Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL03410:Olfr32'

421777

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Olfr32

Ensembl Gene

ENSMUSG00000075066

Gene Name

olfactory receptor 32

Synonyms

MOR227-9_p, GA_x6K02T2Q125-51573576-51572650, MOR227-7P, MTPCR05

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.069) question?

Stock #

IGL03410

Quality Score

Status

Chromosome

Chromosomal Location

90136273-90142296 bp(-) (GRCm38)

Type of Mutation

start gained

DNA Base Change (assembly)

G to A at 90139145 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149175 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099755] [ENSMUST00000213293] [ENSMUST00000214973] [ENSMUST00000215153] [ENSMUST00000215659] [ENSMUST00000215765]

AlphaFold

Q7TQZ0

Predicted Effect

probably benign
Transcript: ENSMUST00000099755

SMART Domains

Protein: ENSMUSP00000097344
Gene: ENSMUSG00000075066

Domain	Start	End	E-Value	Type
Pfam:7tm_4	28	302	1.7e-52	PFAM
Pfam:7tm_1	38	284	6.8e-21	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000213293

Predicted Effect

probably benign
Transcript: ENSMUST00000214973

Predicted Effect

probably benign
Transcript: ENSMUST00000215153

Predicted Effect

probably benign
Transcript: ENSMUST00000215659

Predicted Effect

probably benign
Transcript: ENSMUST00000215765

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	T	A	17: 9,001,896	V409E	probably damaging	Het
1700086D15Rik	A	G	11: 65,152,567		probably benign	Het
Apba1	A	G	19: 23,937,581	N715S	possibly damaging	Het
Arfgef3	G	T	10: 18,600,490	A1527D	probably damaging	Het
Cmtm2a	G	T	8: 104,283,869	P133T	probably damaging	Het
Cyp2d9	T	C	15: 82,456,699	V483A	probably benign	Het
Dclre1b	T	A	3: 103,808,140	D14V	probably damaging	Het
Dock5	T	C	14: 67,846,086	I125V	probably benign	Het
Dok3	G	T	13: 55,524,231	Y211*	probably null	Het
Fat4	T	C	3: 38,891,176	V1406A	probably damaging	Het
Fbn2	A	G	18: 58,050,243	F1790S	possibly damaging	Het
Gm13083	C	A	4: 143,615,281	H93Q	probably benign	Het
Gm4787	A	T	12: 81,379,174	M70K	probably damaging	Het
Gulp1	A	T	1: 44,708,617	D10V	probably damaging	Het
Hagh	T	C	17: 24,860,942		probably benign	Het
Htt	A	G	5: 34,799,445	E206G	probably damaging	Het
Hyou1	A	G	9: 44,388,058	E682G	probably benign	Het
Igkv4-59	G	T	6: 69,438,466	A35E	probably damaging	Het
Krt78	A	G	15: 101,953,986	V80A	probably damaging	Het
Lars2	G	A	9: 123,418,776	A333T	possibly damaging	Het
Lrrc4	G	A	6: 28,830,516	R367W	probably damaging	Het
Med1	A	T	11: 98,189,183	M44K	possibly damaging	Het
Mep1a	T	A	17: 43,478,095		probably null	Het
Mmrn1	A	G	6: 60,975,835	I367V	probably benign	Het
Myo18a	T	C	11: 77,848,004	L1677P	probably damaging	Het
Neb	T	C	2: 52,319,705	T246A	probably benign	Het
Nkiras1	A	G	14: 18,280,073	R155G	probably benign	Het
Nrip1	T	C	16: 76,292,491	N726S	probably benign	Het
Nyap2	A	G	1: 81,241,441	T393A	possibly damaging	Het
Olfr1029	T	A	2: 85,975,420	M59K	probably damaging	Het
Olfr1272	A	G	2: 90,282,213	Y121H	probably damaging	Het
Oprm1	A	T	10: 6,830,051	I238F	probably damaging	Het
Pcnx2	T	A	8: 125,887,040	E557D	probably damaging	Het
Pole	A	G	5: 110,324,559	I1563V	probably benign	Het
Prdx3	T	G	19: 60,871,410		probably benign	Het
Rgsl1	C	T	1: 153,793,755	R295K	probably null	Het
Rhbdl2	T	A	4: 123,829,670	L289*	probably null	Het
Rnps1	A	G	17: 24,421,861		probably benign	Het
Rpgrip1	A	G	14: 52,158,366		probably benign	Het
Ryr2	A	T	13: 11,588,147	Y4518N	probably damaging	Het
Scyl3	A	G	1: 163,944,867	N296S	probably damaging	Het
Sipa1l3	G	A	7: 29,348,539	T1308M	probably damaging	Het
Slc39a9	A	G	12: 80,644,888	D3G	probably damaging	Het
Slc4a9	A	G	18: 36,529,687	E165G	probably benign	Het
Slc6a3	A	T	13: 73,538,657	I48F	probably benign	Het
Stxbp3	C	T	3: 108,802,160	C354Y	probably damaging	Het
Terb1	C	A	8: 104,473,042		probably benign	Het
Tfrc	G	A	16: 32,624,831		probably null	Het
Toporsl	A	C	4: 52,611,134	R342S	probably benign	Het
Ttc26	T	C	6: 38,385,500	L70P	probably damaging	Het
Ube2d3	T	A	3: 135,465,217	W141R	probably damaging	Het
Vps13b	G	T	15: 35,910,340	V3417L	probably benign	Het

