Incidental Mutation 'R5354:Fmo1'
ID 423944
Institutional Source Beutler Lab
Gene Symbol Fmo1
Ensembl Gene ENSMUSG00000040181
Gene Name flavin containing monooxygenase 1
Synonyms
MMRRC Submission 042933-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # R5354 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 162657130-162694179 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 162657714 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 476 (T476A)
Ref Sequence ENSEMBL: ENSMUSP00000037259 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046049] [ENSMUST00000134098]
AlphaFold P50285
Predicted Effect probably benign
Transcript: ENSMUST00000046049
AA Change: T476A

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000037259
Gene: ENSMUSG00000040181
AA Change: T476A

DomainStartEndE-ValueType
Pfam:FMO-like 2 532 1.5e-279 PFAM
Pfam:Pyr_redox_2 3 228 3.8e-13 PFAM
Pfam:NAD_binding_8 7 63 8e-7 PFAM
Pfam:K_oxygenase 73 226 3.4e-9 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000134098
SMART Domains Protein: ENSMUSP00000117398
Gene: ENSMUSG00000040181

DomainStartEndE-ValueType
Pfam:FMO-like 2 303 1.4e-168 PFAM
Pfam:Pyr_redox_2 4 280 8e-9 PFAM
Pfam:Pyr_redox_3 6 220 5.5e-16 PFAM
Pfam:NAD_binding_8 7 65 9.5e-8 PFAM
Pfam:K_oxygenase 72 224 2.1e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136120
Predicted Effect noncoding transcript
Transcript: ENSMUST00000143902
Predicted Effect noncoding transcript
Transcript: ENSMUST00000193766
Meta Mutation Damage Score 0.0637 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 100% (80/80)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A630010A05Rik A G 16: 14,436,535 (GRCm39) K196R probably benign Het
Ablim1 T C 19: 57,119,355 (GRCm39) E243G probably benign Het
Acat1 T A 9: 53,500,483 (GRCm39) E271V possibly damaging Het
Aco1 T C 4: 40,180,290 (GRCm39) probably null Het
Adam22 C A 5: 8,140,182 (GRCm39) G202W probably damaging Het
Agbl3 T A 6: 34,791,687 (GRCm39) H596Q probably benign Het
Anxa7 A G 14: 20,514,977 (GRCm39) L177P possibly damaging Het
Atp11a A T 8: 12,856,753 (GRCm39) N48I probably damaging Het
Bcas1 T A 2: 170,191,316 (GRCm39) N492I possibly damaging Het
Bclaf1 A G 10: 20,209,278 (GRCm39) Y498C probably damaging Het
Bltp3a G A 17: 28,106,489 (GRCm39) S1005N probably benign Het
Bod1l A C 5: 41,988,880 (GRCm39) V409G probably damaging Het
Ccdc170 G A 10: 4,484,188 (GRCm39) C338Y probably benign Het
Cdc45 C T 16: 18,614,647 (GRCm39) R205H probably damaging Het
Ckap2 A C 8: 22,667,581 (GRCm39) N93K probably damaging Het
Clca3a1 A T 3: 144,442,766 (GRCm39) S759R possibly damaging Het
Coro1c A T 5: 113,984,226 (GRCm39) I347N possibly damaging Het
Cpox A G 16: 58,491,205 (GRCm39) T139A probably damaging Het
Cyp4a12b C A 4: 115,290,661 (GRCm39) probably null Het
Dctn1 T G 6: 83,160,108 (GRCm39) V116G possibly damaging Het
Dhx38 A G 8: 110,282,378 (GRCm39) V683A probably damaging Het
Dnah12 G A 14: 26,496,299 (GRCm39) probably null Het
Dnajb7 T C 15: 81,292,208 (GRCm39) E43G probably damaging Het
Dsc1 A T 18: 20,220,632 (GRCm39) V714E probably damaging Het
Dusp29 G A 14: 21,727,091 (GRCm39) R186W probably benign Het
Egfem1 T C 3: 29,136,361 (GRCm39) probably null Het
