Incidental Mutation 'R5426:Olfr159'
ID 426866
Institutional Source Beutler Lab
Gene Symbol Olfr159
Ensembl Gene ENSMUSG00000044801
Gene Name olfactory receptor 159
Synonyms Olfr37e, mOR37e, MOR262-5, GA_x6K02T2N78B-16165641-16166600
MMRRC Submission 042992-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R5426 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 43770050-43771009 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43770168 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 281 (I281T)
Ref Sequence ENSEMBL: ENSMUSP00000060784 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053931]
AlphaFold Q9QZ19
Predicted Effect probably benign
Transcript: ENSMUST00000053931
AA Change: I281T

PolyPhen 2 Score 0.038 (Sensitivity: 0.94; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000060784
Gene: ENSMUSG00000044801
AA Change: I281T

Pfam:7tm_4 32 315 6.9e-60 PFAM
Pfam:7tm_1 42 297 2.4e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000120783
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.6%
Validation Efficiency 97% (85/88)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2010315B03Rik T A 9: 124,294,003 (GRCm38) H122L probably damaging Het
9330182O14Rik G A 15: 40,148,536 (GRCm38) M90I unknown Het
9330182O14Rik G A 15: 40,148,537 (GRCm38) D91N unknown Het
Abca13 T A 11: 9,290,722 (GRCm38) S862T probably damaging Het
Acyp2 C T 11: 30,506,354 (GRCm38) E98K possibly damaging Het
Adgb C A 10: 10,350,260 (GRCm38) A1405S probably benign Het
Adpgk T A 9: 59,297,549 (GRCm38) V86E probably damaging Het
Agfg2 G C 5: 137,667,758 (GRCm38) P80A probably damaging Het
Akap11 G A 14: 78,498,864 (GRCm38) Q1829* probably null Het
Aldh1l1 G A 6: 90,559,299 (GRCm38) R62Q probably benign Het
Als2cr12 T A 1: 58,666,886 (GRCm38) K275* probably null Het
Amd1 G T 10: 40,290,187 (GRCm38) D265E probably damaging Het
Aox4 A T 1: 58,220,094 (GRCm38) Q106L probably damaging Het
Arap2 A T 5: 62,642,816 (GRCm38) N1289K probably benign Het
Arhgef12 T C 9: 42,986,584 (GRCm38) S874G probably damaging Het
BC067074 G A 13: 113,369,053 (GRCm38) V2239I probably benign Het
C87499 T A 4: 88,629,410 (GRCm38) probably benign Het
Ccdc166 T C 15: 75,982,096 (GRCm38) Q45R possibly damaging Het
Cdc45 C T 16: 18,795,897 (GRCm38) R205H probably damaging Het
Cdk14 A G 5: 4,888,975 (GRCm38) S388P possibly damaging Het
Chgb A T 2: 132,793,533 (GRCm38) Q465L possibly damaging Het
Commd9 T A 2: 101,898,875 (GRCm38) W109R probably damaging Het
Cyp2b9 T C 7: 26,187,655 (GRCm38) V163A probably benign Het
Dcpp2 T A 17: 23,899,313 (GRCm38) H27Q possibly damaging Het
Ddn T A 15: 98,806,466 (GRCm38) E315V possibly damaging Het
Defb29 C A 2: 152,538,948 (GRCm38) C47F probably damaging Het
Dnah7b T C 1: 46,242,206 (GRCm38) M2809T possibly damaging Het
Dock4 A T 12: 40,745,745 (GRCm38) I854F probably damaging Het
Dsg4 T C 18: 20,458,484 (GRCm38) Y427H probably damaging Het
E130114P18Rik C T 4: 97,690,670 (GRCm38) A23T unknown Het
Gemin5 A G 11: 58,125,287 (GRCm38) S1297P probably benign Het
Gm10309 A C 17: 86,498,733 (GRCm38) probably benign Het
Gm884 A T 11: 103,620,760 (GRCm38) H127Q unknown Het
Gpatch11 T A 17: 78,841,234 (GRCm38) S155R possibly damaging Het
Grin2b C A 6: 135,732,368 (GRCm38) Q1393H probably damaging Het
Heatr5b C T 17: 78,773,713 (GRCm38) C1370Y probably damaging Het
Hmcn2 C T 2: 31,336,544 (GRCm38) T177I possibly damaging Het
Ildr1 A T 16: 36,709,619 (GRCm38) I123F probably damaging Het
Kalrn A T 16: 34,262,653 (GRCm38) V644D probably damaging Het
Kifap3 A G 1: 163,779,871 (GRCm38) M1V probably null Het
Klhl11 A G 11: 100,464,116 (GRCm38) L293P probably damaging Het
Klrc3 G A 6: 129,641,550 (GRCm38) S98L probably benign Het
