Incidental Mutation 'R5395:Atp13a4'
| ID |
426160 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Atp13a4
|
| Ensembl Gene |
ENSMUSG00000038094 |
| Gene Name |
ATPase type 13A4 |
| Synonyms |
9330174J19Rik, 4631413J11Rik |
| MMRRC Submission |
042967-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R5395 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
16 |
| Chromosomal Location |
29395853-29544864 bp(-) (GRCm38) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
A to T
at 29420888 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Stop codon
at position 835
(Y835*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000048753
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000039090]
[ENSMUST00000057018]
[ENSMUST00000182013]
[ENSMUST00000182627]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000039090
AA Change: Y835*
|
| SMART Domains |
Protein: ENSMUSP00000048753
Gene: ENSMUSG00000038094
AA Change: Y835*
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:P5-ATPase
|
17 |
143 |
8.4e-31 |
PFAM |
|
Cation_ATPase_N
|
147 |
223 |
1.09e-1 |
SMART |
|
Pfam:E1-E2_ATPase
|
229 |
476 |
1.7e-36 |
PFAM |
|
Pfam:Hydrolase
|
481 |
769 |
3.9e-11 |
PFAM |
|
Pfam:HAD
|
484 |
787 |
4.1e-14 |
PFAM |
|
Pfam:Hydrolase_like2
|
574 |
637 |
1.2e-9 |
PFAM |
|
transmembrane domain
|
824 |
846 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000057018
|
| SMART Domains |
Protein: ENSMUSP00000060987
Gene: ENSMUSG00000038094
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:P5-ATPase
|
17 |
142 |
9.6e-34 |
PFAM |
|
Cation_ATPase_N
|
147 |
223 |
1.09e-1 |
SMART |
|
Pfam:E1-E2_ATPase
|
228 |
476 |
1.6e-34 |
PFAM |
|
Pfam:Hydrolase
|
481 |
767 |
1.1e-10 |
PFAM |
|
Pfam:HAD
|
484 |
858 |
3.3e-23 |
PFAM |
|
Pfam:Cation_ATPase
|
573 |
637 |
4.9e-8 |
PFAM |
|
transmembrane domain
|
902 |
924 |
N/A |
INTRINSIC |
|
transmembrane domain
|
934 |
951 |
N/A |
INTRINSIC |
|
transmembrane domain
|
972 |
994 |
N/A |
INTRINSIC |
|
low complexity region
|
1014 |
1023 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1040 |
1057 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1070 |
1092 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1107 |
1126 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182013
|
| SMART Domains |
Protein: ENSMUSP00000138583
Gene: ENSMUSG00000038094
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:P5-ATPase
|
17 |
84 |
4.2e-26 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182168
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000182357
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182573
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000182627
|
| SMART Domains |
Protein: ENSMUSP00000138479
Gene: ENSMUSG00000038094
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:P5-ATPase
|
17 |
143 |
2.1e-29 |
PFAM |
|
Cation_ATPase_N
|
147 |
223 |
1.09e-1 |
SMART |
|
Pfam:E1-E2_ATPase
|
229 |
476 |
3.9e-35 |
PFAM |
|
Pfam:Hydrolase
|
481 |
861 |
4.2e-16 |
PFAM |
|
Pfam:HAD
|
484 |
