Incidental Mutation 'R5387:Idh2'
| ID |
425333 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Idh2
|
| Ensembl Gene |
ENSMUSG00000030541 |
| Gene Name |
isocitrate dehydrogenase 2 (NADP+), mitochondrial |
| Synonyms |
Idh-2, IDPm |
| MMRRC Submission |
042959-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5387 (G1)
|
| Quality Score |
217 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
80094846-80115392 bp(-) (GRCm38) |
| Type of Mutation |
intron |
| DNA Base Change (assembly) |
TCCCAGG to T
at 80098331 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000146084
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000107384]
[ENSMUST00000125542]
[ENSMUST00000134328]
[ENSMUST00000164056]
[ENSMUST00000206714]
|
| AlphaFold |
P54071 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107384
|
| SMART Domains |
Protein: ENSMUSP00000103007
Gene: ENSMUSG00000030541
| Domain | Start | End | E-Value | Type |
|---|
|
Iso_dh
|
49 |
441 |
5.32e-135 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125542
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000134070
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000134328
|
| SMART Domains |
Protein: ENSMUSP00000118184
Gene: ENSMUSG00000030541
| Domain | Start | End | E-Value | Type |
|---|
|
Iso_dh
|
49 |
284 |
1.59e-8 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000139178
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156761
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164056
|
| SMART Domains |
Protein: ENSMUSP00000132361
Gene: ENSMUSG00000048897
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
76 |
88 |
N/A |
INTRINSIC |
|
low complexity region
|
106 |
127 |
N/A |
INTRINSIC |
|
low complexity region
|
169 |
181 |
N/A |
INTRINSIC |
|
low complexity region
|
187 |
201 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
297 |
319 |
2.71e-2 |
SMART |
|
ZnF_C2H2
|
325 |
347 |
1.92e-2 |
SMART |
|
ZnF_C2H2
|
353 |
375 |
2.71e-2 |
SMART |
|
ZnF_C2H2
|
381 |
403 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
409 |
431 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
437 |
459 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
465 |
487 |
3.83e-2 |
SMART |
|
ZnF_C2H2
|
493 |
515 |
2.12e-4 |
SMART |
|
ZnF_C2H2
|
521 |
543 |
3.63e-3 |
SMART |
|
ZnF_C2H2
|
549 |
571 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
577 |
600 |
3.69e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000206714
|
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.8%
- 10x: 97.6%
- 20x: 96.0%
|
| Validation Efficiency |
99% (80/81) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit suppression of tumorigenesis from B16F10 melanoma cells. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 0610009B22Rik |
A |
T |
11: 51,685,974 (GRCm38) |
D32E |
probably benign |
Het |
| 2210408I21Rik |
T |
A |
13: 77,259,973 (GRCm38) |
S140T |
probably benign |
Het |
| Ahnak |
T |
C |
19: 9,003,691 (GRCm38) |
S780P |
probably damaging |
Het |
| Ankhd1 |
C |
A |
18: 36,634,644 (GRCm38) |
H1205N |
probably damaging |
Het |
| Ano1 |
T |
C |
7: 144,648,619 (GRCm38) |
K139R |
probably benign |
Het |
| Anp32b |
T |
G |
4: 46,468,573 (GRCm38) |
C114W |
probably damaging |
Het |
| Ascl1 |
C |
T |
10: 87,492,689 (GRCm38) |
A134T |
probably damaging |
Het |
| Atl2 |
C |
T |
17: 79,852,800 (GRCm38) |
E453K |
probably benign |
Het |
| Aup1 |
C |
T |
6: 83,055,024 (GRCm38) |
A84V |
probably damaging |
Het |
| Btbd7 |
A |
T |
12: 102,837,785 (GRCm38) |
M332K |
probably damaging |
Het |
| Cacna1d |
A |
G |
14: 30,100,751 (GRCm38) |
V1107A |
probably damaging |
Het |
| Cd33 |
G |
A |
7: 43,532,053 (GRCm38) |
Q114* |
probably null |