Med12l G A 3: 59,248,722 (GRCm38) M1220I probably damaging Het
Ms4a7 C T 19: 11,325,802 (GRCm38) probably null Het
Mybpc2 A G 7: 44,509,829 (GRCm38) V599A probably benign Het
Naalad2 T C 9: 18,347,519 (GRCm38) N487D probably benign Het
Nat8f7 T G 6: 85,707,823 (GRCm38) S12R probably benign Het
Nefm T A 14: 68,120,066 (GRCm38) probably benign Het
Nlrp5 T C 7: 23,418,201 (GRCm38) V450A probably damaging Het
Nps G A 7: 135,268,647 (GRCm38) probably null Het
Olfr1247 T C 2: 89,609,739 (GRCm38) Y121C probably damaging Het
Olfr142 T A 2: 90,252,611 (GRCm38) K126* probably null Het
Olfr192 G T 16: 59,098,302 (GRCm38) P230Q possibly damaging Het
Olfr492 T C 7: 108,322,810 (GRCm38) N289D probably damaging Het
Olfr513 T C 7: 108,755,717 (GRCm38) L287P possibly damaging Het
Olfr698 C A 7: 106,752,566 (GRCm38) S274I probably benign Het
Oxct2a C A 4: 123,322,713 (GRCm38) G292W possibly damaging Het
Prr27 T C 5: 87,850,885 (GRCm38) probably benign Het
Ptx3 T C 3: 66,220,722 (GRCm38) M68T probably damaging Het
Rufy1 A G 11: 50,421,734 (GRCm38) L131S probably damaging Het
Sept7 T A 9: 25,286,690 (GRCm38) I100N possibly damaging Het
Sgms2 T C 3: 131,341,797 (GRCm38) I143V probably benign Het
Slc25a34 A G 4: 141,623,566 (GRCm38) V44A probably damaging Het
Slc28a3 T A 13: 58,563,154 (GRCm38) D518V probably damaging Het
Slc6a7 C T 18: 61,003,236 (GRCm38) probably null Het
Slco4a1 C A 2: 180,471,235 (GRCm38) A420D possibly damaging Het
Smap1 T C 1: 23,849,390 (GRCm38) T180A probably benign Het
Specc1l T C 10: 75,267,550 (GRCm38) S920P probably benign Het
Tgtp2 A G 11: 49,059,256 (GRCm38) M163T probably benign Het
Tiam1 G T 16: 89,865,392 (GRCm38) Q613K possibly damaging Het
Vsig10l T A 7: 43,464,823 (GRCm38) S190T probably damaging Het
Vwa3b A G 1: 37,115,671 (GRCm38) Y512C probably damaging Het
Wdfy3 T A 5: 101,919,446 (GRCm38) N1207Y probably damaging Het
Wdr17 C T 8: 54,681,399 (GRCm38) G349R probably damaging Het
Wdr70 A G 15: 7,922,105 (GRCm38) L417S possibly damaging Het
Wdr81 A C 11: 75,450,896 (GRCm38) S1182A possibly damaging Het
Zfp458 A T 13: 67,257,192 (GRCm38) C391* probably null Het
Zfp638 A G 6: 83,976,414 (GRCm38) E1167G probably damaging Het
Zfp763 T A 17: 33,019,595 (GRCm38) D192V probably benign Het
Zfp853 T G 5: 143,288,869 (GRCm38) Q332P unknown Het
Other mutations in Olfr159
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01401:Olfr159 APN 4 43,770,112 (GRCm38) missense probably damaging 1.00
IGL02701:Olfr159 APN 4 43,770,366 (GRCm38) missense probably benign 0.31
IGL02839:Olfr159 APN 4 43,770,943 (GRCm38) nonsense probably null
IGL02956:Olfr159 APN 4 43,770,399 (GRCm38) missense probably benign 0.15
IGL03058:Olfr159 APN 4 43,770,255 (GRCm38) missense probably damaging 1.00
R1164:Olfr159 UTSW 4 43,770,991 (GRCm38) missense probably benign 0.03
R1796:Olfr159 UTSW 4 43,770,495 (GRCm38) missense possibly damaging 0.90
R1812:Olfr159 UTSW 4 43,770,230 (GRCm38) nonsense probably null
R4906:Olfr159 UTSW 4 43,770,476 (GRCm38) missense possibly damaging 0.76
R5684:Olfr159 UTSW 4 43,770,624 (GRCm38) missense probably benign 0.03
R6002:Olfr159 UTSW 4 43,770,063 (GRCm38) missense probably benign
R7174:Olfr159 UTSW 4 43,770,691 (GRCm38) missense not run
R7431:Olfr159 UTSW 4 43,770,882 (GRCm38) missense probably damaging 1.00
R8423:Olfr159 UTSW 4 43,770,598 (GRCm38) missense possibly damaging 0.65
R8770:Olfr159 UTSW 4 43,770,813 (GRCm38) missense probably damaging 1.00
R8789:Olfr159 UTSW 4 43,770,793 (GRCm38) missense probably damaging 0.96
R8989:Olfr159 UTSW 4 43,770,346 (GRCm38) missense possibly damaging 0.76
R9616:Olfr159 UTSW 4 43,770,193 (GRCm38) nonsense probably null
Z1176:Olfr159 UTSW 4 43,770,267 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2016-09-01