Mutagenetix > Incidental Mutation

Incidental Mutation 'R5385:Duox2'

425047

Institutional Source

Beutler Lab

Gene Symbol

Duox2

Ensembl Gene

ENSMUSG00000068452

Gene Name

dual oxidase 2

Synonyms

A430065P05Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R5385 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

122279247-122298165 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 122295136 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Alanine at position 330 (V330A)

Ref Sequence

ENSEMBL: ENSMUSP00000050314 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000028656] [ENSMUST00000053734]

AlphaFold

A0A494BAW1

Predicted Effect

probably benign
Transcript: ENSMUST00000028656

SMART Domains

Protein: ENSMUSP00000028656
Gene: ENSMUSG00000027225

Domain	Start	End	E-Value	Type
Pfam:DuoxA	10	286	5.5e-114	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000053734
AA Change: V330A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000050314
Gene: ENSMUSG00000068452
AA Change: V330A

Domain	Start	End	E-Value	Type
signal peptide	1	25	N/A	INTRINSIC
Pfam:An_peroxidase	35	560	5e-131	PFAM
transmembrane domain	600	622	N/A	INTRINSIC
EFh	823	851	3.7e-5	SMART
EFh	859	887	2.09e-4	SMART
transmembrane domain	1010	1032	N/A	INTRINSIC
Pfam:Ferric_reduct	1053	1202	1.8e-22	PFAM
Pfam:FAD_binding_8	1238	1340	3.1e-20	PFAM
Pfam:NAD_binding_6	1346	1500	1.5e-33	PFAM

