Incidental Mutation 'R5325:Olfr908'
ID 421898
Institutional Source Beutler Lab
Gene Symbol Olfr908
Ensembl Gene ENSMUSG00000063732
Gene Name olfactory receptor 908
Synonyms GA_x6K02T2PVTD-32216179-32217111, MOR165-2
MMRRC Submission 042908-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.116) question?
Stock # R5325 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 38427330-38428261 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 38427454 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 42 (N42I)
Ref Sequence ENSEMBL: ENSMUSP00000151016 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000215139]
AlphaFold no structure available at present
Predicted Effect noncoding transcript
Transcript: ENSMUST00000075798
Predicted Effect noncoding transcript
Transcript: ENSMUST00000104052
Predicted Effect probably damaging
Transcript: ENSMUST00000215139
AA Change: N42I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency 98% (55/56)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ace3 T A 11: 105,896,079 (GRCm39) M675K probably benign Het
Ccdc186 A T 19: 56,801,613 (GRCm39) I168N probably damaging Het
Ccnb1 C G 13: 100,918,283 (GRCm39) Q121H possibly damaging Het
Cep83 A G 10: 94,573,768 (GRCm39) E219G probably damaging Het
Ctsj T C 13: 61,151,839 (GRCm39) T73A possibly damaging Het
Ddr2 T A 1: 169,829,406 (GRCm39) T283S probably benign Het
Ehbp1 T A 11: 22,045,370 (GRCm39) D768V possibly damaging Het
Evpl T C 11: 116,112,191 (GRCm39) D1833G probably damaging Het
Exoc1 A G 5: 76,685,549 (GRCm39) N87S probably benign Het
Fam98b A C 2: 117,101,132 (GRCm39) I315L possibly damaging Het
Fancg A G 4: 43,006,564 (GRCm39) V330A probably damaging Het
Fbxo30 G A 10: 11,166,846 (GRCm39) V523I possibly damaging Het
Fbxw27 A G 9: 109,599,161 (GRCm39) C419R probably damaging Het
Flt3 C A 5: 147,312,459 (GRCm39) V161L probably benign Het
Fndc7 G A 3: 108,790,765 (GRCm39) T87I probably damaging Het
Gm4787 G C 12: 81,424,604 (GRCm39) T518S probably benign Het
Gm6457 A T 18: 14,703,498 (GRCm39) noncoding transcript Het
Gpr63 T C 4: 25,007,294 (GRCm39) V6A probably benign Het
Grhl3 T A 4: 135,286,415 (GRCm39) K89* probably null Het
H2-M10.2 C A 17: 36,596,471 (GRCm39) V125L probably benign Het
Hrh4 C T 18: 13,155,054 (GRCm39) Q198* probably null Het
Lrch4 A G 5: 137,636,168 (GRCm39) E373G probably damaging Het
Mroh9 C G 1: 162,888,329 (GRCm39) G249R probably damaging Het
Noa1 A C 5: 77,452,042 (GRCm39) D547E probably damaging Het
Nr2e1 G A 10: 42,448,780 (GRCm39) R153W probably damaging Het
Nudt9 A C 5: 104,198,487 (GRCm39) M1L possibly damaging Het
Odf2 T A 2: 29,802,583 (GRCm39) D282E probably benign Het
Or13a25 C A 7: 140,247,705 (GRCm39) H168Q probably benign Het
Or6ae1 T A 7: 139,742,026 (GRCm39) Y279F probably damaging Het
Osbpl5 C G 7: 143,245,665 (GRCm39) A816P probably damaging Het
Pan2 T C 10: 128,153,503 (GRCm39) I924T possibly damaging Het
Ppat A G 5: 77,076,269 (GRCm39) probably benign Het
Rad50 T G 11: 53,583,690 (GRCm39) I364L probably benign Het
Rnf7l A G 10: 63,257,458 (GRCm39) S21P probably benign Het
Robo2 A G 16: 73,770,673 (GRCm39) I484T possibly damaging Het
Ryr2 A T 13: 11,705,249 (GRCm39) M2839K probably damaging Het
Sin3b A G 8: 73,477,154 (GRCm39) D807G probably damaging Het
Sirpb1a G A 3: 15,476,503 (GRCm39) T98I possibly damaging Het
Smim17 G A 7: 6,432,321 (GRCm39) V88M probably damaging Het
Spib T C 7: 44,177,505 (GRCm39) T229A probably damaging Het
St14 A T 9: 31,008,274 (GRCm39) probably null Het
Syne4 A T 7: 30,018,401 (GRCm39) Y381F probably damaging Het
Sytl1 T C 4: 132,988,382 (GRCm39) probably benign Het
Tnpo3 A C 6: 29,602,012 (GRCm39) probably benign Het
Trim12a T A 7: 103,953,413 (GRCm39) I233F probably damaging Het
Tspan1 T A 4: 116,021,536 (GRCm39) N82Y probably damaging Het
Vmn1r60 T A 7: 5,547,201 (GRCm39) M300L probably benign Het
Wdr17 G A 8: 55,112,716 (GRCm39) A788V possibly damaging Het
Wwtr1 A T 3: 57,482,658 (GRCm39) V63E probably benign Het
Ylpm1 A G 12: 85,060,735 (GRCm39) probably benign Het
Zfp956 T C 6: 47,928,012 (GRCm39) probably benign Het
Other mutations in Olfr908
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4656:Olfr908 UTSW 9 38,427,852 (GRCm39) missense probably damaging 1.00
R4772:Olfr908 UTSW 9 38,427,897 (GRCm39) unclassified probably benign
R4795:Olfr908 UTSW 9 38,427,799 (GRCm39) missense probably damaging 0.98
R5296:Olfr908 UTSW 9 38,427,412 (GRCm39) missense probably damaging 1.00
R5371:Olfr908 UTSW 9 38,427,434 (GRCm39) small deletion probably benign
R5374:Olfr908 UTSW 9 38,427,434 (GRCm39) small deletion probably benign
R5473:Olfr908 UTSW 9 38,427,508 (GRCm39) missense probably damaging 1.00
R6761:Olfr908 UTSW 9 38,427,561 (GRCm39) missense probably damaging 1.00
R7743:Olfr908 UTSW 9 38,427,624 (GRCm39) missense possibly damaging 0.66
R9560:Olfr908 UTSW 9 38,427,385 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TCATGTGCCCTTATAATTGTCACAG -3'
(R):5'- GGCCATTGATGACAGAACAC -3'

Sequencing Primer
(F):5'- TGCAGGGATTGACAAGTG -3'
(R):5'- ATAGAGCTGGGTCATACATCCTAC -3'
Posted On 2016-08-04