Incidental Mutation 'R5429:Zfp998'
ID 427086
Institutional Source Beutler Lab
Gene Symbol Zfp998
Ensembl Gene ENSMUSG00000074832
Gene Name zinc finger protein 998
Synonyms Gt(Ayu21)35Imeg, Gt(pU21)35Imeg, 2410141K09Rik, Snerv1
MMRRC Submission 042995-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # R5429 (G1)
Quality Score 103
Status Not validated
Chromosome 13
Chromosomal Location 66566173-66589179 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 66579887 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Proline to Serine at position 199 (P199S)
Ref Sequence ENSEMBL: ENSMUSP00000134352 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091541] [ENSMUST00000172579] [ENSMUST00000173583]
AlphaFold K7N769
Predicted Effect probably benign
Transcript: ENSMUST00000091541
SMART Domains Protein: ENSMUSP00000089126
Gene: ENSMUSG00000074832

DomainStartEndE-ValueType
KRAB 4 66 6.16e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000172579
AA Change: P199S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000134352
Gene: ENSMUSG00000074832
AA Change: P199S

DomainStartEndE-ValueType
KRAB 4 66 3.3e-15 SMART
ZnF_C2H2 75 97 1.72e-4 SMART
ZnF_C2H2 103 125 1.06e-4 SMART
ZnF_C2H2 131 153 5.81e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000173583
SMART Domains Protein: ENSMUSP00000134048
Gene: ENSMUSG00000074832

