Incidental Mutation 'R5327:Fndc1'
ID 422089
Institutional Source Beutler Lab
Gene Symbol Fndc1
Ensembl Gene ENSMUSG00000071984
Gene Name fibronectin type III domain containing 1
Synonyms 1110027O12Rik
MMRRC Submission 042910-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R5327 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 7957401-8046134 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 7991540 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 719 (S719P)
Ref Sequence ENSEMBL: ENSMUSP00000095036 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000097425]
AlphaFold A0A6I8MWX0
Predicted Effect unknown
Transcript: ENSMUST00000097425
AA Change: S719P
SMART Domains Protein: ENSMUSP00000095036
Gene: ENSMUSG00000071984
AA Change: S719P

DomainStartEndE-ValueType
Blast:FN3 1 50 6e-25 BLAST
FN3 54 137 7.82e-4 SMART
FN3 156 240 1.48e-4 SMART
FN3 256 340 3.67e-9 SMART
low complexity region 377 388 N/A INTRINSIC
low complexity region 579 601 N/A INTRINSIC
low complexity region 646 676 N/A INTRINSIC
low complexity region 766 777 N/A INTRINSIC
low complexity region 868 884 N/A INTRINSIC
low complexity region 1021 1027 N/A INTRINSIC
low complexity region 1036 1050 N/A INTRINSIC
low complexity region 1076 1090 N/A INTRINSIC
Blast:FN3 1227 1276 2e-18 BLAST
low complexity region 1277 1354 N/A INTRINSIC
low complexity region 1395 1403 N/A INTRINSIC
low complexity region 1407 1423 N/A INTRINSIC
FN3 1494 1577 4.32e-6 SMART
Meta Mutation Damage Score 0.0742 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 100% (101/101)
Allele List at MGI
Other mutations in this stock
Total: 94 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AA986860 A G 1: 130,668,740 (GRCm39) S36G probably damaging Het
Aarsd1 T C 11: 101,301,203 (GRCm39) N280D probably benign Het
Abca2 T A 2: 25,335,686 (GRCm39) M2099K probably damaging Het
Abcb5 T A 12: 118,875,278 (GRCm39) E631D probably benign Het
Acss2 T A 2: 155,415,149 (GRCm39) L682Q probably null Het
Adamts14 G A 10: 61,034,267 (GRCm39) P1207L probably benign Het
Adora1 G A 1: 134,130,748 (GRCm39) R308* probably null Het
Arcn1 A T 9: 44,668,444 (GRCm39) V264E probably benign Het
B3galt1 G A 2: 67,949,112 (GRCm39) G276S probably damaging Het
Bms1 A T 6: 118,382,179 (GRCm39) M453K possibly damaging Het
Bnip3l T C 14: 67,225,180 (GRCm39) Y218C probably damaging Het
Cacna2d2 A G 9: 107,390,805 (GRCm39) E379G probably null Het
Cacng6 G A 7: 3,483,376 (GRCm39) G235R probably damaging Het
Capn8 A T 1: 182,456,169 (GRCm39) T640S probably benign Het
Ccdc106 T C 7: 5,063,159 (GRCm39) probably benign Het
Ccdc33 A T 9: 57,993,860 (GRCm39) N95K probably benign Het
Celsr3 T A 9: 108,719,907 (GRCm39) probably benign Het
Cemip A T 7: 83,604,509 (GRCm39) N844K probably damaging Het
Chrdl2 A T 7: 99,677,948 (GRCm39) T284S probably damaging Het
Ckm A G 7: 19,154,090 (GRCm39) Y279C probably damaging Het
Clvs1 A T 4: 9,424,261 (GRCm39) I236F probably damaging Het
Col9a1 T C 1: 24,234,620 (GRCm39) probably null Het
Csmd1 T C 8: 17,266,728 (GRCm39) E66G possibly damaging Het
Ctdsp2 A G 10: 126,831,923 (GRCm39) D26G probably damaging Het
Ctsll3 C A 13: 60,946,721 (GRCm39) probably null Het
Cyp2d12 A T 15: 82,439,423 (GRCm39) M26L probably benign Het
