Incidental Mutation 'R5389:Cadps2'
| ID |
425467 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cadps2
|
| Ensembl Gene |
ENSMUSG00000017978 |
| Gene Name |
Ca2+-dependent activator protein for secretion 2 |
| Synonyms |
Caps2, A230044C21Rik, cpd2 |
| MMRRC Submission |
042961-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5389 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
23262772-23839420 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 23329103 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 938
(V938A)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000018122]
[ENSMUST00000069074]
[ENSMUST00000115358]
[ENSMUST00000115361]
[ENSMUST00000125350]
[ENSMUST00000142913]
[ENSMUST00000163871]
[ENSMUST00000166458]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000018122
AA Change: V943A
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000018122
Gene: ENSMUSG00000017978
AA Change: V943A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000069074
AA Change: V936A
PolyPhen 2
Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000064876
Gene: ENSMUSG00000017978
AA Change: V936A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
895 |
5.54e-51 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115357
AA Change: V938A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000111014
Gene: ENSMUSG00000017978
AA Change: V938A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
806 |
897 |
1.9e-49 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115358
AA Change: V943A
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000111015
Gene: ENSMUSG00000017978
AA Change: V943A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
1.14e-52 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115361
AA Change: V933A
PolyPhen 2
Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000111018
Gene: ENSMUSG00000017978
AA Change: V933A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
892 |
1.9e-49 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000125350
AA Change: V578A
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000115866
Gene: ENSMUSG00000017978
AA Change: V578A
| Domain | Start | End | E-Value | Type |
|---|
|
C2
|
14 |
112 |
1.51e-1 |
SMART |
|
PH
|
137 |
241 |
2.94e-11 |
SMART |
|
DUF1041
|
446 |
537 |
1.9e-49 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000142913
AA Change: V914A
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000138167
Gene: ENSMUSG00000017978
AA Change: V914A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
22 |
39 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.14e-52 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000163871
AA Change: V943A
PolyPhen 2
Score 0.911 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000128905
Gene: ENSMUSG00000017978
AA Change: V943A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
31 |
65 |
N/A |
INTRINSIC |
|
low complexity region
|
114 |
126 |
N/A |
INTRINSIC |
|
coiled coil region
|
265 |
285 |
N/A |
INTRINSIC |
|
C2
|
369 |
467 |
1.51e-1 |
SMART |
|
PH
|
492 |
596 |
2.94e-11 |
SMART |
|
DUF1041
|
801 |
902 |
7.2e-50 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000166458
AA Change: V914A
PolyPhen 2
Score 0.909 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000125972
Gene: ENSMUSG00000017978
AA Change: V914A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
5 |
21 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
97 |
N/A |
INTRINSIC |
|
coiled coil region
|
236 |
256 |
N/A |
INTRINSIC |
|
C2
|
340 |
438 |
1.51e-1 |
SMART |
|
PH
|
463 |
567 |
2.94e-11 |
SMART |
|
DUF1041
|
772 |
873 |
