Mutagenetix > Incidental Mutation

Incidental Mutation 'R5394:Hydin'

426052

Institutional Source

Beutler Lab

Gene Symbol

Hydin

Ensembl Gene

ENSMUSG00000059854

Gene Name

HYDIN, axonemal central pair apparatus protein

Synonyms

hy-3, hyrh, hy3, 1700034M11Rik, 4930545D19Rik

MMRRC Submission

042966-MU

Accession Numbers

Ncbi RefSeq: NM_172916; MGI: 2389007

Essential gene?

Probably essential (E-score: 0.784) question?

Stock #

R5394 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

110266977-110610253 bp(+) (GRCm38)

Type of Mutation

splice site (4 bp from exon)

DNA Base Change (assembly)

A to G at 110539842 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000046204 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043141]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000043141

SMART Domains

Protein: ENSMUSP00000046204
Gene: ENSMUSG00000059854

Domain	Start	End	E-Value	Type
Pfam:Motile_Sperm	246	325	5.6e-8	PFAM
Pfam:ASH	559	659	9.4e-17	PFAM
low complexity region	788	798	N/A	INTRINSIC
Pfam:PapD-like	848	906	1.2e-6	PFAM
low complexity region	998	1024	N/A	INTRINSIC
low complexity region	1279	1292	N/A	INTRINSIC
internal_repeat_6	1317	1549	5.96e-5	PROSPERO
internal_repeat_5	1355	1502	3.23e-5	PROSPERO
low complexity region	1574	1590	N/A	INTRINSIC
internal_repeat_4	1712	1940	5.14e-6	PROSPERO
coiled coil region	1947	1977	N/A	INTRINSIC
low complexity region	2009	2020	N/A	INTRINSIC
low complexity region	2034	2049	N/A	INTRINSIC
SCOP:d1eq1a_	2305	2403	3e-4	SMART
low complexity region	2404	2419	N/A	INTRINSIC
coiled coil region	2543	2588	N/A	INTRINSIC
low complexity region	2636	2656	N/A	INTRINSIC
internal_repeat_7	2772	3008	8.1e-5	PROSPERO
low complexity region	3660	3670	N/A	INTRINSIC
low complexity region	3919	3934	N/A	INTRINSIC
internal_repeat_5	4046	4190	3.23e-5	PROSPERO
internal_repeat_2	4106	4251	6.03e-7	PROSPERO
internal_repeat_4	4317	4532	5.14e-6	PROSPERO
internal_repeat_3	4403	4689	2.05e-6	PROSPERO
internal_repeat_2	4549	4697	6.03e-7	PROSPERO
low complexity region	4951	4964	N/A	INTRINSIC

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

97% (96/99)

MGI Phenotype

Strain: 1856913; 3801608
Lethality: D28-D42
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that may be involved in cilia motility. Mutations in this gene cause of autosomal recessive primary ciliary dyskinesia-5, a disorder characterized by the accumulation of cerebrospinal fluid within the ventricles of the brain. A duplicate copy of this gene has been found in humans on chromosome 1. [provided by RefSeq, Jan 2013]
PHENOTYPE: Mice homozygous for a mutation in this gene develop hydrocephaly after birth. Symptoms develop after 3-5 days. Affected animals usually die before 2 months of age. [provided by MGI curators]

Allele List at MGI

All alleles(7) : Targeted(1) Gene trapped(3) Transgenic(1) Spontaneous(2)

