Incidental Mutation 'R5361:Or1o4'
ID 422836
Institutional Source Beutler Lab
Gene Symbol Or1o4
Ensembl Gene ENSMUSG00000061972
Gene Name olfactory receptor family 1 subfamily O member 4
Synonyms MOR156-1, GA_x6K02T2PSCP-1720261-1719344, Olfr99
MMRRC Submission 042940-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.174) question?
Stock # R5361 (G1)
Quality Score 225
Status Not validated
Chromosome 17
Chromosomal Location 37590392-37591309 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 37590501 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 270 (V270A)
Ref Sequence ENSEMBL: ENSMUSP00000148900 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077585] [ENSMUST00000216328]
AlphaFold Q8VFE4
Predicted Effect probably benign
Transcript: ENSMUST00000077585
AA Change: V270A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
SMART Domains Protein: ENSMUSP00000076781
Gene: ENSMUSG00000061972
AA Change: V270A

DomainStartEndE-ValueType
Pfam:7tm_4 28 305 1.8e-58 PFAM
Pfam:7TM_GPCR_Srsx 32 302 1.4e-6 PFAM
Pfam:7tm_1 38 287 1e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000173568
Predicted Effect probably benign
Transcript: ENSMUST00000216328
AA Change: V270A

PolyPhen 2 Score 0.021 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216370
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017B05Rik T A 9: 57,164,468 (GRCm39) K635N probably damaging Het
Afg3l2 G T 18: 67,554,329 (GRCm39) L458M probably damaging Het
Ahnak T A 19: 8,992,705 (GRCm39) M4663K possibly damaging Het
C4b T A 17: 34,960,212 (GRCm39) T280S probably benign Het
Ccdc166 A G 15: 75,852,869 (GRCm39) V366A probably benign Het
Cdh23 A G 10: 60,493,044 (GRCm39) probably null Het
Col7a1 A G 9: 108,792,292 (GRCm39) T1281A unknown Het
Cul9 TTCCTCCTCCTCCTCCTCCTCCTC TTCCTCCTCCTCCTCCTCCTC 17: 46,811,775 (GRCm39) probably benign Het
Dbndd1 T A 8: 124,233,484 (GRCm39) D127V probably damaging Het
Ddx20 T A 3: 105,590,825 (GRCm39) E197V probably damaging Het
Dennd10 A G 19: 60,814,324 (GRCm39) M96V probably benign Het
Dnm3 A G 1: 161,838,471 (GRCm39) S826P probably damaging Het
Dnmt3a T C 12: 3,945,643 (GRCm39) V24A probably benign Het
Dop1b C A 16: 93,567,392 (GRCm39) A1273E probably damaging Het
Dsg1c T C 18: 20,416,703 (GRCm39) V868A possibly damaging Het
Dtx4 A G 19: 12,462,626 (GRCm39) probably null Het
Elovl4 A G 9: 83,672,154 (GRCm39) L55P possibly damaging Het
Fbxo40 T A 16: 36,789,914 (GRCm39) T399S possibly damaging Het
Fkbpl G A 17: 34,864,303 (GRCm39) A24T probably benign Het
Gm14399 T C 2: 174,973,371 (GRCm39) E96G probably damaging Het
Gm14496 T G 2: 181,642,147 (GRCm39) V606G probably benign Het
Gpr156 A G 16: 37,826,087 (GRCm39) E768G probably damaging Het
Grm5 A T 7: 87,723,704 (GRCm39) T665S probably damaging Het
Hsdl2 A G 4: 59,592,301 (GRCm39) probably benign Het
Htt T C 5: 35,064,928 (GRCm39) V3047A possibly damaging Het
Igkv3-2 A T 6: 70,676,011 (GRCm39) T107S probably benign Het
Insyn2b G A 11: 34,352,788 (GRCm39) E277K probably damaging Het
Itih2 T A 2: 10,101,272 (GRCm39) T899S probably benign Het
Lhcgr T A 17: 89,050,281 (GRCm39) Y415F probably damaging Het
Ltbr G A 6: 125,289,757 (GRCm39) R146W probably damaging Het
Med4 C A 14: 73,747,553 (GRCm39) S18* probably null Het
Nefl T C 14: 68,322,088 (GRCm39) V226A probably damaging Het
Nploc4 T A 11: 120,275,389 (GRCm39) N516Y probably damaging Het
