Mutagenetix > Incidental Mutations

Incidental Mutation 'R5354:Adam22'

423959

Institutional Source

Beutler Lab

Gene Symbol

Adam22

Ensembl Gene

ENSMUSG00000040537

Gene Name

a disintegrin and metallopeptidase domain 22

Synonyms

2900022I03Rik, MDC2

MMRRC Submission

042933-MU

Accession Numbers

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

R5354 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

8072352-8368160 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 8090182 bp

Zygosity

Heterozygous

Amino Acid Change

Glycine to Tryptophan at position 202 (G202W)

Ref Sequence

ENSEMBL: ENSMUSP00000119409 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000046838] [ENSMUST00000050166] [ENSMUST00000088744] [ENSMUST00000088761] [ENSMUST00000115386] [ENSMUST00000115388] [ENSMUST00000123168] [ENSMUST00000126384] [ENSMUST00000130315] [ENSMUST00000136524] [ENSMUST00000136808] [ENSMUST00000139048] [ENSMUST00000139841] [ENSMUST00000144241] [ENSMUST00000153427] [ENSMUST00000153889] [ENSMUST00000154935] [ENSMUST00000197700] [ENSMUST00000199853]

Predicted Effect

probably benign
Transcript: ENSMUST00000046838

SMART Domains

Protein: ENSMUSP00000049120
Gene: ENSMUSG00000040537

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:Pep_M12B_propep	44	186	7e-27	PFAM
low complexity region	214	230	N/A	INTRINSIC
Pfam:Reprolysin_5	235	405	9.3e-9	PFAM
Pfam:Reprolysin	237	436	1.1e-58	PFAM
Pfam:Reprolysin_3	261	379	3e-12	PFAM
DISIN	451	527	3.38e-31	SMART
ACR	528	669	3.05e-58	SMART
EGF	676	710	1.28e1	SMART
transmembrane domain	735	757	N/A	INTRINSIC
low complexity region	789	808	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000050166

SMART Domains

Protein: ENSMUSP00000055000
Gene: ENSMUSG00000040537

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:Pep_M12B_propep	44	186	7.6e-27	PFAM
low complexity region	214	230	N/A	INTRINSIC
Pfam:Reprolysin_5	235	405	1.1e-8	PFAM
Pfam:Reprolysin	237	436	1.1e-58	PFAM
Pfam:Reprolysin_3	261	379	3.4e-12	PFAM
DISIN	451	527	3.38e-31	SMART
ACR	528	669	3.05e-58	SMART
EGF	676	710	1.28e1	SMART
transmembrane domain	735	757	N/A	INTRINSIC
low complexity region	824	839	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000088744

SMART Domains

Protein: ENSMUSP00000086122
Gene: ENSMUSG00000040537

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:Pep_M12B_propep	41	186	4.2e-29	PFAM
low complexity region	214	230	N/A	INTRINSIC
Pfam:Reprolysin_5	235	405	1.2e-8	PFAM
Pfam:Reprolysin	237	436	2.9e-65	PFAM
Pfam:Reprolysin_3	261	378	9.2e-13	PFAM
DISIN	451	527	3.38e-31	SMART
ACR	528	669	3.05e-58	SMART
EGF	676	710	1.28e1	SMART
transmembrane domain	736	758	N/A	INTRINSIC
low complexity region	785	800	N/A	INTRINSIC
low complexity region	883	898	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000088761

SMART Domains

Protein: ENSMUSP00000086139
Gene: ENSMUSG00000040537

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:Pep_M12B_propep	44	186	8.1e-27	PFAM
low complexity region	214	230	N/A	INTRINSIC
Pfam:Reprolysin_5	235	405	1.2e-8	PFAM
Pfam:Reprolysin	237	436	1.1e-58	PFAM
Pfam:Reprolysin_3	261	379	3.6e-12	PFAM
DISIN	451	527	3.38e-31	SMART
ACR	528	669	3.05e-58	SMART
EGF	676	710	1.28e1	SMART
transmembrane domain	735	757	N/A	INTRINSIC
low complexity region	789	808	N/A	INTRINSIC
low complexity region	860	875	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000115386

