Incidental Mutation 'R5376:Kif15'
ID 425566
Institutional Source Beutler Lab
Gene Symbol Kif15
Ensembl Gene ENSMUSG00000036768
Gene Name kinesin family member 15
Synonyms N-10 kinesin, 3930402I10Rik, 3110023M17Rik, HKLP2, Knsl7
MMRRC Submission 042952-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R5376 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 122780146-122847798 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 122823036 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Lysine at position 700 (N700K)
Ref Sequence ENSEMBL: ENSMUSP00000035490 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040717] [ENSMUST00000214652]
AlphaFold Q6P9L6
Predicted Effect probably benign
Transcript: ENSMUST00000040717
AA Change: N700K

PolyPhen 2 Score 0.041 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000035490
Gene: ENSMUSG00000036768
AA Change: N700K

DomainStartEndE-ValueType
KISc 24 371 2.86e-179 SMART
Pfam:Kinesin-relat_1 463 551 6.6e-26 PFAM
coiled coil region 579 643 N/A INTRINSIC
coiled coil region 706 1037 N/A INTRINSIC
coiled coil region 1065 1133 N/A INTRINSIC
Pfam:HMMR_C 1265 1387 3.5e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214183
Predicted Effect probably benign
Transcript: ENSMUST00000214652
AA Change: N472K

