Incidental Mutation 'R5389:Zfp322a'
ID 425490
Institutional Source Beutler Lab
Gene Symbol Zfp322a
Ensembl Gene ENSMUSG00000046351
Gene Name zinc finger protein 322A
Synonyms 9630054P07Rik
MMRRC Submission 042961-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R5389 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 23537273-23553378 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 23541149 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Serine at position 198 (C198S)
Ref Sequence ENSEMBL: ENSMUSP00000061524 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000050101] [ENSMUST00000125328] [ENSMUST00000145451] [ENSMUST00000152557]
AlphaFold Q8BZ89
Predicted Effect probably damaging
Transcript: ENSMUST00000050101
AA Change: C198S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000061524
Gene: ENSMUSG00000046351
AA Change: C198S

DomainStartEndE-ValueType
ZnF_C2H2 81 103 6.42e-4 SMART
ZnF_C2H2 109 131 3.34e-2 SMART
ZnF_C2H2 137 159 1.28e-3 SMART
ZnF_C2H2 165 187 2.95e-3 SMART
ZnF_C2H2 193 215 1.95e-3 SMART
ZnF_C2H2 221 243 4.79e-3 SMART
ZnF_C2H2 249 271 5.14e-3 SMART
ZnF_C2H2 277 299 8.94e-3 SMART
ZnF_C2H2 303 325 5.68e1 SMART
ZnF_C2H2 361 383 1.89e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122940
Predicted Effect probably benign
Transcript: ENSMUST00000125328
SMART Domains Protein: ENSMUSP00000120804
Gene: ENSMUSG00000046351

DomainStartEndE-ValueType
ZnF_C2H2 81 103 6.42e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000145451
SMART Domains Protein: ENSMUSP00000119883
Gene: ENSMUSG00000046351

DomainStartEndE-ValueType
ZnF_C2H2 81 103 6.42e-4 SMART
ZnF_C2H2 109 131 3.34e-2 SMART
ZnF_C2H2 137 159 1.28e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000152557
SMART Domains Protein: ENSMUSP00000118754
Gene: ENSMUSG00000046351

