Incidental Mutation 'R4778:Vmn1r41'
ID 426213
Institutional Source Beutler Lab
Gene Symbol Vmn1r41
Ensembl Gene ENSMUSG00000094586
Gene Name vomeronasal 1 receptor 41
Synonyms V1rb9
MMRRC Submission 042414-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R4778 (G1)
Quality Score 38
Status Validated
Chromosome 6
Chromosomal Location 89717870-89724396 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 89724257 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Threonine at position 266 (K266T)
Ref Sequence ENSEMBL: ENSMUSP00000154326 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000089417] [ENSMUST00000204949] [ENSMUST00000226337] [ENSMUST00000226562] [ENSMUST00000227039] [ENSMUST00000227630] [ENSMUST00000228068]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000089417
AA Change: K266T

PolyPhen 2 Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000100705
Gene: ENSMUSG00000094553
AA Change: K266T

DomainStartEndE-ValueType
Pfam:V1R 39 303 9.8e-139 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000204949
AA Change: K266T

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000145199
Gene: ENSMUSG00000094586
AA Change: K266T

DomainStartEndE-ValueType
Pfam:V1R 39 303 9.8e-139 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000226337
Predicted Effect probably benign
Transcript: ENSMUST00000226562
Predicted Effect unknown
Transcript: ENSMUST00000227039
AA Change: Q82H
Predicted Effect unknown
Transcript: ENSMUST00000227630
AA Change: Q82H
Predicted Effect probably damaging
Transcript: ENSMUST00000228068
AA Change: K266T

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency 98% (54/55)
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 T C 17: 46,615,342 (GRCm39) N1349S probably damaging Het
Ahnak T C 19: 8,989,339 (GRCm39) V3541A possibly damaging Het
Arhgap33 T A 7: 30,231,518 (GRCm39) T156S probably benign Het
Bltp1 T A 3: 36,991,214 (GRCm39) M897K possibly damaging Het
Card11 G T 5: 140,869,537 (GRCm39) probably null Het
Cdh3 T A 8: 107,270,458 (GRCm39) I445N probably damaging Het
Csrp3 T G 7: 48,482,311 (GRCm39) K169N probably damaging Het
Cyp2c69 T C 19: 39,866,038 (GRCm39) N185S probably benign Het
Czib T C 4: 107,749,195 (GRCm39) V64A probably damaging Het
Dpysl3 C T 18: 43,487,867 (GRCm39) V159I probably benign Het
Erc1 A T 6: 119,774,298 (GRCm39) probably null Het
Fat1 T C 8: 45,491,363 (GRCm39) V3808A probably benign Het
Fbxw19 T C 9: 109,323,714 (GRCm39) D87G probably damaging Het
Gm1123 T C 9: 98,900,560 (GRCm39) I99V probably benign Het
Gm11677 C T 11: 111,615,537 (GRCm39) noncoding transcript Het
Hand1 T C 11: 57,722,449 (GRCm39) D55G possibly damaging Het
Lrguk T A 6: 34,033,015 (GRCm39) I227K probably damaging Het
Mdn1 C T 4: 32,683,583 (GRCm39) R726* probably null Het
Minar1 T A 9: 89,485,155 (GRCm39) I81F probably damaging Het
Myo16 T A 8: 10,619,694 (GRCm39) V1415E probably damaging Het
Myof T C 19: 37,938,011 (GRCm39) D901G probably damaging Het
Naip1 A G 13: 100,563,156 (GRCm39) Y670H probably damaging Het
Nmd3 T A 3: 69,638,924 (GRCm39) Y171* probably null Het
Notch4 C T 17: 34,801,485 (GRCm39) A1111V possibly damaging Het
Nphp4 T A 4: 152,640,748 (GRCm39) D1038E probably benign Het
Or2ag1b A C 7: 106,288,874 (GRCm39) S21R probably damaging Het
Or5p60 A T 7: 107,723,687 (GRCm39) I261N possibly damaging Het
Osbpl10 C T 9: 114,938,598 (GRCm39) S86L probably damaging Het
Pcsk6 G A 7: 65,608,893 (GRCm39) G252R probably damaging Het
Pole T G 5: 110,478,698 (GRCm39) H15Q probably benign Het
Pstpip1 A G 9: 56,035,904 (GRCm39) D383G possibly damaging Het
Ptprq T C 10: 107,426,883 (GRCm39) T1551A probably benign Het
Rasgrf2 A G 13: 92,131,780 (GRCm39) F626L probably damaging Het
Retreg1 C A 15: 25,971,871 (GRCm39) N394K possibly damaging Het
Rpl7-ps8 T A 15: 59,083,252 (GRCm39) noncoding transcript Het
Rpp14 T A 14: 8,090,203 (GRCm38) D42E probably benign Het
Rrp8 T A 7: 105,386,481 (GRCm39) probably benign Het
Rufy4 T C 1: 74,186,822 (GRCm39) C537R probably damaging Het
Snx1 T C 9: 66,008,698 (GRCm39) probably benign Het
Stau1 A T 2: 166,805,442 (GRCm39) N51K probably benign Het
Tdrd5 T A 1: 156,083,157 (GRCm39) D960V probably damaging Het
Tex10 T C 4: 48,436,468 (GRCm39) D750G probably damaging Het
Tmem43 T C 6: 91,459,237 (GRCm39) V236A probably damaging Het
Tmem89 T C 9: 108,744,443 (GRCm39) V112A probably damaging Het
Traf7 C G 17: 24,729,412 (GRCm39) probably benign Het
Vmn2r65 T C 7: 84,592,801 (GRCm39) K469E possibly damaging Het
Zfp831 A G 2: 174,488,600 (GRCm39) T1092A possibly damaging Het
Zfp981 T A 4: 146,622,112 (GRCm39) S346T probably benign Het
Other mutations in Vmn1r41
AlleleSourceChrCoordTypePredicted EffectPPH Score
R6889:Vmn1r41 UTSW 6 89,724,352 (GRCm39) missense probably damaging 0.99
R6892:Vmn1r41 UTSW 6 89,724,163 (GRCm39) missense possibly damaging 0.50
R7221:Vmn1r41 UTSW 6 89,724,034 (GRCm39) missense probably benign 0.00
R7506:Vmn1r41 UTSW 6 89,724,159 (GRCm39) nonsense probably null
R9002:Vmn1r41 UTSW 6 89,724,109 (GRCm39) missense possibly damaging 0.91
R9080:Vmn1r41 UTSW 6 89,724,138 (GRCm39) missense unknown
R9276:Vmn1r41 UTSW 6 89,724,080 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTACATGGTGGCTCTCCTATG -3'
(R):5'- AATGTTCCCACATGCCATGAC -3'

Sequencing Primer
(F):5'- CTCCTATGGAGGCACAAGAAGC -3'
(R):5'- ATGACCCGTAGCTCTGATGG -3'
Posted On 2016-08-25