Incidental Mutation 'R0492:Vps8'
| ID |
42592 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vps8
|
| Ensembl Gene |
ENSMUSG00000033653 |
| Gene Name |
VPS8 CORVET complex subunit |
| Synonyms |
|
| MMRRC Submission |
038690-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0492 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
21241868-21463430 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 21261107 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 82
(F82L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000112636
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096191]
[ENSMUST00000096192]
[ENSMUST00000115397]
[ENSMUST00000117598]
[ENSMUST00000118923]
[ENSMUST00000122235]
|
| AlphaFold |
Q0P5W1 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000096191
AA Change: F82L
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000093905
Gene: ENSMUSG00000033653
AA Change: F82L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
7e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.7e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
Blast:RING
|
1257 |
1277 |
1e-5 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000096192
AA Change: F82L
PolyPhen 2
Score 0.054 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000093906
Gene: ENSMUSG00000033653
AA Change: F82L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
1e-8 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.4e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000115397
AA Change: F82L
PolyPhen 2
Score 0.141 (Sensitivity: 0.92; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000111055
Gene: ENSMUSG00000033653
AA Change: F82L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
8e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
613 |
796 |
1.3e-61 |
PFAM |
|
low complexity region
|
994 |
1009 |
N/A |
INTRINSIC |
|
low complexity region
|
1087 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1128 |
1139 |
N/A |
INTRINSIC |
|
RING
|
1259 |
1310 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000117598
AA Change: F82L
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000112937
Gene: ENSMUSG00000033653
AA Change: F82L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
296 |
1e-8 |
SMART |
|
Blast:WD40
|
184 |
225 |
8e-22 |
BLAST |
|
Blast:WD40
|
228 |
268 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
610 |
794 |
1.9e-61 |
PFAM |
|
low complexity region
|
992 |
1007 |
N/A |
INTRINSIC |
|
low complexity region
|
1085 |
1097 |
N/A |
INTRINSIC |
|
low complexity region
|
1126 |
1137 |
N/A |
INTRINSIC |
|
RING
|
1257 |
1308 |
1.23e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000118923
AA Change: F82L
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000112636
Gene: ENSMUSG00000033653
AA Change: F82L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
SCOP:d1g72a_
|
158 |
298 |
9e-9 |
SMART |
|
Blast:WD40
|
186 |
227 |
8e-22 |
BLAST |
|
Blast:WD40
|
230 |
270 |
5e-20 |
BLAST |
|
Pfam:Vps8
|
612 |
796 |
1.9e-61 |
PFAM |
|
low complexity region
|
969 |
979 |
N/A |
INTRINSIC |
|
low complexity region
|
1057 |
1069 |
N/A |
INTRINSIC |
|
low complexity region
|
1098 |
1109 |
N/A |
INTRINSIC |
|
RING
|
1229 |
1280 |
1.23e-4 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000122235
AA Change: F82L
|
| SMART Domains |
Protein: ENSMUSP00000112622
Gene: ENSMUSG00000033653
AA Change: F82L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
96 |
112 |
N/A |
INTRINSIC |
|
WD40
|
184 |
225 |
2.66e0 |
SMART |
|
WD40
|
228 |
269 |
5.5e1 |
SMART |
|
low complexity region
|
371 |
386 |
N/A |
INTRINSIC |
|
low complexity region
|
480 |
491 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.7%
- 20x: 93.7%
|
| Validation Efficiency |
99% (99/100) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrb2 |
C |
G |
4: 129,901,624 (GRCm39) |
P416R |
probably damaging |
Het |
| Adgre1 |
A |
G |
17: 57,709,742 (GRCm39) |
D133G |
unknown |
Het |
| Alpl |
