Incidental Mutation 'R5289:Zmynd15'
ID 424607
Institutional Source Beutler Lab
Gene Symbol Zmynd15
Ensembl Gene ENSMUSG00000040829
Gene Name zinc finger, MYND-type containing 15
Synonyms
MMRRC Submission 042872-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.158) question?
Stock # R5289 (G1)
Quality Score 216
Status Not validated
Chromosome 11
Chromosomal Location 70350259-70357028 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to G at 70356830 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Arginine at position 580 (P580R)
Ref Sequence ENSEMBL: ENSMUSP00000104203 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039093] [ENSMUST00000092958] [ENSMUST00000108563]
AlphaFold Q8C0R7
Predicted Effect unknown
Transcript: ENSMUST00000039093
AA Change: P710R
SMART Domains Protein: ENSMUSP00000048816
Gene: ENSMUSG00000040829
AA Change: P710R

DomainStartEndE-ValueType
low complexity region 71 85 N/A INTRINSIC
low complexity region 110 126 N/A INTRINSIC
low complexity region 164 186 N/A INTRINSIC
Pfam:zf-MYND 307 353 6.7e-12 PFAM
low complexity region 438 452 N/A INTRINSIC
low complexity region 523 535 N/A INTRINSIC
low complexity region 702 736 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000092958
AA Change: P670R
SMART Domains Protein: ENSMUSP00000090635
Gene: ENSMUSG00000040829
AA Change: P670R

DomainStartEndE-ValueType
low complexity region 71 85 N/A INTRINSIC
low complexity region 110 126 N/A INTRINSIC
low complexity region 164 186 N/A INTRINSIC
Pfam:zf-MYND 306 352 6.5e-11 PFAM
low complexity region 437 451 N/A INTRINSIC
low complexity region 483 495 N/A INTRINSIC
low complexity region 662 696 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000108563
AA Change: P580R
SMART Domains Protein: ENSMUSP00000104203
Gene: ENSMUSG00000040829
AA Change: P580R