1.05e-51 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156986
|
| Meta Mutation Damage Score |
0.1978 |
| Coding Region Coverage |
- 1x: 99.4%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.7%
|
| Validation Efficiency |
98% (65/66) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium binding proteins that regulate the exocytosis of synaptic and dense-core vesicles in neurons and neuroendocrine cells. Mutations in this gene may contribute to autism susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009]
PHENOTYPE: Mice homozygous for a null allele exhibit defects in cerebellum, Purkinje cell and interneuron morphology, paired-pulse facilitation, and behaviors including emotional behavior, vestibuoocular reflex, circadium and sleep patterns, social investigation and nurturing behavior. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921524L21Rik |
T |
C |
18: 6,638,795 (GRCm39) |
V398A |
probably benign |
Het |
| A430033K04Rik |
T |
A |
5: 138,644,559 (GRCm39) |
V148E |
probably benign |
Het |
| Acyp2 |
C |
T |
11: 30,456,354 (GRCm39) |
E98K |
possibly damaging |
Het |
| Ankrd26 |
T |
A |
6: 118,485,536 (GRCm39) |
Q1446L |
possibly damaging |
Het |
| Anks6 |
A |
T |
4: 47,038,900 (GRCm39) |
|
probably benign |
Het |
| Arrb2 |
T |
C |
11: 70,329,484 (GRCm39) |
S265P |
probably damaging |
Het |
| Baiap2 |
T |
C |
11: 119,887,496 (GRCm39) |
S264P |
probably damaging |
Het |
| Cavin4 |
G |
T |
4: 48,663,907 (GRCm39) |
V96F |
probably damaging |
Het |
| Cenpe |
T |
C |
3: 134,965,149 (GRCm39) |
|
probably null |
Het |
| Crocc2 |
C |
A |
1: 93,143,363 (GRCm39) |
Q1322K |
probably benign |
Het |
| Cryzl2 |
T |
A |
1: 157,289,546 (GRCm39) |
C61* |
probably null |
Het |
| Dazl |
T |
C |
17: 50,595,718 (GRCm39) |
I56V |
probably benign |
Het |
| Dnah12 |
A |
T |
14: 26,456,904 (GRCm39) |
D890V |
probably damaging |
Het |
| Dnah9 |
C |
A |
11: 65,986,140 (GRCm39) |
E1165* |
probably null |
Het |
| Dnmt3l |
T |
A |
10: 77,892,665 (GRCm39) |
|
probably null |
Het |
| Elp2 |
A |
G |
18: 24,739,960 (GRCm39) |
N62S |
possibly damaging |
Het |
| Entr1 |
T |
C |
2: 26,275,559 (GRCm39) |
D244G |
probably damaging |
Het |
| Fam216b |
T |
A |
14: 78,322,503 (GRCm39) |
H26L |
possibly damaging |
Het |
| Fbxw25 |
T |
A |
9: 109,481,954 (GRCm39) |
Q244L |
possibly damaging |
Het |
| G530012D18Rik |
G |
C |
1: 85,504,923 (GRCm39) |
|
probably benign |
Het |
| Gvin3 |
T |
C |
7: 106,197,442 (GRCm39) |
|
noncoding transcript |
Het |
| Igf2r |
T |
C |
17: 12,944,303 (GRCm39) |
Y400C |
probably damaging |
Het |
| Iqcc |
A |
G |
4: 129,512,413 (GRCm39) |
F20L |
probably benign |
Het |
| Klhl5 |
T |
A |
5: 65,298,625 (GRCm39) |
L135M |
possibly damaging |
Het |
| Klk1b16 |
A |
T |
7: 43,790,412 (GRCm39) |
M196L |
possibly damaging |
Het |
| Ltf |
T |
C |
9: 110,858,719 (GRCm39) |
M489T |
possibly damaging |
Het |
| Mctp2 |
G |
T |
7: 71,863,835 (GRCm39) |
R343S |
possibly damaging |
Het |
| Nbas |
T |
A |
12: 13,584,578 (GRCm39) |
|
probably null |
Het |
| Ncr1 |
A |
T |
7: 4,343,932 (GRCm39) |
M177L |
probably benign |
Het |
| Net1 |
C |
T |
13: 3,936,170 (GRCm39) |
E305K |
probably damaging |
Het |
| Nfx1 |
T |
C |
4: 40,985,000 (GRCm39) |
F375L |
probably damaging |
Het |
| Notch3 |
T |
A |
17: 32,358,163 (GRCm39) |
I1687L |
probably benign |
Het |
| Obsl1 |
A |
T |
1: 75,479,905 (GRCm39) |
|
probably benign |
Het |
| Or2ag16 |
A |
T |
7: 106,352,290 (GRCm39) |
F102I |
probably damaging |
Het |
| Or2t46 |
C |
G |
11: 58,471,825 (GRCm39) |
L52V |
possibly damaging |
Het |
| Or51v14 |
G |
T |
7: 103,260,797 (GRCm39) |
Y254* |
probably null |
Het |
| Or5g23 |
A |
G |
2: 85,438,627 (GRCm39) |