Other mutations in this stock

Total: 88 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2310050C09Rik	T	C	3: 92,868,698	E226G	probably damaging	Het
4930503B20Rik	A	G	3: 146,650,608	F182L	probably damaging	Het
4930503B20Rik	T	C	3: 146,650,958	Y65C	probably damaging	Het
4930590J08Rik	A	G	6: 91,919,193	T341A	probably benign	Het
4932438A13Rik	G	T	3: 36,917,668	V517F	probably damaging	Het
Adamts13	G	A	2: 26,986,558	V495I	probably benign	Het
Alms1	C	A	6: 85,623,088	T2101K	probably benign	Het
Als2	T	C	1: 59,174,946	D1361G	probably benign	Het
Ankdd1a	A	T	9: 65,505,214	M275K	probably benign	Het
Arfip2	A	T	7: 105,636,976	Y161*	probably null	Het
Asap3	A	T	4: 136,241,259	E707D	probably benign	Het
Atm	C	T	9: 53,507,777		probably null	Het
Atp9b	A	T	18: 80,776,837	S577R	probably benign	Het
Camk1d	G	C	2: 5,303,366	D274E	probably benign	Het
Cebpz	C	T	17: 78,922,205	D907N	probably benign	Het
Cmtm1	CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT	CGGCACGTACTGAAGGTCGCTGACTGGATGGTGTGGCACGTACTGAAGGTCGCTGACTGGATGGT	8: 104,309,470		probably benign	Het
Cnst	T	A	1: 179,601,736		probably benign	Het
Cog2	G	T	8: 124,532,529	V196L	probably benign	Het
Col11a1	A	G	3: 114,194,184		probably null	Het
Cops6	T	A	5: 138,163,500		probably null	Het
Cspg4	A	G	9: 56,890,200	E1316G	probably damaging	Het
Cwc22	G	C	2: 77,929,339	D122E	possibly damaging	Het
Dapk2	G	A	9: 66,268,718	V300M	probably benign	Het
Dcp1b	C	A	6: 119,175,367	D25E	probably damaging	Het
Ddx10	A	T	9: 53,233,857	Y273*	probably null	Het
Dhx58	T	C	11: 100,698,208	E504G	probably benign	Het
Dync2h1	C	T	9: 7,120,899	W2129*	probably null	Het
Egr4	A	T	6: 85,512,460	L206Q	probably damaging	Het
Eif4g3	A	G	4: 138,103,398		probably null	Het
Fbxo46	A	G	7: 19,136,616	N387D	possibly damaging	Het
Fpr-rs3	T	G	17: 20,624,208	M224L	probably benign	Het
Gm14325	G	A	2: 177,832,984	H102Y	possibly damaging	Het
Gxylt2	A	G	6: 100,705,114	K91E	probably benign	Het
H2afy2	G	A	10: 61,751,687	T156M	possibly damaging	Het
Hecw1	A	T	13: 14,322,589	V278E	probably damaging	Het
Iars	T	C	13: 49,722,165	L776P	probably damaging	Het
Kcnh2	T	A	5: 24,332,041	T182S	probably benign	Het
Lats2	T	G	14: 57,691,353	S1022R	probably benign	Het
Lef1	C	T	3: 131,194,659	P264S	probably damaging	Het
Lyrm1	A	C	7: 119,914,248	I79L	possibly damaging	Het
Man2b2	T	G	5: 36,814,518	Q618P	probably benign	Het
Mei1	T	C	15: 82,092,756	V180A	possibly damaging	Het