Het |
| Col4a4 |
C |
T |
1: 82,493,591 (GRCm38) |
G681E |
unknown |
Het |
| Defb22 |
C |
A |
2: 152,485,906 (GRCm38) |
A120S |
unknown |
Het |
| Dnah7b |
A |
G |
1: 46,188,659 (GRCm38) |
I1347M |
probably damaging |
Het |
| Efcab5 |
A |
G |
11: 77,134,842 (GRCm38) |
I549T |
possibly damaging |
Het |
| Esp15 |
T |
A |
17: 39,644,577 (GRCm38) |
|
probably null |
Het |
| Fbxo7 |
A |
G |
10: 86,024,654 (GRCm38) |
T42A |
probably benign |
Het |
| Filip1 |
A |
G |
9: 79,818,274 (GRCm38) |
I1021T |
probably benign |
Het |
| Gad1 |
C |
A |
2: 70,563,851 (GRCm38) |
S7* |
probably null |
Het |
| Gm281 |
C |
A |
14: 13,914,438 (GRCm38) |
M1I |
probably null |
Het |
| H2-Q7 |
C |
T |
17: 35,439,542 (GRCm38) |
T52M |
probably damaging |
Het |
| H2-T3 |
C |
T |
17: 36,186,702 (GRCm38) |
G28R |
probably benign |
Het |
| Hist1h2ad |
T |
A |
13: 23,574,667 (GRCm38) |
|
probably null |
Het |
| Ift81 |
A |
G |
5: 122,555,535 (GRCm38) |
Y604H |
probably damaging |
Het |
| Igsf11 |
A |
G |
16: 39,022,423 (GRCm38) |
Y154C |
probably damaging |
Het |
| Kif26b |
G |
T |
1: 178,914,876 (GRCm38) |
A846S |
probably benign |
Het |
| Lnx2 |
G |
A |
5: 147,028,154 (GRCm38) |
P420S |
probably benign |
Het |
| Lrit2 |
A |
G |
14: 37,072,259 (GRCm38) |
T427A |
probably damaging |
Het |
| Lrrc43 |
G |
T |
5: 123,499,671 (GRCm38) |
|
probably null |
Het |
| Mug1 |
T |
C |
6: 121,884,394 (GRCm38) |
Y1325H |
probably damaging |
Het |
| Naglu |
A |
T |
11: 101,076,724 (GRCm38) |
Y500F |
probably damaging |
Het |
| Npy4r |
A |
G |
14: 34,146,983 (GRCm38) |
M116T |
probably benign |
Het |
| Nrd1 |
A |
G |
4: 109,039,762 (GRCm38) |
Y526C |
probably damaging |
Het |
| Nrp2 |
T |
C |
1: 62,762,813 (GRCm38) |
S472P |
probably benign |
Het |
| Olfr102 |
T |
A |
17: 37,314,292 (GRCm38) |
T31S |
probably benign |
Het |
| Olfr361 |
T |
C |
2: 37,085,719 (GRCm38) |
T10A |
possibly damaging |
Het |
| Otogl |
T |
A |
10: 107,780,933 (GRCm38) |
T1828S |
probably benign |
Het |
| Pank2 |
C |
T |
2: 131,274,262 (GRCm38) |
T200I |
probably benign |
Het |
| Pbrm1 |
A |
G |
14: 31,082,610 (GRCm38) |
Y946C |
probably damaging |
Het |
| Pde12 |
A |
T |
14: 26,666,453 (GRCm38) |
S437T |
probably benign |
Het |
| Pikfyve |
A |
G |
1: 65,265,268 (GRCm38) |
K1710E |
possibly damaging |
Het |
| Plcd3 |
A |
G |
11: 103,078,455 (GRCm38) |
S229P |
probably damaging |
Het |
| Polr3a |
T |
C |
14: 24,454,941 (GRCm38) |
I1084V |
possibly damaging |
Het |
| Prkaa2 |
C |
A |
4: 105,040,177 (GRCm38) |
D280Y |
probably damaging |
Het |
| Ptprg |
T |
A |
14: 12,153,873 (GRCm38) |
S531R |
probably damaging |
Het |
| R3hdm2 |
T |
C |
10: 127,485,434 (GRCm38) |
S620P |
probably damaging |
Het |
| Rab33b |
A |
G |
3: 51,493,455 (GRCm38) |
T117A |
probably damaging |
Het |
| Rasal2 |
T |
C |
1: 157,157,765 (GRCm38) |
D804G |
possibly damaging |
Het |
| Rbp3 |
A |
G |
14: 33,956,413 (GRCm38) |
T773A |
possibly damaging |
Het |
| Rrnad1 |
A |
T |
3: 87,930,011 (GRCm38) |
|
probably benign |
Het |
| Rspry1 |
A |
G |
8: 94,638,286 (GRCm38) |
T185A |
possibly damaging |
Het |
| Sec61a2 |
G |
T |
2: 5,882,545 (GRCm38) |
|
probably benign |
Het |
| Setx |
C |
T |
2: 29,147,594 (GRCm38) |
R1364C |
probably benign |
Het |
| Shtn1 |
G |
T |
19: 59,038,369 (GRCm38) |
L97M |
probably damaging |
Het |
| Slc35f1 |
T |
C |
10: 53,108,164 (GRCm38) |
L340P |
probably damaging |
Het |
| Slc45a1 |
T |
A |
4: 150,643,909 (GRCm38) |
|
probably benign |
Het |
| Slmap |
T |
C |
14: 26,459,933 (GRCm38) |
E386G |
probably benign |
Het |
| Smc2 |
C |
T |
4: 52,475,096 (GRCm38) |
A924V |
probably benign |
Het |
| Sp110 |
C |
G |
1: 85,589,118 (GRCm38) |
E219D |
probably damaging |
Het |
