Incidental Mutation 'R5289:Tas2r110'
ID424593
Institutional Source Beutler Lab
Gene Symbol Tas2r110
Ensembl Gene ENSMUSG00000062952
Gene Nametaste receptor, type 2, member 110
SynonymsSTC 9-1, Tas2r10, T2R10, mt2r57
MMRRC Submission 042872-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.047) question?
Stock #R5289 (G1)
Quality Score225
Status Not validated
Chromosome6
Chromosomal Location132868008-132869009 bp(+) (GRCm38)
Type of Mutationstart codon destroyed
DNA Base Change (assembly) T to C at 132868009 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Threonine at position 1 (M1T)
Ref Sequence ENSEMBL: ENSMUSP00000080674 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000082014]
Predicted Effect probably null
Transcript: ENSMUST00000082014
AA Change: M1T
SMART Domains Protein: ENSMUSP00000080674
Gene: ENSMUSG00000062952
AA Change: M1T

DomainStartEndE-ValueType
Pfam:TAS2R 6 322 3.1e-82 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik C A 3: 37,000,109 Q3126K probably damaging Het
Adgrv1 A G 13: 81,521,084 V1731A probably benign Het
Ahcyl1 A G 3: 107,669,890 probably null Het
Aox1 T A 1: 58,092,558 M1042K probably damaging Het
Atp10d C A 5: 72,255,123 Q590K probably benign Het
Atp8b1 G T 18: 64,546,087 N774K possibly damaging Het
Atrnl1 C T 19: 57,657,082 T458M probably damaging Het
BC005561 G A 5: 104,519,657 V682I probably benign Het
Cnr1 T A 4: 33,943,910 C99* probably null Het
Cnr2 A G 4: 135,917,007 Y132C probably damaging Het
Commd9 C T 2: 101,898,894 A115V probably benign Het
Diaph3 A G 14: 86,981,678 F426S probably damaging Het
Diras1 G A 10: 81,022,244 Q58* probably null Het
Dpy19l2 A G 9: 24,695,997 L56P probably benign Het
Dsc1 A T 18: 20,101,853 V248D possibly damaging Het
Frem3 A G 8: 80,612,319 M414V probably benign Het
Frmd4b G T 6: 97,302,348 probably null Het
Gabarapl2 T C 8: 111,942,595 W62R probably damaging Het
Glt1d1 A G 5: 127,644,356 R36G probably benign Het
Grb10 T C 11: 11,944,924 silent Het
Gtf2h3 C T 5: 124,584,297 T121I probably benign Het
Hc A G 2: 34,996,014 probably null Het
Hgd A G 16: 37,628,551 E379G possibly damaging Het
Ifi30 A T 8: 70,766,601 probably benign Het
Iqgap1 T C 7: 80,738,724 I842V possibly damaging Het
Iqsec3 T A 6: 121,386,700 probably null Het
Kalrn A G 16: 34,252,341 S724P possibly damaging Het
Lama2 C A 10: 27,212,073 G903* probably null Het
Lrrc10 T C 10: 117,045,487 V22A probably benign Het
Lzts3 T C 2: 130,636,101 E245G probably benign Het
Man2a1 A G 17: 64,651,227 T246A probably damaging Het
Mfsd13a A G 19: 46,368,280 E240G probably benign Het
Mtor T C 4: 148,466,092 I735T possibly damaging Het
Naa15 A T 3: 51,455,894 H333L probably damaging Het
Nes C A 3: 87,978,418 T1284K probably damaging Het
Nexn T G 3: 152,248,072 H173P probably benign Het
Nid2 T C 14: 19,805,311 V1173A possibly damaging Het
Npepps A G 11: 97,240,927 probably null Het
Pgm2 T A 4: 99,967,069 M313K probably damaging Het
Pih1d3 A T 1: 31,223,527 I197F probably benign Het
Plag1 T A 4: 3,905,545 K48N probably damaging Het
Prok1 G C 3: 107,239,619 L11V probably benign Het
Ptpn9 T C 9: 57,060,063 probably null Het
Skint8 C A 4: 111,950,193 L359M probably damaging Het
Slc38a4 A T 15: 97,010,348 F171I possibly damaging Het
Sycp1 A T 3: 102,934,253 N78K possibly damaging Het
Tmem260 G A 14: 48,486,810 V182M possibly damaging Het
Tmem30a A T 9: 79,776,154 N144K probably damaging Het
Vmn2r108 A G 17: 20,471,604 L219P probably damaging Het
Vmn2r57 A G 7: 41,399,974 S784P probably damaging Het
Vwf T C 6: 125,667,510 probably benign Het
Wdr62 A C 7: 30,267,875 V318G probably damaging Het
Zfp398 T A 6: 47,863,181 S115T probably benign Het
Zfp62 T A 11: 49,217,148 C689S probably damaging Het
Zmynd15 C G 11: 70,466,004 P580R unknown Het
Other mutations in Tas2r110
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03103:Tas2r110 APN 6 132868480 missense probably benign 0.09
IGL03275:Tas2r110 APN 6 132868098 missense probably damaging 0.99
R0111:Tas2r110 UTSW 6 132868203 missense probably benign 0.00
R0539:Tas2r110 UTSW 6 132868371 missense possibly damaging 0.63
R1432:Tas2r110 UTSW 6 132868368 missense probably damaging 1.00
R1672:Tas2r110 UTSW 6 132868066 missense probably damaging 1.00
R2483:Tas2r110 UTSW 6 132868470 missense probably benign 0.00
R3110:Tas2r110 UTSW 6 132868024 missense unknown
R3112:Tas2r110 UTSW 6 132868024 missense unknown
R3623:Tas2r110 UTSW 6 132868470 missense probably benign 0.00
R3847:Tas2r110 UTSW 6 132868675 missense probably damaging 1.00
R3849:Tas2r110 UTSW 6 132868675 missense probably damaging 1.00
R3850:Tas2r110 UTSW 6 132868675 missense probably damaging 1.00
R4871:Tas2r110 UTSW 6 132868128 missense probably benign 0.09
R5010:Tas2r110 UTSW 6 132868475 nonsense probably null
R5108:Tas2r110 UTSW 6 132868705 missense probably damaging 1.00
R5938:Tas2r110 UTSW 6 132868053 missense probably benign 0.39
R6262:Tas2r110 UTSW 6 132868675 missense probably damaging 0.96
R6286:Tas2r110 UTSW 6 132868527 missense probably benign 0.01
R6582:Tas2r110 UTSW 6 132868285 missense possibly damaging 0.94
R7236:Tas2r110 UTSW 6 132868704 missense possibly damaging 0.76
X0024:Tas2r110 UTSW 6 132868633 missense probably damaging 1.00
Z1176:Tas2r110 UTSW 6 132868611 missense probably benign 0.37
Predicted Primers PCR Primer
(F):5'- GACACAGTGTCTGGATGAAGC -3'
(R):5'- TGGCCAAAGCAGTGAGAATCTG -3'

Sequencing Primer
(F):5'- TCTGGATGAAGCAGAGGTGATCTC -3'
(R):5'- CTGATCCGCTGATGAAATGC -3'
Posted On2016-08-04