SMART Domains

Protein: ENSMUSP00000111044
Gene: ENSMUSG00000040537

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:Pep_M12B_propep	44	186	3.4e-27	PFAM
low complexity region	214	230	N/A	INTRINSIC
Pfam:Reprolysin_5	235	405	5.1e-9	PFAM
Pfam:Reprolysin	237	436	5e-59	PFAM
Pfam:Reprolysin_3	261	379	1.6e-12	PFAM
DISIN	451	527	3.38e-31	SMART
ACR	528	669	3.05e-58	SMART
EGF	676	710	1.28e1	SMART
transmembrane domain	735	757	N/A	INTRINSIC
low complexity region	850	870	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000115388
AA Change: G839W

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000111046
Gene: ENSMUSG00000040537
AA Change: G839W

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
Pfam:Pep_M12B_propep	44	186	8e-27	PFAM
low complexity region	214	230	N/A	INTRINSIC
Pfam:Reprolysin_5	235	405	1.1e-8	PFAM
Pfam:Reprolysin	237	436	1.1e-58	PFAM
Pfam:Reprolysin_3	261	379	3.5e-12	PFAM
DISIN	451	527	3.38e-31	SMART
ACR	528	669	3.05e-58	SMART
EGF	676	710	1.28e1	SMART
transmembrane domain	735	757	N/A	INTRINSIC
low complexity region	852	872	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000123168

SMART Domains

Protein: ENSMUSP00000122758
Gene: ENSMUSG00000040537

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
low complexity region	123	143	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000124121

SMART Domains

Protein: ENSMUSP00000122652
Gene: ENSMUSG00000040537

Domain	Start	End	E-Value	Type
Blast:ACR	2	52	5e-28	BLAST
EGF	59	93	1.28e1	SMART
transmembrane domain	118	140	N/A	INTRINSIC
low complexity region	207	222	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000126384

SMART Domains

Protein: ENSMUSP00000118571
Gene: ENSMUSG00000040537

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
low complexity region	83	98	N/A	INTRINSIC
low complexity region	181	196	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000130315
AA Change: G137W

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000121156
Gene: ENSMUSG00000040537
AA Change: G137W

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
low complexity region	150	170	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000136524

SMART Domains

Protein: ENSMUSP00000116422
Gene: ENSMUSG00000040537

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
low complexity region	152	172	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000136808

SMART Domains

Protein: ENSMUSP00000122426
Gene: ENSMUSG00000040537

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
low complexity region	83	98	N/A	INTRINSIC
low complexity region	207	227	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000139048
AA Change: G173W

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000116736
Gene: ENSMUSG00000040537
AA Change: G173W

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
low complexity region	81	100	N/A	INTRINSIC
low complexity region	186	206	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000139841
AA Change: G131W

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000115775
Gene: ENSMUSG00000040537
AA Change: G131W

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
low complexity region	144	164	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000144241

SMART Domains

Protein: ENSMUSP00000138353
Gene: ENSMUSG00000040537

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
low complexity region	75	94	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000153427
AA Change: G167W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000120995
Gene: ENSMUSG00000040537
AA Change: G167W

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
low complexity region	75	94	N/A	INTRINSIC
low complexity region	209	229	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000153889

SMART Domains

Protein: ENSMUSP00000123196
Gene: ENSMUSG00000040537

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
low complexity region	81	100	N/A	INTRINSIC
low complexity region	152	167	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000154935
AA Change: G202W

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000119409
Gene: ENSMUSG00000040537
AA Change: G202W

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
low complexity region	83	98	N/A	INTRINSIC
low complexity region	225	245	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000196356

Predicted Effect

probably benign
Transcript: ENSMUST00000197700

SMART Domains

Protein: ENSMUSP00000142580
Gene: ENSMUSG00000040537

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC
low complexity region	129	145	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000199853

SMART Domains

Protein: ENSMUSP00000143097
Gene: ENSMUSG00000040537

Domain	Start	End	E-Value	Type
transmembrane domain	27	49	N/A	INTRINSIC

Meta Mutation Damage Score

0.1281

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.3%
20x: 95.4%

Validation Efficiency

100% (80/80)

