Incidental Mutation 'R5377:Olfr881'
ID 425623
Institutional Source Beutler Lab
Gene Symbol Olfr881
Ensembl Gene ENSMUSG00000060583
Gene Name olfactory receptor 881
Synonyms GA_x6K02T2PVTD-31676771-31677700, MOR162-7
MMRRC Submission 042845-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.071) question?
Stock # R5377 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 37991825-37996408 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 37992612 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 40 (Y40F)
Ref Sequence ENSEMBL: ENSMUSP00000074193 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000074611] [ENSMUST00000212489]
AlphaFold Q8VF63
Predicted Effect probably benign
Transcript: ENSMUST00000074611
AA Change: Y40F

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000074193
Gene: ENSMUSG00000060583
AA Change: Y40F

Pfam:7tm_4 36 311 4.6e-46 PFAM
Pfam:7tm_1 46 293 1.4e-24 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000212489
AA Change: Y35F

PolyPhen 2 Score 0.107 (Sensitivity: 0.93; Specificity: 0.86)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 62 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m G T 6: 121,645,253 (GRCm38) V372F probably benign Het
Adcy10 G A 1: 165,519,895 (GRCm38) C393Y probably damaging Het
Adgrg7 A C 16: 56,730,306 (GRCm38) I681S possibly damaging Het
Akap8l T C 17: 32,321,511 (GRCm38) probably benign Het
Akr1a1 A T 4: 116,639,895 (GRCm38) V156E probably damaging Het
Alk T G 17: 71,895,739 (GRCm38) D1167A probably damaging Het
Ankrd11 T C 8: 122,893,714 (GRCm38) probably null Het
Aspm A G 1: 139,470,395 (GRCm38) probably null Het
Aspm T A 1: 139,457,483 (GRCm38) N288K probably damaging Het
Asxl2 G A 12: 3,474,618 (GRCm38) probably null Het
Atp6v0a1 A G 11: 101,055,587 (GRCm38) H802R probably damaging Het
B4galnt1 A G 10: 127,171,822 (GRCm38) T531A possibly damaging Het
Ccdc114 C T 7: 45,942,082 (GRCm38) R257* probably null Het
Cecr2 A G 6: 120,756,569 (GRCm38) N506D possibly damaging Het
Crebrf T C 17: 26,759,865 (GRCm38) V509A probably damaging Het
Cyp4f40 A T 17: 32,675,616 (GRCm38) I413F probably null Het
Defb12 C A 8: 19,114,326 (GRCm38) probably null Het
Dnah2 T C 11: 69,421,848 (GRCm38) E4297G probably damaging Het
Dpysl5 A T 5: 30,791,513 (GRCm38) N371Y probably damaging Het
Eef1d G T 15: 75,903,189 (GRCm38) T207N probably benign Het
Esrrb C T 12: 86,519,009 (GRCm38) Q416* probably null Het
Exd2 T C 12: 80,489,448 (GRCm38) L284P probably damaging Het
Fat3 T A 9: 16,376,443 (GRCm38) I595F probably benign Het
Gm9920 A G 15: 55,108,975 (GRCm38) probably benign Het
Hephl1 T C 9: 15,069,788 (GRCm38) K783E probably damaging Het
Irs2 A G 8: 11,005,277 (GRCm38) S1052P probably benign Het
Kctd18 T C 1: 57,963,093 (GRCm38) I192V probably benign Het
Lama3 A G 18: 12,453,746 (GRCm38) D722G probably damaging Het
Lepr T C 4: 101,815,019 (GRCm38) V1080A possibly damaging Het
Lpin1 C T 12: 16,563,655 (GRCm38) G504S probably damaging Het
Lrit2 A C 14: 37,069,183 (GRCm38) Q273P possibly damaging Het
Mgea5 A T 19: 45,758,022 (GRCm38) Y779* probably null Het
