Incidental Mutation 'R5334:Olfr171'
ID 423440
Institutional Source Beutler Lab
Gene Symbol Olfr171
Ensembl Gene ENSMUSG00000060480
Gene Name olfactory receptor 171
Synonyms MOR273-1, MOR273-5, GA_x54KRFPKG5P-16071018-16070077
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # R5334 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 19623930-19629916 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to G at 19624491 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glycine to Alanine at position 203 (G203A)
Ref Sequence ENSEMBL: ENSMUSP00000145692 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079891] [ENSMUST00000205467]
AlphaFold G5E8J1
Predicted Effect probably benign
Transcript: ENSMUST00000079891
AA Change: G204A

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000078814
Gene: ENSMUSG00000060480
AA Change: G204A

DomainStartEndE-ValueType
Pfam:7tm_4 29 309 2.6e-43 PFAM
Pfam:7TM_GPCR_Srsx 36 261 8.6e-6 PFAM
Pfam:7tm_1 42 291 3.3e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205467
AA Change: G203A

PolyPhen 2 Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anapc15 C T 7: 101,898,603 P68L probably damaging Het
Ap4s1 C T 12: 51,738,671 S142L probably benign Het
Apol11a A G 15: 77,516,753 T147A probably benign Het
Aqp9 T C 9: 71,123,010 probably null Het
Arhgap25 T A 6: 87,463,261 N468I possibly damaging Het
Arhgef2 T A 3: 88,646,329 S924R probably damaging Het
Atad3a A T 4: 155,755,689 L144Q probably damaging Het
Ccbe1 T C 18: 66,083,245 I136V probably damaging Het
Col24a1 C A 3: 145,461,525 P1119Q possibly damaging Het
Dgkd T C 1: 87,938,267 probably null Het
Dnah7a A G 1: 53,503,646 I2455T probably benign Het
Dock2 T C 11: 34,228,643 T1795A probably benign Het
Dpp6 A T 5: 27,709,540 E541V probably benign Het
Edem1 T C 6: 108,848,832 probably null Het
Fbxo41 A G 6: 85,478,483 V573A probably damaging Het
Fech A C 18: 64,464,120 V256G probably damaging Het
Gad1-ps G A 10: 99,445,147 noncoding transcript Het
Gal3st4 T G 5: 138,265,721 K339Q probably benign Het
Gm11487 T A 4: 73,403,517 M94L probably benign Het
Gm884 T C 11: 103,613,873 Q2423R probably benign Het
Gpr158 T A 2: 21,827,505 S1139T probably benign Het
Gpr180 A T 14: 118,160,056 S321C probably damaging Het
Grik1 CGG CGGG 16: 87,923,194 probably null Het
Grin2c T G 11: 115,256,055 N438T possibly damaging Het
Hcn2 T C 10: 79,726,291 S374P probably damaging Het
Hmcn1 T A 1: 150,755,372 I892F probably damaging Het
Ifi207 C T 1: 173,727,531 V869I probably benign Het
Itgad T C 7: 128,189,286 Y390H probably damaging Het
Itgb4 C T 11: 115,984,157 R447W probably benign Het
Kcnj15 A G 16: 95,296,649 K377E probably damaging Het
Kcnq3 A G 15: 66,025,224 S276P probably damaging Het
Klhl26 T C 8: 70,452,318 D280G probably damaging Het
Lmnb2 C T 10: 80,903,957 V376I probably benign Het
Mepce T A 5: 137,786,627 R29S probably benign Het
Mlh3 A G 12: 85,245,761 probably null Het
Mlip T A 9: 77,243,676 T33S probably damaging Het
Mtpn C T 6: 35,512,290 D100N probably benign Het
Ncapg2 T C 12: 116,426,637 I402T probably damaging Het
Olfr1026 T C 2: 85,923,714 Y149H probably damaging Het
Pcsk5 T C 19: 17,461,851 D1301G probably benign Het
Pilrb1 T C 5: 137,854,903 M213V probably benign Het
Plxdc1 T C 11: 97,956,105 T163A possibly damaging Het
Pnpla2 T C 7: 141,459,493 L373P probably damaging Het
Prickle2 A G 6: 92,425,684 Y52H probably damaging Het
Rnf220 A G 4: 117,272,351 C294R probably damaging Het
Slc12a1 A G 2: 125,217,889 D903G probably damaging Het
Slc17a2 T C 13: 23,819,051 F228S probably damaging Het
Sptbn1 T C 11: 30,137,364 E1025G possibly damaging Het
Sult1c1 T G 17: 53,964,730 D143A probably damaging Het
Taar1 T G 10: 23,920,545 I47R probably damaging Het
Tctn3 G T 19: 40,602,822 Q514K probably benign Het
Tg T C 15: 66,678,055 F222S probably damaging Het
Tmem236 C A 2: 14,219,060 T220K possibly damaging Het
Trim50 C T 5: 135,367,476 T426M probably damaging Het
Vmn1r237 T C 17: 21,314,680 F222L probably benign Het
Wrap73 G A 4: 154,145,274 R34Q probably damaging Het
Zfp85 T C 13: 67,751,684 Y52C probably damaging Het
Other mutations in Olfr171
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02023:Olfr171 APN 16 19624408 missense probably benign 0.03
IGL02256:Olfr171 APN 16 19625006 missense probably benign 0.07
IGL02572:Olfr171 APN 16 19625098 start codon destroyed probably benign 0.01
IGL02966:Olfr171 APN 16 19624301 missense probably damaging 1.00
R0062:Olfr171 UTSW 16 19624417 missense probably benign 0.10
R3614:Olfr171 UTSW 16 19624765 missense probably damaging 1.00
R4899:Olfr171 UTSW 16 19624200 missense probably benign 0.33
R5070:Olfr171 UTSW 16 19624992 missense possibly damaging 0.47
R5718:Olfr171 UTSW 16 19624389 missense probably benign 0.06
R6490:Olfr171 UTSW 16 19624444 missense probably benign 0.03
R6632:Olfr171 UTSW 16 19625023 missense probably benign
R7801:Olfr171 UTSW 16 19624623 missense probably damaging 0.99
R8858:Olfr171 UTSW 16 19624359 missense probably damaging 1.00
R9036:Olfr171 UTSW 16 19624545 nonsense probably null
R9056:Olfr171 UTSW 16 19625041 missense probably benign 0.03
R9110:Olfr171 UTSW 16 19624993 missense possibly damaging 0.86
R9576:Olfr171 UTSW 16 19624211 missense probably damaging 1.00
X0057:Olfr171 UTSW 16 19624926 missense probably damaging 1.00
X0063:Olfr171 UTSW 16 19624708 missense possibly damaging 0.65
Predicted Primers PCR Primer
(F):5'- TTATCCTGCCCTGGAGTGTG -3'
(R):5'- GATAACTTCAGTGGGCTCCTG -3'

Sequencing Primer
(F):5'- GCGAGGTCTCATATATGTGAAAATG -3'
(R):5'- CTCCTGGCTGCAGGCTC -3'
Posted On 2016-08-04