MGI Phenotype

FUNCTION: This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional protein. The protein encoded by this gene is believed to lack metalloproteinase activity due to the lack of a critical catalytic motif. Mice lacking the encoded protein exhibit severe ataxia, hypomyelination and premature death. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
PHENOTYPE: Homozygous mutant mice exhibit severe ataxia, die before weaning and have marked hypomyelination of the peripheral nerves. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 73 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A630010A05Rik	A	G	16: 14,618,671	K196R	probably benign	Het
Ablim1	T	C	19: 57,130,923	E243G	probably benign	Het
Acat1	T	A	9: 53,589,183	E271V	possibly damaging	Het
Aco1	T	C	4: 40,180,290		probably null	Het
Agbl3	T	A	6: 34,814,752	H596Q	probably benign	Het
Anxa7	A	G	14: 20,464,909	L177P	possibly damaging	Het
Atp11a	A	T	8: 12,806,753	N48I	probably damaging	Het
Bcas1	T	A	2: 170,349,396	N492I	possibly damaging	Het
Bclaf1	A	G	10: 20,333,532	Y498C	probably damaging	Het
Bod1l	A	C	5: 41,831,537	V409G	probably damaging	Het
Ccdc170	G	A	10: 4,534,188	C338Y	probably benign	Het
Cdc45	C	T	16: 18,795,897	R205H	probably damaging	Het
Ckap2	A	C	8: 22,177,565	N93K	probably damaging	Het
Clca3a1	A	T	3: 144,737,005	S759R	possibly damaging	Het
Coro1c	A	T	5: 113,846,165	I347N	possibly damaging	Het
Cpox	A	G	16: 58,670,842	T139A	probably damaging	Het
Cyp4a12b	C	A	4: 115,433,464		probably null	Het
Dctn1	T	G	6: 83,183,126	V116G	possibly damaging	Het
Dhx38	A	G	8: 109,555,746	V683A	probably damaging	Het
Dnah12	G	A	14: 26,774,342		probably null	Het
Dnajb7	T	C	15: 81,408,007	E43G	probably damaging	Het
Dsc1	A	T	18: 20,087,575	V714E	probably damaging	Het
Dupd1	G	A	14: 21,677,023	R186W	probably benign	Het
Egfem1	T	C	3: 29,082,212		probably null	Het
Fchsd1	C	T	18: 37,959,873		probably benign	Het
Fmo1	T	C	1: 162,830,145	T476A	probably benign	Het
Gm10237	T	C	16: 35,920,729		noncoding transcript	Het
Gm14496	A	G	2: 182,000,809	S758G	probably damaging	Het
Gpat2	T	A	2: 127,428,723	L97Q	probably damaging	Het
Gpr162	T	C	6: 124,859,637	D357G	probably benign	Het
Hax1	A	T	3: 89,997,955	D34E	probably damaging	Het
Hmgcr	C	T	13: 96,654,896	V97M	probably benign	Het
Hsd3b2	T	C	3: 98,712,315	T105A	probably benign	Het
Ints1	A	G	5: 139,766,428		probably null	Het
Islr	T	C	9: 58,157,612	E204G	probably damaging	Het
Lrrc36	A	G	8: 105,425,364	N60D	probably damaging	Het
Maf1	T	C	15: 76,353,130		probably benign	Het
Mrgprb4	T	A	7: 48,198,329	R284W	probably benign	Het
Myh4	A	T	11: 67,255,725	N1508I	possibly damaging	Het
Nufip2	A	G	11: 77,686,277	H17R	unknown	Het
Oasl1	A	T	5: 114,936,996	I372L	probably damaging	Het
Olfr290	T	A	7: 84,916,149	Y123*	probably null	Het
Olfr414	T	C	1: 174,430,686	L86P	probably damaging	Het
Pald1	A	T	10: 61,348,661	Y226N	probably damaging	Het
Pcdhb13	G	T	18: 37,444,791	G741C	probably damaging	Het
Pcdhga10	A	G	18: 37,748,206	D340G	probably damaging	Het
Pclo	C	A	5: 14,678,808		probably benign	Het
Pcsk4	G	T	10: 80,323,689	N416K	probably damaging	Het
Pde10a	C	A	17: 8,961,980	R398S	probably damaging	Het
Plin1	T	A	7: 79,725,721	T227S	possibly damaging	Het
Pnpt1	A	G	11: 29,154,166	D542G	probably damaging	Het
Ppp4r3b	T	A	11: 29,211,646	D673E	probably benign	Het
Prr18	C	A	17: 8,341,060	P16Q	probably damaging	Het
Psmc3	T	A	2: 91,059,353	Y440N	probably damaging	Het
Rassf5	T	C	1: 131,180,648	I232V	probably benign	Het
Rims1	T	A	1: 22,538,511	D218V	probably damaging	Het
Skint10	T	C	4: 112,711,593	N309S	possibly damaging	Het
Slc6a1	T	C	6: 114,302,623	M121T	possibly damaging	Het
Slit3	A	G	11: 35,675,913	D1004G	probably damaging	Het
Snap91	C	T	9: 86,835,124	V215I	possibly damaging	Het
Son	T	C	16: 91,655,739	L458S	probably damaging	Het
St18	C	T	1: 6,844,171	A782V	probably damaging	Het
Synpo	A	G	18: 60,602,231		probably null	Het
Thbs3	A	G	3: 89,221,377	D458G	probably damaging	Het
Tpr	C	T	1: 150,445,924	R3C	probably damaging	Het
Trp63	A	G	16: 25,684,355		probably null	Het
Uhrf1bp1	G	A	17: 27,887,515	S1005N	probably benign	Het
Vmn1r27	C	A	6: 58,215,596	R141L	probably benign	Het
Wnk1	T	C	6: 119,968,523	I699V	probably benign	Het
Xkr6	A	G	14: 63,818,904	D88G	possibly damaging	Het
Zan	A	G	5: 137,380,788		probably benign	Het
Zbtb7b	T	C	3: 89,379,606		probably benign	Het
Zfp618	A	T	4: 63,080,028	D33V	probably damaging	Het