F209S |
probably benign |
Het |
| Or5j3 |
G |
A |
2: 86,128,561 (GRCm39) |
V134M |
possibly damaging |
Het |
| Or5p79 |
A |
C |
7: 108,221,924 (GRCm39) |
I302L |
probably damaging |
Het |
| Orai1 |
A |
T |
5: 123,167,564 (GRCm39) |
M246L |
probably benign |
Het |
| Pcdhga12 |
G |
A |
18: 37,899,785 (GRCm39) |
A206T |
probably damaging |
Het |
| Plxdc2 |
C |
A |
2: 16,654,998 (GRCm39) |
T199K |
probably damaging |
Het |
| Prkd1 |
T |
A |
12: 50,389,920 (GRCm39) |
I819F |
probably damaging |
Het |
| Ptpn9 |
T |
C |
9: 56,964,121 (GRCm39) |
|
probably benign |
Het |
| Rabl6 |
T |
C |
2: 25,478,666 (GRCm39) |
E255G |
probably damaging |
Het |
| Sema3e |
T |
C |
5: 14,286,099 (GRCm39) |
|
probably benign |
Het |
| Serpina3c |
T |
C |
12: 104,115,699 (GRCm39) |
M282V |
possibly damaging |
Het |
| Slco1a7 |
A |
G |
6: 141,686,193 (GRCm39) |
F216L |
probably benign |
Het |
| Slco2b1 |
A |
G |
7: 99,335,132 (GRCm39) |
I216T |
probably damaging |
Het |
| Slco6b1 |
T |
C |
1: 96,916,309 (GRCm39) |
|
noncoding transcript |
Het |
| Slco6d1 |
A |
T |
1: 98,371,369 (GRCm39) |
I285F |
probably benign |
Het |
| Sp110 |
C |
G |
1: 85,516,839 (GRCm39) |
E219D |
probably damaging |
Het |
| Sp9 |
C |
A |
2: 73,104,641 (GRCm39) |
N398K |
probably damaging |
Het |
| Sycp2 |
A |
C |
2: 178,019,495 (GRCm39) |
|
probably null |
Het |
| Tbc1d23 |
T |
C |
16: 57,019,291 (GRCm39) |
D219G |
probably damaging |
Het |
| Tdpoz3 |
A |
G |
3: 93,734,179 (GRCm39) |
R285G |
probably benign |
Het |
| Trim2 |
T |
A |
3: 84,074,960 (GRCm39) |
Q694L |
probably null |
Het |
| Trim23 |
T |
A |
13: 104,328,541 (GRCm39) |
V293D |
probably damaging |
Het |
| Ttn |
A |
G |
2: 76,665,183 (GRCm39) |
|
probably benign |
Het |
| Vmn2r12 |
T |
A |
5: 109,238,261 (GRCm39) |
Y493F |
probably benign |
Het |
| Vps41 |
T |
A |
13: 19,046,708 (GRCm39) |
I753N |
probably damaging |
Het |
| Vps51 |
T |
G |
19: 6,121,063 (GRCm39) |
E283D |
probably benign |
Het |
| Yme1l1 |
G |
A |
2: 23,083,246 (GRCm39) |
G571R |
probably damaging |
Het |
| Zfp322a |
A |
T |
13: 23,541,149 (GRCm39) |
C198S |
probably damaging |
Het |
|
| Other mutations in Cadps2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01014:Cadps2
|
APN |
6 |
23,496,873 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL01105:Cadps2
|
APN |
6 |
23,321,699 (GRCm39) |
splice site |
probably benign |
|
|
IGL01317:Cadps2
|
APN |
6 |
23,314,172 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL01409:Cadps2
|
APN |
6 |
23,587,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01477:Cadps2
|
APN |
6 |
23,263,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01620:Cadps2
|
APN |
6 |
23,587,461 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL01674:Cadps2
|
APN |
6 |
23,355,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01675:Cadps2
|
APN |
6 |
23,382,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01895:Cadps2
|
APN |
6 |
23,427,274 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02095:Cadps2
|
APN |
6 |
23,427,309 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02200:Cadps2
|
APN |
6 |
23,385,527 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02380:Cadps2
|
APN |
6 |
23,287,731 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02680:Cadps2
|
APN |
6 |
23,838,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02814:Cadps2
|
APN |
6 |
23,321,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02940:Cadps2
|
APN |
6 |
23,496,808 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL03061:Cadps2
|
APN |
6 |
23,287,659 (GRCm39) |
splice site |
probably null |
|
|
IGL03233:Cadps2
|
APN |
6 |
23,263,600 (GRCm39) |
missense |
