Mutagenetix > Incidental Mutation

Incidental Mutation 'R5384:Vmn2r118'

425003

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r118

Ensembl Gene

ENSMUSG00000091504

Gene Name

vomeronasal 2, receptor 118

Synonyms

EG383258, Vmn2r119, EG668547

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.125) question?

Stock #

R5384 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

55592341-55624672 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 55611565 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Glycine to Aspartic acid at position 109 (G109D)

Ref Sequence

ENSEMBL: ENSMUSP00000131128 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000168440]

AlphaFold

E9Q1C1

Predicted Effect

probably benign
Transcript: ENSMUST00000168440
AA Change: G109D

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000131128
Gene: ENSMUSG00000091504
AA Change: G109D

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	142	470	4.6e-27	PFAM
Pfam:NCD3G	513	566	2.6e-20	PFAM
Pfam:7tm_3	599	834	5.9e-55	PFAM

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 126 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833420G17Rik	T	C	13: 119,469,960	V246A	probably benign	Het
Abcc10	T	C	17: 46,304,435	S1343G	possibly damaging	Het
Abcd3	C	A	3: 121,761,410		probably null	Het
Actl6a	T	A	3: 32,720,493	M335K	probably damaging	Het
Adamts9	A	C	6: 92,798,018	C1090W	probably damaging	Het
Ajuba	T	C	14: 54,570,398	Y459C	probably damaging	Het
Aldh7a1	T	A	18: 56,534,253	N316Y	possibly damaging	Het
Ankhd1	A	G	18: 36,591,495	E402G	probably damaging	Het
Ankrd36	A	G	11: 5,689,340		probably benign	Het
Apeh	A	T	9: 108,086,463	L551H	probably damaging	Het
Avpr1a	T	A	10: 122,449,369	F189I	probably damaging	Het
BC034090	T	A	1: 155,242,027	H115L	possibly damaging	Het
C4b	A	T	17: 34,737,661	D654E	possibly damaging	Het
Carns1	T	A	19: 4,171,901		probably null	Het
Ccdc146	T	A	5: 21,308,713	E469V	probably benign	Het
Cdc27	A	G	11: 104,507,140	I804T	probably benign	Het
Cdh23	G	A	10: 60,337,762	T1651I	probably damaging	Het
Cenpo	G	A	12: 4,216,646	P154L	probably damaging	Het
Cenpu	G	A	8: 46,562,499	G150R	probably benign	Het
Chrna10	C	A	7: 102,114,353	L78F	probably damaging	Het
Chrne	A	T	11: 70,615,087	N457K	possibly damaging	Het
Cidea	A	T	18: 67,360,166	D85V	probably damaging	Het
Cldn18	T	C	9: 99,709,858	S31G	possibly damaging	Het
Clpb	T	A	7: 101,779,341	I436N	probably damaging	Het
Col11a2	T	C	17: 34,059,174		probably null	Het
Cul7	T	C	17: 46,654,477	V527A	probably benign	Het
Dchs1	T	A	7: 105,772,055	D386V	probably damaging	Het
Dchs1	A	C	7: 105,758,029	V2119G	probably damaging	Het
Dcstamp	A	C	15: 39,759,319	Q345H	probably damaging	Het
Dlgap3	A	G	4: 127,236,330	I955V	probably damaging	Het
Dvl1	A	G	4: 155,853,686	D97G	probably damaging	Het
Dync2h1	T	C	9: 7,016,791	D3573G	probably damaging	Het
Efr3b	G	T	12: 3,983,419	F129L	probably benign	Het
Etaa1	G	A	11: 17,947,539	L193F	probably damaging	Het
Fam13c	G	A	10: 70,553,069	S474N	probably benign	Het
Fam171a2	C	A	11: 102,437,867	V689L	possibly damaging	Het
Fastkd3	T	C	13: 68,584,585	F342L	probably benign	Het
Fat4	T	C	3: 38,995,946	S3986P	possibly damaging	Het
Fbxo38	A	G	18: 62,540,971	M13T	probably benign	Het
Fbxo48	G	T	11: 16,954,329	L160F	possibly damaging	Het
Fgr	G	A	4: 132,986,353		probably null	Het
Gbx2	T	C	1: 89,928,913	T252A	probably damaging	Het
Gm20671	A	G	5: 32,819,942	S1823P	probably damaging	Het
Gpatch8	A	T	11: 102,508,227		probably null	Het
Gsdma	A	T	11: 98,666,449		probably null	Het
Gucy2g	G	A	19: 55,215,116	A750V	probably damaging	Het
Hdac9	A	G	12: 34,429,558	Y223H	probably damaging	Het
Igsf5	C	A	16: 96,391,026	T275N	probably benign	Het
Il23r	G	A	6: 67,486,291	H73Y	probably benign	Het
Ipo4	G	T	14: 55,626,196	R1026S	probably benign	Het
Jade1	T	A	3: 41,591,702	I54N	probably damaging	Het
Khdrbs1	G	T	4: 129,741,936	D75E	possibly damaging	Het