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.4%
20x: 95.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a spontaneous mutation fail to breed and are congenitally hypothyroid (low T4, high TSH), dwarf, and hearing impaired. Anterior pituitaries are dysplastic. Cochlear defects include delayed formation of the inner sulcus and tunnel of Corti and a thickened tectorial membrane. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 129 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abhd17a	T	C	10: 80,585,612 (GRCm38)	T175A	probably benign	Het
Adam23	A	G	1: 63,551,811 (GRCm38)	D479G	possibly damaging	Het
Adgrl3	T	G	5: 81,726,801 (GRCm38)	Y1050D	probably damaging	Het
Ago4	A	G	4: 126,517,556 (GRCm38)	I103T	probably benign	Het
Ajuba	T	C	14: 54,570,398 (GRCm38)	Y459C	probably damaging	Het
Aldh7a1	T	A	18: 56,534,253 (GRCm38)	N316Y	possibly damaging	Het
Alyref2	A	G	1: 171,503,703 (GRCm38)	N16S	probably benign	Het
Ankhd1	A	G	18: 36,591,495 (GRCm38)	E402G	probably damaging	Het
Ankrd36	A	G	11: 5,689,340 (GRCm38)		probably benign	Het
Ap2b1	T	C	11: 83,342,601 (GRCm38)	V480A	probably damaging	Het
Arhgap30	A	G	1: 171,408,280 (GRCm38)	R741G	probably benign	Het
Canx	A	G	11: 50,301,812 (GRCm38)	L325P	probably damaging	Het
Ccpg1	G	A	9: 73,013,044 (GRCm38)	S647N	probably benign	Het
Cdc37l1	T	G	19: 29,011,943 (GRCm38)	S267A	possibly damaging	Het
Ces1f	A	T	8: 93,265,760 (GRCm38)	C354*	probably null	Het
Col4a3bp	A	G	13: 96,629,067 (GRCm38)	T447A	possibly damaging	Het
Cpne1	A	T	2: 156,074,364 (GRCm38)	V350D	probably damaging	Het
Ctdsp2	A	G	10: 126,996,457 (GRCm38)	T262A	probably benign	Het
Cypt4	A	G	9: 24,625,300 (GRCm38)	K29E	possibly damaging	Het
Dlg2	T	C	7: 92,088,576 (GRCm38)	V422A	probably damaging	Het
Dmxl2	A	G	9: 54,378,757 (GRCm38)	S2715P	probably benign	Het
Dnah3	T	A	7: 119,924,903 (GRCm38)	K3953N	probably damaging	Het
Dnmt1	A	G	9: 20,918,480 (GRCm38)	V647A	probably damaging	Het
Dusp8	T	A	7: 142,089,993 (GRCm38)	Q61L	possibly damaging	Het
Dync2h1	T	C	9: 7,016,791 (GRCm38)	D3573G	probably damaging	Het
Ears2	G	C	7: 122,044,377 (GRCm38)	T426S	probably benign	Het
Ext1	C	A	15: 53,075,817 (GRCm38)	W612L	probably damaging	Het
Fam91a1	G	A	15: 58,448,394 (GRCm38)	S645N	probably benign	Het
Fat3	A	T	9: 15,922,675 (GRCm38)	L4207Q	possibly damaging	Het
Fbxo38	A	G	18: 62,540,971 (GRCm38)	M13T	probably benign	Het
Fbxo48	G	T	11: 16,954,329 (GRCm38)	L160F	possibly damaging	Het
Fer1l4	G	A	2: 156,037,366 (GRCm38)	Q906*	probably null	Het
Fpr2	C	A	17: 17,893,047 (GRCm38)	H102N	probably benign	Het
Gm10134	T	A	2: 28,506,360 (GRCm38)		probably benign	Het
Gm14085	C	A	2: 122,522,778 (GRCm38)	L480I	probably benign	Het
Gpr107	A	G	2: 31,214,251 (GRCm38)	T523A	probably benign	Het
Grin3a	G	A	4: 49,719,313 (GRCm38)	P811L	probably damaging	Het