| Tecta |
G |
A |
9: 42,375,063 (GRCm38) |
L766F |
probably damaging |
Het |
| Tle3 |
C |
T |
9: 61,407,489 (GRCm38) |
|
probably null |
Het |
| Top3a |
A |
G |
11: 60,762,490 (GRCm38) |
F53L |
probably damaging |
Het |
| Trem1 |
T |
C |
17: 48,241,513 (GRCm38) |
I26T |
possibly damaging |
Het |
| Ttc7b |
G |
T |
12: 100,446,963 (GRCm38) |
Q199K |
possibly damaging |
Het |
| Ubap2l |
T |
C |
3: 90,006,596 (GRCm38) |
Y975C |
probably benign |
Het |
| Ubxn11 |
C |
A |
4: 134,123,426 (GRCm38) |
D196E |
probably damaging |
Het |
| Unc80 |
A |
G |
1: 66,530,021 (GRCm38) |
H945R |
possibly damaging |
Het |
| Usp15 |
A |
G |
10: 123,131,286 (GRCm38) |
I405T |
probably damaging |
Het |
| Uty |
C |
T |
Y: 1,189,339 (GRCm38) |
E138K |
probably damaging |
Het |
| Wapl |
A |
G |
14: 34,677,295 (GRCm38) |
E107G |
probably benign |
Het |
| Wbp1l |
T |
C |
19: 46,644,457 (GRCm38) |
|
probably null |
Het |
| Zfp184 |
T |
G |
13: 21,949,640 (GRCm38) |
|
probably benign |
Het |
| Zfp36 |
A |
C |
7: 28,377,868 (GRCm38) |
L205R |
possibly damaging |
Het |
|
| Other mutations in Idh2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01529:Idh2
|
APN |
7 |
80,097,945 (GRCm38) |
missense |
probably benign |
|
|
IGL02281:Idh2
|
APN |
7 |
80,095,802 (GRCm38) |
splice site |
probably null |
|
|
IGL02874:Idh2
|
APN |
7 |
80,097,873 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02892:Idh2
|
APN |
7 |
80,095,670 (GRCm38) |
missense |
probably benign |
|
|
IGL02937:Idh2
|
APN |
7 |
80,098,913 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02989:Idh2
|
APN |
7 |
80,099,108 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0040:Idh2
|
UTSW |
7 |
80,097,822 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0040:Idh2
|
UTSW |
7 |
80,097,822 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0090:Idh2
|
UTSW |
7 |
80,097,914 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0322:Idh2
|
UTSW |
7 |
80,098,257 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0384:Idh2
|
UTSW |
7 |
80,098,257 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0385:Idh2
|
UTSW |
7 |
80,098,257 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0386:Idh2
|
UTSW |
7 |
80,098,257 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0387:Idh2
|
UTSW |
7 |
80,098,257 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0494:Idh2
|
UTSW |
7 |
80,098,257 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1603:Idh2
|
UTSW |
7 |
80,099,158 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1681:Idh2
|
UTSW |
7 |
80,099,158 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1711:Idh2
|
UTSW |
7 |
80,099,158 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1844:Idh2
|
UTSW |
7 |
80,098,877 (GRCm38) |
missense |
probably benign |
0.31 |
|
R3700:Idh2
|
UTSW |
7 |
80,099,147 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4941:Idh2
|
UTSW |
7 |
80,096,099 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5234:Idh2
|
UTSW |
7 |
80,096,105 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5582:Idh2
|
UTSW |
7 |
80,098,339 (GRCm38) |
frame shift |
probably null |
|
|
R5655:Idh2
|
UTSW |
7 |
80,098,248 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6191:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R6261:Idh2
|
UTSW |
7 |
80,098,329 (GRCm38) |
intron |
probably benign |
|
|
R6311:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R6351:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R6413:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R6561:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R6709:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R6772:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R6781:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R6848:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R6861:Idh2
