Incidental Mutation 'R5386:Lrp1'
ID 425247
Institutional Source Beutler Lab
Gene Symbol Lrp1
Ensembl Gene ENSMUSG00000040249
Gene Name low density lipoprotein receptor-related protein 1
Synonyms b2b1554Clo, CD91, A2mr
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5386 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 127374030-127457017 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 127427983 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 530 (V530E)
Ref Sequence ENSEMBL: ENSMUSP00000044004 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049149] [ENSMUST00000121829]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000049149
AA Change: V530E

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000044004
Gene: ENSMUSG00000040249
AA Change: V530E

DomainStartEndE-ValueType
low complexity region 2 13 N/A INTRINSIC
LDLa 27 67 1.03e-15 SMART
LDLa 72 111 1.04e-11 SMART
EGF 115 150 8.78e-2 SMART
EGF_CA 151 190 4.49e-8 SMART
low complexity region 222 232 N/A INTRINSIC
LY 273 315 7.07e-6 SMART
LY 316 359 2.31e-10 SMART
LY 360 402 8.3e-12 SMART
EGF 478 521 9.93e-1 SMART
LY 552 594 8.84e-7 SMART
LY 595 638 6.54e-10 SMART
LY 641 690 2.5e-15 SMART
LY 691 734 1.06e-9 SMART
EGF 807 844 1.38e1 SMART
LDLa 854 893 3.39e-16 SMART
LDLa 895 934 1.73e-13 SMART
LDLa 936 974 4.47e-16 SMART
LDLa 976 1014 2.53e-15 SMART
LDLa 1015 1054 2.95e-16 SMART
LDLa 1062 1100 3.24e-13 SMART
LDLa 1104 1143 2.97e-12 SMART
LDLa 1145 1185 1.24e-9 SMART
EGF 1185 1223 4.97e-1 SMART
EGF 1227 1263 6.02e0 SMART
LY 1290 1332 3.76e-1 SMART
LY 1337 1379 8.56e-14 SMART
LY 1380 1424 8.43e-13 SMART
LY 1425 1469 3.05e-10 SMART
LY 1471 1513 3.88e-3 SMART
EGF 1540 1580 1.85e0 SMART
LY 1606 1650 2.83e-5 SMART
LY 1651 1695 2.01e-10 SMART
LY 1698 1735 1.87e-5 SMART
LY 1736 1777 3.54e-6 SMART
LY 1778 1820 4.17e1 SMART
EGF 1850 1888 1.24e-1 SMART
LY 1915 1957 3.2e-4 SMART
LY 1958 2000 2.33e-15 SMART
LY 2001 2044 7.45e-14 SMART
LY 2045 2087 3.87e-12 SMART
LY 2089 2131 1.37e0 SMART
EGF 2159 2196 1.66e1 SMART
LY 2276 2318 5.57e-4 SMART
LY 2324 2369 3.3e-6 SMART
LY 2370 2412 3.93e-13 SMART
LY 2413 2454 3.62e-3 SMART
EGF_like 2482 2519 3.16e1 SMART
LDLa 2524 2564 3.31e-10 SMART
LDLa 2566 2603 7.21e-11 SMART
LDLa 2605 2642 1.09e-10 SMART
LDLa 2660 2691 6.05e-4 SMART
LDLa 2696 2733 2.49e-14 SMART
LDLa 2734 2772 4.65e-14 SMART
LDLa 2774 2815 3.92e-12 SMART
LDLa 2818 2856 1.51e-13 SMART
LDLa 2858 2900 1.93e-11 SMART
LDLa 2904 2942 1.73e-13 SMART
EGF_CA 2941 2982 6.16e-6 SMART
EGF_CA 2983 3023 2.66e-10 SMART
LY 3050 3094 6.64e-11 SMART
LY 3095 3137 7.17e-16 SMART
LY 3138 3181 4.28e-14 SMART
LY 3182 3224 8.11e-15 SMART
LY 3225 3265 1.44e-6 SMART
EGF 3294 3332 1.02e-2 SMART
LDLa 3334 3372 2.25e-12 SMART
LDLa 3374 3411 9.81e-13 SMART
LDLa 3413 3451 9.81e-13 SMART
LDLa 3453 3492 5.67e-18 SMART
LDLa 3494 3534 7.15e-15 SMART
LDLa 3536 3573 1.79e-15 SMART
EGF_like 3575 3611 4.83e1 SMART
LDLa 3575 3612 1.92e-15 SMART
LDLa 3613 3650 1.18e-15 SMART
LDLa 3654 3693 7.55e-14 SMART
LDLa 3695 3734 1.14e-8 SMART
LDLa 3741 3779 6.28e-11 SMART
EGF 3785 3824 1.06e1 SMART
EGF 3828 3862 1.51e0 SMART
LY 3893 3935 9.43e0 SMART
LY 3951 3993 1.23e-14 SMART
LY 3994 4037 2.98e-13 SMART
LY 4038 4080 4.28e-14 SMART
EGF 4151 4184 3.76e-1 SMART
low complexity region 4185 4198 N/A INTRINSIC
EGF 4200 4233 3.82e-2 SMART
EGF 4236 4269 4.03e-1 SMART
EGF 4272 4305 5.2e-4 SMART
EGF 4308 4341 1.22e0 SMART
EGF_like 4344 4376 4.11e1 SMART
EGF 4377 4410 5.12e-3 SMART
transmembrane domain 4423 4445 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000121829
AA Change: V530E

PolyPhen 2 Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000113584
Gene: ENSMUSG00000040249
AA Change: V530E