DomainStartEndE-ValueType
ZnF_C2H2 81 103 6.42e-4 SMART
ZnF_C2H2 109 131 3.34e-2 SMART
ZnF_C2H2 137 159 1.28e-3 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224779
Meta Mutation Damage Score 0.9009 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.7%
Validation Efficiency 98% (65/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921524L21Rik T C 18: 6,638,795 (GRCm39) V398A probably benign Het
A430033K04Rik T A 5: 138,644,559 (GRCm39) V148E probably benign Het
Acyp2 C T 11: 30,456,354 (GRCm39) E98K possibly damaging Het
Ankrd26 T A 6: 118,485,536 (GRCm39) Q1446L possibly damaging Het
Anks6 A T 4: 47,038,900 (GRCm39) probably benign Het
Arrb2 T C 11: 70,329,484 (GRCm39) S265P probably damaging Het
Baiap2 T C 11: 119,887,496 (GRCm39) S264P probably damaging Het
Cadps2 A G 6: 23,329,103 (GRCm39) V938A probably damaging Het
Cavin4 G T 4: 48,663,907 (GRCm39) V96F probably damaging Het
Cenpe T C 3: 134,965,149 (GRCm39) probably null Het
Crocc2 C A 1: 93,143,363 (GRCm39) Q1322K probably benign Het
Cryzl2 T A 1: 157,289,546 (GRCm39) C61* probably null Het
Dazl T C 17: 50,595,718 (GRCm39) I56V probably benign Het
Dnah12 A T 14: 26,456,904 (GRCm39) D890V probably damaging Het
Dnah9 C A 11: 65,986,140 (GRCm39) E1165* probably null Het
Dnmt3l T A 10: 77,892,665 (GRCm39) probably null Het
Elp2 A G 18: 24,739,960 (GRCm39) N62S possibly damaging Het
Entr1 T C 2: 26,275,559 (GRCm39) D244G probably damaging Het
Fam216b T A 14: 78,322,503 (GRCm39) H26L possibly damaging Het
Fbxw25 T A 9: 109,481,954 (GRCm39) Q244L possibly damaging Het
G530012D18Rik G C 1: 85,504,923 (GRCm39) probably benign Het
Gvin3 T C 7: 106,197,442 (GRCm39) noncoding transcript Het
Igf2r T C 17: 12,944,303 (GRCm39) Y400C probably damaging Het
Iqcc A G 4: 129,512,413 (GRCm39) F20L probably benign Het
Klhl5 T A 5: 65,298,625 (GRCm39) L135M possibly damaging Het
Klk1b16 A T 7: 43,790,412 (GRCm39) M196L possibly damaging Het
Ltf T C 9: 110,858,719 (GRCm39) M489T possibly damaging Het
Mctp2 G T 7: 71,863,835 (GRCm39) R343S possibly damaging Het
Nbas T A 12: 13,584,578 (GRCm39) probably null Het
Ncr1 A T 7: 4,343,932 (GRCm39) M177L probably benign Het
Net1 C T 13: 3,936,170 (GRCm39) E305K probably damaging Het
Nfx1 T C 4: 40,985,000 (GRCm39) F375L probably damaging Het
Notch3 T A 17: 32,358,163 (GRCm39) I1687L probably benign Het
Obsl1 A T 1: 75,479,905 (GRCm39) probably benign Het
Or2ag16 A T 7: 106,352,290 (GRCm39) F102I probably damaging Het
Or2t46 C G 11: 58,471,825 (GRCm39) L52V possibly damaging Het
Or51v14 G T 7: 103,260,797 (GRCm39) Y254* probably null Het
Or5g23 A G 2: 85,438,627 (GRCm39) F209S probably benign Het
Or5j3 G A 2: 86,128,561 (GRCm39) V134M possibly damaging Het
Or5p79 A C 7: 108,221,924 (GRCm39) I302L probably damaging Het
Orai1 A T 5: 123,167,564 (GRCm39) M246L probably benign Het
Pcdhga12 G A 18: 37,899,785 (GRCm39) A206T probably damaging Het
Plxdc2 C A 2: 16,654,998 (GRCm39) T199K probably damaging Het
Prkd1 T A 12: 50,389,920 (GRCm39) I819F probably damaging Het
Ptpn9 T C 9: 56,964,121 (GRCm39) probably benign Het
Rabl6 T C 2: 25,478,666 (GRCm39) E255G probably damaging Het
Sema3e T C 5: 14,286,099 (GRCm39) probably benign Het
Serpina3c T C 12: 104,115,699 (GRCm39) M282V possibly damaging Het
Slco1a7 A G 6: 141,686,193 (GRCm39) F216L probably benign Het
Slco2b1 A G 7: 99,335,132 (GRCm39) I216T probably damaging Het
Slco6b1 T C 1: 96,916,309 (GRCm39) noncoding transcript Het
Slco6d1 A T 1: 98,371,369 (GRCm39) I285F probably benign Het
Sp110 C G 1: 85,516,839 (GRCm39) E219D probably damaging Het
Sp9 C A 2: 73,104,641 (GRCm39) N398K probably damaging Het
Sycp2 A C 2: 178,019,495 (GRCm39) probably null Het
Tbc1d23 T C 16: 57,019,291 (GRCm39) D219G probably damaging Het
Tdpoz3 A G 3: 93,734,179 (GRCm39) R285G probably benign Het
Trim2 T A 3: 84,074,960 (GRCm39) Q694L probably null Het
Trim23 T A 13: 104,328,541 (GRCm39) V293D probably damaging Het
Ttn A G 2: 76,665,183 (GRCm39) probably benign Het
Vmn2r12 T A 5: 109,238,261 (GRCm39) Y493F probably benign Het
Vps41 T A 13: 19,046,708 (GRCm39) I753N probably damaging Het
Vps51 T G 19: 6,121,063 (GRCm39) E283D probably benign Het
Yme1l1 G A 2: 23,083,246 (GRCm39) G571R probably damaging Het
Other mutations in Zfp322a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02579:Zfp322a APN 13 23,541,613 (GRCm39) missense probably damaging 0.97
R1395:Zfp322a UTSW 13 23,540,945 (GRCm39) missense probably benign 0.01
R1975:Zfp322a UTSW 13 23,541,074 (GRCm39) missense probably damaging 1.00
R2100:Zfp322a UTSW 13 23,541,460 (GRCm39) missense possibly damaging 0.85
R2332:Zfp322a UTSW 13 23,541,494 (GRCm39) missense probably damaging 1.00
R2571:Zfp322a UTSW 13 23,540,614 (GRCm39) missense probably damaging 1.00
R4959:Zfp322a UTSW 13 23,541,052 (GRCm39) missense probably damaging 1.00
R5245:Zfp322a UTSW 13 23,541,156 (GRCm39) nonsense probably null
R5310:Zfp322a UTSW 13 23,541,532 (GRCm39) missense possibly damaging 0.90
R5525:Zfp322a UTSW 13 23,541,685 (GRCm39) missense probably benign
R5810:Zfp322a UTSW 13 23,541,579 (GRCm39) nonsense probably null
R7299:Zfp322a UTSW 13 23,541,314 (GRCm39) missense probably benign 0.22
R7299:Zfp322a UTSW 13 23,541,313 (GRCm39) missense probably damaging 0.97
R7301:Zfp322a UTSW 13 23,541,314 (GRCm39) missense probably benign 0.22
R7301:Zfp322a UTSW 13 23,541,313 (GRCm39) missense probably damaging 0.97
R8670:Zfp322a UTSW 13 23,541,274 (GRCm39) missense possibly damaging 0.83
R9108:Zfp322a UTSW 13 23,541,437 (GRCm39) missense probably benign 0.01
R9789:Zfp322a UTSW 13 23,540,558 (GRCm39) missense possibly damaging 0.83
Predicted Primers PCR Primer
(F):5'- GGAAGTCACTCTCACACATAGAC -3'
(R):5'- AGTGCCTTGAACGTGAACAA -3'

Sequencing Primer
(F):5'- AAGGTCTGATTTCTGGCCAAAGC -3'
(R):5'- GAAGAGCTTTTGGCACCACTTAGC -3'
Posted On 2016-08-04