Incidental Mutation 'R5387:Nrp2'
| ID |
425304 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Nrp2
|
| Ensembl Gene |
ENSMUSG00000025969 |
| Gene Name |
neuropilin 2 |
| Synonyms |
Npn2, NP-2, NP2, Npn-2, 1110048P06Rik |
| MMRRC Submission |
042959-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.963)
|
| Stock # |
R5387 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
62703285-62818695 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 62762813 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 472
(S472P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000099886
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000027112]
[ENSMUST00000063594]
[ENSMUST00000075144]
[ENSMUST00000102822]
[ENSMUST00000114155]
[ENSMUST00000114157]
|
| AlphaFold |
O35375 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000027112
AA Change: S472P
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000027112
Gene: ENSMUSG00000025969
AA Change: S472P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
Pfam:DUF3481
|
822 |
906 |
1.4e-35 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000063594
AA Change: S472P
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000069379
Gene: ENSMUSG00000025969
AA Change: S472P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
low complexity region
|
816 |
831 |
N/A |
INTRINSIC |
|
Pfam:DUF3481
|
839 |
923 |
1.6e-25 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000075144
AA Change: S472P
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000074642
Gene: ENSMUSG00000025969
AA Change: S472P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
Pfam:DUF3481
|
827 |
911 |
2.3e-25 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102822
AA Change: S472P
PolyPhen 2
Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000099886
Gene: ENSMUSG00000025969
AA Change: S472P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
Pfam:DUF3481
|
822 |
906 |
2.3e-25 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000114155
AA Change: S472P
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000109792
Gene: ENSMUSG00000025969
AA Change: S472P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
Pfam:DUF3481
|
817 |
901 |
9.4e-36 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000114157
AA Change: S472P
PolyPhen 2
Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
|
| SMART Domains |
Protein: ENSMUSP00000109794
Gene: ENSMUSG00000025969
AA Change: S472P
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
22 |
N/A |
INTRINSIC |
|
CUB
|
28 |
142 |
3.4e-45 |
SMART |
|
CUB
|
149 |
267 |
1.04e-40 |
SMART |
|
FA58C
|
276 |
427 |
1.63e-45 |
SMART |
|
FA58C
|
433 |
592 |
9.33e-14 |
SMART |
|
MAM
|
641 |
802 |
2.31e-60 |
SMART |
|
low complexity region
|
821 |
836 |
N/A |
INTRINSIC |
|
Pfam:DUF3481
|
844 |
928 |
2.4e-25 |
PFAM |
|
| Meta Mutation Damage Score |
0.2709 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.6%
- 20x: 96.0%
|
| Validation Efficiency |
99% (80/81) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Nullizygous mice may exhibit pre- or postnatal lethality, reduced fertility, hydrocephalus, aberrant sensory innervation, reduced interneuron count, seizure susceptibility and abnormal lymphangiogenesis. Homozygotes for a gene trap allele show abnormal neuronal development and axonal trajectories. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
T |
A |
13: 77,259,973 (GRCm38) |
S140T |
probably benign |
Het |
| Ahnak |
T |
C |
19: 9,003,691 (GRCm38) |
S780P |
probably damaging |
Het |
| Ankhd1 |
C |
A |
18: 36,634,644 (GRCm38) |
H1205N |
probably damaging |
Het |
| Ano1 |
T |
C |
7: 144,648,619 (GRCm38) |
K139R |
probably benign |
Het |
| Anp32b |
T |
G |
4: 46,468,573 (GRCm38) |