Mmp15	A	T	8: 95,366,404	N137I	probably damaging	Het
Mms22l	A	G	4: 24,517,115	D222G	possibly damaging	Het
Mut	T	A	17: 40,947,184	S414T	probably benign	Het
Myo18a	T	C	11: 77,853,350	M1846T	probably benign	Het
Neo1	A	T	9: 58,990,234	N146K	probably benign	Het
Nos3	A	G	5: 24,383,890	T1174A	probably benign	Het
Olfr1233	A	T	2: 89,339,462	I280N	probably damaging	Het
Olfr417	T	C	1: 174,369,270	Y118H	probably damaging	Het
Olfr566	A	T	7: 102,856,479	S268T	probably damaging	Het
Olfr960	A	T	9: 39,623,134	T4S	probably benign	Het
Pax8	A	T	2: 24,442,910		probably benign	Het
Pde5a	G	A	3: 122,818,009	C532Y	probably damaging	Het
Pigq	T	C	17: 25,931,472	D442G	possibly damaging	Het
Pik3c2g	T	C	6: 139,720,082	V43A	probably benign	Het
Pik3cb	T	C	9: 99,088,663	N325S	probably benign	Het
Pot1b	T	C	17: 55,700,063	K18R	probably benign	Het
Ppp1r42	A	T	1: 9,999,405	L144Q	probably damaging	Het
Prdm13	T	A	4: 21,679,455	Q345L	unknown	Het
Pyroxd2	T	A	19: 42,740,459	K167N	probably benign	Het
Rnf123	T	C	9: 108,070,731	Y131C	probably damaging	Het
Rnf25	T	C	1: 74,595,252	D204G	probably damaging	Het
Rpf2	G	A	10: 40,233,185	T60I	possibly damaging	Het
Scaf11	T	C	15: 96,419,458	N742D	probably benign	Het
Shank1	G	A	7: 44,352,651	D1257N	possibly damaging	Het
Shc2	A	G	10: 79,630,099	V168A	probably damaging	Het
Slc16a4	G	A	3: 107,292,442	V2M	probably benign	Het
Slc24a3	T	C	2: 145,613,574	V461A	probably benign	Het
Slc45a2	C	T	15: 11,027,785	T480I	probably damaging	Het
Slc4a4	T	A	5: 89,197,764		probably null	Het
Snx30	T	A	4: 59,879,329	D189E	probably benign	Het
Sspo	A	G	6: 48,495,260	Q4653R	possibly damaging	Het
Tpte	G	T	8: 22,327,790	R264I	probably damaging	Het
Tsc22d4	T	A	5: 137,758,774		probably benign	Het
Ubn1	T	C	16: 5,074,369	L585P	possibly damaging	Het
Usp24	A	T	4: 106,408,013	D1781V	probably damaging	Het
Utp20	A	T	10: 88,772,915	Y1514*	probably null	Het
Vmn1r55	A	T	7: 5,146,996	Y143N	probably damaging	Het
Vmn2r65	A	G	7: 84,946,654	V274A	probably benign	Het
Wdr17	A	G	8: 54,639,489	S1087P	possibly damaging	Het
Wnt5b	C	A	6: 119,440,322	R156L	probably damaging	Het
Zan	T	C	5: 137,435,634	D2279G	unknown	Het
Zan	T	C	5: 137,464,074	T948A	unknown	Het
Zfp758	T	C	17: 22,372,068	S4P	probably damaging	Het
Zfp839	A	G	12: 110,855,586	E278G	probably benign	Het
Zfp994	T	A	17: 22,200,525	H481L	probably damaging	Het
Zswim9	G	A	7: 13,260,983	R416C	probably damaging	Het