Hivep1	A	T	13: 42,164,395 (GRCm38)		probably null	Het
Hmcn2	A	G	2: 31,460,321 (GRCm38)	T5077A	probably benign	Het
Hpse	C	T	5: 100,708,724 (GRCm38)	W136*	probably null	Het
Ifitm3	T	C	7: 141,010,641 (GRCm38)	N2S	probably benign	Het
Ifnar2	T	A	16: 91,404,198 (GRCm38)	D442E	possibly damaging	Het
Jade1	T	A	3: 41,591,702 (GRCm38)	I54N	probably damaging	Het
Jag1	A	T	2: 137,095,544 (GRCm38)	H303Q	possibly damaging	Het
Kcnh4	T	C	11: 100,752,250 (GRCm38)	D397G	probably damaging	Het
Kcnj1	A	G	9: 32,396,723 (GRCm38)	R148G	probably damaging	Het
Lct	T	G	1: 128,311,617 (GRCm38)	K277N	possibly damaging	Het
Loxl3	A	G	6: 83,050,612 (GRCm38)	M712V	probably damaging	Het
Ly75	A	G	2: 60,303,641 (GRCm38)	C1547R	probably damaging	Het
Marcks	A	G	10: 37,138,457 (GRCm38)	S27P	probably damaging	Het
Mef2c	A	G	13: 83,662,413 (GRCm38)	T347A	probably benign	Het
Mmp3	C	T	9: 7,451,759 (GRCm38)	R366*	probably null	Het
Mrgprx2	T	C	7: 48,483,005 (GRCm38)	T22A	probably benign	Het
Msc	C	A	1: 14,755,420 (GRCm38)	R110L	probably damaging	Het
Myh11	A	T	16: 14,208,008 (GRCm38)	V1366D	possibly damaging	Het
Ncf1	A	G	5: 134,221,805 (GRCm38)	L373P	probably damaging	Het
Neb	A	T	2: 52,189,861 (GRCm38)	I85N	probably damaging	Het
Nfkb1	A	G	3: 135,612,542 (GRCm38)	V310A	possibly damaging	Het
Nop2	T	C	6: 125,144,361 (GRCm38)	V702A	probably benign	Het
Nudt12	A	G	17: 59,003,439 (GRCm38)	W390R	probably damaging	Het
Olfr1115	C	T	2: 87,252,483 (GRCm38)	P182L	probably benign	Het
Olfr1418	T	A	19: 11,855,177 (GRCm38)	I259F	probably damaging	Het
Olfr160	A	T	9: 37,712,021 (GRCm38)	V86E	probably damaging	Het
Olfr251	A	T	9: 38,377,985 (GRCm38)	I29F	probably benign	Het
Olfr366	G	T	2: 37,219,587 (GRCm38)	A33S	possibly damaging	Het
Olfr430	A	T	1: 174,069,470 (GRCm38)	K57N	probably benign	Het
Olfr558	T	C	7: 102,709,346 (GRCm38)	L29P	probably damaging	Het
Olfr739	T	A	14: 50,425,389 (GRCm38)	V290E	possibly damaging	Het
Olfr784	A	G	10: 129,387,764 (GRCm38)	I44V	probably benign	Het
Olfr971	A	G	9: 39,839,830 (GRCm38)	Y132C	possibly damaging	Het
Otub2	G	A	12: 103,392,796 (GRCm38)		probably benign	Het
Pck2	A	G	14: 55,545,231 (GRCm38)	E339G	probably damaging	Het
Pdcd7	G	A	9: 65,358,692 (GRCm38)	W477*	probably null	Het
Pdpk1	G	A	17: 24,098,140 (GRCm38)	Q250*	probably null	Het
Pigb	T	A	9: 73,039,545 (GRCm38)	H16L	probably benign	Het
Pitpnm1	T	C	19: 4,103,435 (GRCm38)	F197S	probably damaging	Het
Plekhh2	T	C	17: 84,557,466 (GRCm38)	V94A	probably benign	Het
Pnpla7	C	A	2: 25,041,019 (GRCm38)	P882Q	probably damaging	Het
Pold2	A	G	11: 5,876,760 (GRCm38)	L58P	probably damaging	Het
Pomt1	C	G	2: 32,244,299 (GRCm38)	Y277*	probably null	Het
Prex2	A	G	1: 11,139,980 (GRCm38)	D548G	probably damaging	Het
Prkra	T	G	2: 76,639,278 (GRCm38)	T146P	probably damaging	Het
Prss51	T	A	14: 64,097,094 (GRCm38)	V108E	probably damaging	Het
