Incidental Mutation 'R5409:Or5ac16'
ID 426470
Institutional Source Beutler Lab
Gene Symbol Or5ac16
Ensembl Gene ENSMUSG00000052537
Gene Name olfactory receptor family 5 subfamily AC member 16
Synonyms MOR182-8, GA_x54KRFPKG5P-55416332-55415412, Olfr198
MMRRC Submission 042978-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.068) question?
Stock # R5409 (G1)
Quality Score 225
Status Not validated
Chromosome 16
Chromosomal Location 59021867-59022787 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 59021920 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 290 (Y290H)
Ref Sequence ENSEMBL: ENSMUSP00000146813 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064452] [ENSMUST00000208244]
AlphaFold Q7TS40
Predicted Effect probably damaging
Transcript: ENSMUST00000064452
AA Change: Y290H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000065535
Gene: ENSMUSG00000052537
AA Change: Y290H

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 4.9e-45 PFAM
Pfam:7tm_1 41 290 4.2e-19 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000208244
AA Change: Y290H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.8%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca7 T C 10: 79,850,154 (GRCm39) L2002P probably damaging Het
Acot11 C T 4: 106,617,327 (GRCm39) G240R probably damaging Het
Adgrl1 A G 8: 84,656,371 (GRCm39) T230A probably damaging Het
Anapc4 A G 5: 53,005,941 (GRCm39) E316G probably damaging Het
Asic1 GCACC GCACCACC 15: 99,596,684 (GRCm39) probably benign Het
Aurka T G 2: 172,209,036 (GRCm39) Q33P possibly damaging Het
Ccn5 G A 2: 163,667,158 (GRCm39) C53Y probably damaging Het
Cenpm T C 15: 82,118,564 (GRCm39) T153A probably benign Het
Clca4b T A 3: 144,622,452 (GRCm39) K538* probably null Het
Clip2 G A 5: 134,551,645 (GRCm39) T159M possibly damaging Het
Col5a1 C T 2: 27,850,457 (GRCm39) T518I unknown Het
Dis3 A T 14: 99,323,368 (GRCm39) M566K possibly damaging Het
Dnah1 C T 14: 30,985,212 (GRCm39) R3869H probably damaging Het
Gm4775 A T 14: 106,338,386 (GRCm39) noncoding transcript Het
Hipk2 C T 6: 38,706,977 (GRCm39) G637D probably damaging Het
Igkv4-61 T C 6: 69,394,111 (GRCm39) K18E possibly damaging Het
Kcnk4 A G 19: 6,903,578 (GRCm39) S324P probably benign Het
Larp4 T C 15: 99,883,945 (GRCm39) C61R probably damaging Het
Nid2 T C 14: 19,856,030 (GRCm39) F986L probably damaging Het
Or5aq1b T C 2: 86,902,214 (GRCm39) E88G possibly damaging Het
Or5h22 C T 16: 58,894,559 (GRCm39) V295I possibly damaging Het
Pgbd5 T A 8: 125,098,619 (GRCm39) I359F probably damaging Het
Plekhh2 T C 17: 84,893,906 (GRCm39) probably null Het
Pomgnt2 A T 9: 121,811,303 (GRCm39) S493T possibly damaging Het
Rnf7l A T 10: 63,257,403 (GRCm39) M39K possibly damaging Het
Rp1l1 T C 14: 64,268,070 (GRCm39) S1219P probably benign Het
Rprd1b T A 2: 157,916,987 (GRCm39) F322L probably damaging Het
Sh3rf1 G A 8: 61,827,279 (GRCm39) V678M probably benign Het
Smpd5 C A 15: 76,179,914 (GRCm39) T321K probably damaging Het
Spag8 T A 4: 43,653,134 (GRCm39) probably benign Het
Tanc2 T C 11: 105,758,311 (GRCm39) C691R possibly damaging Het
Tnc A C 4: 63,884,773 (GRCm39) M1834R probably damaging Het
Tnc A T 4: 63,925,654 (GRCm39) Y961N probably damaging Het
Ttn T C 2: 76,700,893 (GRCm39) probably benign Het
Ufl1 A G 4: 25,280,706 (GRCm39) V47A probably damaging Het
Unc13c T A 9: 73,485,672 (GRCm39) D1676V possibly damaging Het
Vmn1r65 T C 7: 6,012,012 (GRCm39) N74S possibly damaging Het
Vmn2r30 A G 7: 7,315,547 (GRCm39) F762S probably damaging Het
Other mutations in Or5ac16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01395:Or5ac16 APN 16 59,022,460 (GRCm39) missense possibly damaging 0.94
IGL03053:Or5ac16 APN 16 59,022,610 (GRCm39) missense probably damaging 1.00
IGL03168:Or5ac16 APN 16 59,022,610 (GRCm39) missense probably damaging 1.00
R1355:Or5ac16 UTSW 16 59,022,043 (GRCm39) missense probably damaging 1.00
R1370:Or5ac16 UTSW 16 59,022,043 (GRCm39) missense probably damaging 1.00
R1510:Or5ac16 UTSW 16 59,022,546 (GRCm39) missense probably damaging 0.99
R1777:Or5ac16 UTSW 16 59,022,379 (GRCm39) missense probably benign 0.35
R1962:Or5ac16 UTSW 16 59,022,271 (GRCm39) missense possibly damaging 0.88
R1964:Or5ac16 UTSW 16 59,022,271 (GRCm39) missense possibly damaging 0.88
R5642:Or5ac16 UTSW 16 59,022,369 (GRCm39) missense probably damaging 1.00
R5704:Or5ac16 UTSW 16 59,022,369 (GRCm39) missense probably damaging 1.00
R6323:Or5ac16 UTSW 16 59,022,645 (GRCm39) missense probably damaging 1.00
R6829:Or5ac16 UTSW 16 59,021,898 (GRCm39) missense probably damaging 1.00
R7315:Or5ac16 UTSW 16 59,022,496 (GRCm39) missense probably benign 0.00
R7738:Or5ac16 UTSW 16 59,022,318 (GRCm39) missense probably benign 0.00
R8540:Or5ac16 UTSW 16 59,022,323 (GRCm39) missense possibly damaging 0.56
R8815:Or5ac16 UTSW 16 59,022,264 (GRCm39) missense possibly damaging 0.78
R8844:Or5ac16 UTSW 16 59,021,929 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CATGACGAGATGCTCACTGC -3'
(R):5'- CCTTCTTGCCATCCTGAAAACAAAG -3'

Sequencing Primer
(F):5'- GAGATGCTCACTGCCTTCAACAG -3'
(R):5'- TTGCCATCCTGAAAACAAAGTCTGAG -3'
Posted On 2016-09-01