Mutagenetix > Incidental Mutation

Incidental Mutation 'R5421:Vmn2r110'

426596

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r110

Ensembl Gene

ENSMUSG00000091259

Gene Name

vomeronasal 2, receptor 110

Synonyms

EG224582

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.196) question?

Stock #

R5421 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

20573829-20596259 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 20583620 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Serine at position 231 (L231S)

Ref Sequence

ENSEMBL: ENSMUSP00000129347 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169559]

AlphaFold

E9PWD5

Predicted Effect

probably damaging
Transcript: ENSMUST00000169559
AA Change: L231S

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)

SMART Domains

Protein: ENSMUSP00000129347
Gene: ENSMUSG00000091259
AA Change: L231S

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	3.1e-33	PFAM
Pfam:NCD3G	510	563	5.2e-22	PFAM
Pfam:7tm_3	594	831	4.2e-51	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.1%
20x: 94.8%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adgrb1	A	T	15: 74,550,027	Q882L	probably damaging	Het
Afdn	T	C	17: 13,832,406	V525A	probably benign	Het
AI987944	T	C	7: 41,374,776	T263A	probably benign	Het
Aldh1l2	T	C	10: 83,527,407	S31G	probably damaging	Het
Asxl1	T	C	2: 153,399,584	S685P	probably benign	Het
BC005561	A	T	5: 104,518,395	N261I	probably benign	Het
Blnk	C	A	19: 40,968,523	V47F	probably damaging	Het
Bmp4	T	A	14: 46,385,898	M64L	probably damaging	Het
Bmpr2	T	A	1: 59,870,418	V1017E	possibly damaging	Het
C1ra	C	T	6: 124,522,790	P645L	probably benign	Het
Cadm2	A	T	16: 66,771,627	C248*	probably null	Het
Cd163l1	T	C	7: 140,223,900	L337P	probably damaging	Het
Cdk6	T	C	5: 3,473,120	V180A	probably damaging	Het
Colec12	A	T	18: 9,858,580	R454S	probably damaging	Het
Dennd3	T	C	15: 73,567,115	S1111P	probably benign	Het
Dmxl1	T	C	18: 49,863,119		probably null	Het
Dnah2	G	A	11: 69,435,636	T3613I	probably damaging	Het
Elp6	A	G	9: 110,314,064	Q115R	probably benign	Het
Enpp1	A	G	10: 24,669,757	Y262H	probably damaging	Het
Far2	A	G	6: 148,146,192		probably null	Het
Flnb	C	T	14: 7,926,494	T1846I	probably damaging	Het
Folr2	C	T	7: 101,840,644	R139H	probably benign	Het
Fxn	A	T	19: 24,277,285		probably null	Het
Galnt13	A	C	2: 54,857,896	N263T	probably damaging	Het
Gje1	G	A	10: 14,716,684	S118L	probably damaging	Het
Htr5a	G	T	5: 27,850,987	W325C	possibly damaging	Het
Itga4	T	A	2: 79,316,041	Y772*	probably null	Het
Kif12	T	C	4: 63,171,428	S59G	probably benign	Het
Kifc3	C	T	8: 95,109,845	R96Q	probably damaging	Het
Klrd1	T	C	6: 129,598,443	Y191H	probably damaging	Het
Ndst3	A	T	3: 123,634,359		probably null	Het
Nek1	A	C	8: 61,006,677	R6S	possibly damaging	Het
Olfr142	G	A	2: 90,252,745	T81I	probably benign	Het
Olfr421-ps1	C	T	1: 174,152,295	R260*	probably null	Het
Olfr493	G	C	7: 108,346,975	A2G	probably benign	Het
Palld	C	T	8: 61,516,550	E1005K	probably damaging	Het
Ppp2r1a	T	A	17: 20,956,706	Y169N	probably benign	Het
Rad50	T	C	11: 53,674,946	D960G	probably benign	Het
Rad51ap2	A	T	12: 11,459,367	K915*	probably null	Het
Rasal2	T	C	1: 157,299,141	K109R	probably benign	Het
Rc3h1	G	A	1: 160,951,830		probably null	Het
Rnf6	C	T	5: 146,210,529	V560I	probably benign	Het
Samd8	A	G	14: 21,792,495	D295G	probably damaging	Het
Serpinb2	T	C	1: 107,523,851	Y245H	probably damaging	Het
Sh3bp5	C	A	14: 31,377,495	R265L	probably benign	Het
Slc28a3	A	T	13: 58,574,265	F268L	possibly damaging	Het
Slc7a14	T	C	3: 31,224,197	T420A	probably damaging	Het
Speer4f2	A	T	5: 17,374,358	T52S	possibly damaging	Het
Spta1	A	G	1: 174,215,529	N1414D	probably damaging	Het
Sptbn5	A	G	2: 120,080,780		noncoding transcript	Het
Syt9	T	C	7: 107,425,356	V152A	probably benign	Het
Tln1	G	A	4: 43,533,609	A2315V	possibly damaging	Het
Tox	C	A	4: 6,842,409	M40I	possibly damaging	Het
Ucp1	G	A	8: 83,290,691	A37T	probably benign	Het
Vapa	A	G	17: 65,595,036	V33A	possibly damaging	Het
Vmn2r15	C	T	5: 109,286,535	A768T	probably damaging	Het
Vmn2r86	T	C	10: 130,446,936	T604A	probably benign	Het
Vps51	T	G	19: 6,071,033	E283D	probably benign	Het
Wnk1	A	G	6: 119,952,818	V1246A	probably damaging	Het
Wwc1	T	G	11: 35,876,063	D455A	possibly damaging	Het
Wwc1	C	T	11: 35,910,296	E105K	possibly damaging	Het
Zfp426	G	A	9: 20,470,719	A309V	probably damaging	Het
Zfp626	T	A	7: 27,817,910	N105K	probably damaging	Het