C114W |
probably damaging |
Het |
| Ascl1 |
C |
T |
10: 87,492,689 (GRCm38) |
A134T |
probably damaging |
Het |
| Atl2 |
C |
T |
17: 79,852,800 (GRCm38) |
E453K |
probably benign |
Het |
| Aup1 |
C |
T |
6: 83,055,024 (GRCm38) |
A84V |
probably damaging |
Het |
| Btbd7 |
A |
T |
12: 102,837,785 (GRCm38) |
M332K |
probably damaging |
Het |
| Cacna1d |
A |
G |
14: 30,100,751 (GRCm38) |
V1107A |
probably damaging |
Het |
| Cd33 |
G |
A |
7: 43,532,053 (GRCm38) |
Q114* |
probably null |
Het |
| Cdhr18 |
C |
A |
14: 13,914,438 (GRCm38) |
M1I |
probably null |
Het |
| Col4a4 |
C |
T |
1: 82,493,591 (GRCm38) |
G681E |
unknown |
Het |
| Defb22 |
C |
A |
2: 152,485,906 (GRCm38) |
A120S |
unknown |
Het |
| Dnah7b |
A |
G |
1: 46,188,659 (GRCm38) |
I1347M |
probably damaging |
Het |
| Efcab5 |
A |
G |
11: 77,134,842 (GRCm38) |
I549T |
possibly damaging |
Het |
| Esp15 |
T |
A |
17: 39,644,577 (GRCm38) |
|
probably null |
Het |
| Fbxo7 |
A |
G |
10: 86,024,654 (GRCm38) |
T42A |
probably benign |
Het |
| Filip1 |
A |
G |
9: 79,818,274 (GRCm38) |
I1021T |
probably benign |
Het |
| Gad1 |
C |
A |
2: 70,563,851 (GRCm38) |
S7* |
probably null |
Het |
| H2ac7 |
T |
A |
13: 23,574,667 (GRCm38) |
|
probably null |
Het |
| H2-Q7 |
C |
T |
17: 35,439,542 (GRCm38) |
T52M |
probably damaging |
Het |
| H2-T3 |
C |
T |
17: 36,186,702 (GRCm38) |
G28R |
probably benign |
Het |
| Idh2 |
TCCCAGG |
T |
7: 80,098,331 (GRCm38) |
|
probably benign |
Het |
| Ift81 |
A |
G |
5: 122,555,535 (GRCm38) |
Y604H |
probably damaging |
Het |
| Igsf11 |
A |
G |
16: 39,022,423 (GRCm38) |
Y154C |
probably damaging |
Het |
| Kif26b |
G |
T |
1: 178,914,876 (GRCm38) |
A846S |
probably benign |
Het |
| Lnx2 |
G |
A |
5: 147,028,154 (GRCm38) |
P420S |
probably benign |
Het |
| Lrit2 |
A |
G |
14: 37,072,259 (GRCm38) |
T427A |
probably damaging |
Het |
| Lrrc43 |
G |
T |
5: 123,499,671 (GRCm38) |
|
probably null |
Het |
| Mettl25b |
A |
T |
3: 87,930,011 (GRCm38) |
|
probably benign |
Het |
| Mug1 |
T |
C |
6: 121,884,394 (GRCm38) |
Y1325H |
probably damaging |
Het |
| Naglu |
A |
T |
11: 101,076,724 (GRCm38) |
Y500F |
probably damaging |
Het |
| Npy4r |
A |
G |
14: 34,146,983 (GRCm38) |
M116T |
probably benign |
Het |
| Nrdc |
A |
G |
4: 109,039,762 (GRCm38) |
Y526C |
probably damaging |
Het |
| Or12d2 |
T |
A |
17: 37,314,292 (GRCm38) |
T31S |
probably benign |
Het |
| Or12k8 |
T |
C |
2: 37,085,719 (GRCm38) |
T10A |
possibly damaging |
Het |
| Otogl |
T |
A |
10: 107,780,933 (GRCm38) |
T1828S |
probably benign |
Het |
| Pank2 |
C |
T |
2: 131,274,262 (GRCm38) |
T200I |
probably benign |
Het |
| Pbrm1 |
A |
G |
14: 31,082,610 (GRCm38) |
Y946C |
probably damaging |
Het |
| Pde12 |
A |
T |
14: 26,666,453 (GRCm38) |
S437T |
probably benign |
Het |
| Pikfyve |
A |
G |
1: 65,265,268 (GRCm38) |
K1710E |
possibly damaging |
Het |
| Plcd3 |
A |
G |
11: 103,078,455 (GRCm38) |
S229P |
probably damaging |
Het |
| Polr3a |
T |
C |
14: 24,454,941 (GRCm38) |
I1084V |
possibly damaging |
Het |
| Prkaa2 |
C |
A |
4: 105,040,177 (GRCm38) |
D280Y |
probably damaging |
Het |
| Ptprg |
T |
A |
14: 12,153,873 (GRCm38) |
S531R |
probably damaging |
Het |
| R3hdm2 |
T |
C |
10: 127,485,434 (GRCm38) |
S620P |
probably damaging |
Het |
| Rab33b |
A |
G |
3: 51,493,455 (GRCm38) |
T117A |
probably damaging |
Het |
| Rasal2 |
T |
C |
1: 157,157,765 (GRCm38) |
D804G |
possibly damaging |
Het |
| Rbp3 |
A |
G |
14: 33,956,413 (GRCm38) |
T773A |
possibly damaging |
Het |
| Rspry1 |
A |
G |
8: 94,638,286 (GRCm38) |
T185A |
possibly damaging |
Het |
| Sec61a2 |
G |
T |
2: 5,882,545 (GRCm38) |
|
probably benign |
Het |
| Setx |
C |
T |
2: 29,147,594 (GRCm38) |
R1364C |
probably benign |
Het |
| Shtn1 |
G |
T |
19: 59,038,369 (GRCm38) |