Other mutations in Hydin

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00338:Hydin	APN	8	110569802	missense	possibly damaging	0.69
IGL00432:Hydin	APN	8	110601252	missense	probably damaging	0.98
IGL01025:Hydin	APN	8	110326401	missense	probably benign	0.38
IGL01140:Hydin	APN	8	110398062	missense	probably benign	0.14
IGL01317:Hydin	APN	8	110326446	missense	probably damaging	0.98
IGL01473:Hydin	APN	8	110312160	missense	probably benign	0.08
IGL01473:Hydin	APN	8	110354953	missense	probably damaging	1.00
IGL01610:Hydin	APN	8	110557713	missense	probably benign	0.00
IGL01685:Hydin	APN	8	110355033	nonsense	probably null
IGL01734:Hydin	APN	8	110490789	nonsense	probably null
IGL01743:Hydin	APN	8	110592776	missense	possibly damaging	0.94
IGL01829:Hydin	APN	8	110589522	missense	possibly damaging	0.68
IGL01919:Hydin	APN	8	110519174	missense	possibly damaging	0.89
IGL01946:Hydin	APN	8	110490718	missense	possibly damaging	0.91
IGL01983:Hydin	APN	8	110514895	missense	probably benign	0.02
IGL02122:Hydin	APN	8	110494415	missense	possibly damaging	0.86
IGL02140:Hydin	APN	8	110566938	missense	probably benign
IGL02158:Hydin	APN	8	110609966	missense	possibly damaging	0.89
IGL02167:Hydin	APN	8	110418423	missense	possibly damaging	0.96
IGL02171:Hydin	APN	8	110451958	nonsense	probably null
IGL02185:Hydin	APN	8	110506476	missense	possibly damaging	0.86
IGL02517:Hydin	APN	8	110566972	missense	probably benign	0.01
IGL02639:Hydin	APN	8	110538449	missense	probably benign	0.01
IGL02644:Hydin	APN	8	110538468	missense	probably damaging	1.00
IGL02652:Hydin	APN	8	110589522	missense	possibly damaging	0.68
IGL02658:Hydin	APN	8	110413276	missense	possibly damaging	0.86
IGL02706:Hydin	APN	8	110410566	missense	probably damaging	0.99
IGL02892:Hydin	APN	8	110598959	missense	possibly damaging	0.89
IGL02947:Hydin	APN	8	110418462	missense	probably damaging	0.96
IGL03136:Hydin	APN	8	110418524	missense	probably benign	0.22
IGL03248:Hydin	APN	8	110595289	missense	probably damaging	0.97
IGL03251:Hydin	APN	8	110490596	missense	probably damaging	1.00
IGL03350:Hydin	APN	8	110312224	missense	possibly damaging	0.86
IGL03366:Hydin	APN	8	110267363	missense	unknown
IGL03404:Hydin	APN	8	110569777	missense	probably benign	0.06
Franz_joseph	UTSW	8	110601318	missense	probably damaging	1.00
jahreszeiten	UTSW	8	110569359	missense	probably damaging	1.00
maria	UTSW	8	110509127	splice site	probably benign
schoepfung	UTSW	8	110600245	missense	possibly damaging	0.68
surprise	UTSW	8	110528016	missense	probably benign
teresa	UTSW	8	110609671	missense	possibly damaging	0.79
BB001:Hydin	UTSW	8	110418471	missense	possibly damaging	0.93
BB004:Hydin	UTSW	8	110580844	missense	possibly damaging	0.89
BB011:Hydin	UTSW	8	110418471	missense	possibly damaging	0.93
BB014:Hydin	UTSW	8	110580844	missense	possibly damaging	0.89
P0005:Hydin	UTSW	8	110494289	critical splice acceptor site	probably null
R0099:Hydin	UTSW	8	110589561	missense	probably damaging	1.00
R0125:Hydin	UTSW	8	110462531	missense	probably benign	0.12
R0157:Hydin	UTSW	8	110300010	missense	possibly damaging	0.86
R0241:Hydin	UTSW	8	110398023	missense	probably benign	0.04
R0241:Hydin	UTSW	8	110398023	missense	probably benign	0.04
R0255:Hydin	UTSW	8	110565018	missense	probably benign	0.00
R0352:Hydin	UTSW	8	110569901	critical splice donor site	probably null
R0379:Hydin	UTSW	8	110509127	splice site	probably benign
R0468:Hydin	UTSW	8	110413223	missense	possibly damaging	0.96
R0477:Hydin	UTSW	8	110418498	missense	probably damaging	1.00