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LDLa 27 67 1.03e-15 SMART
LDLa 72 111 1.04e-11 SMART
EGF 115 150 8.78e-2 SMART
EGF_CA 151 190 4.49e-8 SMART
low complexity region 222 232 N/A INTRINSIC
LY 273 315 7.07e-6 SMART
LY 316 359 2.31e-10 SMART
LY 360 402 8.3e-12 SMART
EGF 478 521 9.93e-1 SMART
LY 552 594 8.84e-7 SMART
LY 595 638 6.54e-10 SMART
LY 641 690 2.5e-15 SMART
LY 691 734 1.06e-9 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124182
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125480
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a null allele exhibit lethality during late organogenesis. [provided by MGI curators]
Allele List at MGI

All alleles(42) : Targeted(9) Gene trapped(33)

Other mutations in this stock
Total: 134 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 T G 8: 87,244,118 (GRCm39) K1012Q possibly damaging Het
Afmid G A 11: 117,718,968 (GRCm39) G33R probably benign Het
Agbl3 G T 6: 34,776,131 (GRCm39) W207C probably damaging Het
Ajuba T C 14: 54,807,855 (GRCm39) Y459C probably damaging Het
Ak2 T C 4: 128,901,965 (GRCm39) S213P probably benign Het
Alk T A 17: 72,182,007 (GRCm39) N1339Y probably damaging Het
Angpt1 T C 15: 42,301,761 (GRCm39) S416G probably damaging Het
Ank2 C T 3: 126,775,582 (GRCm39) V854M probably benign Het
Ankrd61 G T 5: 143,828,482 (GRCm39) N122K possibly damaging Het
Armc9 T A 1: 86,126,011 (GRCm39) L34Q probably null Het
Aspg T A 12: 112,089,466 (GRCm39) V418E probably benign Het
Baz1b C T 5: 135,266,913 (GRCm39) R1241C probably damaging Het
Bclaf1 T C 10: 20,201,338 (GRCm39) V201A possibly damaging Het
C1ql3 A T 2: 13,009,169 (GRCm39) D225E probably damaging Het
Capn9 A G 8: 125,332,279 (GRCm39) T417A possibly damaging Het
Card14 C T 11: 119,208,115 (GRCm39) R62C probably damaging Het
Cc2d2a A G 5: 43,887,383 (GRCm39) N1271S probably benign Het
Ccpg1 G A 9: 72,920,326 (GRCm39) S647N probably benign Het
Cdv3 T C 9: 103,232,429 (GRCm39) K133R possibly damaging Het
Cep128 A C 12: 90,966,345 (GRCm39) S1087R probably benign Het
Cep70 T A 9: 99,163,128 (GRCm39) L325Q probably damaging Het
Chit1 T G 1: 134,077,192 (GRCm39) F332V probably damaging Het
Chodl C A 16: 78,743,585 (GRCm39) T219K probably damaging Het
Cntn4 T C 6: 106,158,765 (GRCm39) L10P possibly damaging Het
Copg1 G T 6: 87,867,189 (GRCm39) M87I possibly damaging Het
Cplane1 G A 15: 8,223,897 (GRCm39) G887R probably damaging Het
Cyp3a59 A G 5: 146,022,578 (GRCm39) Y28C probably benign Het
Dchs1 A C 7: 105,407,236 (GRCm39) V2119G probably damaging Het
Dedd T C 1: 171,165,951 (GRCm39) L23P probably damaging Het
Dmxl2 A G 9: 54,286,041 (GRCm39) S2715P probably benign Het
Dnah9 T C 11: 65,920,182 (GRCm39) N2237S probably damaging Het
Drosha A G 15: 12,842,207 (GRCm39) I337V probably benign Het
Duox2 A G 2: 122,125,617 (GRCm39) V330A probably benign Het
Dusp11 T C 6: 85,924,587 (GRCm39) *322W probably null Het
Dusp8 T A 7: 141,643,730 (GRCm39) Q61L possibly damaging Het
Ears2 G C 7: 121,643,600 (GRCm39) T426S probably benign Het
Elmo1 T C 13: 20,784,380 (GRCm39) Y646H probably benign Het
Eps15 T A 4: 109,178,422 (GRCm39) I220K possibly damaging Het
Faap100 T A 11: 120,268,458 (GRCm39) E105V possibly damaging Het
Fam171a2 C A 11: 102,328,693 (GRCm39) V689L possibly damaging Het
Fam91a1 G A 15: 58,320,243 (GRCm39) S645N probably benign Het
Fancg G A 4: 43,007,076 (GRCm39) Q234* probably null Het
Garre1 A G 7: 33,941,813 (GRCm39) F120L probably damaging Het
Gid4 T A 11: 60,323,268 (GRCm39) probably null Het
Gm7361 A C 5: 26,463,903 (GRCm39) T53P probably benign Het
Golgb1 T A 16: 36,732,677 (GRCm39) C641* probably null Het
Gon4l T A 3: 88,765,803 (GRCm39) M409K probably benign Het
Gpatch8 A T 11: 102,399,053 (GRCm39) probably null Het
