Mutagenetix > Incidental Mutations

Incidental Mutation 'R5290:Zfp937'

424632

Institutional Source

Beutler Lab

Gene Symbol

Zfp937

Ensembl Gene

ENSMUSG00000060336

Gene Name

zinc finger protein 937

Synonyms

Gm4979

MMRRC Submission

042873-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.075) question?

Stock #

R5290 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

150218073-150240725 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 150238309 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 86 (Y86*)

Ref Sequence

ENSEMBL: ENSMUSP00000073454 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000073782]

Predicted Effect

probably null
Transcript: ENSMUST00000073782
AA Change: Y86*

SMART Domains

Protein: ENSMUSP00000073454
Gene: ENSMUSG00000060336
AA Change: Y86*

Domain	Start	End	E-Value	Type
KRAB	4	66	8.19e-20	SMART
ZnF_C2H2	103	125	1.28e-3	SMART
ZnF_C2H2	131	153	2.53e-2	SMART
ZnF_C2H2	159	181	9.58e-3	SMART
ZnF_C2H2	187	209	2.09e-3	SMART
ZnF_C2H2	215	237	2.2e-2	SMART
ZnF_C2H2	243	265	2.2e-2	SMART
ZnF_C2H2	271	293	2.2e-2	SMART
ZnF_C2H2	299	321	1.82e-3	SMART
ZnF_C2H2	327	349	3.69e-4	SMART
ZnF_C2H2	355	377	4.47e-3	SMART
ZnF_C2H2	383	405	3.89e-3	SMART
ZnF_C2H2	411	433	4.79e-3	SMART
ZnF_C2H2	439	461	8.47e-4	SMART
ZnF_C2H2	467	490	7.26e-3	SMART

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.1%
20x: 94.8%

Validation Efficiency

97% (70/72)

Allele List at MGI

Other mutations in this stock

Total: 62 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1110008E08Rik	A	T	16: 90,554,210		noncoding transcript	Het
2700049A03Rik	C	A	12: 71,188,791	P1172T	probably benign	Het
Abi3bp	T	A	16: 56,642,475		probably null	Het
Apod	T	A	16: 31,311,066	H24L	probably damaging	Het
Arfgef3	T	C	10: 18,600,460	E1537G	probably damaging	Het
B020004C17Rik	T	C	14: 57,016,579	V53A	possibly damaging	Het
Ccdc113	C	A	8: 95,540,796		probably null	Het
Cd7	T	G	11: 121,038,110	D105A	probably damaging	Het
Celsr3	C	T	9: 108,843,158	T2550M	probably benign	Het
Col6a5	C	T	9: 105,946,083	G25D	unknown	Het
Cps1	A	G	1: 67,172,709	M679V	probably benign	Het
Dync1h1	A	T	12: 110,615,068	T316S	probably benign	Het
Edrf1	T	C	7: 133,650,566	Y449H	probably damaging	Het
Fam92a	T	C	4: 12,171,195	Q86R	probably benign	Het
Fkbpl	G	A	17: 34,645,329	A24T	probably benign	Het
Flg2	A	T	3: 93,220,566	I2262L	unknown	Het
Flnc	T	C	6: 29,457,554	L2417P	probably damaging	Het
Gabrp	A	T	11: 33,567,310	Y121N	probably damaging	Het
Gdpd4	A	G	7: 97,966,336	T123A	possibly damaging	Het
Gm4763	T	C	7: 24,723,411	E79G	probably benign	Het
Gpr162	C	A	6: 124,861,269	M139I	probably benign	Het
Greb1l	G	A	18: 10,542,427	E1341K	probably damaging	Het
Gsn	G	A	2: 35,296,472	S410N	probably benign	Het
Gtf2f2	T	C	14: 75,897,649	Y212C	probably damaging	Het
Hao2	C	T	3: 98,877,177	A291T	probably damaging	Het
Igkv1-133	A	G	6: 67,725,579	T94A	possibly damaging	Het
Irf2bp1	G	A	7: 19,004,998	A188T	possibly damaging	Het
Itpr1	T	C	6: 108,406,145	V1478A	possibly damaging	Het
Kdm5b	T	C	1: 134,622,099		probably null	Het
Kif5b	A	T	18: 6,234,882	D49E	probably damaging	Het
Lmbr1l	A	G	15: 98,912,242	W113R	probably damaging	Het
Lrp2	T	C	2: 69,513,354	D887G	probably damaging	Het
Lrrc14	T	A	15: 76,713,943	M291K	probably benign	Het
Mgarp	G	A	3: 51,388,966	A205V	possibly damaging	Het
Msl2	T	C	9: 101,101,407		probably null	Het
Nfix	G	A	8: 84,713,777	Q487*	probably null	Het
Notch4	T	C	17: 34,565,289	V22A	probably benign	Het
Npc1l1	T	A	11: 6,222,221	Q823L	probably benign	Het
Obox3	T	C	7: 15,626,849	K122E	probably benign	Het
Olfr282	T	C	15: 98,438,332	Y288H	probably damaging	Het
Olfr446	A	G	6: 42,928,038	K269R	probably damaging	Het
Olfr509	C	T	7: 108,646,548	M9I	probably benign	Het
Plekhh3	T	A	11: 101,166,571	M287L	possibly damaging	Het
Prpf3	A	T	3: 95,853,545	I15K	probably benign	Het
Rpl12-ps1	G	T	1: 36,958,342		noncoding transcript	Het
Rps8	G	C	4: 117,155,155		probably benign	Het
Setd2	T	C	9: 110,617,831	V2489A	probably damaging	Het
Slfn10-ps	T	A	11: 83,029,025		noncoding transcript	Het
Smad2	C	T	18: 76,262,724	P78L	probably damaging	Het
Spen	G	A	4: 141,473,816	T2500I	probably damaging	Het
Stmnd1	A	G	13: 46,299,598	D250G	probably benign	Het
Tjp2	T	G	19: 24,131,204	E181D	probably benign	Het
Tmem131l	T	C	3: 83,899,265	D1478G	probably benign	Het
Trim72	G	T	7: 128,010,004	R326L	probably benign	Het
Ttn	A	T	2: 76,897,240		probably benign	Het
Vmn1r177	A	T	7: 23,866,073	M126K	probably damaging	Het
Vmn1r57	A	G	7: 5,221,320	I281M	probably damaging	Het
Vmn2r108	C	A	17: 20,471,403	R286L	probably benign	Het
Wdr25	T	C	12: 108,898,042	S38P	probably benign	Het
Wdr78	A	T	4: 103,049,533	D694E	probably benign	Het
Zfr2	CTCAGACTGGTGTCAGAC	CTCAGAC	10: 81,246,710		probably null	Het
Zswim1	C	T	2: 164,825,925	H366Y	probably damaging	Het

