign Het
Myo18a T C 11: 77,848,004 L1677P probably damaging Het
Neb T C 2: 52,319,705 T246A probably benign Het
Nrip1 T C 16: 76,292,491 N726S probably benign Het
Nyap2 A G 1: 81,241,441 T393A possibly damaging Het
Olfr1029 T A 2: 85,975,420 M59K probably damaging Het
Olfr1272 A G 2: 90,282,213 Y121H probably damaging Het
Olfr32 G A 2: 90,139,145 probably benign Het
Oprm1 A T 10: 6,830,051 I238F probably damaging Het
Pcnx2 T A 8: 125,887,040 E557D probably damaging Het
Pole A G 5: 110,324,559 I1563V probably benign Het
Prdx3 T G 19: 60,871,410 probably benign Het
Rgsl1 C T 1: 153,793,755 R295K probably null Het
Rhbdl2 T A 4: 123,829,670 L289* probably null Het
Rnps1 A G 17: 24,421,861 probably benign Het
Rpgrip1 A G 14: 52,158,366 probably benign Het
Ryr2 A T 13: 11,588,147 Y4518N probably damaging Het
Scyl3 A G 1: 163,944,867 N296S probably damaging Het
Sipa1l3 G A 7: 29,348,539 T1308M probably damaging Het
Slc39a9 A G 12: 80,644,888 D3G probably damaging Het
Slc4a9 A G 18: 36,529,687 E165G probably benign Het
Slc6a3 A T 13: 73,538,657 I48F probably benign Het
Stxbp3 C T 3: 108,802,160 C354Y probably damaging Het
Terb1 C A 8: 104,473,042 probably benign Het
Tfrc G A 16: 32,624,831 probably null Het
Toporsl A C 4: 52,611,134 R342S probably benign Het
Ttc26 T C 6: 38,385,500 L70P probably damaging Het
Ube2d3 T A 3: 135,465,217 W141R probably damaging Het
Vps13b G T 15: 35,910,340 V3417L probably benign Het
Other mutations in Nkiras1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00518:Nkiras1 APN 14 18278435 missense probably benign 0.03
IGL01986:Nkiras1 APN 14 18280071 missense probably damaging 0.99
IGL02593:Nkiras1 APN 14 18278475 missense possibly damaging 0.49
R0230:Nkiras1 UTSW 14 18280185 missense probably benign 0.01
R0508:Nkiras1 UTSW 14 18278524 missense probably damaging 1.00
R1835:Nkiras1 UTSW 14 18276732 missense probably damaging 1.00
R2400:Nkiras1 UTSW 14 18280011 missense possibly damaging 0.50
R4789:Nkiras1 UTSW 14 18276935 start gained probably benign
R7232:Nkiras1 UTSW 14 18276732 missense probably damaging 1.00
R8201:Nkiras1 UTSW 14 18276908 start gained probably benign
Posted On2016-08-02