Incidental Mutation 'R5386:Dchs1'
| ID |
425222 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dchs1
|
| Ensembl Gene |
ENSMUSG00000036862 |
| Gene Name |
dachsous cadherin related 1 |
| Synonyms |
3110041P15Rik, C130033F22Rik |
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R5386 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
105752990-105787654 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to C
at 105758029 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glycine
at position 2119
(V2119G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000077574
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000078482]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000078482
AA Change: V2119G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000077574
Gene: ENSMUSG00000036862
AA Change: V2119G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
36 |
N/A |
INTRINSIC |
|
CA
|
58 |
135 |
5.2e-11 |
SMART |
|
CA
|
159 |
247 |
6.1e-17 |
SMART |
|
CA
|
271 |
354 |
2.6e-30 |
SMART |
|
CA
|
382 |
464 |
7.8e-26 |
SMART |
|
CA
|
489 |
570 |
1.2e-34 |
SMART |
|
CA
|
594 |
677 |
1.9e-27 |
SMART |
|
CA
|
701 |
782 |
5.3e-11 |
SMART |
|
CA
|
806 |
886 |
1e-12 |
SMART |
|
CA
|
910 |
990 |
3.3e-14 |
SMART |
|
CA
|
1016 |
1097 |
3.6e-18 |
SMART |
|
CA
|
1121 |
1203 |
3.1e-34 |
SMART |
|
CA
|
1233 |
1307 |
8.8e-16 |
SMART |
|
low complexity region
|
1323 |
1335 |
N/A |
INTRINSIC |
|
CA
|
1344 |
1427 |
9.9e-9 |
SMART |
|
CA
|
1451 |
1537 |
1.5e-23 |
SMART |
|
CA
|
1560 |
1640 |
7.2e-32 |
SMART |
|
CA
|
1664 |
1742 |
1.8e-31 |
SMART |
|
CA
|
1765 |
1846 |
7.8e-30 |
SMART |
|
CA
|
1870 |
1951 |
3.7e-26 |
SMART |
|
low complexity region
|
1957 |
1965 |
N/A |
INTRINSIC |
|
CA
|
1979 |
2059 |
1.1e-6 |
SMART |
|
CA
|
2083 |
2162 |
2.7e-18 |
SMART |
|
CA
|
2186 |
2268 |
2.2e-26 |
SMART |
|
CA
|
2291 |
2367 |
1e-18 |
SMART |
|
CA
|
2391 |
2473 |
1.8e-23 |
SMART |
|
CA
|
2497 |
2593 |
3.5e-21 |
SMART |
|
CA
|
2617 |
2697 |
1.2e-25 |
SMART |
|
CA
|
2721 |
2804 |
1.9e-18 |
SMART |
|
CA
|
2828 |
2919 |
3e-3 |
SMART |
|
transmembrane domain
|
2932 |
2954 |
N/A |
INTRINSIC |
|
low complexity region
|
3001 |
3017 |
N/A |
INTRINSIC |
|
low complexity region
|
3046 |
3055 |
N/A |
INTRINSIC |
|
low complexity region
|
3088 |
3097 |
N/A |
INTRINSIC |
|
low complexity region
|
3185 |
3196 |
N/A |
INTRINSIC |
|
low complexity region
|
3237 |
3259 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131504
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000140959
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.3%
- 20x: 95.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit postnatal lethality, growth retardation, small lungs, abnormal cochlea morphology, abnormal kidney morphology, cardiovascular abnormalities and skeletal abnormalities. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 134 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2410089E03Rik |
G |
A |
15: 8,194,413 (GRCm38) |
G887R |
probably damaging |
Het |
| 4931406P16Rik |
A |
G |
7: 34,242,388 (GRCm38) |
F120L |
probably damaging |
Het |
| Abcc12 |
T |
G |
8: 86,517,489 (GRCm38) |
K1012Q |
possibly damaging |
Het |
| Afmid |
G |
A |
11: 117,828,142 (GRCm38) |
G33R |
probably benign |
Het |
| Agbl3 |
G |
T |
6: 34,799,196 (GRCm38) |
W207C |
probably damaging |
Het |
| Ajuba |
T |
C |
14: 54,570,398 (GRCm38) |
Y459C |
probably damaging |
Het |
| Ak2 |
T |
C |
4: 129,008,172 (GRCm38) |
S213P |
probably benign |
Het |
| Alk |
T |
A |
17: 71,875,012 (GRCm38) |
N1339Y |
probably damaging |
Het |
| Angpt1 |
T |
C |