Gpr156 T A 16: 37,768,671 (GRCm39) V64E possibly damaging Het
Grid2 T A 6: 63,908,089 (GRCm39) I243K probably damaging Het
Gucy2g G A 19: 55,203,548 (GRCm39) A750V probably damaging Het
Hdac5 T C 11: 102,092,967 (GRCm39) E590G possibly damaging Het
Herc3 T A 6: 58,851,263 (GRCm39) M504K probably damaging Het
Hif1a A G 12: 73,990,867 (GRCm39) E713G probably benign Het
Hmx3 A G 7: 131,146,033 (GRCm39) D247G probably damaging Het
Hoxd11 G T 2: 74,513,163 (GRCm39) E143* probably null Het
Ifitm3 T C 7: 140,590,554 (GRCm39) N2S probably benign Het
Il17f T C 1: 20,848,181 (GRCm39) Q99R probably benign Het
Itga6 T A 2: 71,671,494 (GRCm39) S341R probably damaging Het
Itgam A G 7: 127,707,152 (GRCm39) N661S probably benign Het
Jag1 A T 2: 136,937,464 (GRCm39) H303Q possibly damaging Het
Kcnh8 T A 17: 53,033,023 (GRCm39) N103K probably benign Het
Kdm6b T C 11: 69,291,636 (GRCm39) probably benign Het
Keg1 A C 19: 12,691,902 (GRCm39) N63T probably damaging Het
Klf12 T A 14: 100,137,595 (GRCm39) H317L probably damaging Het
Mrgpra6 A G 7: 46,838,629 (GRCm39) C190R probably damaging Het
Myo1a G T 10: 127,541,766 (GRCm39) E102* probably null Het
Napa A T 7: 15,850,397 (GRCm39) E265D probably benign Het
Ncam1 A C 9: 49,476,174 (GRCm39) V305G probably damaging Het
Nek8 T C 11: 78,061,263 (GRCm39) probably null Het
Or10ag53 C T 2: 87,082,827 (GRCm39) P182L probably benign Het
Or11g24 T A 14: 50,662,846 (GRCm39) V290E possibly damaging Het
Or4a70 G T 2: 89,324,481 (GRCm39) Y58* probably null Het
Or4f52 T C 2: 111,061,539 (GRCm39) T200A probably benign Het
Or52a20 T C 7: 103,366,562 (GRCm39) F254L probably benign Het
Or5ak4 T C 2: 85,161,979 (GRCm39) T88A probably benign Het
Or5h23 T A 16: 58,906,253 (GRCm39) M198L probably benign Het
Or8c11 A T 9: 38,289,281 (GRCm39) I29F probably benign Het
Or8g2b A G 9: 39,751,126 (GRCm39) Y132C possibly damaging Het
Pabpc4 A G 4: 123,188,790 (GRCm39) Q417R probably benign Het
Panx3 A T 9: 37,580,320 (GRCm39) M11K probably damaging Het
Pcbp1 C T 6: 86,502,471 (GRCm39) E143K probably damaging Het
Pdcd7 G A 9: 65,265,974 (GRCm39) W477* probably null Het
Pi4k2a G A 19: 42,078,954 (GRCm39) S5N probably damaging Het
Plag1 T A 4: 3,904,075 (GRCm39) Q372L probably benign Het
Plce1 C A 19: 38,748,535 (GRCm39) N1755K probably damaging Het
Pld4 G T 12: 112,730,422 (GRCm39) E102* probably null Het
Pnlip A G 19: 58,668,039 (GRCm39) N345S probably benign Het
Ppm1e A T 11: 87,249,377 (GRCm39) L118Q possibly damaging Het
Prkra T G 2: 76,469,622 (GRCm39) T146P probably damaging Het
Prpf8 A G 11: 75,386,625 (GRCm39) D1038G probably damaging Het
Prss51 T A 14: 64,334,543 (GRCm39) V108E probably damaging Het
Prxl2b T A 4: 154,983,462 (GRCm39) M1L probably benign Het
Ptch1 A G 13: 63,692,857 (GRCm39) Y181H probably damaging Het
Reln A G 5: 22,244,527 (GRCm39) V817A probably benign Het
Rictor C A 15: 6,818,985 (GRCm39) Q1403K probably benign Het
Rims1 T A 1: 22,482,469 (GRCm39) I882F probably damaging Het
Rnf19a A G 15: 36,242,185 (GRCm39) V618A probably benign Het
Ryr1 A T 7: 28,816,841 (GRCm39) I65N probably damaging Het
S1pr2 T C 9: 20,878,890 (GRCm39) T313A probably benign Het
Serpine2 A T 1: 79,799,004 (GRCm39) Y83* probably null Het
Sfi1 A ATCTTCCCAAAGCCAGTGC 11: 3,103,384 (GRCm39) probably benign Het
Sgip1 T C 4: 102,772,256 (GRCm39) V215A probably benign Het
Sgsm3 T C 15: 80,892,200 (GRCm39) V256A probably benign Het
Shroom4 T A X: 6,497,523 (GRCm39) C894* probably null Het
Slc14a2 T A 18: 78,229,055 (GRCm39) D306V possibly damaging Het
Slc28a2b C A 2: 122,353,259 (GRCm39) L480I probably benign Het
Slc4a10 A T 2: 62,120,402 (GRCm39) E843V probably damaging Het
Smyd4 T A 11: 75,280,982 (GRCm39) C152S probably damaging Het
Snx10 T C 6: 51,552,952 (GRCm39) Y32H probably damaging Het
