Incidental Mutation 'R5358:Zfp738'
ID 424198
Institutional Source Beutler Lab
Gene Symbol Zfp738
Ensembl Gene ENSMUSG00000048280
Gene Name zinc finger protein 738
Synonyms 6720487G11Rik, 3830402I07Rik
MMRRC Submission 042937-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R5358 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 67815560-67831631 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 67819131 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 287 (Y287H)
Ref Sequence ENSEMBL: ENSMUSP00000121275 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000110973] [ENSMUST00000125495] [ENSMUST00000137496] [ENSMUST00000175678] [ENSMUST00000175821]
AlphaFold B8JJX8
Predicted Effect probably benign
Transcript: ENSMUST00000110973
SMART Domains Protein: ENSMUSP00000106600
Gene: ENSMUSG00000048280

DomainStartEndE-ValueType
KRAB 2 62 1.97e-31 SMART
SCOP:d1fgja_ 76 119 1e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000125495
SMART Domains Protein: ENSMUSP00000135683
Gene: ENSMUSG00000048280

DomainStartEndE-ValueType
KRAB 5 65 1.97e-31 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000137496
AA Change: Y287H

PolyPhen 2 Score 0.975 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000121275
Gene: ENSMUSG00000048280
AA Change: Y287H

DomainStartEndE-ValueType
KRAB 15 75 1.97e-31 SMART
ZnF_C2H2 91 111 3.13e1 SMART
ZnF_C2H2 119 141 9.56e1 SMART
ZnF_C2H2 147 169 3.58e-2 SMART
ZnF_C2H2 175 197 3.21e-4 SMART
ZnF_C2H2 203 225 6.78e-3 SMART
ZnF_C2H2 231 253 8.34e-3 SMART
ZnF_C2H2 259 281 6.67e-2 SMART
ZnF_C2H2 287 309 1.12e-3 SMART
ZnF_C2H2 315 337 3.83e-2 SMART
ZnF_C2H2 343 365 8.34e-3 SMART
ZnF_C2H2 371 393 4.87e-4 SMART
ZnF_C2H2 427 449 9.58e-3 SMART
ZnF_C2H2 455 477 1.38e-3 SMART
ZnF_C2H2 483 505 3.89e-3 SMART
ZnF_C2H2 511 533 7.49e-5 SMART
ZnF_C2H2 539 561 5.5e-3 SMART
ZnF_C2H2 567 589 5.42e-2 SMART
ZnF_C2H2 595 617 7.78e-3 SMART
ZnF_C2H2 623 645 2.05e-2 SMART
ZnF_C2H2 651 673 2.57e-3 SMART
ZnF_C2H2 679 701 7.26e-3 SMART
ZnF_C2H2 735 757 5.42e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000175678
SMART Domains Protein: ENSMUSP00000134865
Gene: ENSMUSG00000048280

DomainStartEndE-ValueType
KRAB 15 75 1.97e-31 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000175821
SMART Domains Protein: ENSMUSP00000135050
Gene: ENSMUSG00000048280