A |
C |
4: 137,476,887 (GRCm39) |
|
probably null |
Het |
| Ankrd65 |
T |
C |
4: 155,875,133 (GRCm39) |
|
probably benign |
Het |
| Baalc |
A |
T |
15: 38,797,480 (GRCm39) |
|
probably benign |
Het |
| Bpifb5 |
A |
G |
2: 154,070,820 (GRCm39) |
T204A |
probably benign |
Het |
| Bud31 |
A |
G |
5: 145,083,265 (GRCm39) |
Y77C |
probably damaging |
Het |
| Calhm6 |
G |
A |
10: 34,003,647 (GRCm39) |
R87* |
probably null |
Het |
| Capsl |
A |
G |
15: 9,461,930 (GRCm39) |
|
probably benign |
Het |
| Ccna1 |
A |
G |
3: 54,956,004 (GRCm39) |
V116A |
probably damaging |
Het |
| Cdc42bpa |
C |
A |
1: 179,928,755 (GRCm39) |
H723N |
probably benign |
Het |
| Cfap161 |
T |
C |
7: 83,443,245 (GRCm39) |
I40V |
possibly damaging |
Het |
| CK137956 |
C |
T |
4: 127,845,093 (GRCm39) |
V217I |
probably benign |
Het |
| Cog5 |
A |
G |
12: 31,919,460 (GRCm39) |
T540A |
probably damaging |
Het |
| Cps1 |
T |
C |
1: 67,196,995 (GRCm39) |
W349R |
probably damaging |
Het |
| Crispld2 |
G |
T |
8: 120,752,806 (GRCm39) |
V285L |
probably benign |
Het |
| Crtc2 |
T |
A |
3: 90,170,804 (GRCm39) |
F626I |
probably damaging |
Het |
| Daam1 |
G |
A |
12: 71,991,154 (GRCm39) |
R256H |
unknown |
Het |
| Dhx38 |
G |
T |
8: 110,288,576 (GRCm39) |
|
probably benign |
Het |
| Dok4 |
G |
A |
8: 95,591,764 (GRCm39) |
A324V |
probably benign |
Het |
| Dscam |
T |
C |
16: 96,626,982 (GRCm39) |
|
probably null |
Het |
| Dusp16 |
A |
T |
6: 134,695,365 (GRCm39) |
S489T |
probably benign |
Het |
| Ecpas |
A |
G |
4: 58,864,418 (GRCm39) |
W288R |
probably damaging |
Het |
| Erbin |
A |
T |
13: 103,970,866 (GRCm39) |
Y917N |
probably damaging |
Het |
| F13b |
A |
T |
1: 139,450,297 (GRCm39) |
|
probably null |
Het |
| Fdx1 |
C |
A |
9: 51,874,725 (GRCm39) |
A15S |
probably benign |
Het |
| Ffar4 |
A |
T |
19: 38,085,630 (GRCm39) |
Q19L |
probably benign |
Het |
| Folh1 |
A |
C |
7: 86,395,400 (GRCm39) |
V344G |
probably damaging |
Het |
| Fscb |
T |
A |
12: 64,520,292 (GRCm39) |
E391D |
possibly damaging |
Het |
| Gigyf2 |
G |
A |
1: 87,368,568 (GRCm39) |
G1083R |
probably damaging |
Het |
| Gm14403 |
C |
A |
2: 177,200,359 (GRCm39) |
H102N |
probably benign |
Het |
| Gm4847 |
A |
G |
1: 166,457,961 (GRCm39) |
F464S |
probably damaging |
Het |
| Gpam |
A |
T |
19: 55,084,611 (GRCm39) |
M56K |
possibly damaging |
Het |
| Gpr165 |
T |
A |
X: 95,760,778 (GRCm39) |
F352I |
probably damaging |
Het |
| Grik2 |
T |
G |
10: 48,977,260 (GRCm39) |
I891L |
probably damaging |
Het |
| Gsr |
T |
C |
8: 34,171,603 (GRCm39) |
|
probably benign |
Het |
| Hhla1 |
A |
G |
15: 65,808,140 (GRCm39) |
F302L |
probably benign |
Het |
| Impg1 |
T |
C |
9: 80,252,590 (GRCm39) |
D453G |
possibly damaging |
Het |
| Inpp5d |
T |
A |
1: 87,625,872 (GRCm39) |
V495E |
possibly damaging |
Het |
| Iqca1l |
A |
T |
5: 24,759,626 (GRCm39) |
L48Q |
probably damaging |
Het |
| Iqce |
A |
T |
5: 140,660,990 (GRCm39) |
L450H |
probably damaging |
Het |
| Itfg2 |
A |
G |
6: 128,390,486 (GRCm39) |
|
probably null |
Het |
| Kif13a |
A |
G |
13: 46,966,218 (GRCm39) |
V400A |
possibly damaging |
Het |
| Kif7 |
T |
C |
7: 79,363,629 (GRCm39) |
Y93C |
probably damaging |
Het |
| Krt33a |
A |
G |
11: 99,906,909 (GRCm39) |
V22A |
probably benign |
Het |
| Lct |
T |
C |
1: 128,228,319 (GRCm39) |
D1058G |
probably damaging |
Het |
| Lrp6 |
G |
T |
6: 134,457,481 (GRCm39) |
D774E |
possibly damaging |
Het |
| Lrrc9 |
T |
A |
12: 72,525,537 (GRCm39) |
S828R |
possibly damaging |
Het |
| Ly75 |
A |
G |
2: 60,138,620 (GRCm39) |
W1416R |
probably damaging |
Het |
| Mdh2 |
T |
C |
5: 135,819,004 (GRCm39) |
I320T |
possibly damaging |
Het |
| Med13l |
T |
A |
5: 118,876,560 (GRCm39) |
V912E |
probably damaging |
Het |
| Mgarp |
T |
C |
3: 51,296,456 (GRCm39) |
D182G |
possibly damaging |
Het |
| Mllt10 |
T |
C |
2: 18,151,698 (GRCm39) |
|
probably benign |
Het |
| Mmp28 |
G |
A |
11: 83,334,629 (GRCm39) |
A375V |
probably damaging |
Het |
| Mrps23 |
T |
A |
11: 88,101,511 (GRCm39) |