L97M |
probably damaging |
Het |
| Slc35f1 |
T |
C |
10: 53,108,164 (GRCm38) |
L340P |
probably damaging |
Het |
| Slc45a1 |
T |
A |
4: 150,643,909 (GRCm38) |
|
probably benign |
Het |
| Slmap |
T |
C |
14: 26,459,933 (GRCm38) |
E386G |
probably benign |
Het |
| Smc2 |
C |
T |
4: 52,475,096 (GRCm38) |
A924V |
probably benign |
Het |
| Sp110 |
C |
G |
1: 85,589,118 (GRCm38) |
E219D |
probably damaging |
Het |
| Tecta |
G |
A |
9: 42,375,063 (GRCm38) |
L766F |
probably damaging |
Het |
| Tle3 |
C |
T |
9: 61,407,489 (GRCm38) |
|
probably null |
Het |
| Top3a |
A |
G |
11: 60,762,490 (GRCm38) |
F53L |
probably damaging |
Het |
| Trappc2b |
A |
T |
11: 51,685,974 (GRCm38) |
D32E |
probably benign |
Het |
| Trem1 |
T |
C |
17: 48,241,513 (GRCm38) |
I26T |
possibly damaging |
Het |
| Ttc7b |
G |
T |
12: 100,446,963 (GRCm38) |
Q199K |
possibly damaging |
Het |
| Ubap2l |
T |
C |
3: 90,006,596 (GRCm38) |
Y975C |
probably benign |
Het |
| Ubxn11 |
C |
A |
4: 134,123,426 (GRCm38) |
D196E |
probably damaging |
Het |
| Unc80 |
A |
G |
1: 66,530,021 (GRCm38) |
H945R |
possibly damaging |
Het |
| Usp15 |
A |
G |
10: 123,131,286 (GRCm38) |
I405T |
probably damaging |
Het |
| Uty |
C |
T |
Y: 1,189,339 (GRCm38) |
E138K |
probably damaging |
Het |
| Wapl |
A |
G |
14: 34,677,295 (GRCm38) |
E107G |
probably benign |
Het |
| Wbp1l |
T |
C |
19: 46,644,457 (GRCm38) |
|
probably null |
Het |
| Zfp184 |
T |
G |
13: 21,949,640 (GRCm38) |
|
probably benign |
Het |
| Zfp36 |
A |
C |
7: 28,377,868 (GRCm38) |
L205R |
possibly damaging |
Het |
|
| Other mutations in Nrp2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00765:Nrp2
|
APN |
1 |
62,704,251 (GRCm38) |
nonsense |
probably null |
|
|
IGL01912:Nrp2
|
APN |
1 |
62,771,737 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01996:Nrp2
|
APN |
1 |
62,749,260 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02184:Nrp2
|
APN |
1 |
62,718,940 (GRCm38) |
nonsense |
probably null |
|
|
IGL02682:Nrp2
|
APN |
1 |
62,771,837 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02928:Nrp2
|
APN |
1 |
62,815,446 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03024:Nrp2
|
APN |
1 |
62,771,734 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Euphorbia
|
UTSW |
1 |
62,762,813 (GRCm38) |
missense |
probably benign |
0.02 |
|
Sabra
|
UTSW |
1 |
62,783,521 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0068:Nrp2
|
UTSW |
1 |
62,745,377 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R0068:Nrp2
|
UTSW |
1 |
62,745,377 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R0683:Nrp2
|
UTSW |
1 |
62,744,318 (GRCm38) |
missense |
probably benign |
0.41 |
|
R0789:Nrp2
|
UTSW |
1 |
62,745,450 (GRCm38) |
missense |
probably benign |
0.44 |
|
R1418:Nrp2
|
UTSW |
1 |
62,783,332 (GRCm38) |
nonsense |
probably null |
|
|
R1468:Nrp2
|
UTSW |
1 |
62,738,299 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1468:Nrp2
|
UTSW |
1 |
62,738,299 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1544:Nrp2
|
UTSW |
1 |
62,762,904 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1645:Nrp2
|
UTSW |
1 |
62,785,124 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1677:Nrp2
|
UTSW |
1 |
62,783,320 (GRCm38) |
missense |
probably benign |
0.18 |
|
R1752:Nrp2
|
UTSW |
1 |
62,738,441 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1840:Nrp2
|
UTSW |
1 |
62,738,339 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1916:Nrp2
|
UTSW |
1 |
62,762,747 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1962:Nrp2
|
UTSW |
1 |
62,718,931 (GRCm38) |
missense |
probably benign |
0.03 |
|
R2108:Nrp2
|
UTSW |
1 |
62,744,277 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2164:Nrp2
|
UTSW |
1 |