DomainStartEndE-ValueType
KRAB 5 65 1.97e-31 SMART
ZnF_C2H2 81 101 3.13e1 SMART
ZnF_C2H2 109 131 9.56e1 SMART
ZnF_C2H2 137 159 3.58e-2 SMART
ZnF_C2H2 165 187 3.21e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225507
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 T C 10: 79,849,165 (GRCm39) V1842A probably damaging Het
Abi3 A T 11: 95,732,934 (GRCm39) F13L probably benign Het
Adgre4 A G 17: 56,125,758 (GRCm39) K538R probably benign Het
Bcas3 C T 11: 85,342,581 (GRCm39) H191Y probably benign Het
Bicdl2 A G 17: 23,886,538 (GRCm39) T376A probably benign Het
Ceacam18 C A 7: 43,286,497 (GRCm39) N123K possibly damaging Het
Celsr3 C T 9: 108,709,224 (GRCm39) R1357C possibly damaging Het
Chek2 T C 5: 110,989,148 (GRCm39) probably benign Het
Chmp7 A G 14: 69,958,684 (GRCm39) V210A probably benign Het
Chrm2 A G 6: 36,500,290 (GRCm39) K49R probably damaging Het
Ciao2b T C 8: 105,368,282 (GRCm39) N14S probably damaging Het
Daam1 T A 12: 71,999,233 (GRCm39) L623* probably null Het
Ddx31 T A 2: 28,753,782 (GRCm39) C448S probably damaging Het
Dnah7a A G 1: 53,586,331 (GRCm39) S1507P probably damaging Het
Dnah8 C A 17: 30,965,928 (GRCm39) T2420K probably damaging Het
Dyrk3 C T 1: 131,057,432 (GRCm39) R247H probably damaging Het
Exoc4 A G 6: 33,242,934 (GRCm39) E49G probably damaging Het
Fkbpl G A 17: 34,864,303 (GRCm39) A24T probably benign Het
Foxj3 A G 4: 119,476,596 (GRCm39) E258G probably damaging Het
Gata4 C T 14: 63,478,075 (GRCm39) A175T probably benign Het
Helz2 C T 2: 180,877,321 (GRCm39) E1106K probably damaging Het
Hip1 G T 5: 135,465,252 (GRCm39) S385R probably benign Het
Igsf9 C T 1: 172,312,078 (GRCm39) T8I probably benign Het
Insyn2b G A 11: 34,352,788 (GRCm39) E277K probably damaging Het
Katnal2 A G 18: 77,105,190 (GRCm39) Y86H possibly damaging Het
Kcnh6 A T 11: 105,918,417 (GRCm39) I756F possibly damaging Het
Kdm5b C T 1: 134,535,432 (GRCm39) R570* probably null Het
Kif16b T A 2: 142,582,889 (GRCm39) R545S probably damaging Het
Kif21b T A 1: 136,100,030 (GRCm39) I1528N possibly damaging Het
Kmt2a T C 9: 44,730,571 (GRCm39) probably benign Het
Ltbr G A 6: 125,289,757 (GRCm39) R146W probably damaging Het
Melk C T 4: 44,363,730 (GRCm39) T592M probably damaging Het
Mknk2 T C 10: 80,507,597 (GRCm39) T60A probably benign Het
Ncoa6 T C 2: 155,248,907 (GRCm39) K1466E probably damaging Het
Ntsr2 A C 12: 16,704,083 (GRCm39) T109P probably damaging Het
Nup214 C A 2: 31,907,158 (GRCm39) S995Y unknown Het
Or2a5 A T 6: 42,873,454 (GRCm39) Q23L probably benign Het
Pclo T A 5: 14,762,750 (GRCm39) L456* probably null Het
Pde5a A G 3: 122,541,825 (GRCm39) D105G probably damaging Het
Pik3c3 C A 18: 30,456,597 (GRCm39) P709H probably damaging Het
R3hdm4 C T 10: 79,748,292 (GRCm39) E162K possibly damaging Het
Rab3c T C 13: 110,198,497 (GRCm39) N179S possibly damaging Het
Setdb2 T A 14: 59,646,885 (GRCm39) R559S probably benign Het
Sf3b1 A G 1: 55,042,469 (GRCm39) Y474H probably benign Het
Slc6a6 G T 6: 91,712,155 (GRCm39) W228L probably benign Het
Slc8a2 T G 7: 15,891,228 (GRCm39) I750S probably damaging Het
Slco2b1 T A 7: 99,309,251 (GRCm39) I194L unknown Het
Smarcd1 C T 15: 99,601,128 (GRCm39) Q45* probably null Het
Srcap T G 7: 127,139,492 (GRCm39) L1271R probably damaging Het
Srsf12 A T 4: 33,209,330 (GRCm39) N9Y probably damaging Het
St7 T C 6: 17,819,317 (GRCm39) S74P probably damaging Het
Stxbp5l T A 16: 36,994,688 (GRCm39) E739V probably damaging Het
Sun3 T A 11: 8,981,496 (GRCm39) Q36L possibly damaging Het
Tbc1d32 T C 10: 56,047,033 (GRCm39) H545R possibly damaging Het
Tcp11 A T 17: 28,296,994 (GRCm39) C133S probably benign Het
Tm6sf2 T C 8: 70,526,939 (GRCm39) V36A possibly damaging Het
Tmem108 T C 9: 103,376,717 (GRCm39) Y244C probably damaging Het
Tra2a A T 6: 49,227,949 (GRCm39) probably benign Het
Trpm3 A T 19: 22,903,332 (GRCm39) I1031F probably damaging Het
Ttll3 A G 6: 113,378,292 (GRCm39) K381E probably benign Het
Uaca T C 9: 60,778,430 (GRCm39) V937A probably benign Het