15: 42,438,365 (GRCm38) |
S416G |
probably damaging |
Het |
| Ank2 |
C |
T |
3: 126,981,933 (GRCm38) |
V854M |
probably benign |
Het |
| Ankrd61 |
G |
T |
5: 143,891,664 (GRCm38) |
N122K |
possibly damaging |
Het |
| Armc9 |
T |
A |
1: 86,198,289 (GRCm38) |
L34Q |
probably null |
Het |
| Aspg |
T |
A |
12: 112,123,032 (GRCm38) |
V418E |
probably benign |
Het |
| Baz1b |
C |
T |
5: 135,238,059 (GRCm38) |
R1241C |
probably damaging |
Het |
| Bclaf1 |
T |
C |
10: 20,325,592 (GRCm38) |
V201A |
possibly damaging |
Het |
| C1ql3 |
A |
T |
2: 13,004,358 (GRCm38) |
D225E |
probably damaging |
Het |
| Capn9 |
A |
G |
8: 124,605,540 (GRCm38) |
T417A |
possibly damaging |
Het |
| Card14 |
C |
T |
11: 119,317,289 (GRCm38) |
R62C |
probably damaging |
Het |
| Cc2d2a |
A |
G |
5: 43,730,041 (GRCm38) |
N1271S |
probably benign |
Het |
| Ccpg1 |
G |
A |
9: 73,013,044 (GRCm38) |
S647N |
probably benign |
Het |
| Cdv3 |
T |
C |
9: 103,355,230 (GRCm38) |
K133R |
possibly damaging |
Het |
| Cep128 |
A |
C |
12: 90,999,571 (GRCm38) |
S1087R |
probably benign |
Het |
| Cep70 |
T |
A |
9: 99,281,075 (GRCm38) |
L325Q |
probably damaging |
Het |
| Chit1 |
T |
G |
1: 134,149,454 (GRCm38) |
F332V |
probably damaging |
Het |
| Chodl |
C |
A |
16: 78,946,697 (GRCm38) |
T219K |
probably damaging |
Het |
| Cntn4 |
T |
C |
6: 106,181,804 (GRCm38) |
L10P |
possibly damaging |
Het |
| Copg1 |
G |
T |
6: 87,890,207 (GRCm38) |
M87I |
possibly damaging |
Het |
| Cyp3a59 |
A |
G |
5: 146,085,768 (GRCm38) |
Y28C |
probably benign |
Het |
| Dedd |
T |
C |
1: 171,338,383 (GRCm38) |
L23P |
probably damaging |
Het |
| Dmxl2 |
A |
G |
9: 54,378,757 (GRCm38) |
S2715P |
probably benign |
Het |
| Dnah9 |
T |
C |
11: 66,029,356 (GRCm38) |
N2237S |
probably damaging |
Het |
| Drosha |
A |
G |
15: 12,842,121 (GRCm38) |
I337V |
probably benign |
Het |
| Duox2 |
A |
G |
2: 122,295,136 (GRCm38) |
V330A |
probably benign |
Het |
| Dusp11 |
T |
C |
6: 85,947,605 (GRCm38) |
*322W |
probably null |
Het |
| Dusp8 |
T |
A |
7: 142,089,993 (GRCm38) |
Q61L |
possibly damaging |
Het |
| Ears2 |
G |
C |
7: 122,044,377 (GRCm38) |
T426S |
probably benign |
Het |
| Elmo1 |
T |
C |
13: 20,600,210 (GRCm38) |
Y646H |
probably benign |
Het |
| Eps15 |
T |
A |
4: 109,321,225 (GRCm38) |
I220K |
possibly damaging |
Het |
| Faap100 |
T |
A |
11: 120,377,632 (GRCm38) |
E105V |
possibly damaging |
Het |
| Fam171a2 |
C |
A |
11: 102,437,867 (GRCm38) |
V689L |
possibly damaging |
Het |
| Fam213b |
T |
A |
4: 154,899,005 (GRCm38) |
M1L |
probably benign |
Het |
| Fam91a1 |
G |
A |
15: 58,448,394 (GRCm38) |
S645N |
probably benign |
Het |
| Fancg |
G |
A |
4: 43,007,076 (GRCm38) |
Q234* |
probably null |
Het |
| Gid4 |
T |
A |
11: 60,432,442 (GRCm38) |
|
probably null |
Het |
| Gm14085 |
C |
A |
2: 122,522,778 (GRCm38) |
L480I |
probably benign |
Het |
| Gm7361 |
A |
C |
5: 26,258,905 (GRCm38) |
T53P |
probably benign |
Het |
| Golgb1 |
T |
A |
16: 36,912,315 (GRCm38) |
C641* |
probably null |
Het |
| Gon4l |
T |
A |
3: 88,858,496 (GRCm38) |
M409K |
probably benign |
Het |
| Gpatch8 |
A |
T |
11: 102,508,227 (GRCm38) |
|
probably null |
Het |
| Gpr156 |
T |
A |
16: 37,948,309 (GRCm38) |
V64E |
possibly damaging |
Het |
| Grid2 |
T |
A |
6: 63,931,105 (GRCm38) |
I243K |
probably damaging |
Het |
| Gucy2g |
G |
A |
19: 55,215,116 (GRCm38) |
A750V |
probably damaging |
Het |
| Hdac5 |
T |
C |
11: 102,202,141 (GRCm38) |
E590G |
possibly damaging |
Het |
| Herc3 |
T |
A |
6: 58,874,278 (GRCm38) |
M504K |
probably damaging |
Het |
| Hif1a |
A |
G |
12: 73,944,093 (GRCm38) |