Mlkl T A 8: 111,327,937 (GRCm38) E189D probably benign Het
Mttp C T 3: 138,105,029 (GRCm38) R608H probably benign Het
Nav2 T C 7: 49,589,160 (GRCm38) V2011A probably benign Het
Nos2 A T 11: 78,957,491 (GRCm38) I1075F probably benign Het
Npat A G 9: 53,550,036 (GRCm38) probably null Het
Nucks1 T C 1: 131,919,033 (GRCm38) F16L probably damaging Het
Nus1 T C 10: 52,429,213 (GRCm38) S150P possibly damaging Het
Olfr1230 G T 2: 89,297,162 (GRCm38) T36K probably damaging Het
Pclo A G 5: 14,681,353 (GRCm38) T3290A unknown Het
Pign A T 1: 105,657,812 (GRCm38) F4Y probably benign Het
Rfx4 A G 10: 84,860,542 (GRCm38) N233D possibly damaging Het
Rpgrip1 A T 14: 52,160,195 (GRCm38) M1325L possibly damaging Het
Rufy4 T C 1: 74,147,663 (GRCm38) C537R probably damaging Het
Scaf11 T A 15: 96,417,120 (GRCm38) H1227L possibly damaging Het
Sec31b G T 19: 44,518,637 (GRCm38) P840T probably damaging Het
Slc16a9 T A 10: 70,283,128 (GRCm38) L426I probably damaging Het
Slc17a2 T C 13: 23,812,592 (GRCm38) S27P probably damaging Het
Slc22a30 G A 19: 8,344,393 (GRCm38) Q436* probably null Het
Tacc1 A G 8: 25,182,283 (GRCm38) S310P possibly damaging Het
Tmem245 G A 4: 56,947,084 (GRCm38) R110C probably damaging Het
Trip12 T C 1: 84,757,431 (GRCm38) Y953C probably damaging Het
Trpm7 C A 2: 126,842,855 (GRCm38) probably null Het
Ush2a G A 1: 188,912,123 (GRCm38) V4561I probably benign Het
Vmn1r192 C T 13: 22,187,631 (GRCm38) V140I probably benign Het
Vmn2r66 A T 7: 85,006,818 (GRCm38) I330N probably damaging Het
Vmn2r99 T C 17: 19,379,269 (GRCm38) V405A probably damaging Het
Wdhd1 A C 14: 47,272,221 (GRCm38) V172G probably benign Het
Zfhx3 C T 8: 108,951,185 (GRCm38) R2956C possibly damaging Het
Zfp446 T C 7: 12,982,251 (GRCm38) L283P possibly damaging Het
Zfp82 T C 7: 30,057,166 (GRCm38) K164E probably damaging Het
Other mutations in Olfr881
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01882:Olfr881 APN 9 37,992,560 (GRCm38) missense probably damaging 1.00
IGL02282:Olfr881 APN 9 37,993,022 (GRCm38) missense probably damaging 0.98
IGL02714:Olfr881 APN 9 37,993,086 (GRCm38) missense possibly damaging 0.83
R0308:Olfr881 UTSW 9 37,992,845 (GRCm38) missense probably benign 0.01
R0486:Olfr881 UTSW 9 37,992,702 (GRCm38) missense possibly damaging 0.72
R0504:Olfr881 UTSW 9 37,993,142 (GRCm38) missense probably benign 0.05
R1939:Olfr881 UTSW 9 37,993,089 (GRCm38) missense probably benign 0.12
R4669:Olfr881 UTSW 9 37,993,085 (GRCm38) missense possibly damaging 0.83
R5468:Olfr881 UTSW 9 37,993,011 (GRCm38) missense probably damaging 1.00
R5601:Olfr881 UTSW 9 37,992,714 (GRCm38) missense possibly damaging 0.79
R6799:Olfr881 UTSW 9 37,993,182 (GRCm38) missense possibly damaging 0.79
R7212:Olfr881 UTSW 9 37,992,957 (GRCm38) missense possibly damaging 0.47
R7648:Olfr881 UTSW 9 37,992,560 (GRCm38) missense probably damaging 1.00
R8286:Olfr881 UTSW 9 37,993,105 (GRCm38) nonsense probably null
X0064:Olfr881 UTSW 9 37,993,340 (GRCm38) missense probably benign 0.07
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2016-08-04