Umod C T 7: 119,071,577 (GRCm39) G388D probably damaging Het
Vmn2r90 G A 17: 17,924,412 (GRCm39) probably null Het
Zbtb47 T A 9: 121,594,661 (GRCm39) F540Y probably damaging Het
Zfp644 G A 5: 106,783,541 (GRCm39) T1002I probably damaging Het
Zfyve16 T C 13: 92,644,771 (GRCm39) T1144A probably benign Het
Zgrf1 T C 3: 127,361,352 (GRCm39) probably null Het
Other mutations in Zfp738
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01511:Zfp738 APN 13 67,831,520 (GRCm39) critical splice donor site probably null
IGL01734:Zfp738 APN 13 67,831,563 (GRCm39) utr 5 prime probably benign
IGL01980:Zfp738 APN 13 67,818,096 (GRCm39) missense possibly damaging 0.80
IGL02052:Zfp738 APN 13 67,819,600 (GRCm39) missense possibly damaging 0.87
IGL02330:Zfp738 APN 13 67,819,550 (GRCm39) missense probably damaging 0.99
IGL02686:Zfp738 APN 13 67,821,771 (GRCm39) missense probably damaging 1.00
I2505:Zfp738 UTSW 13 67,821,186 (GRCm39) missense probably benign 0.36
R0219:Zfp738 UTSW 13 67,831,508 (GRCm39) intron probably benign
R0491:Zfp738 UTSW 13 67,818,140 (GRCm39) missense possibly damaging 0.87
R0722:Zfp738 UTSW 13 67,819,643 (GRCm39) missense probably benign 0.09
R1116:Zfp738 UTSW 13 67,818,362 (GRCm39) splice site probably null
R1425:Zfp738 UTSW 13 67,818,894 (GRCm39) missense possibly damaging 0.77
R1854:Zfp738 UTSW 13 67,818,476 (GRCm39) missense probably damaging 1.00
R2095:Zfp738 UTSW 13 67,819,422 (GRCm39) missense probably damaging 1.00
R2171:Zfp738 UTSW 13 67,819,096 (GRCm39) nonsense probably null
R2180:Zfp738 UTSW 13 67,819,313 (GRCm39) missense probably damaging 1.00
R2225:Zfp738 UTSW 13 67,818,431 (GRCm39) missense probably damaging 1.00
R2226:Zfp738 UTSW 13 67,818,431 (GRCm39) missense probably damaging 1.00
R2907:Zfp738 UTSW 13 67,818,231 (GRCm39) missense probably benign 0.33
R3605:Zfp738 UTSW 13 67,819,508 (GRCm39) nonsense probably null
R4731:Zfp738 UTSW 13 67,818,033 (GRCm39) missense probably damaging 1.00
R5037:Zfp738 UTSW 13 67,818,320 (GRCm39) missense probably damaging 1.00
R5223:Zfp738 UTSW 13 67,821,182 (GRCm39) missense probably damaging 0.99
R5259:Zfp738 UTSW 13 67,817,805 (GRCm39) missense probably benign
R6404:Zfp738 UTSW 13 67,819,179 (GRCm39) missense possibly damaging 0.89
R6874:Zfp738 UTSW 13 67,818,382 (GRCm39) missense possibly damaging 0.93
R7041:Zfp738 UTSW 13 67,818,420 (GRCm39) missense probably damaging 1.00
R7172:Zfp738 UTSW 13 67,818,527 (GRCm39) missense probably damaging 1.00
R7178:Zfp738 UTSW 13 67,821,147 (GRCm39) missense probably damaging 1.00
R7308:Zfp738 UTSW 13 67,817,672 (GRCm39) missense probably benign 0.00
R7386:Zfp738 UTSW 13 67,818,369 (GRCm39) missense probably damaging 1.00
R7453:Zfp738 UTSW 13 67,818,474 (GRCm39) missense probably benign 0.42
R7456:Zfp738 UTSW 13 67,817,619 (GRCm39) missense probably damaging 1.00
R7467:Zfp738 UTSW 13 67,821,080 (GRCm39) missense probably benign 0.03
R7615:Zfp738 UTSW 13 67,818,322 (GRCm39) missense probably damaging 0.96
R7663:Zfp738 UTSW 13 67,831,520 (GRCm39) critical splice donor site probably null
R7752:Zfp738 UTSW 13 67,821,110 (GRCm39) nonsense probably null
R7901:Zfp738 UTSW 13 67,821,110 (GRCm39) nonsense probably null
R8042:Zfp738 UTSW 13 67,819,010 (GRCm39) missense probably damaging 0.98
R8288:Zfp738 UTSW 13 67,818,908 (GRCm39) missense possibly damaging 0.88
R8340:Zfp738 UTSW 13 67,819,231 (GRCm39) missense probably damaging 0.98
R8735:Zfp738 UTSW 13 67,819,550 (GRCm39) missense probably damaging 0.99
R8846:Zfp738 UTSW 13 67,818,155 (GRCm39) missense probably benign 0.00
R8896:Zfp738 UTSW 13 67,817,910 (GRCm39) missense
R9124:Zfp738 UTSW 13 67,819,457 (GRCm39) missense possibly damaging 0.94
R9233:Zfp738 UTSW 13 67,819,017 (GRCm39) missense possibly damaging 0.88
R9513:Zfp738 UTSW 13 67,817,635 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TGATGACAGAGAACGGAAAGCCT -3'
(R):5'- AACATCCATCAAGACTTTCCAGA -3'

Sequencing Primer
(F):5'- CGGAAAGCCTTTTGACATACTTCAC -3'
(R):5'- TGTGAAGTATGTGGAAAAGCCTTC -3'
Posted On 2016-08-04