E713G |
probably benign |
Het |
| Hmx3 |
A |
G |
7: 131,544,304 (GRCm38) |
D247G |
probably damaging |
Het |
| Hoxd11 |
G |
T |
2: 74,682,819 (GRCm38) |
E143* |
probably null |
Het |
| Ifitm3 |
T |
C |
7: 141,010,641 (GRCm38) |
N2S |
probably benign |
Het |
| Il17f |
T |
C |
1: 20,777,957 (GRCm38) |
Q99R |
probably benign |
Het |
| Itga6 |
T |
A |
2: 71,841,150 (GRCm38) |
S341R |
probably damaging |
Het |
| Itgam |
A |
G |
7: 128,107,980 (GRCm38) |
N661S |
probably benign |
Het |
| Jag1 |
A |
T |
2: 137,095,544 (GRCm38) |
H303Q |
possibly damaging |
Het |
| Kcnh8 |
T |
A |
17: 52,725,995 (GRCm38) |
N103K |
probably benign |
Het |
| Kdm6b |
T |
C |
11: 69,400,810 (GRCm38) |
|
probably benign |
Het |
| Keg1 |
A |
C |
19: 12,714,538 (GRCm38) |
N63T |
probably damaging |
Het |
| Klf12 |
T |
A |
14: 99,900,159 (GRCm38) |
H317L |
probably damaging |
Het |
| Lrp1 |
A |
T |
10: 127,592,114 (GRCm38) |
V530E |
probably damaging |
Het |
| Mrgpra6 |
A |
G |
7: 47,188,881 (GRCm38) |
C190R |
probably damaging |
Het |
| Myo1a |
G |
T |
10: 127,705,897 (GRCm38) |
E102* |
probably null |
Het |
| Napa |
A |
T |
7: 16,116,472 (GRCm38) |
E265D |
probably benign |
Het |
| Ncam1 |
A |
C |
9: 49,564,874 (GRCm38) |
V305G |
probably damaging |
Het |
| Nek8 |
T |
C |
11: 78,170,437 (GRCm38) |
|
probably null |
Het |
| Olfr1115 |
C |
T |
2: 87,252,483 (GRCm38) |
P182L |
probably benign |
Het |
| Olfr1242 |
G |
T |
2: 89,494,137 (GRCm38) |
Y58* |
probably null |
Het |
| Olfr1275 |
T |
C |
2: 111,231,194 (GRCm38) |
T200A |
probably benign |
Het |
| Olfr191 |
T |
A |
16: 59,085,890 (GRCm38) |
M198L |
probably benign |
Het |
| Olfr243 |
T |
C |
7: 103,717,355 (GRCm38) |
F254L |
probably benign |
Het |
| Olfr251 |
A |
T |
9: 38,377,985 (GRCm38) |
I29F |
probably benign |
Het |
| Olfr739 |
T |
A |
14: 50,425,389 (GRCm38) |
V290E |
possibly damaging |
Het |
| Olfr971 |
A |
G |
9: 39,839,830 (GRCm38) |
Y132C |
possibly damaging |
Het |
| Olfr987 |
T |
C |
2: 85,331,635 (GRCm38) |
T88A |
probably benign |
Het |
| Pabpc4 |
A |
G |
4: 123,294,997 (GRCm38) |
Q417R |
probably benign |
Het |
| Panx3 |
A |
T |
9: 37,669,024 (GRCm38) |
M11K |
probably damaging |
Het |
| Pcbp1 |
C |
T |
6: 86,525,489 (GRCm38) |
E143K |
probably damaging |
Het |
| Pdcd7 |
G |
A |
9: 65,358,692 (GRCm38) |
W477* |
probably null |
Het |
| Pi4k2a |
G |
A |
19: 42,090,515 (GRCm38) |
S5N |
probably damaging |
Het |
| Plag1 |
T |
A |
4: 3,904,075 (GRCm38) |
Q372L |
probably benign |
Het |
| Plce1 |
C |
A |
19: 38,760,091 (GRCm38) |
N1755K |
probably damaging |
Het |
| Pld4 |
G |
T |
12: 112,763,988 (GRCm38) |
E102* |
probably null |
Het |
| Pnlip |
A |
G |
19: 58,679,607 (GRCm38) |
N345S |
probably benign |
Het |
| Ppm1e |
A |
T |
11: 87,358,551 (GRCm38) |
L118Q |
possibly damaging |
Het |
| Prkra |
T |
G |
2: 76,639,278 (GRCm38) |
T146P |
probably damaging |
Het |
| Prpf8 |
A |
G |
11: 75,495,799 (GRCm38) |
D1038G |
probably damaging |
Het |
| Prss51 |
T |
A |
14: 64,097,094 (GRCm38) |
V108E |
probably damaging |
Het |
| Ptch1 |
A |
G |
13: 63,545,043 (GRCm38) |
Y181H |
probably damaging |
Het |
| Reln |
A |
G |
5: 22,039,529 (GRCm38) |
V817A |
probably benign |
Het |
| Rictor |
C |
A |
15: 6,789,504 (GRCm38) |
Q1403K |
probably benign |
Het |
| Rims1 |
T |
A |
1: 22,412,245 (GRCm38) |
I882F |
probably damaging |
Het |
| Rnf19a |
A |
G |
15: 36,242,039 (GRCm38) |
V618A |
probably benign |
Het |
| Ryr1 |
A |
T |
7: 29,117,416 (GRCm38) |
I65N |
probably damaging |
Het |
| S1pr2 |
T |
C |
9: 20,967,594 (GRCm38) |
T313A |
probably benign |
Het |
| Serpine2 |