Sorl1 T C 9: 41,968,580 (GRCm39) T558A possibly damaging Het
Spata31d1b G A 13: 59,866,866 (GRCm39) C1338Y possibly damaging Het
Sppl2c T A 11: 104,078,127 (GRCm39) I309K possibly damaging Het
Stard9 A G 2: 120,531,111 (GRCm39) E2456G probably damaging Het
Stx1b A T 7: 127,414,575 (GRCm39) D16E probably benign Het
Tecpr2 T C 12: 110,881,887 (GRCm39) V152A probably damaging Het
Tedc1 T C 12: 113,120,302 (GRCm39) V47A probably benign Het
Tep1 A T 14: 51,105,774 (GRCm39) L82Q probably damaging Het
Tgm4 A G 9: 122,885,559 (GRCm39) Y367C probably damaging Het
Tle1 C T 4: 72,060,081 (GRCm39) V258M probably damaging Het
Tm9sf1 C T 14: 55,880,301 (GRCm39) G32D possibly damaging Het
Tmco2 A G 4: 120,963,181 (GRCm39) L106P probably damaging Het
Tmem131 A T 1: 36,911,639 (GRCm39) C103S possibly damaging Het
Tmprss7 T A 16: 45,489,891 (GRCm39) I444F possibly damaging Het
Trank1 T C 9: 111,191,470 (GRCm39) V493A probably benign Het
Trim80 A T 11: 115,338,843 (GRCm39) T558S probably benign Het
Trmt6 C A 2: 132,650,703 (GRCm39) A302S probably benign Het
Ttc17 A T 2: 94,133,985 (GRCm39) W1067R probably damaging Het
Tulp4 T A 17: 6,286,568 (GRCm39) V1532D probably damaging Het
Ubqlnl T G 7: 103,798,424 (GRCm39) I358L probably benign Het
Ulk3 T A 9: 57,498,023 (GRCm39) I108N possibly damaging Het
Vps13b A T 15: 35,640,674 (GRCm39) probably null Het
Vwa3a A G 7: 120,389,365 (GRCm39) K68E possibly damaging Het
Zfp746 G T 6: 48,041,110 (GRCm39) H538N possibly damaging Het
Other mutations in Lrp1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00793:Lrp1 APN 10 127,378,074 (GRCm39) missense possibly damaging 0.89
IGL01065:Lrp1 APN 10 127,410,907 (GRCm39) missense probably benign 0.10
IGL01121:Lrp1 APN 10 127,419,722 (GRCm39) nonsense probably null
IGL01360:Lrp1 APN 10 127,381,689 (GRCm39) missense possibly damaging 0.93
IGL01402:Lrp1 APN 10 127,430,901 (GRCm39) missense probably damaging 1.00
IGL01404:Lrp1 APN 10 127,430,901 (GRCm39) missense probably damaging 1.00
IGL01411:Lrp1 APN 10 127,417,634 (GRCm39) nonsense probably null
IGL01469:Lrp1 APN 10 127,420,283 (GRCm39) missense probably damaging 1.00
IGL01552:Lrp1 APN 10 127,424,379 (GRCm39) nonsense probably null
IGL01682:Lrp1 APN 10 127,410,847 (GRCm39) missense probably benign 0.00
IGL01760:Lrp1 APN 10 127,409,370 (GRCm39) missense probably benign 0.00
IGL01918:Lrp1 APN 10 127,390,458 (GRCm39) missense probably damaging 0.99
IGL01989:Lrp1 APN 10 127,413,998 (GRCm39) missense probably damaging 1.00
IGL02105:Lrp1 APN 10 127,380,448 (GRCm39) missense probably damaging 1.00
IGL02158:Lrp1 APN 10 127,390,140 (GRCm39) missense probably benign 0.02
IGL02164:Lrp1 APN 10 127,399,536 (GRCm39) missense probably benign 0.39
IGL02337:Lrp1 APN 10 127,412,756 (GRCm39) missense possibly damaging 0.87
IGL02425:Lrp1 APN 10 127,407,756 (GRCm39) critical splice donor site probably null
IGL02493:Lrp1 APN 10 127,417,647 (GRCm39) missense probably damaging 0.99
IGL02563:Lrp1 APN 10 127,387,555 (GRCm39) missense probably damaging 1.00
IGL02590:Lrp1 APN 10 127,388,660 (GRCm39) missense probably damaging 1.00
IGL02624:Lrp1 APN 10 127,408,291 (GRCm39) missense probably damaging 0.98
IGL02625:Lrp1 APN 10 127,410,355 (GRCm39) missense probably damaging 1.00
IGL02825:Lrp1 APN 10 127,378,474 (GRCm39) missense probably damaging 1.00
IGL02880:Lrp1 APN 10 127,376,091 (GRCm39) missense probably benign 0.12
IGL02900:Lrp1 APN 10 127,412,516 (GRCm39) splice site probably benign
IGL02956:Lrp1 APN 10 127,380,428 (GRCm39) missense probably benign 0.00
IGL02974:Lrp1 APN 10 127,390,885 (GRCm39) missense probably damaging 0.99
IGL02983:Lrp1 APN 10 127,386,068 (GRCm39) missense probably damaging 1.00
IGL03002:Lrp1 APN 10 127,425,505 (GRCm39) missense probably damaging 1.00