62,744,355 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2216:Nrp2
|
UTSW |
1 |
62,762,918 (GRCm38) |
nonsense |
probably null |
|
|
R2679:Nrp2
|
UTSW |
1 |
62,785,078 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4349:Nrp2
|
UTSW |
1 |
62,738,417 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4351:Nrp2
|
UTSW |
1 |
62,738,417 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4352:Nrp2
|
UTSW |
1 |
62,738,417 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4353:Nrp2
|
UTSW |
1 |
62,738,417 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4811:Nrp2
|
UTSW |
1 |
62,719,081 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5362:Nrp2
|
UTSW |
1 |
62,769,062 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5461:Nrp2
|
UTSW |
1 |
62,747,211 (GRCm38) |
nonsense |
probably null |
|
|
R5704:Nrp2
|
UTSW |
1 |
62,785,108 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6143:Nrp2
|
UTSW |
1 |
62,760,815 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6303:Nrp2
|
UTSW |
1 |
62,745,406 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6304:Nrp2
|
UTSW |
1 |
62,745,406 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6376:Nrp2
|
UTSW |
1 |
62,719,017 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R6945:Nrp2
|
UTSW |
1 |
62,760,788 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7347:Nrp2
|
UTSW |
1 |
62,745,504 (GRCm38) |
missense |
probably benign |
0.04 |
|
R7393:Nrp2
|
UTSW |
1 |
62,745,424 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7593:Nrp2
|
UTSW |
1 |
62,719,044 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R7881:Nrp2
|
UTSW |
1 |
62,771,831 (GRCm38) |
missense |
probably benign |
0.42 |
|
R7882:Nrp2
|
UTSW |
1 |
62,783,521 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7948:Nrp2
|
UTSW |
1 |
62,745,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7958:Nrp2
|
UTSW |
1 |
62,745,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7959:Nrp2
|
UTSW |
1 |
62,745,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7960:Nrp2
|
UTSW |
1 |
62,745,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7961:Nrp2
|
UTSW |
1 |
62,745,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8009:Nrp2
|
UTSW |
1 |
62,745,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8012:Nrp2
|
UTSW |
1 |
62,745,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8014:Nrp2
|
UTSW |
1 |
62,745,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8015:Nrp2
|
UTSW |
1 |
62,745,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8068:Nrp2
|
UTSW |
1 |
62,745,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8069:Nrp2
|
UTSW |
1 |
62,745,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8070:Nrp2
|
UTSW |
1 |
62,745,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8071:Nrp2
|
UTSW |
1 |
62,745,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8206:Nrp2
|
UTSW |
1 |
62,747,215 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8791:Nrp2
|
UTSW |
1 |
62,749,197 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9090:Nrp2
|
UTSW |
1 |
62,745,511 (GRCm38) |
missense |
probably benign |
0.21 |
|
R9271:Nrp2
|
UTSW |
1 |
62,745,511 (GRCm38) |
missense |
probably benign |
0.21 |
|
R9287:Nrp2
|
UTSW |
1 |
62,795,855 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9469:Nrp2
|
UTSW |
1 |
62,764,871 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9646:Nrp2
|
UTSW |
1 |
62,738,407 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9752:Nrp2
|
UTSW |
1 |
62,812,567 (GRCm38) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TAAGCATGTGACCTGACGGC -3'
(R):5'- CCATTTAGGCTGTAGGAGACTTTG -3'
Sequencing Primer
(F):5'- GTGGACTCCAATTAGTAGGTCTCAGC -3'
(R):5'- AGGAGACTTTGAACTTGCGTAC -3'
|
| Posted On |
2016-08-04 |
Incidental Mutation