A |
T |
1: 79,821,287 (GRCm38) |
Y83* |
probably null |
Het |
| Sfi1 |
A |
ATCTTCCCAAAGCCAGTGC |
11: 3,153,384 (GRCm38) |
|
probably benign |
Het |
| Sgip1 |
T |
C |
4: 102,915,059 (GRCm38) |
V215A |
probably benign |
Het |
| Sgsm3 |
T |
C |
15: 81,007,999 (GRCm38) |
V256A |
probably benign |
Het |
| Shroom4 |
T |
A |
X: 6,585,469 (GRCm38) |
C894* |
probably null |
Het |
| Slc14a2 |
T |
A |
18: 78,185,840 (GRCm38) |
D306V |
possibly damaging |
Het |
| Slc4a10 |
A |
T |
2: 62,290,058 (GRCm38) |
E843V |
probably damaging |
Het |
| Smyd4 |
T |
A |
11: 75,390,156 (GRCm38) |
C152S |
probably damaging |
Het |
| Snx10 |
T |
C |
6: 51,575,972 (GRCm38) |
Y32H |
probably damaging |
Het |
| Sorl1 |
T |
C |
9: 42,057,284 (GRCm38) |
T558A |
possibly damaging |
Het |
| Spata31d1b |
G |
A |
13: 59,719,052 (GRCm38) |
C1338Y |
possibly damaging |
Het |
| Sppl2c |
T |
A |
11: 104,187,301 (GRCm38) |
I309K |
possibly damaging |
Het |
| Stard9 |
A |
G |
2: 120,700,630 (GRCm38) |
E2456G |
probably damaging |
Het |
| Stx1b |
A |
T |
7: 127,815,403 (GRCm38) |
D16E |
probably benign |
Het |
| Tecpr2 |
T |
C |
12: 110,915,453 (GRCm38) |
V152A |
probably damaging |
Het |
| Tedc1 |
T |
C |
12: 113,156,682 (GRCm38) |
V47A |
probably benign |
Het |
| Tep1 |
A |
T |
14: 50,868,317 (GRCm38) |
L82Q |
probably damaging |
Het |
| Tgm4 |
A |
G |
9: 123,056,494 (GRCm38) |
Y367C |
probably damaging |
Het |
| Tle1 |
C |
T |
4: 72,141,844 (GRCm38) |
V258M |
probably damaging |
Het |
| Tm9sf1 |
C |
T |
14: 55,642,844 (GRCm38) |
G32D |
possibly damaging |
Het |
| Tmco2 |
A |
G |
4: 121,105,984 (GRCm38) |
L106P |
probably damaging |
Het |
| Tmem131 |
A |
T |
1: 36,872,558 (GRCm38) |
C103S |
possibly damaging |
Het |
| Tmprss7 |
T |
A |
16: 45,669,528 (GRCm38) |
I444F |
possibly damaging |
Het |
| Trank1 |
T |
C |
9: 111,362,402 (GRCm38) |
V493A |
probably benign |
Het |
| Trim80 |
A |
T |
11: 115,448,017 (GRCm38) |
T558S |
probably benign |
Het |
| Trmt6 |
C |
A |
2: 132,808,783 (GRCm38) |
A302S |
probably benign |
Het |
| Ttc17 |
A |
T |
2: 94,303,640 (GRCm38) |
W1067R |
probably damaging |
Het |
| Tulp4 |
T |
A |
17: 6,236,293 (GRCm38) |
V1532D |
probably damaging |
Het |
| Ubqlnl |
T |
G |
7: 104,149,217 (GRCm38) |
I358L |
probably benign |
Het |
| Ulk3 |
T |
A |
9: 57,590,740 (GRCm38) |
I108N |
possibly damaging |
Het |
| Vps13b |
A |
T |
15: 35,640,528 (GRCm38) |
|
probably null |
Het |
| Vwa3a |
A |
G |
7: 120,790,142 (GRCm38) |
K68E |
possibly damaging |
Het |
| Zfp746 |
G |
T |
6: 48,064,176 (GRCm38) |
H538N |
possibly damaging |
Het |
|
| Other mutations in Dchs1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00235:Dchs1
|
APN |
7 |
105,758,743 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00422:Dchs1
|
APN |
7 |
105,758,029 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
IGL00427:Dchs1
|
APN |
7 |
105,758,424 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL00469:Dchs1
|
APN |
7 |
105,755,261 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00470:Dchs1
|
APN |
7 |
105,758,207 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00534:Dchs1
|
APN |
7 |
105,757,943 (GRCm38) |
missense |
probably benign |
|
|
IGL01292:Dchs1
|
APN |
7 |
105,760,891 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01380:Dchs1
|
APN |
7 |
105,762,211 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01396:Dchs1
|
APN |
7 |
105,772,283 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01448:Dchs1
|
APN |
7 |
105,771,927 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01759:Dchs1
|
APN |
7 |