IGL03091:Lrp1 APN 10 127,394,993 (GRCm39) missense probably benign 0.30
IGL03109:Lrp1 APN 10 127,402,514 (GRCm39) missense probably benign
IGL03194:Lrp1 APN 10 127,404,554 (GRCm39) missense probably damaging 1.00
IGL03232:Lrp1 APN 10 127,375,245 (GRCm39) missense probably damaging 1.00
calculus UTSW 10 127,393,937 (GRCm39) splice site probably null
Delimiter UTSW 10 127,382,731 (GRCm39) missense probably damaging 1.00
extremis UTSW 10 127,392,857 (GRCm39) missense probably benign 0.00
Jockey UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
peripheral UTSW 10 127,446,250 (GRCm39) missense probably damaging 1.00
tangential UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
P0015:Lrp1 UTSW 10 127,402,532 (GRCm39) missense probably damaging 0.99
PIT4519001:Lrp1 UTSW 10 127,443,843 (GRCm39) missense possibly damaging 0.91
PIT4520001:Lrp1 UTSW 10 127,443,843 (GRCm39) missense possibly damaging 0.91
R0004:Lrp1 UTSW 10 127,377,694 (GRCm39) splice site probably null
R0034:Lrp1 UTSW 10 127,381,520 (GRCm39) missense probably benign 0.42
R0091:Lrp1 UTSW 10 127,376,848 (GRCm39) missense probably damaging 1.00
R0098:Lrp1 UTSW 10 127,388,607 (GRCm39) missense probably benign
R0098:Lrp1 UTSW 10 127,388,607 (GRCm39) missense probably benign
R0143:Lrp1 UTSW 10 127,429,811 (GRCm39) missense probably damaging 1.00
R0372:Lrp1 UTSW 10 127,428,005 (GRCm39) missense probably damaging 1.00
R0379:Lrp1 UTSW 10 127,430,838 (GRCm39) missense probably damaging 1.00
R0445:Lrp1 UTSW 10 127,426,505 (GRCm39) nonsense probably null
R0529:Lrp1 UTSW 10 127,377,463 (GRCm39) splice site probably null
R0551:Lrp1 UTSW 10 127,407,827 (GRCm39) missense probably benign
R0570:Lrp1 UTSW 10 127,390,878 (GRCm39) nonsense probably null
R0600:Lrp1 UTSW 10 127,403,252 (GRCm39) missense probably benign 0.00
R0626:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R0647:Lrp1 UTSW 10 127,407,346 (GRCm39) missense probably damaging 1.00
R0680:Lrp1 UTSW 10 127,425,530 (GRCm39) missense probably damaging 1.00
R0792:Lrp1 UTSW 10 127,411,155 (GRCm39) missense probably benign 0.04
R0792:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R0848:Lrp1 UTSW 10 127,389,231 (GRCm39) splice site probably null
R0866:Lrp1 UTSW 10 127,375,147 (GRCm39) missense probably damaging 1.00
R0918:Lrp1 UTSW 10 127,429,834 (GRCm39) missense probably damaging 1.00
R1076:Lrp1 UTSW 10 127,399,666 (GRCm39) splice site probably benign
R1107:Lrp1 UTSW 10 127,393,304 (GRCm39) missense probably damaging 1.00
R1346:Lrp1 UTSW 10 127,441,735 (GRCm39) missense probably damaging 1.00
R1403:Lrp1 UTSW 10 127,417,760 (GRCm39) critical splice acceptor site probably null
R1403:Lrp1 UTSW 10 127,417,760 (GRCm39) critical splice acceptor site probably null
R1496:Lrp1 UTSW 10 127,374,880 (GRCm39) missense probably damaging 1.00
R1522:Lrp1 UTSW 10 127,411,155 (GRCm39) missense probably benign 0.04
R1522:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R1525:Lrp1 UTSW 10 127,375,398 (GRCm39) missense probably damaging 1.00
R1539:Lrp1 UTSW 10 127,420,250 (GRCm39) splice site probably null
R1589:Lrp1 UTSW 10 127,441,475 (GRCm39) missense probably benign 0.00
R1591:Lrp1 UTSW 10 127,441,475 (GRCm39) missense probably benign 0.00
R1663:Lrp1 UTSW 10 127,392,790 (GRCm39) missense probably damaging 1.00
R1682:Lrp1 UTSW 10 127,410,201 (GRCm39) missense probably damaging 1.00
R1717:Lrp1 UTSW 10 127,399,534 (GRCm39) missense probably damaging 1.00
R1717:Lrp1 UTSW 10 127,392,138 (GRCm39) missense possibly damaging 0.59
R1758:Lrp1 UTSW 10 127,424,453 (GRCm39) missense possibly damaging 0.76
R1826:Lrp1 UTSW 10 127,389,576 (GRCm39) missense probably damaging 1.00
R1842:Lrp1 UTSW 10 127,409,337 (GRCm39) missense possibly damaging 0.93