Other mutations in Olfr32

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01328:Olfr32	APN	2	90139074	missense	probably benign	0.30
IGL01976:Olfr32	APN	2	90138924	missense	probably damaging	1.00
IGL02076:Olfr32	APN	2	90138815	missense	probably damaging	1.00
IGL03030:Olfr32	APN	2	90138662	missense	possibly damaging	0.93
IGL03235:Olfr32	APN	2	90139070	missense	possibly damaging	0.88
R1240:Olfr32	UTSW	2	90138813	missense	possibly damaging	0.48
R1511:Olfr32	UTSW	2	90138404	missense	probably benign	0.13
R1602:Olfr32	UTSW	2	90139055	missense	probably damaging	1.00
R1828:Olfr32	UTSW	2	90138587	missense	probably damaging	0.99
R2023:Olfr32	UTSW	2	90138856	nonsense	probably null
R2177:Olfr32	UTSW	2	90138464	missense	possibly damaging	0.70
R2679:Olfr32	UTSW	2	90138545	missense	possibly damaging	0.93
R4490:Olfr32	UTSW	2	90138917	missense	probably damaging	0.97
R4585:Olfr32	UTSW	2	90138214	missense	probably benign	0.01
R4586:Olfr32	UTSW	2	90138214	missense	probably benign	0.01
R4649:Olfr32	UTSW	2	90139088	missense	probably damaging	0.99
R4688:Olfr32	UTSW	2	90138999	missense	possibly damaging	0.80
R4694:Olfr32	UTSW	2	90138249	nonsense	probably null
R5245:Olfr32	UTSW	2	90138262	missense	probably damaging	1.00
R5509:Olfr32	UTSW	2	90138892	missense	probably damaging	1.00
R5991:Olfr32	UTSW	2	90138234	nonsense	probably null
R6004:Olfr32	UTSW	2	90138999	missense	probably benign	0.32
R6128:Olfr32	UTSW	2	90138610	nonsense	probably null
R6519:Olfr32	UTSW	2	90138812	missense	possibly damaging	0.90
R7472:Olfr32	UTSW	2	90138324	missense	probably damaging	1.00
R7892:Olfr32	UTSW	2	90138492	missense	probably benign	0.00
R8017:Olfr32	UTSW	2	90138826	missense	probably benign	0.02
R8046:Olfr32	UTSW	2	90138815	missense	probably damaging	1.00
R8464:Olfr32	UTSW	2	90138603	missense	possibly damaging	0.67
R8712:Olfr32	UTSW	2	90138770	missense	probably damaging	1.00
R8998:Olfr32	UTSW	2	90139128	missense	probably benign
X0066:Olfr32	UTSW	2	90138390	missense	probably damaging	1.00

Posted On

2016-08-02