Incidental Mutation 'R5392:Olfr809'
ID425915
Institutional Source Beutler Lab
Gene Symbol Olfr809
Ensembl Gene ENSMUSG00000050251
Gene Nameolfactory receptor 809
SynonymsMOR108-4, GA_x6K02T2PULF-11454600-11455541
MMRRC Submission 042964-MU
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.112) question?
Stock #R5392 (G1)
Quality Score225
Status Not validated
Chromosome10
Chromosomal Location129774638-129778937 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to G at 129776315 bp
ZygosityHeterozygous
Amino Acid Change Isoleucine to Valine at position 149 (I149V)
Ref Sequence ENSEMBL: ENSMUSP00000151711 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000059891] [ENSMUST00000203236] [ENSMUST00000203598] [ENSMUST00000204622] [ENSMUST00000218237]
Predicted Effect probably benign
Transcript: ENSMUST00000059891
AA Change: I134V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000054949
Gene: ENSMUSG00000050251
AA Change: I134V

DomainStartEndE-ValueType
Pfam:7tm_4 44 321 3.5e-49 PFAM
Pfam:7tm_1 54 303 1.3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203236
SMART Domains Protein: ENSMUSP00000145315
Gene: ENSMUSG00000049894

DomainStartEndE-ValueType
Pfam:7tm_4 29 308 1.8e-53 PFAM
Pfam:7tm_1 39 288 7.7e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000203598
AA Change: I134V

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000145037
Gene: ENSMUSG00000050251
AA Change: I134V

DomainStartEndE-ValueType
Pfam:7tm_4 29 148 8.1e-20 PFAM
Pfam:7tm_1 39 149 1.8e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204622
AA Change: I149V
SMART Domains Protein: ENSMUSP00000145260
Gene: ENSMUSG00000052818
AA Change: I149V

DomainStartEndE-ValueType
Pfam:7tm_4 44 321 3.5e-49 PFAM
Pfam:7tm_1 54 303 1.3e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000218237
AA Change: I149V

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.4%
  • 20x: 95.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acoxl T C 2: 128,010,168 probably null Het
Acyp1 T C 12: 85,278,985 probably benign Het
Ces1b G A 8: 93,071,962 R199C probably damaging Het
Col6a3 C A 1: 90,801,295 R1308L probably benign Het
Cpa5 C T 6: 30,630,830 Q364* probably null Het
Cyth4 T A 15: 78,606,985 L88Q probably damaging Het
Dock7 A G 4: 99,008,006 V59A probably damaging Het
Drd2 A G 9: 49,395,628 N5D possibly damaging Het
Epsti1 T C 14: 77,986,744 I272T probably benign Het
Fndc3b A T 3: 27,465,787 C568* probably null Het
Frmd4a C T 2: 4,594,573 A161V probably damaging Het
Gfpt1 A G 6: 87,077,157 T465A probably damaging Het
Hecw1 C A 13: 14,245,762 Q1025H probably damaging Het
Irak4 A T 15: 94,556,684 M237L probably benign Het
Irak4 T C 15: 94,556,685 M237T probably benign Het
Kdsr T A 1: 106,753,241 I76F possibly damaging Het
Kif15 T C 9: 122,996,295 F533S probably damaging Het
Kmt5b T C 19: 3,802,127 F103L possibly damaging Het
Krtcap2 C T 3: 89,246,879 L36F probably benign Het
Mroh7 A G 4: 106,711,251 probably null Het
Mta1 T C 12: 113,133,236 V559A probably benign Het
N4bp1 A G 8: 86,860,420 probably null Het
Oas1d T C 5: 120,916,940 S192P possibly damaging Het
Olfr215 A G 6: 116,582,418 F176S probably damaging Het
Olfr353 T A 2: 36,890,674 Y58F probably benign Het
Rabgap1 T A 2: 37,469,489 N21K probably damaging Het
Rad9b A T 5: 122,351,578 C25S probably damaging Het
Spg7 T C 8: 123,087,363 S454P probably damaging Het
Spink2 T A 5: 77,207,025 H40L probably benign Het
Syne1 T A 10: 5,348,661 D1082V probably damaging Het
Syt2 A G 1: 134,744,021 D179G probably damaging Het
Tm7sf2 T C 19: 6,063,968 D181G probably damaging Het
Vmn1r174 A G 7: 23,754,802 I298V unknown Het
Vmn2r23 A T 6: 123,704,364 H77L probably benign Het
Vps51 T G 19: 6,071,033 E283D probably benign Het
Vps9d1 T C 8: 123,254,013 E25G probably damaging Het
Zfp119a T C 17: 55,866,328 R172G probably benign Het
Zfp51 A T 17: 21,465,322 Y733F possibly damaging Het
Zfp658 A C 7: 43,572,931 E210A probably benign Het
Zp2 C A 7: 120,135,764 E433* probably null Het
Other mutations in Olfr809
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01884:Olfr809 APN 10 129776828 missense probably benign 0.34
IGL02000:Olfr809 APN 10 129776069 missense probably benign 0.03
IGL02146:Olfr809 APN 10 129776858 utr 3 prime probably benign
IGL03087:Olfr809 APN 10 129776261 missense probably damaging 0.98
IGL03260:Olfr809 APN 10 129776652 missense probably damaging 1.00
PIT4466001:Olfr809 UTSW 10 129776273 missense probably benign 0.04
R0564:Olfr809 UTSW 10 129776136 missense probably damaging 1.00
R0613:Olfr809 UTSW 10 129776262 missense probably damaging 1.00
R1165:Olfr809 UTSW 10 129776433 missense probably damaging 0.99
R1556:Olfr809 UTSW 10 129776373 missense probably benign 0.05
R6665:Olfr809 UTSW 10 129776247 missense probably damaging 1.00
R7519:Olfr809 UTSW 10 129776222 missense probably benign 0.01
R7804:Olfr809 UTSW 10 129776222 missense probably benign 0.01
R8022:Olfr809 UTSW 10 129776785 missense possibly damaging 0.47
R8301:Olfr809 UTSW 10 129776840 missense probably benign 0.06
R8447:Olfr809 UTSW 10 129776502 missense possibly damaging 0.89
Z1176:Olfr809 UTSW 10 129776042 missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGACACCCATGTATTTCTTCCTCAG -3'
(R):5'- CTCCAAGGTGCTTGTGTCTG -3'

Sequencing Primer
(F):5'- CATTTACTTCTGTCTGTAATCCTAGG -3'
(R):5'- CAAGGTGCTTGTGTCTGTGCAG -3'
Posted On2016-08-04