R0479:Hydin	UTSW	8	110599088	missense	probably damaging	1.00
R0539:Hydin	UTSW	8	110523072	missense	probably benign
R0550:Hydin	UTSW	8	110587775	missense	probably benign	0.01
R0571:Hydin	UTSW	8	110514103	splice site	probably null
R0606:Hydin	UTSW	8	110549798	splice site	probably benign
R0789:Hydin	UTSW	8	110566971	missense	possibly damaging	0.53
R0849:Hydin	UTSW	8	110598984	missense	probably damaging	1.00
R0946:Hydin	UTSW	8	110531053	missense	probably benign	0.25
R1201:Hydin	UTSW	8	110569855	missense	probably benign	0.01
R1375:Hydin	UTSW	8	110506222	critical splice donor site	probably null
R1385:Hydin	UTSW	8	110523204	missense	probably benign	0.40
R1411:Hydin	UTSW	8	110575031	missense	probably benign	0.04
R1437:Hydin	UTSW	8	110581985	nonsense	probably null
R1447:Hydin	UTSW	8	110523166	missense	probably damaging	1.00
R1448:Hydin	UTSW	8	110446585	missense	probably benign	0.27
R1466:Hydin	UTSW	8	110532953	missense	possibly damaging	0.47
R1466:Hydin	UTSW	8	110532953	missense	possibly damaging	0.47
R1523:Hydin	UTSW	8	110533271	missense	probably benign	0.05
R1544:Hydin	UTSW	8	110574854	missense	probably benign	0.30
R1581:Hydin	UTSW	8	110410460	missense	probably benign
R1584:Hydin	UTSW	8	110580815	missense	probably benign	0.27
R1598:Hydin	UTSW	8	110410674	missense	possibly damaging	0.96
R1633:Hydin	UTSW	8	110506982	missense	probably benign	0.10
R1777:Hydin	UTSW	8	110589571	missense	probably benign	0.14
R1817:Hydin	UTSW	8	110532827	missense	probably benign	0.00
R1828:Hydin	UTSW	8	110510894	missense	probably benign	0.03
R1837:Hydin	UTSW	8	110569625	missense	probably benign	0.20
R1848:Hydin	UTSW	8	110569808	missense	probably benign	0.19
R1869:Hydin	UTSW	8	110500705	missense	possibly damaging	0.94
R1909:Hydin	UTSW	8	110587772	missense	probably damaging	1.00
R1928:Hydin	UTSW	8	110502947	missense	possibly damaging	0.93
R1950:Hydin	UTSW	8	110609987	missense	possibly damaging	0.64
R2095:Hydin	UTSW	8	110462657	missense	probably damaging	0.96
R2172:Hydin	UTSW	8	110582049	missense	probably benign	0.42
R2217:Hydin	UTSW	8	110418506	missense	probably benign
R2248:Hydin	UTSW	8	110578203	missense	probably benign	0.09
R2272:Hydin	UTSW	8	110309132	missense	probably benign	0.01
R2294:Hydin	UTSW	8	110299959	missense	probably damaging	0.99
R2315:Hydin	UTSW	8	110398044	missense	probably benign	0.01
R2330:Hydin	UTSW	8	110565009	missense	probably benign	0.01
R2374:Hydin	UTSW	8	110565148	missense	probably damaging	1.00
R2446:Hydin	UTSW	8	110587715	missense	possibly damaging	0.82
R2484:Hydin	UTSW	8	110513115	missense	possibly damaging	0.76
R2698:Hydin	UTSW	8	110609929	missense	possibly damaging	0.70
R2843:Hydin	UTSW	8	110519114	missense	probably benign
R2844:Hydin	UTSW	8	110519114	missense	probably benign
R2846:Hydin	UTSW	8	110519114	missense	probably benign
R2882:Hydin	UTSW	8	110566923	missense	possibly damaging	0.92
R2937:Hydin	UTSW	8	110404295	missense	possibly damaging	0.88
R3031:Hydin	UTSW	8	110603216	missense	possibly damaging	0.83
R3038:Hydin	UTSW	8	110582689	missense	probably damaging	1.00
R3121:Hydin	UTSW	8	110506506	missense	probably benign
R3157:Hydin	UTSW	8	110267373	missense	unknown
R3547:Hydin	UTSW	8	110582067	missense	possibly damaging	0.85
R3696:Hydin	UTSW	8	110603279	missense	probably damaging	1.00
R3850:Hydin	UTSW	8	110563929	missense	probably damaging	0.99
R3896:Hydin	UTSW	8	110509079	missense	possibly damaging	0.93
R3983:Hydin	UTSW	8	110392325	missense	probably damaging	1.00
R4031:Hydin	UTSW	8	110610047	missense	probably benign	0.30