Cyp8b1 C T 9: 121,743,950 (GRCm39) D461N probably damaging Het
Dbt A T 3: 116,322,220 (GRCm39) probably benign Het
Dnah7c A G 1: 46,704,728 (GRCm39) D2247G probably benign Het
Dsg1c A G 18: 20,400,994 (GRCm39) I166V possibly damaging Het
Duoxa1 T A 2: 122,134,361 (GRCm39) E252D probably damaging Het
Ezr T A 17: 7,020,448 (GRCm39) K211M probably damaging Het
Faap100 T A 11: 120,268,458 (GRCm39) E105V possibly damaging Het
Fahd2a T C 2: 127,283,878 (GRCm39) D54G possibly damaging Het
Fbxo9 A T 9: 78,003,146 (GRCm39) probably null Het
Gas7 G T 11: 67,552,916 (GRCm39) G159C probably damaging Het
Gba2 T C 4: 43,574,063 (GRCm39) D130G probably damaging Het
Gli3 T G 13: 15,723,092 (GRCm39) S78A probably damaging Het
Gtpbp6 A G 5: 110,254,770 (GRCm39) F101S probably damaging Het
Gzme G A 14: 56,355,224 (GRCm39) H236Y probably benign Het
Hira T C 16: 18,773,508 (GRCm39) Y943H probably damaging Het
Hmbox1 G A 14: 65,134,144 (GRCm39) S152L possibly damaging Het
Ibtk A G 9: 85,619,519 (GRCm39) probably null Het
Jade1 T C 3: 41,568,413 (GRCm39) I827T possibly damaging Het
Jakmip3 A T 7: 138,627,164 (GRCm39) E389D possibly damaging Het
Klhdc8b A T 9: 108,326,241 (GRCm39) probably benign Het
Lama2 T C 10: 27,014,942 (GRCm39) T1589A probably benign Het
Lbx2 A C 6: 83,064,784 (GRCm39) K107T probably damaging Het
Ldha A G 7: 46,503,522 (GRCm39) M259V probably benign Het
Lrrtm4 A G 6: 79,999,620 (GRCm39) K344R probably damaging Het
Ltb A T 17: 35,414,935 (GRCm39) E245V probably damaging Het
Macf1 GCCCCC GCCCCCC 4: 123,244,784 (GRCm39) probably null Het
Map3k13 T A 16: 21,740,397 (GRCm39) S575T possibly damaging Het
Mcpt2 A T 14: 56,280,833 (GRCm39) I74F probably damaging Het
Mpeg1 T A 19: 12,439,013 (GRCm39) V157D probably damaging Het
Mrpl21 A T 19: 3,337,009 (GRCm39) probably null Het
Nagpa T C 16: 5,017,877 (GRCm39) T99A possibly damaging Het
Nphs1 A T 7: 30,163,250 (GRCm39) I469F probably benign Het
Nyap2 A G 1: 81,169,756 (GRCm39) E171G possibly damaging Het
Oas1e A G 5: 120,930,006 (GRCm39) Y171H probably damaging Het
Or10ag59 T A 2: 87,406,043 (GRCm39) V205D probably damaging Het
Or2y1f T C 11: 49,184,493 (GRCm39) L115P probably damaging Het
Or5ac23 T C 16: 59,149,461 (GRCm39) K137R probably benign Het
Or5h26 T C 16: 58,987,983 (GRCm39) I174M possibly damaging Het
Otud7b C A 3: 96,063,055 (GRCm39) Q765K probably benign Het
Pdzd7 A G 19: 45,017,216 (GRCm39) V851A probably benign Het
Pi4ka T G 16: 17,143,277 (GRCm39) K794T probably damaging Het
Pkhd1l1 T A 15: 44,410,258 (GRCm39) N2588K probably damaging Het
Pla2g6 A T 15: 79,186,837 (GRCm39) M471K probably benign Het
Plagl2 T C 2: 153,077,759 (GRCm39) H74R possibly damaging Het
Prf1 T A 10: 61,136,037 (GRCm39) N104K probably benign Het
Ptprf A T 4: 118,093,586 (GRCm39) I358N probably damaging Het
Rcsd1 A G 1: 165,482,872 (GRCm39) probably null Het
Rev1 G A 1: 38,147,532 (GRCm39) R3* probably null Het
Rp1 T C 1: 4,419,583 (GRCm39) probably null Het
Rrp12 G A 19: 41,881,035 (GRCm39) T132I probably damaging Het
Sema3a T C 5: 13,649,357 (GRCm39) V702A probably benign Het
Serpinb12 A G 1: 106,884,174 (GRCm39) N307D probably damaging Het
Slc35d1 A G 4: 103,070,383 (GRCm39) L103P probably damaging Het
Smyd4 T C 11: 75,281,765 (GRCm39) C413R probably damaging Het