H133Q |
probably benign |
Het |
| Msh6 |
T |
C |
17: 88,282,679 (GRCm39) |
S35P |
probably benign |
Het |
| Myo3a |
A |
G |
2: 22,328,447 (GRCm39) |
D347G |
possibly damaging |
Het |
| Npc1l1 |
T |
C |
11: 6,173,040 (GRCm39) |
K800E |
possibly damaging |
Het |
| Or2ag13 |
A |
T |
7: 106,473,084 (GRCm39) |
Y123N |
probably damaging |
Het |
| Or51ai2 |
T |
C |
7: 103,586,971 (GRCm39) |
I128T |
probably benign |
Het |
| Or5i1 |
T |
G |
2: 87,613,166 (GRCm39) |
I94S |
probably damaging |
Het |
| Or5m9 |
T |
C |
2: 85,876,931 (GRCm39) |
V35A |
probably benign |
Het |
| Or5m9 |
T |
C |
2: 85,877,278 (GRCm39) |
F151L |
possibly damaging |
Het |
| Or5t7 |
G |
A |
2: 86,506,834 (GRCm39) |
P281L |
probably damaging |
Het |
| Or6p1 |
T |
A |
1: 174,258,129 (GRCm39) |
I45N |
possibly damaging |
Het |
| Osmr |
A |
C |
15: 6,853,999 (GRCm39) |
W570G |
probably damaging |
Het |
| Otol1 |
A |
T |
3: 69,935,117 (GRCm39) |
I370F |
probably damaging |
Het |
| Pank2 |
A |
G |
2: 131,122,180 (GRCm39) |
Y235C |
probably damaging |
Het |
| Pias2 |
T |
C |
18: 77,193,581 (GRCm39) |
S187P |
probably damaging |
Het |
| Pkhd1l1 |
A |
G |
15: 44,383,086 (GRCm39) |
N1115S |
probably benign |
Het |
| Pld1 |
G |
T |
3: 28,163,966 (GRCm39) |
A800S |
probably damaging |
Het |
| Prex2 |
T |
C |
1: 11,256,857 (GRCm39) |
|
probably benign |
Het |
| Ptpn3 |
T |
C |
4: 57,194,304 (GRCm39) |
Q908R |
probably benign |
Het |
| Rab3gap2 |
T |
A |
1: 184,984,589 (GRCm39) |
|
probably benign |
Het |
| Rbm24 |
A |
T |
13: 46,573,826 (GRCm39) |
N82Y |
probably damaging |
Het |
| Rpl27 |
T |
C |
11: 101,336,081 (GRCm39) |
V47A |
possibly damaging |
Het |
| Serpina1f |
A |
G |
12: 103,659,826 (GRCm39) |
V152A |
possibly damaging |
Het |
| Serpina5 |
A |
G |
12: 104,068,392 (GRCm39) |
Y151C |
probably damaging |
Het |
| Serpinb7 |
A |
G |
1: 107,379,737 (GRCm39) |
*381W |
probably null |
Het |
| Sh2b2 |
A |
G |
5: 136,261,117 (GRCm39) |
F33S |
probably damaging |
Het |
| Slc22a2 |
A |
C |
17: 12,834,159 (GRCm39) |
I476L |
probably benign |
Het |
| Slc6a12 |
A |
T |
6: 121,332,331 (GRCm39) |
I222F |
probably benign |
Het |
| Smim26 |
G |
A |
2: 144,437,033 (GRCm39) |
D61N |
probably damaging |
Het |
| Soat1 |
A |
T |
1: 156,268,924 (GRCm39) |
Y209N |
probably benign |
Het |
| Sorl1 |
T |
C |
9: 41,902,667 (GRCm39) |
H1630R |
probably null |
Het |
| Sptlc2 |
A |
T |
12: 87,393,580 (GRCm39) |
|
probably null |
Het |
| Strn3 |
G |
A |
12: 51,657,187 (GRCm39) |
T642I |
probably damaging |
Het |
| Syce1l |
T |
A |
8: 114,380,700 (GRCm39) |
D137E |
possibly damaging |
Het |
| Syne2 |
T |
C |
12: 76,028,837 (GRCm39) |
|
probably null |
Het |
| Tcf25 |
C |
A |
8: 124,108,203 (GRCm39) |
P86Q |
probably benign |
Het |
| Tmem19 |
A |
T |
10: 115,197,715 (GRCm39) |
Y43* |
probably null |
Het |
| Tmem30b |
T |
C |
12: 73,592,942 (GRCm39) |
N58D |
probably benign |
Het |
| Tnn |
A |
C |
1: 159,948,327 (GRCm39) |
I795M |
probably damaging |
Het |
| Tnpo1 |
A |
G |
13: 98,991,954 (GRCm39) |
Y641H |
probably damaging |
Het |
| Tra2a |
A |
T |
6: 49,227,889 (GRCm39) |
|
probably benign |
Het |
| Trappc8 |
A |
T |
18: 20,999,243 (GRCm39) |
F295I |
probably benign |
Het |
| Vmn2r101 |
T |
A |
17: 19,809,245 (GRCm39) |
W125R |
probably damaging |
Het |
| Ythdf2 |
A |
T |
4: 131,931,779 (GRCm39) |
S460R |
probably damaging |
Het |
|
| Other mutations in Vps8 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00500:Vps8
|
APN |
16 |
21,261,084 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL00596:Vps8
|
APN |
16 |
21,267,162 (GRCm39) |
splice site |
probably benign |
|
|
IGL00985:Vps8
|
APN |
16 |
21,296,334 (GRCm39) |
splice site |
probably benign |
|
|
IGL01356:Vps8
|
APN |
16 |
21,336,107 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01375:Vps8
|
APN |
16 |
21,378,122 (GRCm39) |
nonsense |
probably null |
|
|
IGL01643:Vps8
|
APN |
16 |
21,336,972 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02159:Vps8
|
APN |