105,755,302 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL01829:Dchs1
|
APN |
7 |
105,755,397 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01946:Dchs1
|
APN |
7 |
105,759,105 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01955:Dchs1
|
APN |
7 |
105,757,591 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02012:Dchs1
|
APN |
7 |
105,764,297 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02222:Dchs1
|
APN |
7 |
105,764,887 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02261:Dchs1
|
APN |
7 |
105,772,569 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02365:Dchs1
|
APN |
7 |
105,755,188 (GRCm38) |
missense |
probably benign |
0.22 |
|
IGL02430:Dchs1
|
APN |
7 |
105,771,971 (GRCm38) |
missense |
probably benign |
0.34 |
|
IGL02500:Dchs1
|
APN |
7 |
105,755,806 (GRCm38) |
missense |
probably benign |
|
|
IGL02741:Dchs1
|
APN |
7 |
105,757,323 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02890:Dchs1
|
APN |
7 |
105,756,491 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03213:Dchs1
|
APN |
7 |
105,755,072 (GRCm38) |
missense |
probably damaging |
1.00 |
|
G1patch:Dchs1
|
UTSW |
7 |
105,758,793 (GRCm38) |
missense |
probably damaging |
0.99 |
|
P0026:Dchs1
|
UTSW |
7 |
105,758,405 (GRCm38) |
missense |
probably damaging |
0.99 |
|
PIT4377001:Dchs1
|
UTSW |
7 |
105,757,588 (GRCm38) |
missense |
probably damaging |
1.00 |
|
PIT4791001:Dchs1
|
UTSW |
7 |
105,758,971 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0013:Dchs1
|
UTSW |
7 |
105,755,836 (GRCm38) |
missense |
possibly damaging |
0.90 |
|
R0090:Dchs1
|
UTSW |
7 |
105,755,932 (GRCm38) |
missense |
probably benign |
0.18 |
|
R0091:Dchs1
|
UTSW |
7 |
105,766,094 (GRCm38) |
splice site |
probably benign |
|
|
R0193:Dchs1
|
UTSW |
7 |
105,764,983 (GRCm38) |
missense |
probably benign |
0.40 |
|
R0395:Dchs1
|
UTSW |
7 |
105,758,538 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0448:Dchs1
|
UTSW |
7 |
105,765,927 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0480:Dchs1
|
UTSW |
7 |
105,771,489 (GRCm38) |
missense |
probably benign |
0.14 |
|
R0485:Dchs1
|
UTSW |
7 |
105,772,727 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0566:Dchs1
|
UTSW |
7 |
105,759,195 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0571:Dchs1
|
UTSW |
7 |
105,771,996 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0573:Dchs1
|
UTSW |
7 |
105,758,778 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0577:Dchs1
|
UTSW |
7 |
105,764,255 (GRCm38) |
missense |
possibly damaging |
0.78 |
|
R0622:Dchs1
|
UTSW |
7 |
105,763,449 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0654:Dchs1
|
UTSW |
7 |
105,772,349 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0677:Dchs1
|
UTSW |
7 |
105,764,984 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1171:Dchs1
|
UTSW |
7 |
105,757,714 (GRCm38) |
missense |
probably benign |
|
|
R1241:Dchs1
|
UTSW |
7 |
105,758,178 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1389:Dchs1
|
UTSW |
7 |
105,755,571 (GRCm38) |
missense |
probably benign |
0.40 |
|
R1427:Dchs1
|
UTSW |
7 |
105,766,191 (GRCm38) |
missense |
probably benign |
0.06 |
|
R1458:Dchs1
|
UTSW |
7 |
105,755,244 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1513:Dchs1
|
UTSW |
7 |
105,772,071 (GRCm38) |
nonsense |
probably null |
|
|
R1524:Dchs1
|
UTSW |
7 |
105,764,525 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1525:Dchs1
|
UTSW |
7 |
105,758,931 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1534:Dchs1
|
UTSW |
7 |
105,772,040 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1567:Dchs1