Other mutations in Vmn2r110

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01774:Vmn2r110	APN	17	20583627	missense	probably benign	0.01
IGL01824:Vmn2r110	APN	17	20574667	missense	probably benign	0.44
IGL01879:Vmn2r110	APN	17	20573860	missense	probably benign	0.01
IGL02168:Vmn2r110	APN	17	20583800	splice site	probably benign
IGL02178:Vmn2r110	APN	17	20584444	splice site	probably null
IGL02322:Vmn2r110	APN	17	20573935	missense	probably damaging	1.00
IGL02323:Vmn2r110	APN	17	20596137	missense	probably damaging	0.98
IGL02415:Vmn2r110	APN	17	20583771	missense	probably benign	0.03
IGL02491:Vmn2r110	APN	17	20596138	missense	probably damaging	0.99
IGL02876:Vmn2r110	APN	17	20574296	missense	probably damaging	0.98
IGL03141:Vmn2r110	APN	17	20583714	missense	possibly damaging	0.79
IGL03270:Vmn2r110	APN	17	20583516	missense	probably benign	0.00
IGL03286:Vmn2r110	APN	17	20584206	missense	possibly damaging	0.95
IGL03379:Vmn2r110	APN	17	20583644	missense	probably damaging	0.99
PIT4243001:Vmn2r110	UTSW	17	20582117	missense	probably benign	0.01
R0040:Vmn2r110	UTSW	17	20596084	missense	probably benign	0.10
R0195:Vmn2r110	UTSW	17	20574055	missense	probably benign	0.31
R0716:Vmn2r110	UTSW	17	20573903	missense	probably damaging	0.99
R1199:Vmn2r110	UTSW	17	20583263	missense	probably benign	0.03
R1767:Vmn2r110	UTSW	17	20580578	missense	possibly damaging	0.83
R2212:Vmn2r110	UTSW	17	20573947	splice site	probably null
R3056:Vmn2r110	UTSW	17	20583098	missense	probably damaging	1.00
R4093:Vmn2r110	UTSW	17	20583380	missense	possibly damaging	0.83
R4418:Vmn2r110	UTSW	17	20583689	nonsense	probably null
R4598:Vmn2r110	UTSW	17	20583767	nonsense	probably null
R4754:Vmn2r110	UTSW	17	20596196	missense	probably benign	0.00
R5283:Vmn2r110	UTSW	17	20580637	missense	probably benign	0.00
R5672:Vmn2r110	UTSW	17	20596232	missense	probably benign
R5865:Vmn2r110	UTSW	17	20584295	missense	probably benign	0.00
R6642:Vmn2r110	UTSW	17	20583517	missense	possibly damaging	0.94
R6799:Vmn2r110	UTSW	17	20583536	missense	probably benign
R7167:Vmn2r110	UTSW	17	20574179	missense	probably benign	0.01
R7291:Vmn2r110	UTSW	17	20574209	missense	probably benign	0.13
R7320:Vmn2r110	UTSW	17	20596054	missense	probably benign
R7519:Vmn2r110	UTSW	17	20584262	missense	probably benign
R8089:Vmn2r110	UTSW	17	20583545	missense	probably benign	0.00
R8234:Vmn2r110	UTSW	17	20584429	missense	probably benign	0.12
R8272:Vmn2r110	UTSW	17	20596228	missense	probably damaging	0.97
R8307:Vmn2r110	UTSW	17	20583057	missense	probably benign	0.00
R8506:Vmn2r110	UTSW	17	20584365	missense	probably benign	0.00
R8516:Vmn2r110	UTSW	17	20574613	missense	probably damaging	1.00
R8555:Vmn2r110	UTSW	17	20584356	missense	probably damaging	0.97
R8691:Vmn2r110	UTSW	17	20583142	missense	probably benign	0.19
R8859:Vmn2r110	UTSW	17	20574298	missense	probably damaging	0.99
R8935:Vmn2r110	UTSW	17	20583695	missense	probably benign	0.40
R8986:Vmn2r110	UTSW	17	20583561	missense	probably damaging	0.97
R9012:Vmn2r110	UTSW	17	20583365	missense	probably damaging	1.00
R9101:Vmn2r110	UTSW	17	20574209	missense
R9744:Vmn2r110	UTSW	17	20574586	missense	probably damaging	0.98
R9803:Vmn2r110	UTSW	17	20583468	missense	probably benign	0.00
Z1088:Vmn2r110	UTSW	17	20583680	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGCTGTCAACAATCTTTGCC -3'
(R):5'- TGCTTCAGGAATGGAATTTTGCATG -3'

Sequencing Primer
(F):5'- GCCCAATATTTCTCATTAGACCTGTG -3'
(R):5'- ACTTGGTCCAGCTTTCCTTTGG -3'

Posted On

2016-09-01