DomainStartEndE-ValueType
KRAB 4 66 6.16e-15 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000225647
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap13 T G 7: 75,252,652 (GRCm39) S261A possibly damaging Het
Ankrd34a G A 3: 96,504,837 (GRCm39) G14R probably damaging Het
Auts2 G A 5: 131,501,173 (GRCm39) T289M probably damaging Het
Btaf1 G A 19: 36,972,257 (GRCm39) V1331I possibly damaging Het
Ciz1 T A 2: 32,266,055 (GRCm39) I609K possibly damaging Het
Clca3b C T 3: 144,552,220 (GRCm39) V154I probably damaging Het
Csde1 A G 3: 102,960,157 (GRCm39) T564A possibly damaging Het
Csrnp2 A G 15: 100,379,935 (GRCm39) V452A probably benign Het
Ctnnd1 C T 2: 84,447,133 (GRCm39) V371M probably damaging Het
Dock6 T C 9: 21,744,177 (GRCm39) D677G probably damaging Het
Filip1l A T 16: 57,390,618 (GRCm39) E402V probably damaging Het
Gad1-ps G A 10: 99,281,009 (GRCm39) noncoding transcript Het
Ghr G A 15: 3,418,157 (GRCm39) Q37* probably null Het
Gm10770 C T 2: 150,021,343 (GRCm39) R58H probably benign Het
Gm12789 T C 4: 101,847,158 (GRCm39) Y148H possibly damaging Het
Herc4 T A 10: 63,110,792 (GRCm39) N234K probably benign Het
Itih3 A G 14: 30,645,478 (GRCm39) V10A probably benign Het
Kat14 T A 2: 144,235,243 (GRCm39) D234E probably benign Het
Kif13a A G 13: 46,926,245 (GRCm39) probably null Het
Kif2b A G 11: 91,468,055 (GRCm39) V76A probably benign Het
Mboat1 A G 13: 30,403,650 (GRCm39) T150A probably benign Het
Mfsd1 T A 3: 67,507,293 (GRCm39) L398H probably damaging Het
Myt1l G A 12: 29,882,331 (GRCm39) G509R unknown Het
Nfx1 T C 4: 41,004,343 (GRCm39) C705R probably damaging Het
Or13a27 A G 7: 139,925,186 (GRCm39) F239L possibly damaging Het
Or2ak5 T A 11: 58,611,350 (GRCm39) N175Y probably damaging Het
Pcdh10 T C 3: 45,338,635 (GRCm39) S931P probably benign Het
Pdpk1 T C 17: 24,310,534 (GRCm39) E205G probably benign Het
Ppp2r2a A T 14: 67,261,205 (GRCm39) F172I probably damaging Het
Ppp2r5e T A 12: 75,500,537 (GRCm39) D452V probably damaging Het
Rims2 A T 15: 39,208,751 (GRCm39) T185S probably damaging Het
Rpusd4 T C 9: 35,183,898 (GRCm39) V209A probably benign Het
Safb T C 17: 56,895,822 (GRCm39) V20A probably benign Het
Scaf8 C A 17: 3,247,385 (GRCm39) P903T probably benign Het
Slc30a7 A G 3: 115,800,574 (GRCm39) S31P possibly damaging Het
Slc9b1 T C 3: 135,079,024 (GRCm39) probably null Het
Sntb1 C G 15: 55,506,191 (GRCm39) G461R probably damaging Het
Tbc1d32 T C 10: 55,904,089 (GRCm39) D1226G probably damaging Het
Tlnrd1 G T 7: 83,531,522 (GRCm39) T303N probably damaging Het
Tmc1 G T 19: 20,766,986 (GRCm39) N738K possibly damaging Het
Tmem41a A G 16: 21,753,606 (GRCm39) I255T probably benign Het
Trim7 G A 11: 48,740,782 (GRCm39) C293Y probably damaging Het
Trpc6 C T 9: 8,634,075 (GRCm39) Q385* probably null Het
Ttc39b A G 4: 83,162,190 (GRCm39) I330T possibly damaging Het
Vil1 C T 1: 74,471,490 (GRCm39) T757I probably benign Het
Zfp462 T C 4: 55,060,077 (GRCm39) V1201A probably damaging Het
Zfp473 T A 7: 44,382,272 (GRCm39) E686V possibly damaging Het
Other mutations in Zfp998
AlleleSourceChrCoordTypePredicted EffectPPH Score
R2698:Zfp998 UTSW 13 66,581,495 (GRCm39) missense probably damaging 0.99
R2881:Zfp998 UTSW 13 66,579,329 (GRCm39) missense probably damaging 1.00
R5217:Zfp998 UTSW 13 66,581,787 (GRCm39) missense probably damaging 1.00
R5401:Zfp998 UTSW 13 66,579,722 (GRCm39) missense probably benign 0.01
R5532:Zfp998 UTSW 13 66,579,740 (GRCm39) missense probably damaging 1.00
R5626:Zfp998 UTSW 13 66,580,040 (GRCm39) missense probably benign 0.00
R5686:Zfp998 UTSW 13 66,579,722 (GRCm39) missense probably benign 0.01
R6151:Zfp998 UTSW 13 66,579,740 (GRCm39) missense probably damaging 1.00
R6173:Zfp998 UTSW 13 66,579,608 (GRCm39) missense probably benign 0.00
R6857:Zfp998 UTSW 13 66,580,161 (GRCm39) missense probably benign
R7405:Zfp998 UTSW 13 66,579,118 (GRCm39) missense unknown
R7737:Zfp998 UTSW 13 66,581,738 (GRCm39) critical splice donor site probably null
R8482:Zfp998 UTSW 13 66,579,797 (GRCm39) intron probably benign
R9260:Zfp998 UTSW 13 66,579,375 (GRCm39) missense unknown
Z1088:Zfp998 UTSW 13 66,579,800 (GRCm39) missense probably benign 0.00
Z1088:Zfp998 UTSW 13 66,579,245 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCACTGTGACCGGAAAAGGC -3'
(R):5'- AAGACCTGCTCATCTCCAAAGA -3'

Sequencing Primer
(F):5'- CTGTGACCGGAAAAGGCTTTACC -3'
(R):5'- GTAGTAAAGCCTTTTCCTGTCACAG -3'
Posted On 2016-09-01