|
UTSW |
7 |
105,771,861 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1577:Dchs1
|
UTSW |
7 |
105,765,955 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1603:Dchs1
|
UTSW |
7 |
105,762,770 (GRCm38) |
missense |
probably benign |
0.24 |
|
R1676:Dchs1
|
UTSW |
7 |
105,754,921 (GRCm38) |
missense |
probably benign |
0.40 |
|
R1794:Dchs1
|
UTSW |
7 |
105,771,720 (GRCm38) |
missense |
probably benign |
0.02 |
|
R1826:Dchs1
|
UTSW |
7 |
105,757,627 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1892:Dchs1
|
UTSW |
7 |
105,764,156 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1924:Dchs1
|
UTSW |
7 |
105,772,280 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R1932:Dchs1
|
UTSW |
7 |
105,765,902 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1962:Dchs1
|
UTSW |
7 |
105,764,201 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1985:Dchs1
|
UTSW |
7 |
105,772,398 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R1993:Dchs1
|
UTSW |
7 |
105,762,548 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2007:Dchs1
|
UTSW |
7 |
105,755,325 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2316:Dchs1
|
UTSW |
7 |
105,764,204 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R2351:Dchs1
|
UTSW |
7 |
105,754,094 (GRCm38) |
missense |
probably benign |
|
|
R2474:Dchs1
|
UTSW |
7 |
105,755,074 (GRCm38) |
missense |
probably benign |
0.37 |
|
R2474:Dchs1
|
UTSW |
7 |
105,772,838 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3429:Dchs1
|
UTSW |
7 |
105,756,504 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R3430:Dchs1
|
UTSW |
7 |
105,756,504 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R3737:Dchs1
|
UTSW |
7 |
105,762,316 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R3767:Dchs1
|
UTSW |
7 |
105,757,085 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
R3874:Dchs1
|
UTSW |
7 |
105,761,635 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3883:Dchs1
|
UTSW |
7 |
105,762,563 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4105:Dchs1
|
UTSW |
7 |
105,765,140 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4209:Dchs1
|
UTSW |
7 |
105,766,190 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4329:Dchs1
|
UTSW |
7 |
105,753,759 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4516:Dchs1
|
UTSW |
7 |
105,754,852 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4579:Dchs1
|
UTSW |
7 |
105,758,973 (GRCm38) |
missense |
probably benign |
|
|
R4579:Dchs1
|
UTSW |
7 |
105,754,765 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4588:Dchs1
|
UTSW |
7 |
105,756,041 (GRCm38) |
missense |
probably benign |
|
|
R4613:Dchs1
|
UTSW |
7 |
105,772,724 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4632:Dchs1
|
UTSW |
7 |
105,754,355 (GRCm38) |
missense |
probably benign |
0.02 |
|
R4696:Dchs1
|
UTSW |
7 |
105,764,627 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4725:Dchs1
|
UTSW |
7 |
105,765,552 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4725:Dchs1
|
UTSW |
7 |
105,755,253 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4738:Dchs1
|
UTSW |
7 |
105,758,673 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R4768:Dchs1
|
UTSW |
7 |
105,771,620 (GRCm38) |
missense |
possibly damaging |
0.96 |
|
R4784:Dchs1
|
UTSW |
7 |
105,765,926 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4864:Dchs1
|
UTSW |
7 |
105,755,253 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4880:Dchs1
|
UTSW |
7 |
105,755,730 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4909:Dchs1