Lrwd1	A	T	5: 136,123,874	D511E	possibly damaging	Het
Ly75	A	T	2: 60,334,487	C782*	probably null	Het
Mmp3	C	T	9: 7,451,759	R366*	probably null	Het
Mrgpra6	A	G	7: 47,188,881	C190R	probably damaging	Het
Myh10	T	A	11: 68,801,608	L1369Q	probably damaging	Het
Myof	C	T	19: 37,952,987	A792T	probably damaging	Het
Ncf1	A	G	5: 134,221,805	L373P	probably damaging	Het
Ncoa7	C	A	10: 30,722,817	A37S	probably benign	Het
Nfkb1	A	G	3: 135,612,542	V310A	possibly damaging	Het
Nmur2	T	A	11: 56,040,214	I224F	probably damaging	Het
Nr1d2	A	T	14: 18,211,922	S394T	probably benign	Het
Nudt12	A	G	17: 59,003,439	W390R	probably damaging	Het
Olfr1252	T	A	2: 89,721,305	I269F	possibly damaging	Het
Olfr1508	T	A	14: 52,463,257	T251S	probably benign	Het
Olfr165	A	G	16: 19,407,797	L73P	probably damaging	Het
Olfr243	T	C	7: 103,717,355	F254L	probably benign	Het
Olfr739	T	A	14: 50,425,389	V290E	possibly damaging	Het
Pate2	A	G	9: 35,670,541	M44V	probably damaging	Het
Pikfyve	T	C	1: 65,244,409	L735S	probably damaging	Het
Plce1	C	A	19: 38,760,091	N1755K	probably damaging	Het
Pld1	C	A	3: 28,025,320	R90S	probably damaging	Het
Pnpla7	C	A	2: 25,041,019	P882Q	probably damaging	Het
Pold2	A	G	11: 5,876,760	L58P	probably damaging	Het
Ppm1d	A	G	11: 85,311,783	E104G	probably damaging	Het
Ppm1e	A	T	11: 87,358,551	L118Q	possibly damaging	Het
Ppp1r42	A	G	1: 9,999,435	L134P	probably damaging	Het
Prpf8	A	G	11: 75,495,799	D1038G	probably damaging	Het
Prss36	C	A	7: 127,936,699	R288L	probably damaging	Het
Prss51	T	A	14: 64,097,094	V108E	probably damaging	Het
Psma3	G	T	12: 70,974,765	G7W	probably damaging	Het
Psmc3ip	A	T	11: 101,092,604		probably null	Het
Qser1	T	C	2: 104,786,642	E1275G	probably damaging	Het
Rai2	A	G	X: 161,778,640	N363S	probably benign	Het
Ranbp17	A	T	11: 33,219,241	V991D	possibly damaging	Het
Rcc2	A	T	4: 140,720,566	K468*	probably null	Het
S1pr2	T	C	9: 20,967,594	T313A	probably benign	Het
Sec1	C	A	7: 45,678,840	R261L	probably benign	Het
Sfi1	ACA	ACATCTTCCCAAAGCCAGTCA	11: 3,153,382		probably benign	Homo
Sgip1	G	A	4: 102,934,566	V362I	possibly damaging	Het
Shroom4	T	A	X: 6,585,469	C894*	probably null	Het
Slc12a9	A	T	5: 137,331,014	L126Q	probably damaging	Het
Slx4	A	G	16: 3,990,805	S424P	probably damaging	Het
Smg5	T	C	3: 88,351,293	S524P	probably damaging	Het
Sncaip	A	G	18: 52,885,041	D418G	probably damaging	Het
Soga3	A	G	10: 29,196,770	D686G	probably benign	Het
Spata31d1b	C	A	13: 59,718,218	T1060K	possibly damaging	Het
Spink6	A	G	18: 44,082,280	T66A	probably damaging	Het
Sppl2c	T	A	11: 104,187,301	I309K	possibly damaging	Het
Stk39	T	A	2: 68,410,039	D116V	probably damaging	Het
Supv3l1	A	T	10: 62,430,596	N600K	possibly damaging	Het
Svep1	T	C	4: 58,104,545	K1226R	possibly damaging	Het
Syne1	C	T	10: 5,041,494	V557I	probably benign	Het
Tas2r117	G	T	6: 132,803,154	S85I	probably benign	Het
Tcf20	T	A	15: 82,856,199	Q350H	probably damaging	Het
Tep1	A	T	14: 50,868,317	L82Q	probably damaging	Het
Tfb2m	A	C	1: 179,545,872		probably null	Het
Tm9sf1	C	T	14: 55,642,844	G32D	possibly damaging	Het
Tpd52	A	T	3: 8,931,195		probably null	Het
Trappc8	A	T	18: 20,833,062		probably null	Het
Trbv30	A	G	6: 41,281,920	T88A	probably benign	Het
Trim40	T	A	17: 36,888,865	N107I	probably damaging	Het
Trim80	A	T	11: 115,448,017	T558S	probably benign	Het
Ttn	A	G	2: 76,878,348		probably benign	Het
Vav3	A	G	3: 109,527,475	M441V	possibly damaging	Het
Vmn1r42	T	A	6: 89,845,384	I68F	probably damaging	Het
Vmn2r5	T	A	3: 64,509,510	M76L	probably benign	Het
Vwa7	G	T	17: 35,024,926		probably null	Het
Xndc1	T	C	7: 102,082,188	V378A	probably benign	Het
Zc3h12d	A	T	10: 7,853,250	D126V	probably damaging	Het
Zc3h13	A	G	14: 75,343,619	N1682S	probably benign	Het
Zc3h15	T	C	2: 83,660,230	I236T	possibly damaging	Het
Zfp13	A	T	17: 23,581,182	I34N	probably damaging	Het
Zfp169	A	T	13: 48,490,275	C459S	possibly damaging	Het
Zfyve28	A	G	5: 34,216,967	C568R	probably damaging	Het