Other mutations in Adam22

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01325:Adam22	APN	5	8127333	missense	probably benign	0.44
IGL01368:Adam22	APN	5	8127411	missense	probably damaging	1.00
IGL01406:Adam22	APN	5	8130212	nonsense	probably null
IGL01463:Adam22	APN	5	8092790	missense	probably damaging	1.00
IGL01691:Adam22	APN	5	8092742	missense	probably damaging	1.00
IGL01798:Adam22	APN	5	8232604	splice site	probably null
IGL01975:Adam22	APN	5	8167396	missense	probably damaging	1.00
IGL02076:Adam22	APN	5	8136900	missense	probably damaging	1.00
IGL02170:Adam22	APN	5	8134845	missense	probably benign
IGL02189:Adam22	APN	5	8330029	missense	possibly damaging	0.91
IGL02859:Adam22	APN	5	8167375	missense	probably damaging	1.00
IGL03189:Adam22	APN	5	8111897	nonsense	probably null
IGL03326:Adam22	APN	5	8127421	missense	probably damaging	1.00
IGL03329:Adam22	APN	5	8149210	missense	possibly damaging	0.48
IGL03354:Adam22	APN	5	8158890	missense	possibly damaging	0.82
IGL03394:Adam22	APN	5	8167379	missense	probably benign	0.00
IGL03047:Adam22	UTSW	5	8082220	missense	probably damaging	1.00
R0445:Adam22	UTSW	5	8180591	intron	probably benign
R0486:Adam22	UTSW	5	8330048	missense	probably damaging	1.00
R0669:Adam22	UTSW	5	8143036	splice site	probably benign
R0866:Adam22	UTSW	5	8082156	missense	probably damaging	0.98
R1510:Adam22	UTSW	5	8152408	missense	probably benign	0.06
R1562:Adam22	UTSW	5	8095007	missense	probably damaging	1.00
R1640:Adam22	UTSW	5	8145689	missense	probably damaging	1.00
R1903:Adam22	UTSW	5	8134525	missense	probably damaging	1.00
R1939:Adam22	UTSW	5	8330015	missense	probably damaging	1.00
R1998:Adam22	UTSW	5	8329995	missense	probably damaging	1.00
R2012:Adam22	UTSW	5	8117634	missense	probably damaging	1.00
R2214:Adam22	UTSW	5	8136805	critical splice donor site	probably null
R2270:Adam22	UTSW	5	8121108	missense	probably damaging	0.98
R2271:Adam22	UTSW	5	8121108	missense	probably damaging	0.98
R2286:Adam22	UTSW	5	8145616	missense	probably damaging	1.00
R2304:Adam22	UTSW	5	8092366	missense	probably damaging	1.00
R2406:Adam22	UTSW	5	8180064	intron	probably benign
R2656:Adam22	UTSW	5	8117696	missense	probably damaging	1.00
R3106:Adam22	UTSW	5	8117583	splice site	probably null
R3870:Adam22	UTSW	5	8132418	missense	probably damaging	1.00
R3923:Adam22	UTSW	5	8130514	missense	possibly damaging	0.68
R4092:Adam22	UTSW	5	8095004	missense	probably damaging	1.00