DomainStartEndE-ValueType
low complexity region 35 57 N/A INTRINSIC
Pfam:zf-MYND 177 223 2.5e-11 PFAM
low complexity region 308 322 N/A INTRINSIC
low complexity region 393 405 N/A INTRINSIC
low complexity region 572 606 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136029
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
PHENOTYPE: Mice homozygous for a knock-out allele of Cxcl16 and Zmynd15 exhibit abnormal spermiogenesis and reduced male fertility. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A G 13: 81,669,203 (GRCm39) V1731A probably benign Het
Ahcyl1 A G 3: 107,577,206 (GRCm39) probably null Het
Aox1 T A 1: 58,131,717 (GRCm39) M1042K probably damaging Het
Atp10d C A 5: 72,412,466 (GRCm39) Q590K probably benign Het
Atp8b1 G T 18: 64,679,158 (GRCm39) N774K possibly damaging Het
Atrnl1 C T 19: 57,645,514 (GRCm39) T458M probably damaging Het
Bltp1 C A 3: 37,054,258 (GRCm39) Q3126K probably damaging Het
Cnr1 T A 4: 33,943,910 (GRCm39) C99* probably null Het
Cnr2 A G 4: 135,644,318 (GRCm39) Y132C probably damaging Het
Commd9 C T 2: 101,729,239 (GRCm39) A115V probably benign Het
Diaph3 A G 14: 87,219,114 (GRCm39) F426S probably damaging Het
Diras1 G A 10: 80,858,078 (GRCm39) Q58* probably null Het
Dnaaf6rt A T 1: 31,262,608 (GRCm39) I197F probably benign Het
Dpy19l2 A G 9: 24,607,293 (GRCm39) L56P probably benign Het
Dsc1 A T 18: 20,234,910 (GRCm39) V248D possibly damaging Het
Frem3 A G 8: 81,338,948 (GRCm39) M414V probably benign Het
Frmd4b G T 6: 97,279,309 (GRCm39) probably null Het
Gabarapl2 T C 8: 112,669,227 (GRCm39) W62R probably damaging Het
Glt1d1 A G 5: 127,721,420 (GRCm39) R36G probably benign Het
Grb10 T C 11: 11,894,924 (GRCm39) silent Het
Gtf2h3 C T 5: 124,722,360 (GRCm39) T121I probably benign Het
Hc A G 2: 34,886,026 (GRCm39) probably null Het
Hgd A G 16: 37,448,913 (GRCm39) E379G possibly damaging Het
Ifi30 A T 8: 71,219,245 (GRCm39) probably benign Het
Iqgap1 T C 7: 80,388,472 (GRCm39) I842V possibly damaging Het
Iqsec3 T A 6: 121,363,659 (GRCm39) probably null Het
Kalrn A G 16: 34,072,711 (GRCm39) S724P possibly damaging Het
Lama2 C A 10: 27,088,069 (GRCm39) G903* probably null Het
Lrrc10 T C 10: 116,881,392 (GRCm39) V22A probably benign Het
Lzts3 T C 2: 130,478,021 (GRCm39) E245G probably benign Het
Man2a1 A G 17: 64,958,222 (GRCm39) T246A probably damaging Het
Mfsd13a A G 19: 46,356,719 (GRCm39) E240G probably benign Het
Mtor T C 4: 148,550,549 (GRCm39) I735T possibly damaging Het
Naa15 A T 3: 51,363,315 (GRCm39) H333L probably damaging Het
Nes C A 3: 87,885,725 (GRCm39) T1284K probably damaging Het
Nexn T G 3: 151,953,709 (GRCm39) H173P probably benign Het
Nid2 T C 14: 19,855,379 (GRCm39) V1173A possibly damaging Het
Npepps A G 11: 97,131,753 (GRCm39) probably null Het
Pgm1 T A 4: 99,824,266 (GRCm39) M313K probably damaging Het
Plag1 T A 4: 3,905,545 (GRCm39) K48N probably damaging Het
Prok1 G C 3: 107,146,935 (GRCm39) L11V probably benign Het
Ptpn9 T C 9: 56,967,347 (GRCm39) probably null Het
Skint8 C A 4: 111,807,390 (GRCm39) L359M probably damaging Het
Slc38a4 A T 15: 96,908,229 (GRCm39) F171I possibly damaging Het
Sycp1 A T 3: 102,841,569 (GRCm39) N78K possibly damaging Het
Tas2r110 T C 6: 132,844,972 (GRCm39) M1T probably null Het
Thoc2l G A 5: 104,667,523 (GRCm39) V682I probably benign Het
Tmem260 G A 14: 48,724,267 (GRCm39) V182M possibly damaging Het
Tmem30a A T 9: 79,683,436 (GRCm39) N144K probably damaging Het
Vmn2r108 A G 17: 20,691,866 (GRCm39) L219P probably damaging Het
Vmn2r57 A G 7: 41,049,398 (GRCm39) S784P probably damaging Het
Vwf T C 6: 125,644,473 (GRCm39) probably benign Het
Wdr62 A C 7: 29,967,300 (GRCm39) V318G probably damaging Het
Zfp398 T A 6: 47,840,115 (GRCm39) S115T probably benign Het
Zfp62 T A 11: 49,107,975 (GRCm39) C689S probably damaging Het
Other mutations in Zmynd15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01010:Zmynd15 APN 11 70,356,742 (GRCm39) missense probably damaging 1.00
IGL01351:Zmynd15 APN 11 70,354,416 (GRCm39) missense probably benign 0.28
R0086:Zmynd15 UTSW 11 70,355,058 (GRCm39) missense probably damaging 1.00
R0196:Zmynd15 UTSW 11 70,355,052 (GRCm39) missense probably damaging 1.00
R0667:Zmynd15 UTSW 11 70,355,944 (GRCm39) missense probably damaging 1.00
R1511:Zmynd15 UTSW 11 70,355,619 (GRCm39) missense probably damaging 0.98
R1660:Zmynd15 UTSW 11 70,354,328 (GRCm39) missense probably damaging 1.00
R1750:Zmynd15 UTSW 11 70,353,393 (GRCm39) missense probably benign 0.00
R4344:Zmynd15 UTSW 11 70,351,894 (GRCm39) nonsense probably null
R4594:Zmynd15 UTSW 11 70,355,008 (GRCm39) missense probably damaging 1.00
R4668:Zmynd15 UTSW 11 70,353,414 (GRCm39) missense probably damaging 1.00
R5029:Zmynd15 UTSW 11 70,353,387 (GRCm39) missense probably damaging 1.00
R5075:Zmynd15 UTSW 11 70,352,946 (GRCm39) missense probably damaging 1.00
R5468:Zmynd15 UTSW 11 70,352,646 (GRCm39) missense probably damaging 1.00
R6350:Zmynd15 UTSW 11 70,355,257 (GRCm39) missense probably damaging 1.00
R6665:Zmynd15 UTSW 11 70,355,636 (GRCm39) missense probably benign 0.01
R7078:Zmynd15 UTSW 11 70,351,581 (GRCm39) missense probably damaging 1.00
R7426:Zmynd15 UTSW 11 70,353,014 (GRCm39) missense probably benign 0.06
R7475:Zmynd15 UTSW 11 70,351,867 (GRCm39) missense probably benign
R7673:Zmynd15 UTSW 11 70,356,866 (GRCm39) missense unknown
R8003:Zmynd15 UTSW 11 70,351,767 (GRCm39) missense probably benign 0.00
R8079:Zmynd15 UTSW 11 70,350,278 (GRCm39) unclassified probably benign
R8536:Zmynd15 UTSW 11 70,353,387 (GRCm39) missense probably damaging 1.00
R8828:Zmynd15 UTSW 11 70,355,017 (GRCm39) missense probably damaging 1.00
R8972:Zmynd15 UTSW 11 70,355,065 (GRCm39) missense possibly damaging 0.73
Z1088:Zmynd15 UTSW 11 70,351,961 (GRCm39) missense possibly damaging 0.67
Predicted Primers PCR Primer
(F):5'- GCCCTGCTCCTGAAAAGATTG -3'
(R):5'- TGTGTTCCGACAATCAGTCTTC -3'

Sequencing Primer
(F):5'- GCTCCTGAAAAGATTGATGCTCC -3'
(R):5'- GACAATCAGTCTTCCCTGGG -3'
Posted On 2016-08-04