Rai2	A	G	X: 161,778,640 (GRCm38)	N363S	probably benign	Het
Ranbp17	A	T	11: 33,219,241 (GRCm38)	V991D	possibly damaging	Het
Riox2	T	A	16: 59,486,616 (GRCm38)	M290K	probably benign	Het
Rnpepl1	T	A	1: 92,917,192 (GRCm38)	L402Q	probably damaging	Het
S1pr2	T	C	9: 20,967,594 (GRCm38)	T313A	probably benign	Het
Sesn2	A	G	4: 132,499,264 (GRCm38)	I173T	probably damaging	Het
Setx	T	G	2: 29,134,033 (GRCm38)		probably null	Het
Sfi1	ACA	ACATCTTCCCAAAGCCAGTCA	11: 3,153,382 (GRCm38)		probably benign	Het
Sgsm3	T	C	15: 81,007,999 (GRCm38)	V256A	probably benign	Het
Shroom4	T	A	X: 6,585,469 (GRCm38)	C894*	probably null	Het
Slc13a5	T	A	11: 72,259,077 (GRCm38)	E159D	probably benign	Het
Slc16a7	A	G	10: 125,294,604 (GRCm38)	Y71H	possibly damaging	Het
Slc4a7	T	C	14: 14,773,345 (GRCm38)	F772L	possibly damaging	Het
Snapc4	A	G	2: 26,374,503 (GRCm38)	S275P	probably benign	Het
Soga3	A	G	10: 29,196,770 (GRCm38)	D686G	probably benign	Het
Sorl1	T	C	9: 42,057,284 (GRCm38)	T558A	possibly damaging	Het
Sspo	C	T	6: 48,462,253 (GRCm38)	P1612S	probably benign	Het
Stard9	A	G	2: 120,700,630 (GRCm38)	E2456G	probably damaging	Het
Stx1b	A	T	7: 127,815,403 (GRCm38)	D16E	probably benign	Het
Supv3l1	A	T	10: 62,430,596 (GRCm38)	N600K	possibly damaging	Het
Syne1	C	T	10: 5,041,494 (GRCm38)	V557I	probably benign	Het
Tanc2	T	A	11: 105,776,846 (GRCm38)	D84E	probably damaging	Het
Tep1	A	T	14: 50,868,317 (GRCm38)	L82Q	probably damaging	Het
Tfip11	T	C	5: 112,331,220 (GRCm38)		probably null	Het
Thtpa	G	T	14: 55,095,833 (GRCm38)	R125L	probably damaging	Het
Tm9sf1	C	T	14: 55,642,844 (GRCm38)	G32D	possibly damaging	Het
Tmcc3	A	T	10: 94,579,153 (GRCm38)	N239I	probably damaging	Het
Tpd52	A	T	3: 8,931,195 (GRCm38)		probably null	Het
Traf6	T	A	2: 101,684,755 (GRCm38)	C85*	probably null	Het
Trim68	T	G	7: 102,678,783 (GRCm38)	D321A	probably damaging	Het
Trmt6	C	A	2: 132,808,783 (GRCm38)	A302S	probably benign	Het
Ttbk1	T	C	17: 46,447,632 (GRCm38)	D692G	probably benign	Het
Ttc17	A	T	2: 94,303,640 (GRCm38)	W1067R	probably damaging	Het
Ttc6	T	A	12: 57,643,035 (GRCm38)		probably null	Het
Txnrd2	T	G	16: 18,477,692 (GRCm38)	I468S	probably damaging	Het
Ube2b	A	T	11: 51,988,644 (GRCm38)	Y100N	probably damaging	Het
Ucn3	A	T	13: 3,941,474 (GRCm38)	F59L	probably benign	Het
Uggt1	A	G	1: 36,184,412 (GRCm38)	Y599H	probably damaging	Het
Ulk3	T	A	9: 57,590,740 (GRCm38)	I108N	possibly damaging	Het
Vav3	A	G	3: 109,527,475 (GRCm38)	M441V	possibly damaging	Het
Vmn2r1	T	A	3: 64,101,398 (GRCm38)	D499E	possibly damaging	Het
Vmn2r118	C	T	17: 55,611,565 (GRCm38)	G109D	probably benign	Het
Vmn2r5	T	A	3: 64,509,510 (GRCm38)	M76L	probably benign	Het
Vwa3a	A	G	7: 120,790,142 (GRCm38)	K68E	possibly damaging	Het
Zcchc6	A	T	13: 59,789,846 (GRCm38)		probably null	Het
Zmiz1	A	T	14: 25,649,813 (GRCm38)	Y459F	probably damaging	Het