R4180:Adam22	UTSW	5	8149218	missense	probably damaging	1.00
R4247:Adam22	UTSW	5	8145626	missense	probably benign
R4486:Adam22	UTSW	5	8180227	intron	probably benign
R4629:Adam22	UTSW	5	8232663	missense	possibly damaging	0.95
R4744:Adam22	UTSW	5	8078699	missense	probably damaging	0.98
R4839:Adam22	UTSW	5	8136813	missense	probably damaging	1.00
R5007:Adam22	UTSW	5	8167393	missense	probably damaging	1.00
R5030:Adam22	UTSW	5	8179645	intron	probably benign
R5061:Adam22	UTSW	5	8180238	intron	probably benign
R5312:Adam22	UTSW	5	8090182	missense	probably damaging	1.00
R5353:Adam22	UTSW	5	8090182	missense	probably damaging	1.00
R5356:Adam22	UTSW	5	8090182	missense	probably damaging	1.00
R5423:Adam22	UTSW	5	8090182	missense	probably damaging	1.00
R5424:Adam22	UTSW	5	8090182	missense	probably damaging	1.00
R5719:Adam22	UTSW	5	8367217	missense	probably benign
R5763:Adam22	UTSW	5	8134544	missense	probably damaging	1.00
R5768:Adam22	UTSW	5	8127426	missense	probably benign	0.35
R5776:Adam22	UTSW	5	8127361	missense	probably benign	0.26
R5839:Adam22	UTSW	5	8136861	missense	probably damaging	0.99
R6314:Adam22	UTSW	5	8127365	nonsense	probably null
R6520:Adam22	UTSW	5	8116635	missense	probably damaging	0.98
R6798:Adam22	UTSW	5	8160784	missense	probably damaging	1.00
R6924:Adam22	UTSW	5	8367322	missense	possibly damaging	0.78
R6938:Adam22	UTSW	5	8146499	missense	probably benign	0.01
R7317:Adam22	UTSW	5	8090202	missense	probably benign
R7402:Adam22	UTSW	5	8095049	missense	possibly damaging	0.95
R7431:Adam22	UTSW	5	8092818	missense	probably damaging	1.00
R7527:Adam22	UTSW	5	8082239	missense	possibly damaging	0.66
R7571:Adam22	UTSW	5	8082160	nonsense	probably null
R7627:Adam22	UTSW	5	8367933	missense	probably benign
R7714:Adam22	UTSW	5	8117587	critical splice donor site	probably null
R7806:Adam22	UTSW	5	8092825	missense	probably damaging	1.00
R7834:Adam22	UTSW	5	8130535	missense	probably damaging	1.00
R7837:Adam22	UTSW	5	8149284	critical splice acceptor site	probably null
R7917:Adam22	UTSW	5	8130535	missense	probably damaging	1.00
R7920:Adam22	UTSW	5	8149284	critical splice acceptor site	probably null
X0067:Adam22	UTSW	5	8127329	missense	probably benign	0.05

Predicted Primers

PCR Primer
(F):5'- GGCTAGGAGTACCACTGAACAG -3'
(R):5'- CATGCACCCCAAGTTCATGC -3'

Sequencing Primer
(F):5'- CCACTGAACAGATATGGGGGCTC -3'
(R):5'- CCAAGTTCATGCATGCTCTGTAAG -3'

Posted On

2016-08-04