Fchsd1 C T 18: 38,092,926 (GRCm39) probably benign Het
Gm10237 T C 16: 35,741,099 (GRCm39) noncoding transcript Het
Gm14496 A G 2: 181,642,602 (GRCm39) S758G probably damaging Het
Gpat2 T A 2: 127,270,643 (GRCm39) L97Q probably damaging Het
Gpr162 T C 6: 124,836,600 (GRCm39) D357G probably benign Het
Hax1 A T 3: 89,905,262 (GRCm39) D34E probably damaging Het
Hmgcr C T 13: 96,791,404 (GRCm39) V97M probably benign Het
Hsd3b2 T C 3: 98,619,631 (GRCm39) T105A probably benign Het
Ints1 A G 5: 139,752,183 (GRCm39) probably null Het
Islr T C 9: 58,064,895 (GRCm39) E204G probably damaging Het
Lrrc36 A G 8: 106,151,996 (GRCm39) N60D probably damaging Het
Maf1 T C 15: 76,237,330 (GRCm39) probably benign Het
Mrgprb4 T A 7: 47,848,077 (GRCm39) R284W probably benign Het
Myh4 A T 11: 67,146,551 (GRCm39) N1508I possibly damaging Het
Nufip2 A G 11: 77,577,103 (GRCm39) H17R unknown Het
Oasl1 A T 5: 115,075,055 (GRCm39) I372L probably damaging Het
Or5ae1 T A 7: 84,565,357 (GRCm39) Y123* probably null Het
Or6p1 T C 1: 174,258,252 (GRCm39) L86P probably damaging Het
Pald1 A T 10: 61,184,440 (GRCm39) Y226N probably damaging Het
Pcdhb13 G T 18: 37,577,844 (GRCm39) G741C probably damaging Het
Pcdhga10 A G 18: 37,881,259 (GRCm39) D340G probably damaging Het
Pclo C A 5: 14,728,822 (GRCm39) probably benign Het
Pcsk4 G T 10: 80,159,523 (GRCm39) N416K probably damaging Het
Pde10a C A 17: 9,180,812 (GRCm39) R398S probably damaging Het
Plin1 T A 7: 79,375,469 (GRCm39) T227S possibly damaging Het
Pnpt1 A G 11: 29,104,166 (GRCm39) D542G probably damaging Het
Ppp4r3b T A 11: 29,161,646 (GRCm39) D673E probably benign Het
Prr18 C A 17: 8,559,892 (GRCm39) P16Q probably damaging Het
Psmc3 T A 2: 90,889,698 (GRCm39) Y440N probably damaging Het
Rassf5 T C 1: 131,108,385 (GRCm39) I232V probably benign Het
Rims1 T A 1: 22,577,592 (GRCm39) D218V probably damaging Het
Skint10 T C 4: 112,568,790 (GRCm39) N309S possibly damaging Het
Slc6a1 T C 6: 114,279,584 (GRCm39) M121T possibly damaging Het
Slit3 A G 11: 35,566,740 (GRCm39) D1004G probably damaging Het
Snap91 C T 9: 86,717,177 (GRCm39) V215I possibly damaging Het
Son T C 16: 91,452,627 (GRCm39) L458S probably damaging Het
St18 C T 1: 6,914,395 (GRCm39) A782V probably damaging Het
Synpo A G 18: 60,735,303 (GRCm39) probably null Het
Thbs3 A G 3: 89,128,684 (GRCm39) D458G probably damaging Het
Tpr C T 1: 150,321,675 (GRCm39) R3C probably damaging Het
Trp63 A G 16: 25,503,105 (GRCm39) probably null Het
Vmn1r27 C A 6: 58,192,581 (GRCm39) R141L probably benign Het
Wnk1 T C 6: 119,945,484 (GRCm39) I699V probably benign Het
Xkr6 A G 14: 64,056,353 (GRCm39) D88G possibly damaging Het
Zan A G 5: 137,379,050 (GRCm39) probably benign Het
Zbtb7b T C 3: 89,286,913 (GRCm39) probably benign Het
Zfp618 A T 4: 62,998,265 (GRCm39) D33V probably damaging Het
Other mutations in Fmo1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00418:Fmo1 APN 1 162,663,815 (GRCm39) missense probably damaging 1.00
IGL00479:Fmo1 APN 1 162,657,632 (GRCm39) missense probably benign 0.00
IGL01612:Fmo1 APN 1 162,661,168 (GRCm39) missense probably benign 0.42
IGL01650:Fmo1 APN 1 162,661,153 (GRCm39) missense probably benign 0.04
IGL02052:Fmo1 APN 1 162,677,629 (GRCm39) critical splice donor site probably null