|
UTSW |
7 |
80,098,218 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6899:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R7063:Idh2
|
UTSW |
7 |
80,095,684 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7076:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R7081:Idh2
|
UTSW |
7 |
80,098,329 (GRCm38) |
intron |
probably benign |
|
|
R7090:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R7254:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
frame shift |
probably null |
|
|
R7298:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R7401:Idh2
|
UTSW |
7 |
80,098,329 (GRCm38) |
intron |
probably benign |
|
|
R7560:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
frame shift |
probably null |
|
|
R7561:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R7694:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R7816:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R7884:Idh2
|
UTSW |
7 |
80,098,329 (GRCm38) |
intron |
probably benign |
|
|
R7919:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R7961:Idh2
|
UTSW |
7 |
80,098,253 (GRCm38) |
missense |
probably benign |
0.18 |
|
R8009:Idh2
|
UTSW |
7 |
80,098,253 (GRCm38) |
missense |
probably benign |
0.18 |
|
R8036:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R8162:Idh2
|
UTSW |
7 |
80,098,329 (GRCm38) |
intron |
probably benign |
|
|
R8321:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R8451:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R8488:Idh2
|
UTSW |
7 |
80,098,329 (GRCm38) |
intron |
probably benign |
|
|
R8501:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R8671:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R8673:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R8707:Idh2
|
UTSW |
7 |
80,098,329 (GRCm38) |
intron |
probably benign |
|
|
R8725:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
frame shift |
probably null |
|
|
R8863:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R8872:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R8892:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R8915:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R8935:Idh2
|
UTSW |
7 |
80,115,198 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8951:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R8954:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R8985:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R9101:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R9111:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R9138:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
frame shift |
probably null |
|
|
R9138:Idh2
|
UTSW |
7 |
80,098,329 (GRCm38) |
intron |
probably benign |
|
|
R9140:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R9555:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R9580:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R9614:Idh2
|
UTSW |
7 |
80,098,177 (GRCm38) |
nonsense |
probably null |
|
|
R9619:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R9697:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R9756:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
R9790:Idh2
|
UTSW |
7 |
80,098,331 (GRCm38) |
intron |
probably benign |
|
|
RF030:Idh2
|
UTSW |
7 |
80,098,329 (GRCm38) |
intron |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCATCAGAGGTTGTTACTTGTC -3'
(R):5'- AGTAGGCGGCTTAAACAAGC -3'
Sequencing Primer
(F):5'- GTCAAAGATCTCCTGGAAGATGTC -3'
(R):5'- GCCTGTACCAGCTATAAGGTCTAG -3'
|
| Posted On |
2016-08-04 |
Incidental Mutation