Incidental Mutation 'R5388:Paxip1'
ID 425401
Institutional Source Beutler Lab
Gene Symbol Paxip1
Ensembl Gene ENSMUSG00000002221
Gene Name PAX interacting (with transcription-activation domain) protein 1
Synonyms D5Ertd149e, PTIP
MMRRC Submission 042960-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R5388 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 27945078-27996689 bp(-) (GRCm39)
Type of Mutation utr 3 prime
DNA Base Change (assembly) C to G at 27986453 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000142578 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000002291] [ENSMUST00000196734]
AlphaFold Q6NZQ4
Predicted Effect unknown
Transcript: ENSMUST00000002291
AA Change: Q97H
SMART Domains Protein: ENSMUSP00000002291
Gene: ENSMUSG00000002221
AA Change: Q97H

DomainStartEndE-ValueType
BRCT 10 83 6.72e1 SMART
BRCT 96 173 8.83e-15 SMART
low complexity region 189 208 N/A INTRINSIC
low complexity region 214 223 N/A INTRINSIC
coiled coil region 489 547 N/A INTRINSIC
BRCT 590 671 5.74e-14 SMART
BRCT 690 766 1.67e-15 SMART
BRCT 845 924 4.03e-9 SMART
BRCT 957 1046 3.54e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000196605
Predicted Effect probably benign
Transcript: ENSMUST00000196734
SMART Domains Protein: ENSMUSP00000142578
Gene: ENSMUSG00000002221

DomainStartEndE-ValueType
Blast:BRCT 10 83 5e-48 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000199993
Meta Mutation Damage Score 0.2047 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.8%
  • 10x: 97.5%
  • 20x: 95.9%
Validation Efficiency 98% (57/58)
MGI Phenotype FUNCTION: This gene encodes a nuclear-localized protein that contains six BRCT1 (C-terminal of breast cancer susceptibility protein) domains. The encoded protein is involved in the repair of DNA double-strand breaks and is necessary for progression through cell division. The protein also functions in the regulation of transcription by recruiting histone methyltransferases to gene promoters bound by the sequence-specific transcription factor paired box protein 2 (Pax2). [provided by RefSeq, Mar 2013]
PHENOTYPE: Homozygous mutant mice are developmentally retarded and embyronic lethal by E9.5. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca16 T C 7: 120,139,969 (GRCm39) probably null Het
Acap2 C A 16: 30,928,543 (GRCm39) C475F probably damaging Het
Ace C A 11: 105,879,284 (GRCm39) P603Q possibly damaging Het
Adamts20 C G 15: 94,243,659 (GRCm39) V657L possibly damaging Het
Antxr2 A G 5: 98,125,458 (GRCm39) probably null Het
Atp6v1b2 G A 8: 69,554,089 (GRCm39) V89I probably benign Het
Cacna1e G A 1: 154,353,542 (GRCm39) P676L probably damaging Het
Camsap3 A T 8: 3,654,276 (GRCm39) I649F probably damaging Het
Camta1 G T 4: 151,159,695 (GRCm39) S490R probably damaging Het
Celsr1 A G 15: 85,809,719 (GRCm39) I2221T probably damaging Het
Cfd A T 10: 79,727,959 (GRCm39) D164V probably damaging Het
Cfdp1 T C 8: 112,495,384 (GRCm39) D278G probably damaging Het
Cntn6 A T 6: 104,809,523 (GRCm39) L519F probably damaging Het