PolyPhen 2 Score 0.017 (Sensitivity: 0.95; Specificity: 0.80)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214880
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216491
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217243
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk G C 11: 119,902,860 (GRCm39) S512W probably damaging Het
Abcc2 A T 19: 43,818,339 (GRCm39) N1275I possibly damaging Het
Adgb T C 10: 10,222,307 (GRCm39) T1455A probably benign Het
Cnnm3 T A 1: 36,559,759 (GRCm39) L566H probably damaging Het
Coa8 A G 12: 111,696,492 (GRCm39) D142G probably damaging Het
Dennd4b C T 3: 90,185,363 (GRCm39) P1229L probably benign Het
Dsc1 T G 18: 20,221,503 (GRCm39) K657N probably benign Het
Dzip1 C T 14: 119,148,805 (GRCm39) M291I probably damaging Het
Eef1d G T 15: 75,775,038 (GRCm39) T207N probably benign Het
Eif4g1 T A 16: 20,502,577 (GRCm39) Y955N probably damaging Het
Evi5l T C 8: 4,260,770 (GRCm39) T1016A probably damaging Het
Fcrl6 G A 1: 172,426,847 (GRCm39) T33M probably damaging Het
Golga3 T C 5: 110,368,811 (GRCm39) probably null Het
Gpbp1 T C 13: 111,563,176 (GRCm39) N425D probably damaging Het
Igkv12-46 A C 6: 69,741,520 (GRCm39) W112G probably benign Het
Kdelr3 T A 15: 79,410,061 (GRCm39) V182E possibly damaging Het
Mycbp2 A T 14: 103,479,868 (GRCm39) L1169* probably null Het
Myof A G 19: 37,904,848 (GRCm39) Y905H probably damaging Het
Or10h1b A T 17: 33,395,621 (GRCm39) I82F probably damaging Het
Or52e5 A T 7: 104,719,564 (GRCm39) T297S probably damaging Het
Or5b113 A T 19: 13,342,762 (GRCm39) M257L possibly damaging Het
Otud7b T A 3: 96,060,841 (GRCm39) probably null Het
Pde4d T C 13: 109,909,178 (GRCm39) C197R probably benign Het
Pde8b T C 13: 95,162,654 (GRCm39) T823A probably benign Het
Plekha5 C T 6: 140,496,870 (GRCm39) T140M probably damaging Het
Plekhg2 G A 7: 28,062,094 (GRCm39) R594W probably damaging Het
Potefam1 T C 2: 111,045,944 (GRCm39) D286G probably benign Het
Ppp2r1b C T 9: 50,778,228 (GRCm39) A315V possibly damaging Het
Psg25 A T 7: 18,260,460 (GRCm39) I146N probably benign Het
Psg26 A T 7: 18,214,030 (GRCm39) S211T probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Sfi1 A ATCTTCCCAAAGCCAGTGT 11: 3,103,384 (GRCm39) probably benign Het
Slc5a9 A T 4: 111,750,414 (GRCm39) V148E possibly damaging Het
Spmip9 C A 6: 70,890,466 (GRCm39) A109S possibly damaging Het
Txndc15 T G 13: 55,866,032 (GRCm39) N165K probably damaging Het
Zfp493 T C 13: 67,934,437 (GRCm39) I130T possibly damaging Het
Other mutations in Kif15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01459:Kif15 APN 9 122,804,820 (GRCm39) missense probably damaging 1.00
IGL01577:Kif15 APN 9 122,825,399 (GRCm39) missense probably benign 0.06
IGL01647:Kif15 APN 9 122,792,536 (GRCm39) intron probably benign
IGL01921:Kif15 APN 9 122,808,569 (GRCm39) missense probably damaging 1.00
IGL02040:Kif15 APN 9 122,846,450 (GRCm39) missense probably damaging 0.99
IGL02191:Kif15 APN 9 122,804,744 (GRCm39) missense probably damaging 1.00
IGL02218:Kif15 APN 9 122,824,892 (GRCm39) splice site probably benign
IGL02537:Kif15 APN 9 122,822,914 (GRCm39) missense probably benign 0.08
IGL02814:Kif15 APN 9 122,832,705 (GRCm39) missense possibly damaging 0.83
PIT4480001:Kif15 UTSW 9 122,840,608 (GRCm39) missense probably benign
R0034:Kif15 UTSW 9 122,828,350 (GRCm39) missense possibly damaging 0.47
R0458:Kif15 UTSW 9 122,838,424 (GRCm39) missense probably benign
R0526:Kif15 UTSW 9 122,826,862 (GRCm39) missense probably damaging 0.96
R0533:Kif15 UTSW 9 122,838,498 (GRCm39) unclassified probably benign
R0726:Kif15 UTSW 9 122,788,993 (GRCm39) missense probably benign 0.21
R1580:Kif15 UTSW 9 122,789,021 (GRCm39) missense probably benign 0.22
R1597:Kif15 UTSW 9 122,823,074 (GRCm39) missense probably benign 0.22
R2096:Kif15 UTSW 9 122,815,252 (GRCm39) missense probably damaging 1.00
R3125:Kif15 UTSW 9 122,817,026 (GRCm39) missense probably damaging 0.99
R3176:Kif15 UTSW 9 122,816,905 (GRCm39) splice site probably benign
R4088:Kif15 UTSW 9 122,815,254 (GRCm39) missense probably benign 0.29
R4308:Kif15 UTSW 9 122,843,047 (GRCm39) missense probably benign 0.00
R4597:Kif15 UTSW 9 122,822,914 (GRCm39) missense probably benign 0.08
R4705:Kif15 UTSW 9 122,789,058 (GRCm39) splice site probably null
R4832:Kif15 UTSW 9 122,831,191 (GRCm39) splice site probably null
R5100:Kif15 UTSW 9 122,821,059 (GRCm39) missense probably damaging 0.98
R5126:Kif15 UTSW 9 122,804,823 (GRCm39) missense probably damaging 1.00
R5180:Kif15 UTSW 9 122,828,275 (GRCm39) missense probably damaging 0.99
R5247:Kif15 UTSW 9 122,815,507 (GRCm39) missense possibly damaging 0.65
R5392:Kif15 UTSW 9 122,825,360 (GRCm39) missense probably damaging 0.99
R5422:Kif15 UTSW 9 122,813,954 (GRCm39) splice site probably null
R5562:Kif15 UTSW 9 122,807,081 (GRCm39) missense probably damaging 1.00
R5663:Kif15 UTSW 9 122,820,916 (GRCm39) splice site probably null
R5767:Kif15 UTSW 9 122,843,039 (GRCm39) missense possibly damaging 0.78
R5927:Kif15 UTSW 9 122,846,326 (GRCm39) missense probably benign 0.00
R6049:Kif15 UTSW 9 122,840,687 (GRCm39) missense probably damaging 0.98
R6435:Kif15 UTSW 9 122,815,556 (GRCm39) missense probably damaging 1.00
R7040:Kif15 UTSW 9 122,840,679 (GRCm39) missense possibly damaging 0.67
R7158:Kif15 UTSW 9 122,828,379 (GRCm39) missense probably benign
R7163:Kif15 UTSW 9 122,846,722 (GRCm39) missense probably damaging 1.00
R7197:Kif15 UTSW 9 122,838,991 (GRCm39) critical splice donor site probably null
R7318:Kif15 UTSW 9 122,817,014 (GRCm39) missense probably damaging 1.00
R7360:Kif15 UTSW 9 122,820,202 (GRCm39) missense probably benign
R8039:Kif15 UTSW 9 122,836,490 (GRCm39) missense possibly damaging 0.82
R8228:Kif15 UTSW 9 122,821,041 (GRCm39) missense possibly damaging 0.82
R8549:Kif15 UTSW 9 122,815,236 (GRCm39) missense probably benign
R9001:Kif15 UTSW 9 122,826,855 (GRCm39) missense probably benign 0.00
R9031:Kif15 UTSW 9 122,846,492 (GRCm39) intron probably benign
R9044:Kif15 UTSW 9 122,840,781 (GRCm39) missense probably benign 0.01
R9063:Kif15 UTSW 9 122,833,706 (GRCm39) missense probably damaging 1.00
R9306:Kif15 UTSW 9 122,807,056 (GRCm39) missense probably damaging 1.00
R9490:Kif15 UTSW 9 122,788,203 (GRCm39) missense probably benign 0.10
R9554:Kif15 UTSW 9 122,828,585 (GRCm39) missense probably damaging 1.00
R9682:Kif15 UTSW 9 122,815,712 (GRCm39) missense probably damaging 0.98
R9752:Kif15 UTSW 9 122,824,890 (GRCm39) critical splice donor site probably null
Z1177:Kif15 UTSW 9 122,780,116 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- GAATACATCCTCTTGATAAACTGATGA -3'
(R):5'- CAGACAAGTCCAAAACCTTTATATACG -3'

Sequencing Primer
(F):5'- CACTCCAACCAAGGCTTAT -3'
(R):5'- GTCCAAAACCTTTATATACGCAAAC -3'
Posted On 2016-08-04