Incidental Mutation 'R5382:Or3a1'
ID 424799
Institutional Source Beutler Lab
Gene Symbol Or3a1
Ensembl Gene ENSMUSG00000063116
Gene Name olfactory receptor family 3 subfamily A member 1
Synonyms Olfr410, GA_x6K02T2P1NL-4467421-4466474, MOR255-5
MMRRC Submission 042957-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.103) question?
Stock # R5382 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 74225108-74226055 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 74225806 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Leucine at position 84 (M84L)
Ref Sequence ENSEMBL: ENSMUSP00000150291 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052254] [ENSMUST00000213831] [ENSMUST00000214490]
AlphaFold Q8VFX7
Predicted Effect probably benign
Transcript: ENSMUST00000052254
AA Change: M84L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000050456
Gene: ENSMUSG00000063116
AA Change: M84L

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 5.4e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 253 5e-6 PFAM
Pfam:7tm_1 44 293 7.7e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213831
AA Change: M84L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000214490
AA Change: M84L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.7%
Validation Efficiency 100% (59/59)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp7 G A 7: 28,314,844 (GRCm39) P250S possibly damaging Het
Actn2 T A 13: 12,323,837 (GRCm39) M133L probably benign Het
Arhgap32 A T 9: 32,063,306 (GRCm39) K105M probably damaging Het
BC034090 A G 1: 155,101,349 (GRCm39) V305A probably benign Het
Brd1 G A 15: 88,613,767 (GRCm39) T376M probably damaging Het
Cbl C T 9: 44,070,318 (GRCm39) A505T probably benign Het
Cga G T 4: 34,904,048 (GRCm39) M14I probably benign Het
Ciao3 A G 17: 25,995,894 (GRCm39) probably benign Het
Cluh T C 11: 74,555,935 (GRCm39) probably benign Het
Col14a1 A T 15: 55,225,832 (GRCm39) D165V unknown Het
Cp T C 3: 20,033,089 (GRCm39) W639R probably damaging Het
Cyp7b1 T A 3: 18,151,385 (GRCm39) D276V possibly damaging Het
Dctd C T 8: 48,590,449 (GRCm39) probably benign Het
Ecpas A T 4: 58,850,934 (GRCm39) M413K probably benign Het
Erc1 T A 6: 119,738,233 (GRCm39) M509L probably benign Het
Evi5l A G 8: 4,228,653 (GRCm39) probably benign Het
Exoc6 T C 19: 37,587,127 (GRCm39) probably null Het
Gm38706 C T 6: 130,460,744 (GRCm39) noncoding transcript Het
Gpr183 T C 14: 122,192,333 (GRCm39) T63A possibly damaging Het
Gpr63 T A 4: 25,007,952 (GRCm39) D225E probably benign Het
Grb14 T A 2: 64,745,078 (GRCm39) K93N probably damaging Het
Igkv4-80 A C 6: 68,993,649 (GRCm39) S81A probably benign Het
Kif28 C T 1: 179,527,847 (GRCm39) G768D probably damaging Het
Krt79 A T 15: 101,839,875 (GRCm39) D373E probably benign Het
Mro G A 18: 74,009,893 (GRCm39) S187N probably benign Het
Ms4a14 G T 19: 11,280,421 (GRCm39) D712E possibly damaging Het
Ndufaf1 T C 2: 119,490,893 (GRCm39) T56A possibly damaging Het
Nell2 A T 15: 95,127,091 (GRCm39) D761E probably damaging Het
Numb A G 12: 83,854,979 (GRCm39) F116L probably damaging Het
Or4c114 A G 2: 88,905,079 (GRCm39) Y119H probably damaging Het
Or5an11 A T 19: 12,245,773 (GRCm39) M60L possibly damaging Het
Or6c66 T A 10: 129,461,876 (GRCm39) D18V probably damaging Het
Or8k27 A G 2: 86,275,660 (GRCm39) L222P probably damaging Het
Or9g20 T C 2: 85,630,492 (GRCm39) N41D probably damaging Het
Otog A C 7: 45,898,428 (GRCm39) N182T probably damaging Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Padi6 A T 4: 140,458,521 (GRCm39) V457E probably damaging Het
Pex16 G A 2: 92,207,875 (GRCm39) R109H possibly damaging Het
Phactr1 T C 13: 43,288,695 (GRCm39) probably benign Het
Phf20 G A 2: 156,109,417 (GRCm39) E255K probably damaging Het
Pim1 A G 17: 29,710,457 (GRCm39) probably benign Het
Prr23a2 T A 9: 98,739,229 (GRCm39) Y196N probably damaging Het
Prune2 A T 19: 16,981,023 (GRCm39) N60I probably damaging Het
Ptprb T A 10: 116,189,776 (GRCm39) Y1812N probably damaging Het
Rab11fip4 A G 11: 79,581,541 (GRCm39) Y512C possibly damaging Het
Resf1 G T 6: 149,227,958 (GRCm39) E335* probably null Het
Rft1 T C 14: 30,388,739 (GRCm39) V221A probably benign Het
Tacr2 T C 10: 62,097,276 (GRCm39) M252T probably damaging Het
Tgfbrap1 A G 1: 43,115,025 (GRCm39) I25T probably benign Het
Th A G 7: 142,449,177 (GRCm39) F191S probably damaging Het
Trim3 C A 7: 105,267,554 (GRCm39) R275L probably benign Het
Trpm3 A G 19: 22,862,705 (GRCm39) probably null Het
Wars1 A T 12: 108,848,706 (GRCm39) D80E probably benign Het
Wdr90 T A 17: 26,064,572 (GRCm39) Y1806F probably damaging Het
Zfp644 A T 5: 106,782,735 (GRCm39) I1182N possibly damaging Het
Other mutations in Or3a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02103:Or3a1 APN 11 74,225,862 (GRCm39) missense probably damaging 1.00
IGL02885:Or3a1 APN 11 74,225,519 (GRCm39) missense possibly damaging 0.95
R0363:Or3a1 UTSW 11 74,225,925 (GRCm39) missense probably damaging 1.00
R1033:Or3a1 UTSW 11 74,225,462 (GRCm39) missense possibly damaging 0.48
R1722:Or3a1 UTSW 11 74,225,271 (GRCm39) missense probably damaging 1.00
R1759:Or3a1 UTSW 11 74,225,808 (GRCm39) missense possibly damaging 0.49
R2007:Or3a1 UTSW 11 74,225,212 (GRCm39) missense possibly damaging 0.57
R2278:Or3a1 UTSW 11 74,225,991 (GRCm39) missense probably benign 0.00
R4756:Or3a1 UTSW 11 74,225,402 (GRCm39) missense probably benign
R6026:Or3a1 UTSW 11 74,225,914 (GRCm39) missense probably damaging 0.99
R6048:Or3a1 UTSW 11 74,225,961 (GRCm39) missense probably benign 0.13
R8488:Or3a1 UTSW 11 74,225,932 (GRCm39) missense probably benign 0.01
R9134:Or3a1 UTSW 11 74,225,670 (GRCm39) missense probably damaging 1.00
R9368:Or3a1 UTSW 11 74,225,193 (GRCm39) missense probably damaging 1.00
X0067:Or3a1 UTSW 11 74,225,776 (GRCm39) missense probably benign 0.00
Z1088:Or3a1 UTSW 11 74,225,518 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCAGTGCATTGCTGAAGGC -3'
(R):5'- AGCTGTGGCCACTTGTCTTC -3'

Sequencing Primer
(F):5'- CACCAAGATCCTCTGGATAGTGTG -3'
(R):5'- GTGGCCACTTGTCTTCATACTC -3'
Posted On 2016-08-04