R1844:Lrp1 UTSW 10 127,431,152 (GRCm39) critical splice donor site probably null
R1845:Lrp1 UTSW 10 127,414,542 (GRCm39) missense probably damaging 1.00
R1896:Lrp1 UTSW 10 127,395,867 (GRCm39) missense possibly damaging 0.64
R1952:Lrp1 UTSW 10 127,403,300 (GRCm39) missense probably damaging 1.00
R2009:Lrp1 UTSW 10 127,380,385 (GRCm39) missense probably damaging 1.00
R2015:Lrp1 UTSW 10 127,376,563 (GRCm39) missense probably benign 0.00
R2116:Lrp1 UTSW 10 127,412,362 (GRCm39) nonsense probably null
R2161:Lrp1 UTSW 10 127,391,607 (GRCm39) missense probably damaging 1.00
R2199:Lrp1 UTSW 10 127,382,709 (GRCm39) missense probably damaging 1.00
R2213:Lrp1 UTSW 10 127,376,571 (GRCm39) missense probably damaging 1.00
R2300:Lrp1 UTSW 10 127,392,784 (GRCm39) nonsense probably null
R2324:Lrp1 UTSW 10 127,402,455 (GRCm39) missense possibly damaging 0.92
R2849:Lrp1 UTSW 10 127,378,165 (GRCm39) missense probably damaging 1.00
R2926:Lrp1 UTSW 10 127,423,982 (GRCm39) missense probably damaging 0.98
R2993:Lrp1 UTSW 10 127,446,250 (GRCm39) missense probably damaging 1.00
R3522:Lrp1 UTSW 10 127,389,424 (GRCm39) missense probably damaging 1.00
R3702:Lrp1 UTSW 10 127,430,972 (GRCm39) missense probably damaging 1.00
R3789:Lrp1 UTSW 10 127,407,838 (GRCm39) missense possibly damaging 0.94
R3898:Lrp1 UTSW 10 127,427,969 (GRCm39) nonsense probably null
R3941:Lrp1 UTSW 10 127,389,265 (GRCm39) missense probably damaging 1.00
R3958:Lrp1 UTSW 10 127,407,827 (GRCm39) missense probably benign
R4369:Lrp1 UTSW 10 127,386,155 (GRCm39) missense possibly damaging 0.87
R4510:Lrp1 UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
R4511:Lrp1 UTSW 10 127,429,717 (GRCm39) missense probably damaging 0.99
R4576:Lrp1 UTSW 10 127,376,057 (GRCm39) small deletion probably benign
R4583:Lrp1 UTSW 10 127,377,241 (GRCm39) missense probably benign 0.00
R4662:Lrp1 UTSW 10 127,388,054 (GRCm39) nonsense probably null
R4721:Lrp1 UTSW 10 127,390,928 (GRCm39) missense possibly damaging 0.58
R4728:Lrp1 UTSW 10 127,399,606 (GRCm39) missense probably damaging 1.00
R4745:Lrp1 UTSW 10 127,385,813 (GRCm39) missense probably benign 0.20
R4785:Lrp1 UTSW 10 127,394,002 (GRCm39) missense probably benign 0.12
R4841:Lrp1 UTSW 10 127,419,805 (GRCm39) missense probably damaging 1.00
R4842:Lrp1 UTSW 10 127,419,805 (GRCm39) missense probably damaging 1.00
R4855:Lrp1 UTSW 10 127,446,311 (GRCm39) missense probably benign 0.03
R4860:Lrp1 UTSW 10 127,389,693 (GRCm39) missense probably damaging 1.00
R4860:Lrp1 UTSW 10 127,389,693 (GRCm39) missense probably damaging 1.00
R4891:Lrp1 UTSW 10 127,377,621 (GRCm39) missense probably damaging 1.00
R4925:Lrp1 UTSW 10 127,410,944 (GRCm39) nonsense probably null
R4970:Lrp1 UTSW 10 127,375,389 (GRCm39) missense probably benign 0.11
R4999:Lrp1 UTSW 10 127,389,648 (GRCm39) missense probably damaging 1.00
R5044:Lrp1 UTSW 10 127,403,364 (GRCm39) missense probably damaging 1.00
R5127:Lrp1 UTSW 10 127,375,503 (GRCm39) intron probably benign
R5188:Lrp1 UTSW 10 127,443,821 (GRCm39) missense probably damaging 1.00
R5218:Lrp1 UTSW 10 127,384,488 (GRCm39) missense probably damaging 1.00
R5225:Lrp1 UTSW 10 127,391,965 (GRCm39) missense probably benign 0.04
R5291:Lrp1 UTSW 10 127,429,747 (GRCm39) missense probably damaging 1.00
R5395:Lrp1 UTSW 10 127,431,166 (GRCm39) missense probably damaging 1.00
R5413:Lrp1 UTSW 10 127,423,936 (GRCm39) critical splice donor site probably null
R5430:Lrp1 UTSW 10 127,376,930 (GRCm39) missense probably damaging 0.99
R5499:Lrp1 UTSW 10 127,408,813 (GRCm39) missense possibly damaging 0.58
R5526:Lrp1 UTSW 10 127,391,593 (GRCm39) missense probably benign 0.37
R5580:Lrp1 UTSW 10 127,424,389 (GRCm39) missense probably benign