probably benign |
0.10 |
|
R0193:Cadps2
|
UTSW |
6 |
23,599,439 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0389:Cadps2
|
UTSW |
6 |
23,321,781 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0571:Cadps2
|
UTSW |
6 |
23,583,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0595:Cadps2
|
UTSW |
6 |
23,321,703 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0620:Cadps2
|
UTSW |
6 |
23,583,395 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0723:Cadps2
|
UTSW |
6 |
23,287,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0831:Cadps2
|
UTSW |
6 |
23,321,739 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R0836:Cadps2
|
UTSW |
6 |
23,328,775 (GRCm39) |
splice site |
probably benign |
|
|
R0942:Cadps2
|
UTSW |
6 |
23,263,561 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1099:Cadps2
|
UTSW |
6 |
23,599,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1120:Cadps2
|
UTSW |
6 |
23,838,793 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1216:Cadps2
|
UTSW |
6 |
23,583,472 (GRCm39) |
splice site |
probably benign |
|
|
R1575:Cadps2
|
UTSW |
6 |
23,429,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1780:Cadps2
|
UTSW |
6 |
23,320,931 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1924:Cadps2
|
UTSW |
6 |
23,688,857 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1944:Cadps2
|
UTSW |
6 |
23,599,479 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1956:Cadps2
|
UTSW |
6 |
23,287,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1986:Cadps2
|
UTSW |
6 |
23,323,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2045:Cadps2
|
UTSW |
6 |
23,839,121 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R2146:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2147:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2148:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2150:Cadps2
|
UTSW |
6 |
23,838,998 (GRCm39) |
intron |
probably benign |
|
|
R2219:Cadps2
|
UTSW |
6 |
23,410,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2264:Cadps2
|
UTSW |
6 |
23,323,339 (GRCm39) |
missense |
probably benign |
0.15 |
|
R2338:Cadps2
|
UTSW |
6 |
23,838,977 (GRCm39) |
splice site |
probably benign |
|
|
R3861:Cadps2
|
UTSW |
6 |
23,355,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3898:Cadps2
|
UTSW |
6 |
23,528,125 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3982:Cadps2
|
UTSW |
6 |
23,263,530 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4213:Cadps2
|
UTSW |
6 |
23,599,462 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4384:Cadps2
|
UTSW |
6 |
23,412,987 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4432:Cadps2
|
UTSW |
6 |
23,626,737 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4609:Cadps2
|
UTSW |
6 |
23,587,578 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4806:Cadps2
|
UTSW |
6 |
23,688,859 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4977:Cadps2
|
UTSW |
6 |
23,599,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5174:Cadps2
|
UTSW |
6 |
23,287,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5267:Cadps2
|
UTSW |
6 |
23,626,667 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R5737:Cadps2
|
UTSW |
6 |
23,328,804 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6074:Cadps2
|
UTSW |
6 |
23,626,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6254:Cadps2
|
UTSW |
6 |
23,329,162 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R6323:Cadps2
|
UTSW |
6 |
23,263,577 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6463:Cadps2
|
UTSW |
6 |
23,323,333 (GRCm39) |
nonsense |
probably null |
|
|
R6907:Cadps2
|
UTSW |
6 |