Other mutations in Vmn2r118

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00091:Vmn2r118	APN	17	55,592,708 (GRCm38)	missense	probably damaging	1.00
IGL00976:Vmn2r118	APN	17	55,593,204 (GRCm38)	missense	probably damaging	1.00
IGL01419:Vmn2r118	APN	17	55,593,000 (GRCm38)	missense	probably benign	0.01
IGL01796:Vmn2r118	APN	17	55,608,585 (GRCm38)	missense	probably benign	0.30
IGL01799:Vmn2r118	APN	17	55,592,990 (GRCm38)	missense	probably damaging	1.00
IGL02002:Vmn2r118	APN	17	55,592,619 (GRCm38)	missense	probably damaging	1.00
IGL02075:Vmn2r118	APN	17	55,610,517 (GRCm38)	missense	probably benign	0.18
IGL02172:Vmn2r118	APN	17	55,624,598 (GRCm38)	missense	probably benign	0.00
IGL02529:Vmn2r118	APN	17	55,610,870 (GRCm38)	missense	possibly damaging	0.58
IGL02712:Vmn2r118	APN	17	55,592,655 (GRCm38)	missense	probably benign	0.21
IGL03096:Vmn2r118	APN	17	55,607,996 (GRCm38)	missense	probably damaging	1.00
R0306:Vmn2r118	UTSW	17	55,608,616 (GRCm38)	missense	possibly damaging	0.89
R0329:Vmn2r118	UTSW	17	55,610,717 (GRCm38)	missense	probably damaging	1.00
R0330:Vmn2r118	UTSW	17	55,610,717 (GRCm38)	missense	probably damaging	1.00
R0396:Vmn2r118	UTSW	17	55,608,643 (GRCm38)	missense	probably benign	0.00
R0411:Vmn2r118	UTSW	17	55,611,021 (GRCm38)	splice site	probably benign
R0513:Vmn2r118	UTSW	17	55,610,970 (GRCm38)	nonsense	probably null
R0627:Vmn2r118	UTSW	17	55,610,772 (GRCm38)	missense	probably benign	0.01
R0638:Vmn2r118	UTSW	17	55,608,466 (GRCm38)	missense	probably benign	0.03
R1328:Vmn2r118	UTSW	17	55,608,620 (GRCm38)	missense	probably benign	0.01
R1366:Vmn2r118	UTSW	17	55,593,237 (GRCm38)	nonsense	probably null
R1465:Vmn2r118	UTSW	17	55,610,935 (GRCm38)	missense	probably benign	0.33
R1465:Vmn2r118	UTSW	17	55,610,935 (GRCm38)	missense	probably benign	0.33
R1511:Vmn2r118	UTSW	17	55,608,496 (GRCm38)	nonsense	probably null
R1515:Vmn2r118	UTSW	17	55,610,643 (GRCm38)	missense	probably benign	0.25
R1550:Vmn2r118	UTSW	17	55,608,083 (GRCm38)	missense	probably damaging	1.00
R1779:Vmn2r118	UTSW	17	55,611,530 (GRCm38)	missense	probably benign	0.03
R1834:Vmn2r118	UTSW	17	55,592,456 (GRCm38)	missense	probably damaging	1.00
R1840:Vmn2r118	UTSW	17	55,610,406 (GRCm38)	nonsense	probably null
R1854:Vmn2r118	UTSW	17	55,611,556 (GRCm38)	missense	possibly damaging	0.57
R1967:Vmn2r118	UTSW	17	55,592,882 (GRCm38)	missense	probably damaging	1.00
R1976:Vmn2r118	UTSW	17	55,592,925 (GRCm38)	missense	probably damaging	1.00
R2308:Vmn2r118	UTSW	17	55,624,650 (GRCm38)	missense	probably benign	0.33
R3700:Vmn2r118	UTSW	17	55,608,421 (GRCm38)	missense	possibly damaging	0.68
R4334:Vmn2r118	UTSW	17	55,610,347 (GRCm38)	missense	possibly damaging	0.58