R5583:Lrp1 UTSW 10 127,424,332 (GRCm39) missense probably benign 0.08
R5599:Lrp1 UTSW 10 127,429,738 (GRCm39) missense probably damaging 1.00
R5639:Lrp1 UTSW 10 127,429,708 (GRCm39) missense probably damaging 0.99
R5677:Lrp1 UTSW 10 127,410,298 (GRCm39) missense probably damaging 1.00
R5730:Lrp1 UTSW 10 127,419,703 (GRCm39) missense probably benign 0.00
R5742:Lrp1 UTSW 10 127,384,216 (GRCm39) missense probably damaging 0.98
R5764:Lrp1 UTSW 10 127,431,187 (GRCm39) missense probably benign 0.41
R5864:Lrp1 UTSW 10 127,403,374 (GRCm39) missense possibly damaging 0.58
R5937:Lrp1 UTSW 10 127,419,745 (GRCm39) missense possibly damaging 0.93
R5947:Lrp1 UTSW 10 127,425,423 (GRCm39) critical splice donor site probably null
R5976:Lrp1 UTSW 10 127,419,770 (GRCm39) missense probably damaging 1.00
R6021:Lrp1 UTSW 10 127,413,883 (GRCm39) missense probably damaging 1.00
R6026:Lrp1 UTSW 10 127,409,272 (GRCm39) missense probably damaging 1.00
R6045:Lrp1 UTSW 10 127,402,469 (GRCm39) missense probably damaging 0.98
R6057:Lrp1 UTSW 10 127,403,359 (GRCm39) missense probably damaging 1.00
R6084:Lrp1 UTSW 10 127,396,422 (GRCm39) missense probably benign 0.09
R6131:Lrp1 UTSW 10 127,396,026 (GRCm39) missense probably benign
R6235:Lrp1 UTSW 10 127,424,046 (GRCm39) missense probably damaging 1.00
R6280:Lrp1 UTSW 10 127,425,453 (GRCm39) missense probably benign 0.04
R6307:Lrp1 UTSW 10 127,427,944 (GRCm39) missense probably damaging 1.00
R6532:Lrp1 UTSW 10 127,385,276 (GRCm39) missense probably damaging 1.00
R6532:Lrp1 UTSW 10 127,377,551 (GRCm39) missense probably damaging 1.00
R6536:Lrp1 UTSW 10 127,393,937 (GRCm39) splice site probably null
R6605:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6607:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6631:Lrp1 UTSW 10 127,410,201 (GRCm39) missense probably damaging 1.00
R6676:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6678:Lrp1 UTSW 10 127,396,005 (GRCm39) missense probably damaging 1.00
R6809:Lrp1 UTSW 10 127,390,925 (GRCm39) missense probably benign 0.04
R6884:Lrp1 UTSW 10 127,394,986 (GRCm39) missense probably benign 0.00
R6925:Lrp1 UTSW 10 127,392,857 (GRCm39) missense probably benign 0.00
R6987:Lrp1 UTSW 10 127,410,874 (GRCm39) missense probably damaging 1.00
R7016:Lrp1 UTSW 10 127,395,836 (GRCm39) critical splice donor site probably null
R7030:Lrp1 UTSW 10 127,388,745 (GRCm39) missense probably damaging 0.97
R7053:Lrp1 UTSW 10 127,376,963 (GRCm39) missense probably damaging 1.00
R7076:Lrp1 UTSW 10 127,386,052 (GRCm39) critical splice donor site probably null
R7136:Lrp1 UTSW 10 127,394,491 (GRCm39) missense probably damaging 1.00
R7180:Lrp1 UTSW 10 127,392,834 (GRCm39) missense probably damaging 1.00
R7199:Lrp1 UTSW 10 127,409,325 (GRCm39) missense probably damaging 0.99
R7219:Lrp1 UTSW 10 127,393,097 (GRCm39) missense probably benign 0.40
R7233:Lrp1 UTSW 10 127,430,930 (GRCm39) missense probably damaging 1.00
R7251:Lrp1 UTSW 10 127,408,423 (GRCm39) missense probably damaging 1.00
R7264:Lrp1 UTSW 10 127,427,962 (GRCm39) missense probably damaging 1.00
R7302:Lrp1 UTSW 10 127,374,856 (GRCm39) missense probably benign 0.01
R7313:Lrp1 UTSW 10 127,389,337 (GRCm39) missense probably damaging 1.00
R7322:Lrp1 UTSW 10 127,381,433 (GRCm39) missense probably benign 0.24
R7354:Lrp1 UTSW 10 127,407,277 (GRCm39) missense probably damaging 1.00
R7375:Lrp1 UTSW 10 127,375,217 (GRCm39) missense probably damaging 1.00
R7388:Lrp1 UTSW 10 127,419,766 (GRCm39) nonsense probably null
R7404:Lrp1 UTSW 10 127,418,577 (GRCm39) missense
R7405:Lrp1 UTSW 10 127,417,620 (GRCm39) missense possibly damaging 0.93
R7477:Lrp1 UTSW 10 127,404,789 (GRCm39) missense probably damaging 1.00
R7555:Lrp1 UTSW 10 127,382,731 (GRCm39) missense probably damaging 1.00