Col4a4 C T 1: 82,471,312 (GRCm39) G681E unknown Het
Cybrd1 T C 2: 70,967,989 (GRCm39) probably null Het
Cyp2e1 T C 7: 140,343,906 (GRCm39) L48P probably damaging Het
Eddm13 T C 7: 6,269,346 (GRCm39) probably null Het
Ep400 G A 5: 110,849,594 (GRCm39) T1409I unknown Het
Exosc7 A T 9: 122,947,972 (GRCm39) D47V probably damaging Het
Fgr T C 4: 132,722,342 (GRCm39) F204L probably damaging Het
Gm10100 G A 10: 77,562,560 (GRCm39) V81M probably benign Het
Gm12367 T C 4: 35,235,690 (GRCm39) noncoding transcript Het
Grxcr1 C A 5: 68,323,538 (GRCm39) T272K probably damaging Het
Kcna5 C T 6: 126,511,859 (GRCm39) D90N probably benign Het
Kdm5b T A 1: 134,536,635 (GRCm39) Y618* probably null Het
Lama5 T A 2: 179,832,539 (GRCm39) H1670L possibly damaging Het
Mtus2 C T 5: 148,243,518 (GRCm39) Q113* probably null Het
Ncam1 A C 9: 49,456,054 (GRCm39) D521E probably benign Het
Nkapl T C 13: 21,651,740 (GRCm39) H291R possibly damaging Het
Nlrp1b T G 11: 71,062,967 (GRCm39) N695H probably damaging Het
Npc1l1 T A 11: 6,164,733 (GRCm39) Q1105H probably damaging Het
Pign A T 1: 105,583,695 (GRCm39) W136R probably damaging Het
Pira1 T C 7: 3,741,856 (GRCm39) T175A possibly damaging Het
Pkn3 T A 2: 29,971,086 (GRCm39) S222T probably damaging Het
Polr3a T C 14: 24,505,009 (GRCm39) I1084V possibly damaging Het
Ppfibp1 T A 6: 146,898,338 (GRCm39) I98N probably damaging Het
Ppfibp1 T G 6: 146,917,828 (GRCm39) S484A probably damaging Het
Ppp1r7 T C 1: 93,280,312 (GRCm39) F127L probably damaging Het
Pramel1 T C 4: 143,123,954 (GRCm39) Y210H probably benign Het
Rad21l C T 2: 151,495,403 (GRCm39) V427I probably benign Het
Ripply1 TTCCTCCTCCTCCTCCTCCTCCTCCTCCTCCT TTCCTCCTCCTCCTCCTCCTCCTCCTCCT X: 138,680,599 (GRCm39) probably benign Het
Rnf225 A G 7: 12,661,932 (GRCm39) D37G probably damaging Het
Smpd2 A G 10: 41,363,967 (GRCm39) probably null Het
Spata31h1 T C 10: 82,119,561 (GRCm39) Q4483R probably damaging Het
Tmem38b C T 4: 53,859,945 (GRCm39) R242W probably benign Het
Topaz1 A T 9: 122,603,158 (GRCm39) K1035I possibly damaging Het
Trhr T C 15: 44,060,873 (GRCm39) I131T possibly damaging Het
Usp1 A G 4: 98,819,294 (GRCm39) D252G probably benign Het
Usp14 C T 18: 10,018,023 (GRCm39) E90K probably damaging Het
Yme1l1 T G 2: 23,052,569 (GRCm39) D74E probably benign Het
Ythdc2 T A 18: 44,990,092 (GRCm39) L732Q possibly damaging Het
Zbbx G T 3: 74,990,977 (GRCm39) A289D probably damaging Het
Zfhx3 G A 8: 109,673,446 (GRCm39) V1499I possibly damaging Het
Zfp622 T C 15: 25,996,285 (GRCm39) V184A possibly damaging Het
Other mutations in Paxip1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00587:Paxip1 APN 5 27,977,550 (GRCm39) utr 3 prime probably benign
IGL01705:Paxip1 APN 5 27,953,857 (GRCm39) missense probably damaging 1.00
IGL01844:Paxip1 APN 5 27,956,036 (GRCm39) missense probably benign 0.17
IGL02143:Paxip1 APN 5 27,980,596 (GRCm39) utr 3 prime probably benign
IGL02863:Paxip1 APN 5 27,964,393 (GRCm39) missense probably benign 0.30