Other mutations in Duox2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00474:Duox2	APN	2	122,283,575 (GRCm38)	missense	probably benign
IGL00790:Duox2	APN	2	122,292,300 (GRCm38)	missense	possibly damaging	0.63
IGL01346:Duox2	APN	2	122,287,202 (GRCm38)	splice site	probably benign
IGL01607:Duox2	APN	2	122,292,319 (GRCm38)	missense	probably benign	0.00
IGL01798:Duox2	APN	2	122,281,908 (GRCm38)	missense	probably damaging	1.00
IGL02000:Duox2	APN	2	122,290,709 (GRCm38)	missense	probably benign
IGL02219:Duox2	APN	2	122,294,664 (GRCm38)	missense	probably benign	0.01
IGL02227:Duox2	APN	2	122,285,153 (GRCm38)	splice site	probably benign
IGL02276:Duox2	APN	2	122,294,085 (GRCm38)	missense	probably benign	0.00
IGL02447:Duox2	APN	2	122,297,468 (GRCm38)	missense	probably damaging	0.98
IGL02806:Duox2	APN	2	122,284,666 (GRCm38)	missense	probably damaging	1.00
IGL03091:Duox2	APN	2	122,289,474 (GRCm38)	missense	probably benign	0.03
Bedazzled	UTSW	2	122,287,121 (GRCm38)	missense	possibly damaging	0.76
Birthday	UTSW	2	122,281,871 (GRCm38)	missense	probably benign
gregorian	UTSW	2	122,289,345 (GRCm38)	nonsense	probably null
julian	UTSW	2	122,289,332 (GRCm38)	missense	probably benign	0.08
mayan	UTSW	2	122,284,583 (GRCm38)	missense	probably benign	0.00
minor	UTSW	2	122,281,496 (GRCm38)	missense	probably damaging	1.00
oaf	UTSW	2	122,295,176 (GRCm38)	missense	probably damaging	0.98
paltry	UTSW	2	122,283,060 (GRCm38)	critical splice donor site	probably null
promethius	UTSW	2	122,296,381 (GRCm38)	missense	probably benign
Recruit	UTSW	2	122,283,897 (GRCm38)	missense	possibly damaging	0.83
schlemiel	UTSW	2	122,289,563 (GRCm38)	missense	probably null	0.89
stumblebum	UTSW	2	122,284,667 (GRCm38)	missense	probably damaging	1.00
Two-bit	UTSW	2	122,281,002 (GRCm38)	missense	probably benign	0.42
R0049:Duox2	UTSW	2	122,296,686 (GRCm38)	missense	possibly damaging	0.48
R0244:Duox2	UTSW	2	122,291,860 (GRCm38)	missense	probably benign	0.00
R0281:Duox2	UTSW	2	122,292,304 (GRCm38)	missense	probably benign	0.10
R0378:Duox2	UTSW	2	122,284,583 (GRCm38)	missense	probably benign	0.00
R0383:Duox2	UTSW	2	122,291,810 (GRCm38)	critical splice donor site	probably null
R0442:Duox2	UTSW	2	122,289,332 (GRCm38)	missense	probably benign	0.08
R0524:Duox2	UTSW	2	122,281,836 (GRCm38)	missense	possibly damaging	0.80
R0560:Duox2	UTSW	2	122,291,554 (GRCm38)	missense	probably benign	0.04
R0562:Duox2	UTSW	2	122,289,599 (GRCm38)	missense	probably damaging	1.00
R0645:Duox2	UTSW	2	122,292,658 (GRCm38)	missense	probably damaging	1.00
R0704:Duox2	UTSW	2	122,284,768 (GRCm38)	missense	probably benign	0.01
R0963:Duox2	UTSW	2	122,287,172 (GRCm38)	missense	probably benign	0.03
R1254:Duox2	UTSW	2	122,283,478 (GRCm38)	missense	probably damaging	1.00
R1442:Duox2	UTSW	2	122,281,751 (GRCm38)	missense	probably benign	0.20
R1473:Duox2	UTSW	2	122,287,121 (GRCm38)	missense	possibly damaging	0.76
R1489:Duox2	UTSW	2	122,293,396 (GRCm38)	missense	probably benign
R1738:Duox2	UTSW	2	122,293,414 (GRCm38)	missense	probably damaging	1.00
R1748:Duox2	UTSW	2	122,287,051 (GRCm38)	missense	probably benign	0.00
R1809:Duox2	UTSW	2	122,283,897 (GRCm38)	missense	possibly damaging	0.83
R1843:Duox2	UTSW	2	122,292,258 (GRCm38)	critical splice donor site	probably null
R1903:Duox2	UTSW	2	122,295,351 (GRCm38)	missense	probably damaging	1.00
R1962:Duox2	UTSW	2	122,297,372 (GRCm38)	splice site	probably null