R7600:Lrp1 UTSW 10 127,391,575 (GRCm39) missense probably benign
R7678:Lrp1 UTSW 10 127,409,922 (GRCm39) missense probably damaging 1.00
R7679:Lrp1 UTSW 10 127,424,297 (GRCm39) nonsense probably null
R7951:Lrp1 UTSW 10 127,374,933 (GRCm39) nonsense probably null
R7964:Lrp1 UTSW 10 127,410,913 (GRCm39) missense possibly damaging 0.94
R8006:Lrp1 UTSW 10 127,425,488 (GRCm39) missense probably damaging 1.00
R8021:Lrp1 UTSW 10 127,384,215 (GRCm39) missense possibly damaging 0.92
R8098:Lrp1 UTSW 10 127,410,324 (GRCm39) missense possibly damaging 0.78
R8112:Lrp1 UTSW 10 127,441,715 (GRCm39) missense probably damaging 1.00
R8210:Lrp1 UTSW 10 127,412,354 (GRCm39) missense probably damaging 1.00
R8249:Lrp1 UTSW 10 127,441,412 (GRCm39) missense probably benign
R8291:Lrp1 UTSW 10 127,425,572 (GRCm39) missense probably damaging 1.00
R8332:Lrp1 UTSW 10 127,407,805 (GRCm39) missense probably damaging 1.00
R8435:Lrp1 UTSW 10 127,392,199 (GRCm39) missense probably damaging 0.97
R8467:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8468:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8474:Lrp1 UTSW 10 127,375,572 (GRCm39) missense probably damaging 1.00
R8481:Lrp1 UTSW 10 127,404,779 (GRCm39) missense probably damaging 1.00
R8483:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8485:Lrp1 UTSW 10 127,394,519 (GRCm39) missense probably damaging 1.00
R8488:Lrp1 UTSW 10 127,396,356 (GRCm39) missense probably damaging 1.00
R8715:Lrp1 UTSW 10 127,396,490 (GRCm39) missense possibly damaging 0.77
R8790:Lrp1 UTSW 10 127,374,946 (GRCm39) missense probably damaging 1.00
R8854:Lrp1 UTSW 10 127,378,968 (GRCm39) missense probably damaging 1.00
R8926:Lrp1 UTSW 10 127,381,671 (GRCm39) missense probably benign
R8949:Lrp1 UTSW 10 127,425,405 (GRCm39) intron probably benign
R8971:Lrp1 UTSW 10 127,391,896 (GRCm39) missense possibly damaging 0.94
R9103:Lrp1 UTSW 10 127,430,979 (GRCm39) nonsense probably null
R9108:Lrp1 UTSW 10 127,390,206 (GRCm39) missense probably damaging 0.99
R9130:Lrp1 UTSW 10 127,382,281 (GRCm39) missense probably benign 0.18
R9157:Lrp1 UTSW 10 127,410,209 (GRCm39) missense probably damaging 1.00
R9162:Lrp1 UTSW 10 127,441,368 (GRCm39) missense probably benign 0.32
R9205:Lrp1 UTSW 10 127,430,850 (GRCm39) nonsense probably null
R9228:Lrp1 UTSW 10 127,382,807 (GRCm39) missense probably damaging 0.98
R9231:Lrp1 UTSW 10 127,382,268 (GRCm39) missense probably benign 0.06
R9287:Lrp1 UTSW 10 127,403,233 (GRCm39) missense probably damaging 1.00
R9381:Lrp1 UTSW 10 127,441,337 (GRCm39) missense probably benign 0.17
R9412:Lrp1 UTSW 10 127,409,287 (GRCm39) missense probably damaging 1.00
R9434:Lrp1 UTSW 10 127,381,689 (GRCm39) missense possibly damaging 0.93
R9463:Lrp1 UTSW 10 127,429,334 (GRCm39) nonsense probably null
R9526:Lrp1 UTSW 10 127,431,229 (GRCm39) missense probably damaging 0.96
R9548:Lrp1 UTSW 10 127,388,733 (GRCm39) missense probably damaging 0.99
R9599:Lrp1 UTSW 10 127,410,246 (GRCm39) missense probably damaging 1.00
R9649:Lrp1 UTSW 10 127,409,368 (GRCm39) missense probably benign 0.14
R9687:Lrp1 UTSW 10 127,402,562 (GRCm39) missense probably damaging 1.00
R9707:Lrp1 UTSW 10 127,408,414 (GRCm39) missense probably benign 0.08
R9770:Lrp1 UTSW 10 127,420,268 (GRCm39) missense probably damaging 1.00
V3553:Lrp1 UTSW 10 127,407,311 (GRCm39) missense probably damaging 1.00
Y5406:Lrp1 UTSW 10 127,390,152 (GRCm39) missense probably damaging 1.00
Z1088:Lrp1 UTSW 10 127,420,248 (GRCm39) missense probably damaging 1.00
Z1176:Lrp1 UTSW 10 127,390,831 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTTTCTGGCGGCCAATGAGG -3'
(R):5'- GCACCTCAGACCCAGATTTC -3'

Sequencing Primer
(F):5'- CGGCCAATGAGGTAGCTG -3'
(R):5'- ACCTCAGACCCAGATTTCAATTTGG -3'
Posted On 2016-08-04