Incidental Mutation 'R5392:Or6d15'
ID 425901
Institutional Source Beutler Lab
Gene Symbol Or6d15
Ensembl Gene ENSMUSG00000050654
Gene Name olfactory receptor family 6 subfamily D member 15
Synonyms GA_x54KRFPKN04-58217732-58216800, MOR119-2, Olfr215
MMRRC Submission 042964-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R5392 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 116558973-116559905 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 116559379 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 176 (F176S)
Ref Sequence ENSEMBL: ENSMUSP00000052425 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061723]
AlphaFold Q8VF82
Predicted Effect probably damaging
Transcript: ENSMUST00000061723
AA Change: F176S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000052425
Gene: ENSMUSG00000050654
AA Change: F176S

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 5e-47 PFAM
Pfam:7TM_GPCR_Srsx 33 258 1.8e-5 PFAM
Pfam:7tm_1 39 288 2.9e-15 PFAM
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acoxl T C 2: 127,852,088 (GRCm39) probably null Het
Acyp1 T C 12: 85,325,759 (GRCm39) probably benign Het
Ces1b G A 8: 93,798,590 (GRCm39) R199C probably damaging Het
Col6a3 C A 1: 90,729,017 (GRCm39) R1308L probably benign Het
Cpa5 C T 6: 30,630,829 (GRCm39) Q364* probably null Het
Cyth4 T A 15: 78,491,185 (GRCm39) L88Q probably damaging Het
Dock7 A G 4: 98,896,243 (GRCm39) V59A probably damaging Het
Drd2 A G 9: 49,306,928 (GRCm39) N5D possibly damaging Het
Epsti1 T C 14: 78,224,184 (GRCm39) I272T probably benign Het
Fndc3b A T 3: 27,519,936 (GRCm39) C568* probably null Het
Frmd4a C T 2: 4,599,384 (GRCm39) A161V probably damaging Het
Gfpt1 A G 6: 87,054,139 (GRCm39) T465A probably damaging Het
Hecw1 C A 13: 14,420,347 (GRCm39) Q1025H probably damaging Het
Irak4 A T 15: 94,454,565 (GRCm39) M237L probably benign Het
Irak4 T C 15: 94,454,566 (GRCm39) M237T probably benign Het
Kdsr T A 1: 106,680,971 (GRCm39) I76F possibly damaging Het
Kif15 T C 9: 122,825,360 (GRCm39) F533S probably damaging Het
Kmt5b T C 19: 3,852,127 (GRCm39) F103L possibly damaging Het
Krtcap2 C T 3: 89,154,186 (GRCm39) L36F probably benign Het
Mroh7 A G 4: 106,568,448 (GRCm39) probably null Het
Mta1 T C 12: 113,096,856 (GRCm39) V559A probably benign Het
N4bp1 A G 8: 87,587,048 (GRCm39) probably null Het
Oas1d T C 5: 121,055,003 (GRCm39) S192P possibly damaging Het
Or1n1b T A 2: 36,780,686 (GRCm39) Y58F probably benign Het
Or6c76 A G 10: 129,612,184 (GRCm39) I149V probably benign Het
Rabgap1 T A 2: 37,359,501 (GRCm39) N21K probably damaging Het
Rad9b A T 5: 122,489,641 (GRCm39) C25S probably damaging Het
Spg7 T C 8: 123,814,102 (GRCm39) S454P probably damaging Het
Spink2 T A 5: 77,354,872 (GRCm39) H40L probably benign Het
Syne1 T A 10: 5,298,661 (GRCm39) D1082V probably damaging Het
Syt2 A G 1: 134,671,759 (GRCm39) D179G probably damaging Het
Tm7sf2 T C 19: 6,113,998 (GRCm39) D181G probably damaging Het
Vmn1r174 A G 7: 23,454,227 (GRCm39) I298V unknown Het
Vmn2r23 A T 6: 123,681,323 (GRCm39) H77L probably benign Het
Vps51 T G 19: 6,121,063 (GRCm39) E283D probably benign Het
Vps9d1 T C 8: 123,980,752 (GRCm39) E25G probably damaging Het
Zfp119a T C 17: 56,173,328 (GRCm39) R172G probably benign Het
Zfp51 A T 17: 21,685,584 (GRCm39) Y733F possibly damaging Het
Zfp658 A C 7: 43,222,355 (GRCm39) E210A probably benign Het
Zp2 C A 7: 119,734,987 (GRCm39) E433* probably null Het
Other mutations in Or6d15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01666:Or6d15 APN 6 116,559,296 (GRCm39) missense possibly damaging 0.93
IGL02959:Or6d15 APN 6 116,559,505 (GRCm39) missense probably damaging 1.00
IGL03053:Or6d15 APN 6 116,559,206 (GRCm39) missense possibly damaging 0.50
R0078:Or6d15 UTSW 6 116,559,701 (GRCm39) missense probably damaging 0.96
R0277:Or6d15 UTSW 6 116,559,562 (GRCm39) missense probably damaging 0.99
R0323:Or6d15 UTSW 6 116,559,562 (GRCm39) missense probably damaging 0.99
R0399:Or6d15 UTSW 6 116,559,742 (GRCm39) missense probably benign 0.00
R0545:Or6d15 UTSW 6 116,559,617 (GRCm39) missense probably benign 0.01
R1213:Or6d15 UTSW 6 116,559,827 (GRCm39) missense probably benign 0.00
R1775:Or6d15 UTSW 6 116,559,925 (GRCm39) start gained probably benign
R1789:Or6d15 UTSW 6 116,559,658 (GRCm39) missense probably damaging 1.00
R4724:Or6d15 UTSW 6 116,559,898 (GRCm39) missense probably damaging 1.00
R5391:Or6d15 UTSW 6 116,559,808 (GRCm39) missense probably damaging 1.00
R5686:Or6d15 UTSW 6 116,559,890 (GRCm39) missense probably benign 0.00
R6124:Or6d15 UTSW 6 116,559,446 (GRCm39) missense probably benign 0.05
R7080:Or6d15 UTSW 6 116,559,314 (GRCm39) missense probably damaging 1.00
R7355:Or6d15 UTSW 6 116,559,916 (GRCm39) start gained probably benign
R9084:Or6d15 UTSW 6 116,559,232 (GRCm39) missense probably benign 0.03
Z1177:Or6d15 UTSW 6 116,559,514 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- ACAGCTGCCATACATCAGAGAG -3'
(R):5'- GGTGTGTAGCTATTTGCAAGCC -3'

Sequencing Primer
(F):5'- CAGGTGGAAAAAGCTCTCTGTCTC -3'
(R):5'- GTGTAGCTATTTGCAAGCCTCTGC -3'
Posted On 2016-08-04