R4072:Hydin	UTSW	8	110505256	missense	possibly damaging	0.68
R4095:Hydin	UTSW	8	110541547	missense	probably damaging	0.98
R4176:Hydin	UTSW	8	110593820	missense	probably benign	0.00
R4213:Hydin	UTSW	8	110456507	missense	possibly damaging	0.91
R4412:Hydin	UTSW	8	110415736	missense	probably damaging	0.99
R4471:Hydin	UTSW	8	110587132	missense	probably damaging	1.00
R4474:Hydin	UTSW	8	110563865	missense	probably benign	0.11
R4495:Hydin	UTSW	8	110595402	missense	probably damaging	0.99
R4508:Hydin	UTSW	8	110519254	missense	possibly damaging	0.91
R4578:Hydin	UTSW	8	110267339	missense	unknown
R4583:Hydin	UTSW	8	110595225	missense	probably benign	0.36
R4600:Hydin	UTSW	8	110566950	missense	probably benign	0.04
R4681:Hydin	UTSW	8	110506471	missense	possibly damaging	0.85
R4685:Hydin	UTSW	8	110462522	missense	probably damaging	0.99
R4689:Hydin	UTSW	8	110595414	missense	probably benign	0.18
R4735:Hydin	UTSW	8	110555632	critical splice donor site	probably null
R4736:Hydin	UTSW	8	110523208	missense	probably benign	0.02
R4740:Hydin	UTSW	8	110446439	missense	probably benign	0.06
R4771:Hydin	UTSW	8	110532883	missense	probably benign
R4777:Hydin	UTSW	8	110410464	missense	probably damaging	0.98
R4859:Hydin	UTSW	8	110506494	missense	possibly damaging	0.93
R4911:Hydin	UTSW	8	110595438	missense	probably benign	0.01
R4964:Hydin	UTSW	8	110490673	missense	possibly damaging	0.86
R4965:Hydin	UTSW	8	110398095	missense	probably benign
R4989:Hydin	UTSW	8	110563922	missense	possibly damaging	0.84
R4995:Hydin	UTSW	8	110569642	missense	probably damaging	0.97
R5059:Hydin	UTSW	8	110505769	missense	probably damaging	0.96
R5071:Hydin	UTSW	8	110538473	missense	probably benign	0.03
R5073:Hydin	UTSW	8	110538473	missense	probably benign	0.03
R5092:Hydin	UTSW	8	110582668	missense	probably benign	0.16
R5156:Hydin	UTSW	8	110609701	missense	probably benign	0.00
R5166:Hydin	UTSW	8	110523142	missense	possibly damaging	0.89
R5189:Hydin	UTSW	8	110413211	critical splice acceptor site	probably null
R5243:Hydin	UTSW	8	110505748	missense	possibly damaging	0.92
R5244:Hydin	UTSW	8	110532819	missense	possibly damaging	0.77
R5256:Hydin	UTSW	8	110587223	missense	possibly damaging	0.92
R5266:Hydin	UTSW	8	110334784	missense	possibly damaging	0.87
R5283:Hydin	UTSW	8	110451980	missense	possibly damaging	0.96
R5343:Hydin	UTSW	8	110485419	missense	probably benign	0.40
R5359:Hydin	UTSW	8	110538372	missense	probably benign	0.00
R5390:Hydin	UTSW	8	110595467	missense	probably benign
R5441:Hydin	UTSW	8	110565109	missense	possibly damaging	0.72
R5461:Hydin	UTSW	8	110519231	missense	probably damaging	0.96
R5662:Hydin	UTSW	8	110580709	missense	probably benign	0.02
R5695:Hydin	UTSW	8	110535283	missense	probably benign	0.35
R5732:Hydin	UTSW	8	110452058	missense	probably benign	0.03
R5774:Hydin	UTSW	8	110571915	nonsense	probably null
R5780:Hydin	UTSW	8	110586080	missense	probably damaging	1.00
R5787:Hydin	UTSW	8	110326353	missense	probably damaging	0.99
R5802:Hydin	UTSW	8	110452060	missense	possibly damaging	0.86
R5841:Hydin	UTSW	8	110533214	missense	possibly damaging	0.76
R5856:Hydin	UTSW	8	110541842	missense	probably damaging	0.99
R5893:Hydin	UTSW	8	110490676	missense	probably benign	0.12
R5963:Hydin	UTSW	8	110494294	missense	possibly damaging	0.93
R6008:Hydin	UTSW	8	110599085	missense	probably benign	0.02
R6019:Hydin	UTSW	8	110566620	missense	probably benign
R6038:Hydin	UTSW	8	110599031	missense	probably benign	0.16
R6038:Hydin	UTSW	8	110599031	missense	probably benign	0.16