IGL02903:Paxip1 APN 5 27,953,870 (GRCm39) missense probably damaging 1.00
IGL03008:Paxip1 APN 5 27,957,764 (GRCm39) missense probably benign 0.01
BB003:Paxip1 UTSW 5 27,996,207 (GRCm39) missense unknown
BB013:Paxip1 UTSW 5 27,996,207 (GRCm39) missense unknown
R0128:Paxip1 UTSW 5 27,949,183 (GRCm39) splice site probably benign
R0130:Paxip1 UTSW 5 27,949,183 (GRCm39) splice site probably benign
R0331:Paxip1 UTSW 5 27,970,230 (GRCm39) missense probably damaging 0.96
R0357:Paxip1 UTSW 5 27,963,621 (GRCm39) splice site probably benign
R0370:Paxip1 UTSW 5 27,965,084 (GRCm39) missense probably damaging 1.00
R0625:Paxip1 UTSW 5 27,970,940 (GRCm39) nonsense probably null
R1969:Paxip1 UTSW 5 27,949,134 (GRCm39) missense probably damaging 1.00
R2214:Paxip1 UTSW 5 27,947,499 (GRCm39) missense probably damaging 1.00
R3424:Paxip1 UTSW 5 27,980,671 (GRCm39) utr 3 prime probably benign
R3808:Paxip1 UTSW 5 27,977,027 (GRCm39) unclassified probably benign
R3809:Paxip1 UTSW 5 27,977,027 (GRCm39) unclassified probably benign
R3881:Paxip1 UTSW 5 27,953,837 (GRCm39) missense probably damaging 1.00
R3882:Paxip1 UTSW 5 27,953,837 (GRCm39) missense probably damaging 1.00
R4685:Paxip1 UTSW 5 27,966,675 (GRCm39) splice site probably null
R4692:Paxip1 UTSW 5 27,977,095 (GRCm39) unclassified probably benign
R4776:Paxip1 UTSW 5 27,970,204 (GRCm39) missense probably damaging 1.00
R5093:Paxip1 UTSW 5 27,971,282 (GRCm39) missense unknown
R5397:Paxip1 UTSW 5 27,977,002 (GRCm39) unclassified probably benign
R5553:Paxip1 UTSW 5 27,980,637 (GRCm39) utr 3 prime probably benign
R6151:Paxip1 UTSW 5 27,966,616 (GRCm39) missense probably damaging 1.00
R6216:Paxip1 UTSW 5 27,971,171 (GRCm39) missense unknown
R6276:Paxip1 UTSW 5 27,966,666 (GRCm39) missense probably damaging 1.00
R6290:Paxip1 UTSW 5 27,970,576 (GRCm39) splice site probably null
R6584:Paxip1 UTSW 5 27,963,450 (GRCm39) missense probably damaging 0.98
R6688:Paxip1 UTSW 5 27,949,135 (GRCm39) missense probably benign 0.18
R6908:Paxip1 UTSW 5 27,996,222 (GRCm39) missense possibly damaging 0.90
R6981:Paxip1 UTSW 5 27,970,766 (GRCm39) nonsense probably null
R7252:Paxip1 UTSW 5 27,965,084 (GRCm39) missense probably damaging 0.96
R7385:Paxip1 UTSW 5 27,986,418 (GRCm39) critical splice donor site probably null
R7585:Paxip1 UTSW 5 27,977,002 (GRCm39) missense unknown
R7665:Paxip1 UTSW 5 27,970,736 (GRCm39) missense unknown
R7926:Paxip1 UTSW 5 27,996,207 (GRCm39) missense unknown
R8169:Paxip1 UTSW 5 27,977,093 (GRCm39) missense unknown
R8335:Paxip1 UTSW 5 27,971,122 (GRCm39) missense unknown
R8732:Paxip1 UTSW 5 27,949,541 (GRCm39) missense probably damaging 1.00
R8790:Paxip1 UTSW 5 27,977,078 (GRCm39) missense unknown
X0066:Paxip1 UTSW 5 27,971,016 (GRCm39) missense unknown
Z1176:Paxip1 UTSW 5 27,988,727 (GRCm39) critical splice donor site probably null
Predicted Primers PCR Primer
(F):5'- TAGACAATGGTAAGTGTGCTGG -3'
(R):5'- CGATATTGCGATGTCCTTTACTG -3'

Sequencing Primer
(F):5'- ACAATGGTAAGTGTGCTGGAAGTTG -3'
(R):5'- GCGATGTCCTTTACTGAAACTTAC -3'
Posted On 2016-08-04