858 |
1.9e-23 |
PFAM |
|
Pfam:Hydrolase_like2
|
574 |
637 |
2.2e-8 |
PFAM |
|
transmembrane domain
|
902 |
924 |
N/A |
INTRINSIC |
|
transmembrane domain
|
934 |
951 |
N/A |
INTRINSIC |
|
transmembrane domain
|
972 |
994 |
N/A |
INTRINSIC |
|
low complexity region
|
1014 |
1023 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1040 |
1057 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1070 |
1092 |
N/A |
INTRINSIC |
|
transmembrane domain
|
1107 |
1126 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.7%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca4 |
A |
G |
3: 122,080,941 (GRCm38) |
I268V |
probably benign |
Het |
| Actn1 |
T |
A |
12: 80,170,703 (GRCm38) |
I782F |
probably benign |
Het |
| Adamdec1 |
A |
C |
14: 68,570,903 (GRCm38) |
S333A |
probably benign |
Het |
| Agbl5 |
C |
A |
5: 30,890,338 (GRCm38) |
T58N |
probably damaging |
Het |
| Apoo-ps |
T |
A |
13: 107,414,493 (GRCm38) |
|
noncoding transcript |
Het |
| Arhgef10l |
T |
C |
4: 140,570,290 (GRCm38) |
N277S |
probably benign |
Het |
| Ascc2 |
A |
G |
11: 4,659,273 (GRCm38) |
E241G |
possibly damaging |
Het |
| Bcas3 |
T |
C |
11: 85,825,249 (GRCm38) |
S426P |
probably damaging |
Het |
| Birc3 |
T |
C |
9: 7,861,174 (GRCm38) |
R48G |
probably damaging |
Het |
| Cacna2d4 |
T |
C |
6: 119,271,418 (GRCm38) |
S397P |
possibly damaging |
Het |
| Ccng2 |
T |
C |
5: 93,269,398 (GRCm38) |
M91T |
possibly damaging |
Het |
| Clk3 |
G |
A |
9: 57,753,339 (GRCm38) |
T473M |
probably damaging |
Het |
| Cog2 |
T |
A |
8: 124,545,221 (GRCm38) |
H491Q |
probably benign |
Het |
| Cyp4f40 |
C |
T |
17: 32,669,853 (GRCm38) |
T202I |
probably benign |
Het |
| Dennd1a |
A |
T |
2: 37,802,128 (GRCm38) |
F181I |
probably damaging |
Het |
| Fcrl6 |
G |
T |
1: 172,598,720 (GRCm38) |
A170D |
possibly damaging |
Het |
| Fev |
T |
C |
1: 74,882,664 (GRCm38) |
|
probably null |
Het |
| Flnb |
A |
G |
14: 7,883,881 (GRCm38) |
N369S |
probably benign |
Het |
| Flt3 |
A |
G |
5: 147,354,823 (GRCm38) |
F606L |
probably damaging |
Het |
| Gdf9 |
T |
C |
11: 53,433,797 (GRCm38) |
V131A |
probably benign |
Het |
| Gdnf |
T |
A |
15: 7,834,684 (GRCm38) |
L192Q |
probably damaging |
Het |
| Gjc2 |
A |
T |
11: 59,177,489 (GRCm38) |
C56S |
possibly damaging |
Het |
| Gli3 |
T |
C |
13: 15,714,950 (GRCm38) |
F550L |
probably damaging |
Het |
| Gm1110 |
T |
C |
9: 26,889,632 (GRCm38) |
E422G |
probably benign |
Het |
| Gm14325 |
G |
A |
2: 177,832,984 (GRCm38) |
H102Y |
possibly damaging |
Het |
| Gnb2 |
A |
G |
5: 137,528,526 (GRCm38) |
S334P |
probably damaging |
Het |
| Icam2 |
A |
T |
11: 106,382,473 (GRCm38) |
|
probably null |
Het |
| Inca1 |
C |
T |
11: 70,690,438 (GRCm38) |
|
probably null |
Het |
| Itgb8 |
A |
C |
12: 119,170,741 (GRCm38) |
C530W |
probably damaging |
Het |
| Lrp1 |
T |
C |
10: 127,595,297 (GRCm38) |
D332G |
probably damaging |
Het |
| Ly75 |
A |
T |
2: 60,365,111 (GRCm38) |
N234K |
probably benign |
Het |
| Mcm5 |
G |
A |
8: 75,123,026 (GRCm38) |
S542N |
probably benign |