R6133:Hydin	UTSW	8	110601276	missense	probably benign	0.00
R6135:Hydin	UTSW	8	110462660	missense	possibly damaging	0.85
R6157:Hydin	UTSW	8	110528016	missense	probably benign
R6209:Hydin	UTSW	8	110593802	missense	probably benign	0.05
R6238:Hydin	UTSW	8	110392111	splice site	probably null
R6293:Hydin	UTSW	8	110597911	missense	possibly damaging	0.83
R6340:Hydin	UTSW	8	110354942	splice site	probably null
R6349:Hydin	UTSW	8	110418459	nonsense	probably null
R6357:Hydin	UTSW	8	110541657	missense	possibly damaging	0.86
R6385:Hydin	UTSW	8	110312224	missense	possibly damaging	0.86
R6396:Hydin	UTSW	8	110506889	missense	probably damaging	0.96
R6466:Hydin	UTSW	8	110506968	missense	possibly damaging	0.85
R6648:Hydin	UTSW	8	110525667	splice site	probably null
R6671:Hydin	UTSW	8	110601318	missense	probably damaging	1.00
R6695:Hydin	UTSW	8	110326460	missense	probably benign	0.05
R6800:Hydin	UTSW	8	110597971	missense	probably benign	0.09
R6841:Hydin	UTSW	8	110538375	missense	probably benign	0.09
R6867:Hydin	UTSW	8	110539802	missense	probably benign	0.08
R6889:Hydin	UTSW	8	110532856	missense	possibly damaging	0.79
R6895:Hydin	UTSW	8	110312251	missense	probably benign	0.00
R6940:Hydin	UTSW	8	110490611	missense	probably damaging	1.00
R6951:Hydin	UTSW	8	110398125	missense	probably benign
R6980:Hydin	UTSW	8	110413284	missense	possibly damaging	0.91
R6981:Hydin	UTSW	8	110531072	missense	possibly damaging	0.89
R7061:Hydin	UTSW	8	110603288	missense	possibly damaging	0.90
R7085:Hydin	UTSW	8	110603330	missense	probably benign	0.03
R7086:Hydin	UTSW	8	110600245	missense	possibly damaging	0.68
R7110:Hydin	UTSW	8	110354951	critical splice acceptor site	probably null
R7158:Hydin	UTSW	8	110609671	missense	possibly damaging	0.79
R7163:Hydin	UTSW	8	110603336	missense	probably benign	0.25
R7209:Hydin	UTSW	8	110489792	nonsense	probably null
R7244:Hydin	UTSW	8	110549675	missense	probably damaging	0.98
R7347:Hydin	UTSW	8	110600362	missense	probably benign	0.06
R7349:Hydin	UTSW	8	110398171	splice site	probably null
R7359:Hydin	UTSW	8	110506101	missense	probably damaging	0.98
R7365:Hydin	UTSW	8	110557662	missense	probably damaging	0.99
R7365:Hydin	UTSW	8	110601273	missense	probably damaging	1.00
R7436:Hydin	UTSW	8	110583914	missense	probably damaging	0.96
R7528:Hydin	UTSW	8	110380572	nonsense	probably null
R7544:Hydin	UTSW	8	110589525	missense	probably benign	0.35
R7625:Hydin	UTSW	8	110541844	missense	probably benign	0.01
R7713:Hydin	UTSW	8	110593812	missense	possibly damaging	0.69
R7763:Hydin	UTSW	8	110505843	missense	possibly damaging	0.92
R7771:Hydin	UTSW	8	110565085	missense	probably damaging	0.97
R7794:Hydin	UTSW	8	110509083	missense	probably damaging	1.00
R7833:Hydin	UTSW	8	110589460	missense	probably damaging	0.99
R7894:Hydin	UTSW	8	110513010	missense	possibly damaging	0.88
R7899:Hydin	UTSW	8	110587748	missense	probably benign	0.00
R7908:Hydin	UTSW	8	110510867	missense	probably benign	0.01
R7912:Hydin	UTSW	8	110555607	missense	possibly damaging	0.68
R7919:Hydin	UTSW	8	110267339	missense	unknown
R7924:Hydin	UTSW	8	110418471	missense	possibly damaging	0.93
R7927:Hydin	UTSW	8	110580844	missense	possibly damaging	0.89
R7970:Hydin	UTSW	8	110309091	missense	probably damaging	0.99
R7993:Hydin	UTSW	8	110579632	missense	probably benign
R8011:Hydin	UTSW	8	110583909	missense	probably damaging	1.00
R8041:Hydin	UTSW	8	110574994	missense	probably benign	0.02
R8080:Hydin	UTSW	8	110535231	missense	probably benign	0.32