Or6c66 A T 10: 129,461,601 (GRCm39) F110I probably damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Pcdha3 T G 18: 37,079,752 (GRCm39) L165V possibly damaging Het
Pcdhb12 T A 18: 37,570,099 (GRCm39) V415D probably damaging Het
Pcdhga10 T C 18: 37,880,503 (GRCm39) I88T probably damaging Het
Pigyl T A 9: 22,069,292 (GRCm39) M1K probably null Het
Prr27 T C 5: 87,991,203 (GRCm39) S272P probably damaging Het
Prss3 C T 6: 41,350,780 (GRCm39) D237N probably benign Het
Pstpip2 A G 18: 77,958,078 (GRCm39) D150G probably damaging Het
Robo4 T A 9: 37,324,674 (GRCm39) D909E probably benign Het
Serpinb3c A T 1: 107,204,661 (GRCm39) Y28* probably null Het
Slc26a3 T C 12: 31,500,980 (GRCm39) probably null Het
Slc6a1 A T 6: 114,279,493 (GRCm39) I91F probably benign Het
Smcr8 T G 11: 60,669,118 (GRCm39) Y89D probably damaging Het
Sspo T A 6: 48,443,247 (GRCm39) M1898K probably benign Het
Tbl1xr1 T A 3: 22,246,233 (GRCm39) I251K probably damaging Het
Thbs4 C T 13: 92,913,501 (GRCm39) D140N probably benign Het
Tmbim6 G A 15: 99,303,633 (GRCm39) A108T probably benign Het
Trim10 T G 17: 37,186,328 (GRCm39) L301R probably benign Het
Trpm7 A T 2: 126,671,161 (GRCm39) I607N possibly damaging Het
Vmn2r9 T A 5: 108,995,929 (GRCm39) I240F probably damaging Het
Xpot T A 10: 121,436,765 (GRCm39) I873F possibly damaging Het
Zfhx4 G A 3: 5,464,267 (GRCm39) S1475N probably damaging Het
Zfp712 A G 13: 67,189,079 (GRCm39) S483P possibly damaging Het
Zswim7 A T 11: 62,158,373 (GRCm39) H122Q probably benign Het
Other mutations in Or1o4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01878:Or1o4 APN 17 37,590,891 (GRCm39) missense possibly damaging 0.46
IGL02954:Or1o4 APN 17 37,591,195 (GRCm39) missense probably damaging 1.00
R0533:Or1o4 UTSW 17 37,591,182 (GRCm39) nonsense probably null
R1480:Or1o4 UTSW 17 37,590,636 (GRCm39) missense probably benign 0.01
R2872:Or1o4 UTSW 17 37,590,867 (GRCm39) missense possibly damaging 0.64
R2872:Or1o4 UTSW 17 37,590,867 (GRCm39) missense possibly damaging 0.64
R3772:Or1o4 UTSW 17 37,590,745 (GRCm39) missense probably benign 0.00
R3826:Or1o4 UTSW 17 37,591,140 (GRCm39) missense probably damaging 1.00
R3827:Or1o4 UTSW 17 37,591,140 (GRCm39) missense probably damaging 1.00
R3829:Or1o4 UTSW 17 37,591,140 (GRCm39) missense probably damaging 1.00
R5210:Or1o4 UTSW 17 37,590,824 (GRCm39) missense probably benign 0.13
R6213:Or1o4 UTSW 17 37,591,264 (GRCm39) missense probably benign
R6399:Or1o4 UTSW 17 37,590,666 (GRCm39) missense probably damaging 1.00
R6881:Or1o4 UTSW 17 37,591,200 (GRCm39) missense probably benign 0.01
R7938:Or1o4 UTSW 17 37,590,991 (GRCm39) missense probably benign 0.03
R8097:Or1o4 UTSW 17 37,590,818 (GRCm39) nonsense probably null
R8125:Or1o4 UTSW 17 37,590,935 (GRCm39) missense probably benign 0.01
R8218:Or1o4 UTSW 17 37,590,711 (GRCm39) missense probably benign
R9050:Or1o4 UTSW 17 37,590,820 (GRCm39) missense probably damaging 0.97
R9126:Or1o4 UTSW 17 37,590,745 (GRCm39) missense probably benign 0.00
R9434:Or1o4 UTSW 17 37,591,254 (GRCm39) missense probably benign 0.01
R9495:Or1o4 UTSW 17 37,591,386 (GRCm39) start gained probably benign
R9514:Or1o4 UTSW 17 37,591,386 (GRCm39) start gained probably benign
Z1176:Or1o4 UTSW 17 37,590,565 (GRCm39) missense probably damaging 0.99
Z1177:Or1o4 UTSW 17 37,591,100 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCATGTAATTCTCCCATGAGCC -3'
(R):5'- AATCAGTGCGGTTCTCTGC -3'

Sequencing Primer
(F):5'- ATGAGCCACGGTGTTAACTGACTC -3'
(R):5'- CGGTTCTCTGCATTGTAAGTTC -3'
Posted On 2016-08-04