Het |
| Mcm9 |
A |
T |
10: 53,538,692 (GRCm38) |
N97K |
possibly damaging |
Het |
| Morc2a |
G |
A |
11: 3,688,232 (GRCm38) |
R986H |
possibly damaging |
Het |
| Neu2 |
T |
A |
1: 87,596,675 (GRCm38) |
|
probably null |
Het |
| Nfatc1 |
G |
A |
18: 80,636,020 (GRCm38) |
P718S |
possibly damaging |
Het |
| Nol6 |
G |
A |
4: 41,118,392 (GRCm38) |
|
probably benign |
Het |
| Olfr1406 |
A |
T |
1: 173,183,680 (GRCm38) |
Y251* |
probably null |
Het |
| Otogl |
T |
C |
10: 107,817,138 (GRCm38) |
N1118D |
probably benign |
Het |
| Pcdh15 |
T |
A |
10: 74,185,287 (GRCm38) |
I111K |
probably damaging |
Het |
| Phkb |
A |
G |
8: 86,017,468 (GRCm38) |
D582G |
probably damaging |
Het |
| Piwil2 |
G |
T |
14: 70,395,397 (GRCm38) |
N575K |
probably benign |
Het |
| Pou4f2 |
T |
A |
8: 78,435,072 (GRCm38) |
I301F |
probably damaging |
Het |
| Prkd1 |
T |
C |
12: 50,391,432 (GRCm38) |
N409S |
probably damaging |
Het |
| Ptpn21 |
T |
G |
12: 98,715,117 (GRCm38) |
K86T |
probably damaging |
Het |
| Raly |
T |
A |
2: 154,864,007 (GRCm38) |
|
probably null |
Het |
| Rangap1 |
A |
G |
15: 81,706,446 (GRCm38) |
F482L |
probably benign |
Het |
| Rapgef1 |
T |
A |
2: 29,737,965 (GRCm38) |
N1052K |
probably damaging |
Het |
| Rnf169 |
A |
T |
7: 99,935,160 (GRCm38) |
|
probably null |
Het |
| Sdr16c5 |
T |
C |
4: 4,016,277 (GRCm38) |
S50G |
probably benign |
Het |
| Sin3a |
G |
A |
9: 57,105,673 (GRCm38) |
R612H |
probably damaging |
Het |
| Six6 |
T |
A |
12: 72,941,701 (GRCm38) |
L216* |
probably null |
Het |
| Slc20a1 |
A |
T |
2: 129,208,337 (GRCm38) |
N472Y |
probably damaging |
Het |
| Slc35d1 |
C |
T |
4: 103,211,375 (GRCm38) |
|
probably null |
Het |
| Slc45a2 |
C |
T |
15: 11,027,785 (GRCm38) |
T480I |
probably damaging |
Het |
| Slc7a8 |
C |
A |
14: 54,733,277 (GRCm38) |
G306* |
probably null |
Het |
| Slc9a8 |
T |
A |
2: 167,467,722 (GRCm38) |
F335L |
probably damaging |
Het |
| Smyd1 |
T |
G |
6: 71,219,390 (GRCm38) |
K338T |
possibly damaging |
Het |
| Snd1 |
T |
A |
6: 28,526,184 (GRCm38) |
V187E |
probably damaging |
Het |
| Spag9 |
T |
G |
11: 94,091,751 (GRCm38) |
|
probably null |
Het |
| Tnfsf9 |
C |
A |
17: 57,105,592 (GRCm38) |
T54K |
probably benign |
Het |
| Trim24 |
T |
G |
6: 37,957,744 (GRCm38) |
V798G |
probably damaging |
Het |
| Tyr |
C |
A |
7: 87,472,490 (GRCm38) |
A365S |
probably damaging |
Het |
| Usp43 |
T |
A |
11: 67,897,358 (GRCm38) |
|
probably null |
Het |
| Vmn2r55 |
T |
C |
7: 12,651,947 (GRCm38) |
D702G |
probably damaging |
Het |
| Vmn2r72 |
A |
G |
7: 85,750,897 (GRCm38) |
S315P |
possibly damaging |
Het |
| Wdr64 |
T |
A |
1: 175,755,598 (GRCm38) |
F367I |
probably damaging |
Het |
| Zc3h7b |
G |
A |
15: 81,772,501 (GRCm38) |
R173K |
possibly damaging |
Het |
| Zfp493 |
T |
A |
13: 67,783,846 (GRCm38) |
C21* |
probably null |
Het |
| Zfp825 |
T |
C |
13: 74,480,546 (GRCm38) |
T284A |
possibly damaging |
Het |
| Zpbp2 |
T |
A |
11: 98,558,213 (GRCm38) |
V275D |
probably damaging |
Het |
|