Other mutations in Zfp937

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0350:Zfp937	UTSW	2	150239302	missense	possibly damaging	0.91
R0449:Zfp937	UTSW	2	150239546	missense	probably benign	0.13
R1403:Zfp937	UTSW	2	150238948	nonsense	probably null
R1403:Zfp937	UTSW	2	150238948	nonsense	probably null
R1465:Zfp937	UTSW	2	150239047	nonsense	probably null
R1465:Zfp937	UTSW	2	150239047	nonsense	probably null
R4510:Zfp937	UTSW	2	150238511	missense	probably damaging	0.98
R4511:Zfp937	UTSW	2	150238511	missense	probably damaging	0.98
R4689:Zfp937	UTSW	2	150236786	missense	probably damaging	1.00
R6287:Zfp937	UTSW	2	150238341	missense	possibly damaging	0.89
R6701:Zfp937	UTSW	2	150239216	missense	probably damaging	1.00
R6746:Zfp937	UTSW	2	150239423	nonsense	probably null
R6838:Zfp937	UTSW	2	150239346	missense	probably benign	0.01
R7162:Zfp937	UTSW	2	150239519	missense	probably benign	0.35
R7213:Zfp937	UTSW	2	150239465	missense	probably damaging	1.00
R7441:Zfp937	UTSW	2	150238710	frame shift	probably null
R7481:Zfp937	UTSW	2	150239346	missense	probably benign	0.01
R7694:Zfp937	UTSW	2	150239348	missense	probably damaging	1.00
X0017:Zfp937	UTSW	2	150218161	utr 5 prime	probably null

Predicted Primers

PCR Primer
(F):5'- TTGCAAATGTATTATGACTCACAGT -3'
(R):5'- TGCCCTCGAAGATGACAGAG -3'

Sequencing Primer
(F):5'- CGATGCTGTAAATGTGAGCC -3'
(R):5'- GAAGAGCAAAGGCCTTATCACACTG -3'

Posted On

2016-08-04