Stab1 G A 14: 30,883,793 (GRCm39) Q255* probably null Het
Synpo T A 18: 60,736,918 (GRCm39) I343F possibly damaging Het
Tcirg1 A G 19: 3,952,342 (GRCm39) probably null Het
Tmem132c A G 5: 127,640,816 (GRCm39) T996A possibly damaging Het
Trim10 A G 17: 37,181,081 (GRCm39) E104G probably damaging Het
Trpc1 T C 9: 95,603,524 (GRCm39) probably null Het
Tspo2 A T 17: 48,756,887 (GRCm39) probably benign Het
Ugt2a3 A T 5: 87,479,174 (GRCm39) I258N probably damaging Het
Usp34 T C 11: 23,418,846 (GRCm39) L2998P probably damaging Het
Vmn1r45 A C 6: 89,910,123 (GRCm39) D162E possibly damaging Het
Vmn2r117 A T 17: 23,696,848 (GRCm39) Y186* probably null Het
Vmn2r67 A G 7: 84,785,698 (GRCm39) F769S probably damaging Het
Zbtb17 A G 4: 141,192,942 (GRCm39) I514V probably benign Het
Zfp329 A C 7: 12,545,421 (GRCm39) D34E probably benign Het
Other mutations in Fndc1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00513:Fndc1 APN 17 7,984,086 (GRCm39) missense unknown
IGL00590:Fndc1 APN 17 7,983,933 (GRCm39) missense unknown
IGL00765:Fndc1 APN 17 7,991,525 (GRCm39) missense unknown
IGL00904:Fndc1 APN 17 7,975,195 (GRCm39) missense probably benign 0.35
IGL01153:Fndc1 APN 17 7,998,874 (GRCm39) critical splice donor site probably null
IGL01557:Fndc1 APN 17 7,975,221 (GRCm39) missense probably damaging 0.99
IGL02493:Fndc1 APN 17 7,994,377 (GRCm39) missense unknown
IGL02501:Fndc1 APN 17 7,984,230 (GRCm39) missense unknown
IGL02503:Fndc1 APN 17 7,990,348 (GRCm39) missense unknown
IGL02887:Fndc1 APN 17 7,992,470 (GRCm39) missense unknown
IGL03348:Fndc1 APN 17 7,991,479 (GRCm39) missense unknown
pinnacle UTSW 17 7,992,154 (GRCm39) missense unknown
spire UTSW 17 7,990,312 (GRCm39) missense unknown
IGL02988:Fndc1 UTSW 17 7,972,355 (GRCm39) missense possibly damaging 0.95
PIT4466001:Fndc1 UTSW 17 7,969,206 (GRCm39) missense probably damaging 1.00
R0336:Fndc1 UTSW 17 7,983,939 (GRCm39) missense unknown
R0403:Fndc1 UTSW 17 7,994,420 (GRCm39) splice site probably null
R0403:Fndc1 UTSW 17 7,972,555 (GRCm39) missense probably damaging 1.00
R0538:Fndc1 UTSW 17 8,003,173 (GRCm39) splice site probably benign
R0646:Fndc1 UTSW 17 7,960,505 (GRCm39) missense possibly damaging 0.92
R1140:Fndc1 UTSW 17 7,994,258 (GRCm39) missense unknown
R1523:Fndc1 UTSW 17 7,992,041 (GRCm39) missense unknown
R1609:Fndc1 UTSW 17 7,991,598 (GRCm39) missense unknown
R1632:Fndc1 UTSW 17 7,992,032 (GRCm39) missense unknown
R1888:Fndc1 UTSW 17 7,990,621 (GRCm39) missense unknown
R1888:Fndc1 UTSW 17 7,990,621 (GRCm39) missense unknown
R2004:Fndc1 UTSW 17 8,023,761 (GRCm39) missense probably damaging 1.00
R2007:Fndc1 UTSW 17 7,997,580 (GRCm39) unclassified probably benign
R2128:Fndc1 UTSW 17 7,997,497 (GRCm39) unclassified probably benign
R2187:Fndc1 UTSW 17 7,960,604 (GRCm39) missense probably damaging 1.00
R2251:Fndc1 UTSW 17 7,972,439 (GRCm39) missense probably damaging 1.00
R2322:Fndc1 UTSW 17 8,007,847 (GRCm39) missense probably damaging 0.98
R2425:Fndc1 UTSW 17 8,023,850 (GRCm39) missense probably damaging 1.00
R2921:Fndc1 UTSW 17 8,023,707 (GRCm39) missense probably damaging 0.98
R2985:Fndc1 UTSW 17 7,975,155 (GRCm39) missense possibly damaging 0.93
R3436:Fndc1 UTSW 17 7,969,189 (GRCm39) missense probably damaging 0.99