R2069:Duox2	UTSW	2	122,287,108 (GRCm38)	missense	probably benign	0.01
R2073:Duox2	UTSW	2	122,295,158 (GRCm38)	missense	probably damaging	1.00
R2074:Duox2	UTSW	2	122,295,158 (GRCm38)	missense	probably damaging	1.00
R2075:Duox2	UTSW	2	122,295,158 (GRCm38)	missense	probably damaging	1.00
R2085:Duox2	UTSW	2	122,280,967 (GRCm38)	missense	probably damaging	1.00
R3123:Duox2	UTSW	2	122,281,073 (GRCm38)	splice site	probably benign
R3907:Duox2	UTSW	2	122,283,060 (GRCm38)	critical splice donor site	probably null
R4572:Duox2	UTSW	2	122,281,726 (GRCm38)	missense	probably benign	0.00
R4614:Duox2	UTSW	2	122,289,557 (GRCm38)	missense	probably damaging	1.00
R4675:Duox2	UTSW	2	122,280,933 (GRCm38)	missense	probably damaging	1.00
R4770:Duox2	UTSW	2	122,284,916 (GRCm38)	missense	probably benign	0.01
R4817:Duox2	UTSW	2	122,296,515 (GRCm38)	missense	probably damaging	0.98
R4931:Duox2	UTSW	2	122,296,755 (GRCm38)	missense	probably benign	0.01
R5138:Duox2	UTSW	2	122,297,531 (GRCm38)	missense	probably damaging	1.00
R5288:Duox2	UTSW	2	122,295,136 (GRCm38)	missense	probably benign
R5344:Duox2	UTSW	2	122,281,871 (GRCm38)	missense	probably benign
R5386:Duox2	UTSW	2	122,295,136 (GRCm38)	missense	probably benign
R5493:Duox2	UTSW	2	122,281,496 (GRCm38)	missense	probably damaging	1.00
R5632:Duox2	UTSW	2	122,281,455 (GRCm38)	missense	probably damaging	1.00
R5742:Duox2	UTSW	2	122,284,921 (GRCm38)	missense	probably benign	0.00
R6228:Duox2	UTSW	2	122,287,193 (GRCm38)	missense	probably benign	0.38
R6380:Duox2	UTSW	2	122,281,002 (GRCm38)	missense	probably benign	0.42
R6398:Duox2	UTSW	2	122,296,370 (GRCm38)	missense	probably benign	0.06
R6409:Duox2	UTSW	2	122,284,667 (GRCm38)	missense	probably damaging	1.00
R6527:Duox2	UTSW	2	122,294,614 (GRCm38)	missense	probably benign	0.29
R6596:Duox2	UTSW	2	122,285,338 (GRCm38)	missense	probably benign
R6719:Duox2	UTSW	2	122,284,386 (GRCm38)	splice site	probably null
R6981:Duox2	UTSW	2	122,291,227 (GRCm38)	missense	possibly damaging	0.95
R7036:Duox2	UTSW	2	122,280,453 (GRCm38)	missense	probably damaging	1.00
R7073:Duox2	UTSW	2	122,289,307 (GRCm38)	missense	probably damaging	1.00
R7105:Duox2	UTSW	2	122,289,552 (GRCm38)	missense	possibly damaging	0.93
R7127:Duox2	UTSW	2	122,291,949 (GRCm38)	missense	probably benign	0.02
R7259:Duox2	UTSW	2	122,295,176 (GRCm38)	missense	probably damaging	0.98
R7698:Duox2	UTSW	2	122,280,764 (GRCm38)	missense	probably damaging	1.00
R7999:Duox2	UTSW	2	122,283,467 (GRCm38)	missense	probably benign	0.00
R8103:Duox2	UTSW	2	122,287,054 (GRCm38)	missense	probably benign
R8231:Duox2	UTSW	2	122,289,563 (GRCm38)	missense	possibly damaging	0.55
R8439:Duox2	UTSW	2	122,298,155 (GRCm38)	missense	probably benign
R8712:Duox2	UTSW	2	122,289,345 (GRCm38)	nonsense	probably null
R8887:Duox2	UTSW	2	122,289,563 (GRCm38)	missense	probably null	0.89
R8909:Duox2	UTSW	2	122,296,381 (GRCm38)	missense	probably benign
R9022:Duox2	UTSW	2	122,280,438 (GRCm38)	makesense	probably null
R9350:Duox2	UTSW	2	122,285,248 (GRCm38)	nonsense	probably null
R9727:Duox2	UTSW	2	122,286,517 (GRCm38)	nonsense	probably null
Z1176:Duox2	UTSW	2	122,296,507 (GRCm38)	missense	probably damaging	1.00
Z1177:Duox2	UTSW	2	122,293,452 (GRCm38)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- GATTTCCTATGGATCCCAAACTTCC -3'
(R):5'- TTCCTGCAGAAAACTCCTCCAG -3'

Sequencing Primer
(F):5'- ACCCCAGGATCCTGCTTCAG -3'
(R):5'- CTCCTCCAGAGTATTCAGGTAATGG -3'

Posted On

2016-08-04