R4647:Vmn2r118	UTSW	17	55,610,665 (GRCm38)	missense	probably damaging	1.00
R4709:Vmn2r118	UTSW	17	55,610,860 (GRCm38)	missense	probably damaging	1.00
R4805:Vmn2r118	UTSW	17	55,592,581 (GRCm38)	missense	probably damaging	1.00
R4858:Vmn2r118	UTSW	17	55,592,894 (GRCm38)	missense	probably damaging	0.98
R5385:Vmn2r118	UTSW	17	55,611,565 (GRCm38)	missense	probably benign	0.00
R5664:Vmn2r118	UTSW	17	55,592,765 (GRCm38)	missense	possibly damaging	0.46
R5740:Vmn2r118	UTSW	17	55,593,103 (GRCm38)	missense	probably benign	0.00
R5927:Vmn2r118	UTSW	17	55,624,494 (GRCm38)	missense	probably benign	0.04
R6143:Vmn2r118	UTSW	17	55,592,871 (GRCm38)	missense	possibly damaging	0.92
R6513:Vmn2r118	UTSW	17	55,608,093 (GRCm38)	missense	probably damaging	1.00
R6573:Vmn2r118	UTSW	17	55,592,996 (GRCm38)	missense	probably damaging	1.00
R6760:Vmn2r118	UTSW	17	55,592,714 (GRCm38)	missense	possibly damaging	0.92
R6794:Vmn2r118	UTSW	17	55,592,348 (GRCm38)	missense	possibly damaging	0.48
R6929:Vmn2r118	UTSW	17	55,610,440 (GRCm38)	missense	probably benign	0.01
R7201:Vmn2r118	UTSW	17	55,608,496 (GRCm38)	nonsense	probably null
R7539:Vmn2r118	UTSW	17	55,592,853 (GRCm38)	missense	probably damaging	0.98
R7836:Vmn2r118	UTSW	17	55,593,242 (GRCm38)	missense	probably damaging	0.99
R8179:Vmn2r118	UTSW	17	55,608,484 (GRCm38)	missense	probably benign	0.36
R8248:Vmn2r118	UTSW	17	55,610,936 (GRCm38)	missense	probably benign	0.18
R8347:Vmn2r118	UTSW	17	55,610,423 (GRCm38)	missense	possibly damaging	0.94
R8415:Vmn2r118	UTSW	17	55,608,057 (GRCm38)	missense	probably benign	0.08
R8428:Vmn2r118	UTSW	17	55,608,642 (GRCm38)	missense	probably benign	0.33
R8917:Vmn2r118	UTSW	17	55,610,216 (GRCm38)	missense	possibly damaging	0.82
R8993:Vmn2r118	UTSW	17	55,610,835 (GRCm38)	missense	possibly damaging	0.72
R9038:Vmn2r118	UTSW	17	55,611,649 (GRCm38)	missense	probably damaging	1.00
R9155:Vmn2r118	UTSW	17	55,610,207 (GRCm38)	missense	probably null	0.83
R9603:Vmn2r118	UTSW	17	55,592,837 (GRCm38)	missense	probably damaging	1.00
R9742:Vmn2r118	UTSW	17	55,611,009 (GRCm38)	missense	probably damaging	0.98
R9749:Vmn2r118	UTSW	17	55,608,415 (GRCm38)	critical splice donor site	probably null
R9792:Vmn2r118	UTSW	17	55,592,496 (GRCm38)	missense	probably damaging	0.99
R9793:Vmn2r118	UTSW	17	55,592,496 (GRCm38)	missense	probably damaging	0.99
R9795:Vmn2r118	UTSW	17	55,592,496 (GRCm38)	missense	probably damaging	0.99
X0022:Vmn2r118	UTSW	17	55,593,218 (GRCm38)	missense	probably damaging	1.00
Z1176:Vmn2r118	UTSW	17	55,610,655 (GRCm38)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- GAAGTTAACAGGCAGTTTCCAAATG -3'
(R):5'- TGCCTGTTGGGTACTACACTC -3'

Sequencing Primer
(F):5'- TAACAGGCAGTTTCCAAATGCTTCC -3'
(R):5'- GGAGATAAACAGTAACCCCTAC -3'

Posted On

2016-08-04