R8081:Hydin	UTSW	8	110365469	missense	possibly damaging	0.93
R8095:Hydin	UTSW	8	110569359	missense	probably damaging	1.00
R8157:Hydin	UTSW	8	110452036	missense	probably benign	0.33
R8186:Hydin	UTSW	8	110609645	missense	probably benign	0.14
R8205:Hydin	UTSW	8	110592638	missense	possibly damaging	0.57
R8263:Hydin	UTSW	8	110452073	missense	probably benign	0.00
R8288:Hydin	UTSW	8	110507029	missense	probably damaging	0.96
R8298:Hydin	UTSW	8	110600383	missense	probably damaging	1.00
R8309:Hydin	UTSW	8	110607902	missense	probably benign	0.18
R8348:Hydin	UTSW	8	110603246	missense	possibly damaging	0.68
R8356:Hydin	UTSW	8	110533124	missense	possibly damaging	0.67
R8406:Hydin	UTSW	8	110609911	missense	possibly damaging	0.94
R8415:Hydin	UTSW	8	110451994	missense	probably damaging	1.00
R8417:Hydin	UTSW	8	110569392	missense	probably benign	0.28
R8432:Hydin	UTSW	8	110597951	missense	probably benign	0.02
R8437:Hydin	UTSW	8	110462735	missense	probably damaging	0.96
R8463:Hydin	UTSW	8	110510921	missense	probably benign	0.22
R8508:Hydin	UTSW	8	110582018	missense	probably benign	0.00
R8510:Hydin	UTSW	8	110506570	missense	probably damaging	1.00
R8560:Hydin	UTSW	8	110538474	missense	probably benign	0.09
R8682:Hydin	UTSW	8	110309166	missense	probably damaging	0.96
R8697:Hydin	UTSW	8	110532883	missense	probably benign
R8857:Hydin	UTSW	8	110571955	critical splice donor site	probably null
R8866:Hydin	UTSW	8	110582147	missense	possibly damaging	0.89
R8878:Hydin	UTSW	8	110309088	missense	probably benign	0.12
R8897:Hydin	UTSW	8	110589480	missense	probably benign
R8987:Hydin	UTSW	8	110513134	nonsense	probably null
R9072:Hydin	UTSW	8	110267451	critical splice donor site	probably null
R9073:Hydin	UTSW	8	110267451	critical splice donor site	probably null
R9102:Hydin	UTSW	8	110508914	missense	probably benign	0.33
R9224:Hydin	UTSW	8	110532884	missense	probably benign
R9255:Hydin	UTSW	8	110535340	missense	probably benign	0.23
R9257:Hydin	UTSW	8	110575016	missense	probably damaging	0.99
R9261:Hydin	UTSW	8	110267415	missense	unknown
R9273:Hydin	UTSW	8	110506948	missense	probably damaging	0.98
R9376:Hydin	UTSW	8	110398063	missense	possibly damaging	0.70
R9380:Hydin	UTSW	8	110563872	missense	probably benign	0.07
R9386:Hydin	UTSW	8	110587730	missense	probably benign
R9406:Hydin	UTSW	8	110587780	missense	probably null	0.96
R9492:Hydin	UTSW	8	110600245	missense	possibly damaging	0.68
R9513:Hydin	UTSW	8	110595482	missense	probably damaging	0.99
R9562:Hydin	UTSW	8	110586154	missense	probably benign	0.11
R9664:Hydin	UTSW	8	110494333	missense	probably benign	0.01
R9733:Hydin	UTSW	8	110535379	missense	probably benign
R9753:Hydin	UTSW	8	110490766	missense	possibly damaging	0.85
X0063:Hydin	UTSW	8	110551319	missense	probably damaging	1.00
Z1088:Hydin	UTSW	8	110299973	missense	probably benign	0.12
Z1088:Hydin	UTSW	8	110586048	missense	probably benign	0.00
Z1088:Hydin	UTSW	8	110592791	frame shift	probably null
Z1176:Hydin	UTSW	8	110541600	missense	possibly damaging	0.65
Z1177:Hydin	UTSW	8	110380610	missense	probably damaging	1.00
Z1177:Hydin	UTSW	8	110450232	missense	possibly damaging	0.47
Z1177:Hydin	UTSW	8	110587142	frame shift	probably null
Z1177:Hydin	UTSW	8	110609989	missense	probably benign	0.10
Z1188:Hydin	UTSW	8	110415787	missense	probably benign	0.40

Predicted Primers

PCR Primer
(F):5'- TCAGACATGGGAGCCTTCAC -3'
(R):5'- AAGCCAAGTTGTCTGTGTGTC -3'

Sequencing Primer
(F):5'- TTGTAGGACACTGAACGCTG -3'
(R):5'- TCTGTGTGTCAGAGCAGAGAC -3'

Posted On

2016-08-04