R3499:Fndc1 UTSW 17 7,972,416 (GRCm39) missense possibly damaging 0.70
R3508:Fndc1 UTSW 17 7,983,940 (GRCm39) nonsense probably null
R3766:Fndc1 UTSW 17 8,003,253 (GRCm39) missense probably damaging 1.00
R3813:Fndc1 UTSW 17 7,992,154 (GRCm39) missense unknown
R3814:Fndc1 UTSW 17 7,992,154 (GRCm39) missense unknown
R4031:Fndc1 UTSW 17 7,988,584 (GRCm39) nonsense probably null
R4544:Fndc1 UTSW 17 7,992,376 (GRCm39) missense unknown
R4583:Fndc1 UTSW 17 7,958,081 (GRCm39) missense probably damaging 1.00
R4619:Fndc1 UTSW 17 7,984,036 (GRCm39) missense unknown
R4700:Fndc1 UTSW 17 7,990,312 (GRCm39) missense unknown
R4743:Fndc1 UTSW 17 7,991,111 (GRCm39) nonsense probably null
R4803:Fndc1 UTSW 17 7,972,538 (GRCm39) missense probably damaging 0.98
R4862:Fndc1 UTSW 17 7,988,567 (GRCm39) missense unknown
R4876:Fndc1 UTSW 17 7,990,471 (GRCm39) missense unknown
R5057:Fndc1 UTSW 17 7,990,802 (GRCm39) nonsense probably null
R5372:Fndc1 UTSW 17 7,984,042 (GRCm39) missense unknown
R5533:Fndc1 UTSW 17 7,991,608 (GRCm39) missense unknown
R5754:Fndc1 UTSW 17 7,988,585 (GRCm39) missense unknown
R5762:Fndc1 UTSW 17 7,990,366 (GRCm39) missense unknown
R5830:Fndc1 UTSW 17 8,007,918 (GRCm39) missense possibly damaging 0.87
R5924:Fndc1 UTSW 17 7,992,442 (GRCm39) missense unknown
R6147:Fndc1 UTSW 17 7,972,594 (GRCm39) splice site probably null
R6175:Fndc1 UTSW 17 7,991,479 (GRCm39) missense unknown
R6303:Fndc1 UTSW 17 7,977,317 (GRCm39) missense probably damaging 0.98
R6377:Fndc1 UTSW 17 7,988,567 (GRCm39) missense unknown
R6704:Fndc1 UTSW 17 7,990,642 (GRCm39) missense unknown
R6857:Fndc1 UTSW 17 7,991,002 (GRCm39) missense unknown
R6865:Fndc1 UTSW 17 7,991,672 (GRCm39) missense unknown
R7069:Fndc1 UTSW 17 7,988,567 (GRCm39) missense unknown
R7153:Fndc1 UTSW 17 8,020,477 (GRCm39) missense probably damaging 1.00
R7159:Fndc1 UTSW 17 8,019,763 (GRCm39) missense probably damaging 0.97
R7359:Fndc1 UTSW 17 8,032,318 (GRCm39) splice site probably null
R7731:Fndc1 UTSW 17 7,992,271 (GRCm39) missense unknown
R7743:Fndc1 UTSW 17 7,983,969 (GRCm39) missense unknown
R7884:Fndc1 UTSW 17 7,992,029 (GRCm39) missense unknown
R8071:Fndc1 UTSW 17 7,991,362 (GRCm39) missense unknown
R8100:Fndc1 UTSW 17 7,990,685 (GRCm39) missense unknown
R8317:Fndc1 UTSW 17 8,019,720 (GRCm39) nonsense probably null
R8362:Fndc1 UTSW 17 8,001,207 (GRCm39) missense unknown
R8835:Fndc1 UTSW 17 7,958,111 (GRCm39) missense probably damaging 1.00
R8841:Fndc1 UTSW 17 7,992,181 (GRCm39) missense unknown
R8912:Fndc1 UTSW 17 8,019,778 (GRCm39) missense probably null 0.26
R9236:Fndc1 UTSW 17 7,992,460 (GRCm39) missense unknown
R9392:Fndc1 UTSW 17 7,991,957 (GRCm39) missense unknown
R9412:Fndc1 UTSW 17 7,991,198 (GRCm39) missense unknown
R9618:Fndc1 UTSW 17 7,990,313 (GRCm39) missense unknown
R9632:Fndc1 UTSW 17 7,991,622 (GRCm39) missense unknown
R9748:Fndc1 UTSW 17 7,991,929 (GRCm39) missense unknown
Z1088:Fndc1 UTSW 17 8,001,311 (GRCm39) missense probably damaging 0.96
Z1176:Fndc1 UTSW 17 8,023,709 (GRCm39) missense possibly damaging 0.90
Z1176:Fndc1 UTSW 17 7,992,425 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- AGCCTCTTCTCAGAGTGTCTG -3'
(R):5'- CGAGGAAGAGGACACTTCTG -3'

Sequencing Primer
(F):5'- TGTCTGAGCCCCCAGAGATTG -3'
(R):5'- AGAGGACACTTCTGATGGTGG -3'
Posted On 2016-08-04