16 |
21,285,234 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02214:Vps8
|
APN |
16 |
21,336,035 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02465:Vps8
|
APN |
16 |
21,340,653 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02651:Vps8
|
APN |
16 |
21,336,086 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03174:Vps8
|
APN |
16 |
21,285,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03337:Vps8
|
APN |
16 |
21,381,918 (GRCm39) |
missense |
probably benign |
|
|
IGL03383:Vps8
|
APN |
16 |
21,254,573 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03402:Vps8
|
APN |
16 |
21,267,148 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
empires
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
porky
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
realm
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
realms
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
Reich
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
reichen
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
IGL03052:Vps8
|
UTSW |
16 |
21,267,115 (GRCm39) |
missense |
probably damaging |
0.99 |
|
PIT4677001:Vps8
|
UTSW |
16 |
21,319,084 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0066:Vps8
|
UTSW |
16 |
21,296,273 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R0125:Vps8
|
UTSW |
16 |
21,288,904 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0137:Vps8
|
UTSW |
16 |
21,323,136 (GRCm39) |
splice site |
probably benign |
|
|
R0362:Vps8
|
UTSW |
16 |
21,426,977 (GRCm39) |
intron |
probably benign |
|
|
R0384:Vps8
|
UTSW |
16 |
21,325,575 (GRCm39) |
splice site |
probably benign |
|
|
R0525:Vps8
|
UTSW |
16 |
21,358,859 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0531:Vps8
|
UTSW |
16 |
21,278,561 (GRCm39) |
intron |
probably benign |
|
|
R0605:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0636:Vps8
|
UTSW |
16 |
21,253,683 (GRCm39) |
missense |
probably benign |
0.32 |
|
R0707:Vps8
|
UTSW |
16 |
21,261,107 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0840:Vps8
|
UTSW |
16 |
21,275,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1170:Vps8
|
UTSW |
16 |
21,278,570 (GRCm39) |
intron |
probably benign |
|
|
R1203:Vps8
|
UTSW |
16 |
21,330,307 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1482:Vps8
|
UTSW |
16 |
21,400,348 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1531:Vps8
|
UTSW |
16 |
21,285,226 (GRCm39) |
nonsense |
probably null |
|
|
R1642:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R1956:Vps8
|
UTSW |
16 |
21,279,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2201:Vps8
|
UTSW |
16 |
21,395,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2287:Vps8
|
UTSW |
16 |
21,387,163 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2423:Vps8
|
UTSW |
16 |
21,378,087 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3151:Vps8
|
UTSW |
16 |
21,261,123 (GRCm39) |
missense |
probably benign |
0.04 |
|
R3943:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Vps8
|
UTSW |
16 |
21,288,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4043:Vps8
|
UTSW |
16 |
21,345,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4302:Vps8
|
UTSW |
16 |
21,314,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4398:Vps8
|
UTSW |
16 |
21,323,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4477:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4478:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4479:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4480:Vps8
|
UTSW |
16 |
21,363,986 (GRCm39) |
intron |
probably benign |
|
|
R4571:Vps8
|
UTSW |
16 |
21,254,525 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4653:Vps8
|
UTSW |
16 |
21,318,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Vps8
|
UTSW |
16 |
21,262,938 (GRCm39) |
splice site |
probably null |
|
|
R4713:Vps8
|
UTSW |
16 |
21,261,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4726:Vps8
|
UTSW |
16 |
