Mutagenetix > Incidental Mutation

Incidental Mutation 'R5332:Scgb2b19'

423306

Institutional Source

Beutler Lab

Gene Symbol

Scgb2b19

Ensembl Gene

ENSMUSG00000096467

Gene Name

secretoglobin, family 2B, member 19

Synonyms

Gm5894, Abpbg19

MMRRC Submission

042914-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.033) question?

Stock #

R5332 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

32977795-32979763 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 32978006 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Serine at position 97 (N97S)

Ref Sequence

ENSEMBL: ENSMUSP00000136155 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000179688]

AlphaFold

J3QM75

Predicted Effect

probably benign
Transcript: ENSMUST00000179688
AA Change: N97S

PolyPhen 2 Score 0.072 (Sensitivity: 0.94; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000136155
Gene: ENSMUSG00000096467
AA Change: N97S

Domain	Start	End	E-Value	Type
low complexity region	3	16	N/A	INTRINSIC
Pfam:Feld-I_B	24	90	2.4e-31	PFAM

Coding Region Coverage

1x: 99.4%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 29 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc12	G	T	8: 87,251,459 (GRCm39)		probably null	Het
Ace	T	A	11: 105,864,705 (GRCm39)		probably null	Het
Bax	T	C	7: 45,116,195 (GRCm39)	D2G	probably damaging	Het
Clec16a	G	A	16: 10,549,543 (GRCm39)	C872Y	probably damaging	Het
Cmya5	T	A	13: 93,232,703 (GRCm39)	Y795F	probably damaging	Het
Coro2b	T	C	9: 62,336,512 (GRCm39)	D254G	probably damaging	Het
Crhbp	G	T	13: 95,572,963 (GRCm39)	P261H	probably damaging	Het
Cyp4f14	T	C	17: 33,125,065 (GRCm39)	D452G	probably benign	Het
Gm8444	T	C	15: 81,727,902 (GRCm39)		probably benign	Het
Gria1	T	A	11: 57,218,447 (GRCm39)	M900K	possibly damaging	Het
Kcnj3	A	G	2: 55,327,559 (GRCm39)	H116R	probably damaging	Het
Lin9	T	A	1: 180,496,763 (GRCm39)	L351I	probably benign	Het
Map3k2	A	G	18: 32,340,509 (GRCm39)	D172G	probably damaging	Het
Mmp1b	T	C	9: 7,384,897 (GRCm39)	I251V	possibly damaging	Het
Mpdz	A	C	4: 81,210,817 (GRCm39)	H1689Q	probably damaging	Het
Mybpc3	C	T	2: 90,953,283 (GRCm39)	A176V	probably damaging	Het
Or5b124	A	T	19: 13,610,729 (GRCm39)	T85S	possibly damaging	Het
Otud7a	T	A	7: 63,385,574 (GRCm39)	I352N	probably damaging	Het
Ptrh1	T	C	2: 32,666,758 (GRCm39)	V109A	probably damaging	Het
Pxn	A	G	5: 115,682,428 (GRCm39)	T14A	probably damaging	Het
Rtn4	T	A	11: 29,683,645 (GRCm39)	L173Q	probably damaging	Het
Ryr3	A	G	2: 112,733,038 (GRCm39)	S603P	probably damaging	Het
Scara5	CG	C	14: 65,997,111 (GRCm39)		probably null	Het
Shank2	T	A	7: 143,965,029 (GRCm39)	I872N	possibly damaging	Het
Spink5	A	G	18: 44,125,984 (GRCm39)	E421G	possibly damaging	Het
Ush2a	A	G	1: 188,083,276 (GRCm39)	Y273C	probably damaging	Het
Vmn2r121	T	C	X: 123,043,272 (GRCm39)	T120A	probably benign	Het
Vmn2r52	T	A	7: 9,903,052 (GRCm39)	I459L	probably benign	Het
Zfp974	A	C	7: 27,625,715 (GRCm39)	S52A	probably benign	Het

Other mutations in Scgb2b19

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01653:Scgb2b19	APN	7	32,979,153 (GRCm39)	missense	probably damaging	0.99
PIT4515001:Scgb2b19	UTSW	7	32,979,036 (GRCm39)	critical splice donor site	probably null
R0580:Scgb2b19	UTSW	7	32,977,995 (GRCm39)	missense	probably benign	0.15
R1437:Scgb2b19	UTSW	7	32,977,980 (GRCm39)	missense	probably benign	0.08
R1445:Scgb2b19	UTSW	7	32,979,037 (GRCm39)	critical splice donor site	probably null
R6424:Scgb2b19	UTSW	7	32,978,022 (GRCm39)	missense	possibly damaging	0.91
R7102:Scgb2b19	UTSW	7	32,979,711 (GRCm39)	missense	probably null
R7576:Scgb2b19	UTSW	7	32,979,211 (GRCm39)	missense	possibly damaging	0.92
R9551:Scgb2b19	UTSW	7	32,979,198 (GRCm39)	missense	probably damaging	1.00
R9552:Scgb2b19	UTSW	7	32,979,198 (GRCm39)	missense	probably damaging	1.00
R9561:Scgb2b19	UTSW	7	32,978,039 (GRCm39)	missense	probably benign	0.04

Predicted Primers

PCR Primer
(F):5'- ATCACAGAACAGAGTTGCAAGC -3'
(R):5'- GCAGAATTTGTTACTAGGGACCTG -3'

Sequencing Primer
(F):5'- GAACAGAGTTGCAAGCTTTTATTAG -3'
(R):5'- GTTACTAGGGACCTGAATCACTGC -3'

Posted On

2016-08-04