| Other mutations in Atp13a4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00563:Atp13a4
|
APN |
16 |
29,403,778 (GRCm38) |
splice site |
probably benign |
|
|
IGL01577:Atp13a4
|
APN |
16 |
29,441,284 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
IGL01834:Atp13a4
|
APN |
16 |
29,415,777 (GRCm38) |
splice site |
probably benign |
|
|
IGL02165:Atp13a4
|
APN |
16 |
29,434,010 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02194:Atp13a4
|
APN |
16 |
29,456,629 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02322:Atp13a4
|
APN |
16 |
29,440,102 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02553:Atp13a4
|
APN |
16 |
29,422,703 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02821:Atp13a4
|
APN |
16 |
29,441,307 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL03349:Atp13a4
|
APN |
16 |
29,456,671 (GRCm38) |
missense |
probably benign |
0.01 |
|
G5030:Atp13a4
|
UTSW |
16 |
29,455,488 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0091:Atp13a4
|
UTSW |
16 |
29,455,395 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0100:Atp13a4
|
UTSW |
16 |
29,421,724 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0278:Atp13a4
|
UTSW |
16 |
29,454,834 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1263:Atp13a4
|
UTSW |
16 |
29,471,953 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
R1378:Atp13a4
|
UTSW |
16 |
29,420,428 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1575:Atp13a4
|
UTSW |
16 |
29,409,710 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1720:Atp13a4
|
UTSW |
16 |
29,408,928 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1759:Atp13a4
|
UTSW |
16 |
29,456,611 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1967:Atp13a4
|
UTSW |
16 |
29,479,854 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2030:Atp13a4
|
UTSW |
16 |
29,422,684 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2113:Atp13a4
|
UTSW |
16 |
29,441,284 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R3409:Atp13a4
|
UTSW |
16 |
29,413,749 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3410:Atp13a4
|
UTSW |
16 |
29,413,749 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4032:Atp13a4
|
UTSW |
16 |
29,418,571 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4163:Atp13a4
|
UTSW |
16 |
29,541,250 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R4652:Atp13a4
|
UTSW |
16 |
29,452,603 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4772:Atp13a4
|
UTSW |
16 |
29,420,835 (GRCm38) |
intron |
probably benign |
|
|
R4795:Atp13a4
|
UTSW |
16 |
29,490,008 (GRCm38) |
critical splice donor site |
probably null |
|
|
R4898:Atp13a4
|
UTSW |
16 |
29,408,961 (GRCm38) |
nonsense |
probably null |
|
|
R4996:Atp13a4
|
UTSW |
16 |
29,472,004 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5112:Atp13a4
|
UTSW |
16 |
29,409,868 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R5259:Atp13a4
|
UTSW |
16 |
29,456,610 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5395:Atp13a4
|
UTSW |
16 |