21,267,154 (GRCm39) |
splice site |
probably null |
|
|
R4959:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4973:Vps8
|
UTSW |
16 |
21,278,536 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4975:Vps8
|
UTSW |
16 |
21,285,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4992:Vps8
|
UTSW |
16 |
21,280,158 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5144:Vps8
|
UTSW |
16 |
21,378,103 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5168:Vps8
|
UTSW |
16 |
21,351,849 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5168:Vps8
|
UTSW |
16 |
21,276,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5222:Vps8
|
UTSW |
16 |
21,400,298 (GRCm39) |
nonsense |
probably null |
|
|
R5231:Vps8
|
UTSW |
16 |
21,395,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5876:Vps8
|
UTSW |
16 |
21,280,189 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5963:Vps8
|
UTSW |
16 |
21,288,871 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6010:Vps8
|
UTSW |
16 |
21,363,955 (GRCm39) |
intron |
probably benign |
|
|
R6023:Vps8
|
UTSW |
16 |
21,279,988 (GRCm39) |
missense |
probably benign |
0.32 |
|
R6173:Vps8
|
UTSW |
16 |
21,314,682 (GRCm39) |
splice site |
probably null |
|
|
R6185:Vps8
|
UTSW |
16 |
21,288,891 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6264:Vps8
|
UTSW |
16 |
21,378,099 (GRCm39) |
nonsense |
probably null |
|
|
R6409:Vps8
|
UTSW |
16 |
21,297,189 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6522:Vps8
|
UTSW |
16 |
21,261,129 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6528:Vps8
|
UTSW |
16 |
21,372,875 (GRCm39) |
nonsense |
probably null |
|
|
R6784:Vps8
|
UTSW |
16 |
21,381,957 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7040:Vps8
|
UTSW |
16 |
21,393,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Vps8
|
UTSW |
16 |
21,400,329 (GRCm39) |
missense |
probably benign |
|
|
R7103:Vps8
|
UTSW |
16 |
21,345,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7149:Vps8
|
UTSW |
16 |
21,278,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7195:Vps8
|
UTSW |
16 |
21,275,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7206:Vps8
|
UTSW |
16 |
21,276,171 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7403:Vps8
|
UTSW |
16 |
21,253,722 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R7782:Vps8
|
UTSW |
16 |
21,330,308 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7806:Vps8
|
UTSW |
16 |
21,278,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7846:Vps8
|
UTSW |
16 |
21,351,070 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7943:Vps8
|
UTSW |
16 |
21,296,622 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8075:Vps8
|
UTSW |
16 |
21,340,644 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8190:Vps8
|
UTSW |
16 |
21,393,780 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8307:Vps8
|
UTSW |
16 |
21,314,652 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8483:Vps8
|
UTSW |
16 |
21,393,763 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8814:Vps8
|
UTSW |
16 |
21,395,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9064:Vps8
|
UTSW |
16 |
21,288,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Vps8
|
UTSW |
16 |
21,340,668 (GRCm39) |
missense |
possibly damaging |
0.45 |
|
R9404:Vps8
|
UTSW |
16 |
21,426,927 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9544:Vps8
|
UTSW |
16 |
21,336,893 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9570:Vps8
|
UTSW |
16 |
21,462,953 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9634:Vps8
|
UTSW |
16 |
21,372,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9702:Vps8
|
UTSW |
16 |
21,462,883 (GRCm39) |
missense |
probably benign |
0.17 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGCTGCTTCTGCTGTAAGAGAAC -3'
(R):5'- AGAGTGTGCCCCAACTAGGCTATG -3'
Sequencing Primer
(F):5'- GACTCATTCTGGGAGTCCTGC -3'
(R):5'- TACTGCATCATGAAGACGCTG -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation