|Institutional Source||Beutler Lab|
|Gene Name||proviral integration site 1|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R5382 (G1)|
|Chromosomal Location||29490812-29496111 bp(+) (GRCm38)|
|Type of Mutation||intron|
|DNA Base Change (assembly)||A to G at 29491483 bp|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000024811 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000024811]|
|Predicted Effect||probably benign
|Predicted Effect||noncoding transcript
|Coding Region Coverage||
|Validation Efficiency||100% (59/59)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for disruptions in this gene have abnormally small erythrocytes but are otherwise phenotypically normal. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Pim1||
(F):5'- CTCTTTCCTAGGCAAAGAGAAGG -3'
(R):5'- GCTCACCTTCTTCAACAGGAC -3'
(F):5'- AGAAGGAGCCCCTGGAGTC -3'
(R):5'- CCATTGGGCTGCAGAGTGAG -3'