|
UTSW |
7 |
105,766,255 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5102:Dchs1
|
UTSW |
7 |
105,772,177 (GRCm38) |
missense |
probably benign |
0.09 |
|
R5109:Dchs1
|
UTSW |
7 |
105,765,014 (GRCm38) |
missense |
probably benign |
|
|
R5126:Dchs1
|
UTSW |
7 |
105,753,517 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5149:Dchs1
|
UTSW |
7 |
105,755,658 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5330:Dchs1
|
UTSW |
7 |
105,754,602 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5384:Dchs1
|
UTSW |
7 |
105,772,055 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5384:Dchs1
|
UTSW |
7 |
105,758,029 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5622:Dchs1
|
UTSW |
7 |
105,755,293 (GRCm38) |
missense |
probably benign |
0.11 |
|
R5623:Dchs1
|
UTSW |
7 |
105,772,769 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5708:Dchs1
|
UTSW |
7 |
105,772,809 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5718:Dchs1
|
UTSW |
7 |
105,755,748 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5743:Dchs1
|
UTSW |
7 |
105,771,596 (GRCm38) |
missense |
probably benign |
|
|
R5759:Dchs1
|
UTSW |
7 |
105,764,176 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5772:Dchs1
|
UTSW |
7 |
105,773,040 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5860:Dchs1
|
UTSW |
7 |
105,772,035 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5916:Dchs1
|
UTSW |
7 |
105,759,166 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5965:Dchs1
|
UTSW |
7 |
105,755,925 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5997:Dchs1
|
UTSW |
7 |
105,754,095 (GRCm38) |
missense |
probably benign |
0.08 |
|
R6065:Dchs1
|
UTSW |
7 |
105,755,421 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6136:Dchs1
|
UTSW |
7 |
105,760,925 (GRCm38) |
missense |
probably benign |
|
|
R6137:Dchs1
|
UTSW |
7 |
105,765,106 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6324:Dchs1
|
UTSW |
7 |
105,764,938 (GRCm38) |
missense |
probably benign |
0.05 |
|
R6363:Dchs1
|
UTSW |
7 |
105,758,472 (GRCm38) |
missense |
probably benign |
0.12 |
|
R6466:Dchs1
|
UTSW |
7 |
105,764,541 (GRCm38) |
missense |
probably benign |
0.09 |
|
R6544:Dchs1
|
UTSW |
7 |
105,758,178 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6572:Dchs1
|
UTSW |
7 |
105,758,806 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R6579:Dchs1
|
UTSW |
7 |
105,762,913 (GRCm38) |
missense |
probably benign |
0.17 |
|
R6632:Dchs1
|
UTSW |
7 |
105,761,878 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6725:Dchs1
|
UTSW |
7 |
105,758,793 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6789:Dchs1
|
UTSW |
7 |
105,757,003 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R6868:Dchs1
|
UTSW |
7 |
105,763,503 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R7058:Dchs1
|
UTSW |
7 |
105,757,021 (GRCm38) |
missense |
probably benign |
|
|
R7064:Dchs1
|
UTSW |
7 |
105,763,185 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7076:Dchs1
|
UTSW |
7 |
105,761,871 (GRCm38) |
missense |
probably benign |
0.04 |
|
R7191:Dchs1
|
UTSW |
7 |
105,765,439 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R7298:Dchs1
|
UTSW |
7 |
105,755,131 (GRCm38) |
nonsense |
probably null |
|
|
R7380:Dchs1
|
UTSW |
7 |
105,758,628 (GRCm38) |
missense |
probably benign |
0.35 |
|
R7438:Dchs1
|
UTSW |
7 |
105,754,948 (GRCm38) |
missense |
probably benign |
0.30 |
|
R7496:Dchs1
|
UTSW |
7 |
105,761,859 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7534:Dchs1
|
UTSW |
7 |