IGL02340:Fmo1 APN 1 162,660,559 (GRCm39) missense probably benign 0.02
IGL03348:Fmo1 APN 1 162,677,720 (GRCm39) missense possibly damaging 0.76
IGL03388:Fmo1 APN 1 162,663,716 (GRCm39) missense probably benign 0.17
PIT1430001:Fmo1 UTSW 1 162,657,622 (GRCm39) missense probably benign 0.00
R0279:Fmo1 UTSW 1 162,657,841 (GRCm39) missense possibly damaging 0.92
R0314:Fmo1 UTSW 1 162,687,031 (GRCm39) missense probably damaging 1.00
R0348:Fmo1 UTSW 1 162,663,704 (GRCm39) missense probably benign 0.00
R0385:Fmo1 UTSW 1 162,663,773 (GRCm39) missense possibly damaging 0.94
R0699:Fmo1 UTSW 1 162,661,341 (GRCm39) missense probably benign 0.00
R1413:Fmo1 UTSW 1 162,661,431 (GRCm39) missense probably damaging 0.98
R1424:Fmo1 UTSW 1 162,657,635 (GRCm39) missense probably damaging 1.00
R1430:Fmo1 UTSW 1 162,667,293 (GRCm39) missense probably damaging 1.00
R1851:Fmo1 UTSW 1 162,657,554 (GRCm39) nonsense probably null
R1929:Fmo1 UTSW 1 162,661,424 (GRCm39) missense probably damaging 1.00
R1982:Fmo1 UTSW 1 162,667,325 (GRCm39) missense possibly damaging 0.83
R2272:Fmo1 UTSW 1 162,661,424 (GRCm39) missense probably damaging 1.00
R2568:Fmo1 UTSW 1 162,663,828 (GRCm39) missense probably benign 0.00
R3787:Fmo1 UTSW 1 162,657,583 (GRCm39) missense possibly damaging 0.54
R3825:Fmo1 UTSW 1 162,678,916 (GRCm39) splice site probably benign
R3904:Fmo1 UTSW 1 162,661,337 (GRCm39) missense possibly damaging 0.54
R4320:Fmo1 UTSW 1 162,661,200 (GRCm39) missense probably damaging 1.00
R4367:Fmo1 UTSW 1 162,661,217 (GRCm39) nonsense probably null
R4431:Fmo1 UTSW 1 162,661,281 (GRCm39) missense possibly damaging 0.76
R4473:Fmo1 UTSW 1 162,677,732 (GRCm39) missense possibly damaging 0.90
R5340:Fmo1 UTSW 1 162,657,551 (GRCm39) missense probably benign 0.39
R5479:Fmo1 UTSW 1 162,677,793 (GRCm39) missense probably damaging 0.99
R5930:Fmo1 UTSW 1 162,667,185 (GRCm39) critical splice donor site probably null
R6148:Fmo1 UTSW 1 162,679,088 (GRCm39) missense probably damaging 0.99
R6160:Fmo1 UTSW 1 162,663,867 (GRCm39) missense probably benign 0.00
R6164:Fmo1 UTSW 1 162,678,979 (GRCm39) missense probably benign 0.24
R6263:Fmo1 UTSW 1 162,677,629 (GRCm39) critical splice donor site probably null
R7046:Fmo1 UTSW 1 162,667,263 (GRCm39) missense possibly damaging 0.92
R7590:Fmo1 UTSW 1 162,687,251 (GRCm39) intron probably benign
R7663:Fmo1 UTSW 1 162,663,866 (GRCm39) missense possibly damaging 0.74
R7692:Fmo1 UTSW 1 162,661,402 (GRCm39) missense probably benign 0.16
R7712:Fmo1 UTSW 1 162,663,704 (GRCm39) missense probably benign 0.00
R8207:Fmo1 UTSW 1 162,677,676 (GRCm39) missense probably benign 0.28
R8895:Fmo1 UTSW 1 162,657,827 (GRCm39) missense probably benign 0.01
R8917:Fmo1 UTSW 1 162,663,773 (GRCm39) missense probably benign 0.03
R9583:Fmo1 UTSW 1 162,686,996 (GRCm39) missense
R9620:Fmo1 UTSW 1 162,661,390 (GRCm39) missense probably benign
X0022:Fmo1 UTSW 1 162,657,569 (GRCm39) missense possibly damaging 0.57
X0066:Fmo1 UTSW 1 162,667,273 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCCAGTTAGATCTTTCACTTACAGG -3'
(R):5'- TCCCAATCTGGTGTCAGTCAG -3'

Sequencing Primer
(F):5'- TTCACTTACAGGAAAATCAAGAAGAC -3'
(R):5'- CAGTCAGGGTTTGCTTTGGAC -3'
Posted On 2016-08-04