23,599,505 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6940:Cadps2
|
UTSW |
6 |
23,302,491 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6964:Cadps2
|
UTSW |
6 |
23,583,458 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7079:Cadps2
|
UTSW |
6 |
23,323,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7139:Cadps2
|
UTSW |
6 |
23,410,888 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7156:Cadps2
|
UTSW |
6 |
23,688,955 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7184:Cadps2
|
UTSW |
6 |
23,583,428 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7325:Cadps2
|
UTSW |
6 |
23,409,934 (GRCm39) |
missense |
unknown |
|
|
R7526:Cadps2
|
UTSW |
6 |
23,496,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7546:Cadps2
|
UTSW |
6 |
23,626,607 (GRCm39) |
missense |
probably benign |
0.15 |
|
R7772:Cadps2
|
UTSW |
6 |
23,390,445 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7870:Cadps2
|
UTSW |
6 |
23,263,641 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8040:Cadps2
|
UTSW |
6 |
23,412,942 (GRCm39) |
splice site |
probably benign |
|
|
R8048:Cadps2
|
UTSW |
6 |
23,838,862 (GRCm39) |
missense |
probably benign |
0.14 |
|
R8082:Cadps2
|
UTSW |
6 |
23,323,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8100:Cadps2
|
UTSW |
6 |
23,838,808 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8115:Cadps2
|
UTSW |
6 |
23,328,897 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8497:Cadps2
|
UTSW |
6 |
23,355,918 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8768:Cadps2
|
UTSW |
6 |
23,382,938 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8783:Cadps2
|
UTSW |
6 |
23,302,303 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R8804:Cadps2
|
UTSW |
6 |
23,496,805 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8832:Cadps2
|
UTSW |
6 |
23,587,536 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8848:Cadps2
|
UTSW |
6 |
23,344,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8854:Cadps2
|
UTSW |
6 |
23,385,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Cadps2
|
UTSW |
6 |
23,410,876 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8910:Cadps2
|
UTSW |
6 |
23,344,223 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8921:Cadps2
|
UTSW |
6 |
23,302,300 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9228:Cadps2
|
UTSW |
6 |
23,688,927 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9297:Cadps2
|
UTSW |
6 |
23,496,887 (GRCm39) |
missense |
probably benign |
|
|
R9318:Cadps2
|
UTSW |
6 |
23,496,887 (GRCm39) |
missense |
probably benign |
|
|
R9348:Cadps2
|
UTSW |
6 |
23,344,262 (GRCm39) |
missense |
probably benign |
0.20 |
|
R9447:Cadps2
|
UTSW |
6 |
23,323,297 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9484:Cadps2
|
UTSW |
6 |
23,626,646 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9492:Cadps2
|
UTSW |
6 |
23,427,238 (GRCm39) |
missense |
probably benign |
|
|
R9630:Cadps2
|
UTSW |
6 |
23,587,571 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9729:Cadps2
|
UTSW |
6 |
23,382,982 (GRCm39) |
missense |
probably benign |
0.28 |
|
Z1176:Cadps2
|
UTSW |
6 |
23,321,800 (GRCm39) |
missense |
probably benign |
0.24 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,838,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,626,694 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cadps2
|
UTSW |
6 |
23,385,477 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAAGACTGTTGGCGATATTCCTG -3'
(R):5'- TGTACAAGCATACCACCTGC -3'
Sequencing Primer
(F):5'- AGACTGTTGGCGATATTCCTGTAAAG -3'
(R):5'- GTTTTGACAGGCATATATGAAAGGC -3'
|
| Posted On |
2016-08-04 |
Incidental Mutation