105,772,373 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7604:Dchs1
|
UTSW |
7 |
105,765,982 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7631:Dchs1
|
UTSW |
7 |
105,759,238 (GRCm38) |
missense |
probably benign |
|
|
R7821:Dchs1
|
UTSW |
7 |
105,765,145 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7834:Dchs1
|
UTSW |
7 |
105,765,567 (GRCm38) |
missense |
probably benign |
0.39 |
|
R7841:Dchs1
|
UTSW |
7 |
105,762,973 (GRCm38) |
missense |
probably benign |
|
|
R7913:Dchs1
|
UTSW |
7 |
105,759,228 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R8041:Dchs1
|
UTSW |
7 |
105,755,188 (GRCm38) |
missense |
probably benign |
0.45 |
|
R8076:Dchs1
|
UTSW |
7 |
105,761,982 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8076:Dchs1
|
UTSW |
7 |
105,755,921 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R8087:Dchs1
|
UTSW |
7 |
105,753,499 (GRCm38) |
missense |
probably benign |
0.41 |
|
R8125:Dchs1
|
UTSW |
7 |
105,764,882 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R8223:Dchs1
|
UTSW |
7 |
105,762,617 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R8239:Dchs1
|
UTSW |
7 |
105,765,511 (GRCm38) |
missense |
probably benign |
0.22 |
|
R8476:Dchs1
|
UTSW |
7 |
105,758,808 (GRCm38) |
missense |
probably benign |
0.05 |
|
R8497:Dchs1
|
UTSW |
7 |
105,758,961 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8770:Dchs1
|
UTSW |
7 |
105,771,738 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8856:Dchs1
|
UTSW |
7 |
105,760,857 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8866:Dchs1
|
UTSW |
7 |
105,755,390 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8948:Dchs1
|
UTSW |
7 |
105,759,005 (GRCm38) |
missense |
probably benign |
0.30 |
|
R8950:Dchs1
|
UTSW |
7 |
105,759,005 (GRCm38) |
missense |
probably benign |
0.30 |
|
R9029:Dchs1
|
UTSW |
7 |
105,753,712 (GRCm38) |
missense |
probably benign |
0.13 |
|
R9039:Dchs1
|
UTSW |
7 |
105,756,008 (GRCm38) |
missense |
probably benign |
0.11 |
|
R9081:Dchs1
|
UTSW |
7 |
105,754,429 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9134:Dchs1
|
UTSW |
7 |
105,755,703 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R9159:Dchs1
|
UTSW |
7 |
105,765,919 (GRCm38) |
missense |
probably benign |
|
|
R9162:Dchs1
|
UTSW |
7 |
105,765,525 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9169:Dchs1
|
UTSW |
7 |
105,772,907 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9262:Dchs1
|
UTSW |
7 |
105,755,626 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9292:Dchs1
|
UTSW |
7 |
105,753,913 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9325:Dchs1
|
UTSW |
7 |
105,766,195 (GRCm38) |
missense |
possibly damaging |
0.51 |
|
R9376:Dchs1
|
UTSW |
7 |
105,765,774 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9392:Dchs1
|
UTSW |
7 |
105,772,662 (GRCm38) |
missense |
probably benign |
0.09 |
|
R9619:Dchs1
|
UTSW |
7 |
105,764,455 (GRCm38) |
missense |
probably benign |
0.07 |
|
R9680:Dchs1
|
UTSW |
7 |
105,762,418 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9687:Dchs1
|
UTSW |
7 |
105,757,984 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9747:Dchs1
|
UTSW |
7 |
105,763,475 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Dchs1
|
UTSW |
7 |
105,757,693 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Dchs1
|
UTSW |
7 |
105,758,551 (GRCm38) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGCCACAAGTAAGCCTGAC -3'
(R):5'- TAGCATTCTCAGTGGGAATGAG -3'
Sequencing Primer
(F):5'- AGTAAGCCTGACCAGCCCTG -3'
(R):5'- TGGGAATGAGAGAGGGATATTCTCC -3'
|
| Posted On |
2016-08-04 |
Incidental Mutation