29,456,604 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5640:Atp13a4
|
UTSW |
16 |
29,415,831 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5809:Atp13a4
|
UTSW |
16 |
29,433,987 (GRCm38) |
missense |
possibly damaging |
0.56 |
|
R5856:Atp13a4
|
UTSW |
16 |
29,433,987 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R5912:Atp13a4
|
UTSW |
16 |
29,456,571 (GRCm38) |
missense |
probably benign |
0.33 |
|
R6282:Atp13a4
|
UTSW |
16 |
29,434,004 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6404:Atp13a4
|
UTSW |
16 |
29,471,901 (GRCm38) |
nonsense |
probably null |
|
|
R6497:Atp13a4
|
UTSW |
16 |
29,479,901 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6577:Atp13a4
|
UTSW |
16 |
29,479,841 (GRCm38) |
missense |
probably benign |
0.03 |
|
R6806:Atp13a4
|
UTSW |
16 |
29,469,280 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7229:Atp13a4
|
UTSW |
16 |
29,420,905 (GRCm38) |
missense |
probably benign |
0.05 |
|
R7438:Atp13a4
|
UTSW |
16 |
29,441,196 (GRCm38) |
missense |
|
|
|
R7493:Atp13a4
|
UTSW |
16 |
29,471,956 (GRCm38) |
missense |
|
|
|
R7712:Atp13a4
|
UTSW |
16 |
29,459,487 (GRCm38) |
missense |
|
|
|
R7739:Atp13a4
|
UTSW |
16 |
29,456,601 (GRCm38) |
missense |
|
|
|
R7897:Atp13a4
|
UTSW |
16 |
29,396,466 (GRCm38) |
missense |
|
|
|
R7950:Atp13a4
|
UTSW |
16 |
29,449,917 (GRCm38) |
missense |
|
|
|
R8217:Atp13a4
|
UTSW |
16 |
29,403,801 (GRCm38) |
missense |
|
|
|
R8227:Atp13a4
|
UTSW |
16 |
29,403,845 (GRCm38) |
missense |
|
|
|
R8273:Atp13a4
|
UTSW |
16 |
29,471,902 (GRCm38) |
missense |
|
|
|
R8488:Atp13a4
|
UTSW |
16 |
29,417,836 (GRCm38) |
missense |
possibly damaging |
0.63 |
|
R8508:Atp13a4
|
UTSW |
16 |
29,454,769 (GRCm38) |
nonsense |
probably null |
|
|
R8773:Atp13a4
|
UTSW |
16 |
29,441,580 (GRCm38) |
missense |
|
|
|
R8921:Atp13a4
|
UTSW |
16 |
29,454,774 (GRCm38) |
missense |
|
|
|
R8940:Atp13a4
|
UTSW |
16 |
29,454,690 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9056:Atp13a4
|
UTSW |
16 |
29,471,888 (GRCm38) |
critical splice donor site |
probably null |
|
|
R9272:Atp13a4
|
UTSW |
16 |
29,449,979 (GRCm38) |
missense |
|
|
|
R9292:Atp13a4
|
UTSW |
16 |
29,422,682 (GRCm38) |
missense |
|
|
|
R9415:Atp13a4
|
UTSW |
16 |
29,409,003 (GRCm38) |
missense |
|
|
|
R9453:Atp13a4
|
UTSW |
16 |
29,420,841 (GRCm38) |
missense |
unknown |
|
|
R9497:Atp13a4
|
UTSW |
16 |
29,469,312 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R9541:Atp13a4
|
UTSW |
16 |
29,422,726 (GRCm38) |
missense |
|
|
|
R9614:Atp13a4
|
UTSW |
16 |
29,441,580 (GRCm38) |
missense |
|
|
|
R9622:Atp13a4
|
UTSW |
16 |
29,420,459 (GRCm38) |
missense |
|
|
|
R9727:Atp13a4
|
UTSW |
16 |
29,409,771 (GRCm38) |
missense |
|
|
|
Z1176:Atp13a4
|
UTSW |
16 |
29,422,587 (GRCm38) |
missense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GAGAAAGTTTGTTCCCAGTGAAATG -3'
(R):5'- TCCAGGGCTCCCTAAGTTTG -3'
Sequencing Primer
(F):5'- GTTTGTTCCCAGTGAAATGATTCC -3'
(R):5'- CTCCCTAAGTTTGGGATTGAAGC -3'
|
| Posted On |
2016-08-04 |
Incidental Mutation